Research output per year
Research output per year
- 46 results
Search results
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2024
NKG2A genetic deletion promotes human primary NK cell anti-tumor responses better than an anti-NKG2A monoclonal antibody
Gong, Y., Germeraad, W. T. V., Zhang, X., Wu, N., Li, B., Janssen, L., He, Z., Gijbels, M. J. J., Wu, B., Gijsbers, B. L. M. G., Olieslagers, T. I., Bos, G. M. J., Zheng, L. & Klein Wolterink, R. G. J., 7 Aug 2024, In: Molecular Therapy. 32, 8, p. 2711-2727 17 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
2023
Low Levels of Serum and Intracellular Vitamin C in Hospitalized COVID-19 Patients
Boerenkamp, L. S., Gijsbers, B. L. M. G., Ververs, E.-J., Pijpers, E. M. S., Spaetgens, B., de Coninck, A., Germeraad, W. T. V., Wodzig, W. K. W. H., Wieten, L., van Gorkom, G. N. Y. & van Elssen, C. H. M. J., 1 Aug 2023, In: Nutrients. 15, 16, 14 p., 3653.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Stressed neuronal cells can recover from profound membrane blebbing, nuclear condensation and mitochondrial fragmentation, but not from cytochrome c release
You, W., Zhou, T., Knoops, K., Berendschot, T. T. J. M., van Zandvoort, M. A. M. J., Germeraad, W. T. V., Benedikter, B., Webers, C. A. B., Reutelingsperger, C. P. M. & Gorgels, T. G. M. F., 8 Jul 2023, In: Scientific Reports. 13, 1, 16 p., 11045.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Tumor cell-induced macrophage senescence plays a pivotal role in tumor initiation followed by stable growth in immunocompetent condition
Wada, H., Otsuka, R., Germeraad, W. T. V., Murata, T., Kondo, T. & Seino, K.-I., 13 Nov 2023, In: Journal for ImmunoTherapy of Cancer. 11, 11, 13 p., e006677.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
2021
Chimeric antigen receptor natural killer (CAR-NK) cell design and engineering for cancer therapy
Gong, Y., Wolterink, R. G. J. K., Wang, J. X., Bos, G. M. J. & Germeraad, W. T. V., 1 May 2021, In: Journal of Hematology & Oncology. 14, 1, 35 p., 73.Research output: Contribution to journal › (Systematic) Review article › peer-review
Open Access -
Defucosylation of Tumor-Specific Humanized Anti-MUC1 Monoclonal Antibody Enhances NK Cell-Mediated Anti-Tumor Cell Cytotoxicity
Gong, Y., Klein Wolterink, R. G. J., Gulaia, V., Cloosen, S., Ehlers, F. A. I., Wieten, L., Graus, Y. F., Bos, G. M. J. & Germeraad, W. T. V., Jun 2021, In: Cancers. 13, 11, 19 p., 2579.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
2020
Rosuvastatin Enhances VSV-G Lentiviral Transduction of NK Cells via Upregulation of the Low-Density Lipoprotein Receptor
Gong, Y., Wolterink, R. G. J. K., Janssen, I., Groot, A. J., Bos, G. M. J. & Germeraad, W. T. V., 12 Jun 2020, In: Molecular Therapy - Methods and Clinical Development. 17, p. 634-646 13 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
2018
Influence of Vitamin C on Lymphocytes: An Overview
van Gorkom, G. N. Y., Wolterink, R. G. J. K., Van Elssen, C. H. M. J., Wieten, L., Germeraad, W. T. V. & Bos, G. M. J., 10 Mar 2018, In: Antioxidants. 7, 3, 14 p., 41.Research output: Contribution to journal › (Systematic) Review article › peer-review
Open Access -
Pathogen recognition by NK cells amplifies the pro-inflammatory cytokine production of monocyte-derived DC via IFN-γ
Oth, T., Habets, T. H. P. M., Germeraad, W. T. V., Zonneveld, M. I., Bos, G. M. J. & Vanderlocht, J., 13 Feb 2018, In: BMC IMMUNOLOGY. 19, 1, 13 p., 8.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
