The Molecular Biology of Phosphodiesterase 4 Enzymes as Pharmacological Targets: An Interplay of Isoforms, Conformational States, and Inhibitors

D. Paes, M. Schepers, B. Rombaut, D. van den Hove, T. Vanmierlo, J. Prickaerts*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

1 Citation (Web of Science)
Original languageEnglish
Pages (from-to)1016-1049
Number of pages34
JournalPharmacological Reviews
Volume73
Issue number3
DOIs
Publication statusPublished - 2021

Keywords

  • CAMP-SPECIFIC PHOSPHODIESTERASE
  • AMP-SPECIFIC PHOSPHODIESTERASE
  • AFFINITY ROLIPRAM BINDING
  • CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES
  • N-TERMINAL REGION
  • 4-(3-CYCLOPENTYLOXY-4-METHOXYPHENYL)-2-PYRROLIDONE ZK 62711
  • SIGNALING SCAFFOLD PROTEINS
  • AREA POSTREMA NEURONS
  • PDE4 INHIBITORS
  • SPLICE VARIANTS

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