Cognitive Improvements After Intermittent Deep Brain Stimulation of the Nucleus Basalis of Meynert in a Transgenic Rat Model for Alzheimer's Disease: A Preliminary Approach

Philippos Koulousakis*, Daniel van den Hove, Veerle Visser-Vandewalle, Thibaut Sesia

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Web of Science)

Abstract

Deep brain stimulation (DBS) of the nucleus basalis of Meynert (NBM) has been shown to exert promising therapeutical effects in a pilot study with patients suffering from Alzheimer's disease (AD). We aimed at comparing the cognitive effects of intermittent and continuous NBM stimulation paradigms in an animal model for AD. In this exploratory study, aged Tgf344-AD rats were behaviorally tested pre-, and post implantation, while being stimulated with unilateral- or bilateral-intermittent and bilateral-continuous patterns. Bilateral-intermittent NBM DBS lead to supernormal performance in a spatial memory task. These findings suggest that NBM DBS could be further refined, thereby improving patient care.

Original languageEnglish
Pages (from-to)461-466
Number of pages6
JournalJournal of Alzheimer's Disease
Volume73
Issue number2
DOIs
Publication statusPublished - 2020

Keywords

  • Alzheimer's disease
  • deep brain stimulation
  • intermittent stimulation
  • nucleus basalis of Meynert
  • NEURONS
  • BETA

Cite this