The immunocytokine L19-IL2: An interplay between radiotherapy and long-lasting systemic anti-tumour immune responses
Rekers, N. H., Pimentel, V. O., Yaromina, A., Lieuwes, N. G., Biemans, R., Zegers, C. M. L., Germeraad, W. T. V., Van Limbergen, E. J., Neri, D., Dubois, L. J. & Lambin, P., 1 Jan 2018, In: OncoImmunology . 7, 4, 15 p., e1414119.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile12 Downloads (Pure) -
2016
Ascorbic acid serum levels are reduced in patients with hematological malignancies
Huijskens, M., Wodzig, W., Walczak, M., Germeraad, W. & Bos, G., 2016, In: Results in Immunology. 6, p. 8-10Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Fractionated Radiotherapy with 3 x 8 Gy Induces Systemic Anti-Tumour Responses and Abscopal Tumour Inhibition without Modulating the Humoral Anti-Tumour Response
Habets, T. H. P. M., Oth, T., Houben, A., Huijskens, M. J. A. J., Senden-Gijsbers, B. L. M. G., Schnijderberg, M. C. A., Brans, B., Dubois, L. J., Lambin, P., De Saint-Hubert, M., Germeraad, W. T. V., Tilanus, M. G. J., Mottaghy, F. M., Bos, G. & Vanderlocht, J., 18 Jul 2016, In: PLOS ONE. 11, 7, e0159515.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Pathogen-Associated Molecular Patterns Induced Crosstalk between Dendritic Cells, T Helper Cells, and Natural Killer Helper Cells Can Improve Dendritic Cell Vaccination
Oth, T., Vanderlocht, J., van Elssen, J., Bos, G. & Germeraad, W. T. V., 2016, In: Mediators of Inflammation. 2016, 12 p., 5740373.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
2015
An acute intake of plant stanol esters alters immune-related pathways in the jejunum of healthy volunteers
De Smet, E., Mensink, R. P., Boekschoten, M. V., de Ridder, R., Germeraad, W. T. V., Wolfs, T. G. A. M. & Plat, J., 14 Mar 2015, In: British Journal of Nutrition. 113, 5, p. 794-802Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Ascorbic acid promotes proliferation of natural killer cell populations in culture systems applicable for natural killer cell therapy
Huijskens, M. J. A. J., Walczak, M., Sarkar, S., Atrafi, F., Senden-Gijsbers, B. L. M. G., Tilanus, M. G. J., Bos, G. M. J., Wieten, L. & Germeraad, W. T. V., May 2015, In: Cytotherapy. 17, 5, p. 613-620Research output: Contribution to journal › Article › Academic › peer-review
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Combination of radiotherapy with the immunocytokine L19-IL2: Additive effect in a NK cell dependent tumour model
Rekers, N. H., Zegers, C. M. L., Yaromina, A., Lieuwes, N. G., Biemans, R., Senden-Gijsbers, B. L. M. G., Losen, M., Van Limbergen, E. J., Germeraad, W. T. V., Neri, D., Dubois, L. & Lambin, P., Sept 2015, In: Radiotherapy and Oncology. 116, 3, p. 438-442Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Heat-Transfer-Method-Based Cell Culture Quality Assay through Cell Detection by Surface Imprinted Polymers
Eersels, K., van Grinsven, B., Khorshid, M., Somers, V., Puttmann, C., Stein, C., Barth, S., Dilien, H., Bos, G. M. J., Germeraad, W. T. V., Cleij, T. J., Thoelen, R., De Ceuninck, W. & Wagner, P., 17 Feb 2015, In: Langmuir. 31, 6, p. 2043-2050Research output: Contribution to journal › Article › Academic › peer-review
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Improving the sensitivity of the heat-transfer method (HTM) for cancer cell detection with optimized sensor chips
Eersels, K., van Grinsven, B., Vandenryt, T., Jimenez-Monroy, K. L., Peeters, M., Somers, V., Puettmann, C., Stein, C., Barth, S., Bos, G. M. J., Germeraad, W. T. V., Dilien, H., Cleij, T. J., Thoelen, R., De Ceuninck, W. & Wagner, P., Jun 2015, In: Physica Status Solidi A-applications and Materials Science. 212, 6, p. 1320-1326Research output: Contribution to journal › Article › Academic › peer-review
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Induced Developmental Arrest of Early Hematopoietic Progenitors Leads to the Generation of Leukocyte Stem Cells
Ikawa, T., Masuda, K., Huijskens, M. J. A. J., Satoh, R., Kakugawa, K., Agata, Y., Miyai, T., Germeraad, W. T. V., Katsura, Y. & Kawamoto, H., 10 Nov 2015, In: Stem Cell Reports. 5, 5, p. 716-727Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Long-lasting antitumor effects provided by radiotherapy combined with the immunocytokine L19-IL2
Rekers, N. H., Zegers, C. M. L., Germeraad, W. T., Dubois, L. & Lambin, P., Aug 2015, In: OncoImmunology . 4, 8, e1021541.Research output: Contribution to journal › Editorial › Academic › peer-review
Open Access -
Multipotent adult progenitor cells for hypoxic-ischemic injury in the preterm brain
Jellema, R. K., Ophelders, D. R. M. G., Zwanenburg, A., Nikiforou, M., Delhaas, T., Andriessen, P., Mays, R. W., Deans, R., Germeraad, W. T. V., Wolfs, T. G. A. M. & Kramer, B. W., 23 Dec 2015, In: Journal of Neuroinflammation. 12, 1, p. 241Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Optimal selection of natural killer cells to kill myeloma: the role of HLA-E and NKG2A
Sarkar, S., van Gelder, M., Noort, W., Xu, Y., Rouschop, K. M. A., Groen, R., Schouten, H. C., Tilanus, M. G. J., Germeraad, W. T. V., Martens, A. C. M., Bos, G. M. J. & Wieten, L., Aug 2015, In: Cancer Immunology Immunotherapy. 64, 8, p. 951-963Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Potency of Both Human Th1 and NK Helper Cell Activation is Determined by IL-12p70-Producing PAMP-Matured DCs
Oth, T., Van Elssen, C. H. M. J., Schnijderberg, M. C. A., Senden-Gijsbers, B. L. M. G., Germeraad, W. T. V., Bos, G. M. J. & Vanderlocht, J., 1 Sept 2015, In: Journal of Interferon and Cytokine Research. 35, 9, p. 748-758Research output: Contribution to journal › Article › Academic › peer-review
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Prophylactic Interleukin-2 Treatment Prevents Fetal Gut Inflammation and Injury in an Ovine Model of Chorioamnionitis
Nikiforou, M., Vanderlocht, J., Chougnet, C. A., Jellema, R. K., Ophelders, D. R. M. G., Joosten, M., Kloosterboer, N., Senden-Gijsbers, B. L. M. G., Germeraad, W. T. V., Kramer, B. W. & Wolfs, T. G. A. M., Sept 2015, In: Inflammatory Bowel Diseases. 21, 9, p. 2026-2038Research output: Contribution to journal › Article › Academic › peer-review
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Radiotherapy Combined with the Immunocytokine L19-IL2 Provides Long-lasting Antitumor Effects
Zegers, C. M. L., Rekers, N. H., Quaden, D. H. F., Lieuwes, N. G., Yaromina, A., Germeraad, W. T. V., Wieten, L., Biessen, E. A. L., Boon, L., Neri, D., Troost, E. G. C., Dubois, L. J. & Lambin, P., Mar 2015, In: Clinical Cancer Research. 21, 5, p. 1151-1160Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile74 Downloads (Pure) -
2014
Five decades of Dutch immunology
Germeraad, W. T. V., de Jong, E. C. & Trouw, L. A., Dec 2014, In: Immunology Letters. 162, 2, p. 83-84Research output: Contribution to journal › Article › Academic › peer-review
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Heat-Transfer Resistance Measurement Method (HTM)-Based Cell Detection at Trace Levels Using a Progressive Enrichment Approach with Highly Selective Cell-Binding Surface Imprints
Bers, K., Eersels, K., van Grinsven, B., Daemen, M., Bogie, J. F. J., Hendriks, J. J. A., Bouwmans, E. E., Puettmann, C., Stein, C., Barth, S., Bos, G. M. J., Germeraad, W. T. V., De Ceuninck, W. & Wagner, P., 1 Apr 2014, In: Langmuir. 30, 12, p. 3631-3639Research output: Contribution to journal › Article › Academic › peer-review
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Monitoring the Initiation and Kinetics of Human Dendritic Cell-Induced Polarization of Autologous Naive CD4(+) T Cells
Oth, T., Schnijderberg, M. C. A., Senden-Gijsbers, B. L. M. G., Germeraad, W. T. V., Bos, G. M. J. & Vanderlocht, J., 21 Aug 2014, In: PLOS ONE. 9, 8Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Natural Killer Cells: The Secret Weapon in Dendritic Cell Vaccination Strategies
Van Elssen, C. H. M. J., Oth, T., Germeraad, W. T. V., Bos, G. M. J. & Vanderlocht, J., 1 Mar 2014, In: Clinical Cancer Research. 20, 5, p. 1095-1103Research output: Contribution to journal › Article › Academic › peer-review
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Stereotactic ablative body radiotherapy combined with immunotherapy: Present status and future perspectives
Rekers, N. H., Troost, E. G. C., Zegers, C. M. L., Germeraad, W. T. V., Dubois, L. J. & Lambin, P., Oct 2014, In: Cancer Radiotherapie. 18, 5-6, p. 391-395Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile91 Downloads (Pure) -
Technical Advance: Ascorbic acid induces development of double-positive T cells from human hematopoietic stem cells in the absence of stromal cells
Huijskens, M. J. A. J., Walczak, M., Koller, N., Briede, J. J., Senden-Gijsbers, B. L. M. G., Schnijderberg, M. C., Bos, G. M. J. & Germeraad, W. T. V., Dec 2014, In: Journal of Leukocyte Biology. 96, 6, p. 1165-1175Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
2013
Cerebral inflammation and mobilization of the peripheral immune system following global hypoxia-ischemia in preterm sheep
Jellema, R. K., Passos, V. L., Zwanenburg, A., Ophelders, D. R. M. G., De Munter, S., Vanderlocht, J., Germeraad, W. T. V., Kuypers, E., Collins, J. J. P., Cleutjens, J. P. M., Jennekens, W., Gavilanes, A. W. D., Seehase, M., Vles, H. J., Steinbusch, H., Andriessen, P., Wolfs, T. G. A. M. & Kramer, B. W., 24 Jan 2013, In: Journal of Neuroinflammation. 10, 13.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Hypoxia Induced Impairment of NK Cell Cytotoxicity against Multiple Myeloma Can Be Overcome by IL-2 Activation of the NK Cells
Sarkar, S., Germeraad, W. T. V., Rouschop, K. M. A., Steeghs, E. M. P., van Gelder, M., Bos, G. M. J. & Wieten, L., 28 May 2013, In: PLOS ONE. 8, 5, e64835.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Mesenchymal Stem Cells Induce T-Cell Tolerance and Protect the Preterm Brain after Global Hypoxia-Ischemia
Jellema, R. K., Wolfs, T. G. A. M., Passos, V. L., Zwanenburg, A., Ophelders, D. R. M. G., Kuypers, E., Hopman, A. H. N., Dudink, J., Steinbusch, H. W., Andriessen, P., Germeraad, W. T. V., Vanderlocht, J. & Kramer, B. W., 26 Aug 2013, In: PLOS ONE. 8, 8, e73031.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Systemic G-CSF attenuates cerebral inflammation and hypomyelination but does not reduce seizure burden in preterm sheep exposed to global hypoxia-ischemia
Jellema, R. K., Passos, V. L., Ophelders, D. R. M. G., Wolfs, T. G. A. M., Zwanenburg, A., De Munter, S., Nikiforou, M., Collins, J. J. P., Kuypers, E., Bos, G. M. J., Steinbusch, H. W., Vanderlocht, J., Andriessen, P., Germeraad, W. T. V. & Kramer, B. W., Dec 2013, In: Experimental Neurology. 250, p. 293-303Research output: Contribution to journal › Article › Academic › peer-review
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2012
Ovine Fetal Thymus Response to Lipopolysaccharide-Induced Chorioamnionitis and Antenatal Corticosteroids
Kuypers, E., Collins, J. J. P., Jellema, R. K., Wolfs, T. G. A. M., Kemp, M. W., Nitsos, I., Pillow, J. J., Polglase, G. R., Newnham, J. P., Germeraad, W. T. V., Kallapur, S. G., Jobe, A. H. & Kramer, B. W., 31 May 2012, In: PLOS ONE. 7, 5, e38257.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Phage display generation of a novel human anti-CD1A monoclonal antibody with potent cytolytic activity
Bechan, G. I., Lee, D. W., Zajonc, D. M., Heckel, D., Xian, R., Throsby, M., van Meijer, M., Germeraad, W. T. V., Kruisbeek, A. M., Egeler, R. M. & Arceci, R. J., Nov 2012, In: British Journal of Haematology. 159, 3, p. 299-310Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
2011
Flow cytometry-based assay to evaluate human serum MUC1-Tn antibodies
Van Elssen, C., Clausen, H., Germeraad, W. T. V., Bennet, E. P., Menheere, P. P. C. A., Bos, G. M. J. & Vanderlocht, J., 28 Feb 2011, In: Journal of Immunological Methods. 365, 1-2, p. 87-94 8 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Inflammation restraining effects of prostaglandin E2 on natural killer-dendritic cell (NK-DC) interaction are imprinted during DC maturation
Van Elssen, C. H. M. J., Vanderlocht, J., Oth, T., Senden-Gijsbers, B. L. M. G., Germeraad, W. T. V. & Bos, G. M. J., 1 Sept 2011, In: Blood. 118, 9, p. 2473-2482Research output: Contribution to journal › Article › Academic › peer-review
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T cells fail to develop in the human skin-cell explants system; an inconvenient truth
Meek, B., Van Elssen, C. H. M. J., Huijskens, M. J. A. J., van der Stegen, S. J. C., Tonnaer, S., Lumeij, S. B. J., Vanderlocht, J., Kirkland, M. A., Hesselink, R., Germeraad, W. T. V. & Bos, G. M. J., 18 Feb 2011, In: BMC IMMUNOLOGY. 12, p. 13Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
2010
Expression of aberrantly glycosylated Mucin-1 in ovarian cancer
Van Elssen, C. H. M. J., Frings, P. W. H., Bot, F. J., Van de Vijver, K. K., Huls, M. B., Meek, B., Hupperets, P., Germeraad, W. T. V. & Bos, G. M. J., Oct 2010, In: Histopathology. 57, 4, p. 597-606Research output: Contribution to journal › Article › Academic › peer-review
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INCREASED TUMOR-SPECIFIC CD8(+) T CELL INDUCTION BY DENDRITIC CELLS MATURED WITH A CLINICAL GRADE TLR-AGONIST IN COMBINATION WITH IFN-gamma
Vanderlocht, J., van Elssen, C. H. M. J., Senden-Gijsbers, B. L. M. G., Meek, B., Cloosen, S., Libon, C., Bos, G. M. J. & Germeraad, W. T. V., 2010, In: International Journal of Immunopathology and Pharmacology. 23, 1, p. 35-50Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
In vitro-differentiated T/natural killer-cell progenitors derived from human CD34(+) cells mature in the thymus
Meek, B., Cloosen, S., Borsotti, C., Van Elssen, C. H. M. J., Vanderlocht, J., Schnijderberg, M. C. A., van der Poel, M. W. M., Leewis, B., Hesselink, R., Manz, M. G., Katsura, Y., Kawamoto, H., Germeraad, W. T. V. & Bos, G. M. J., 14 Jan 2010, In: Blood. 115, 2, p. 261-264Research output: Contribution to journal › Article › Academic › peer-review
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Klebsiella pneumoniae-triggered DC recruit human NK cells in a CCR5-dependent manner leading to increased CCL19-responsiveness and activation of NK cells
Van Elssen, C. H. M. J., Vanderlocht, J., Frings, P. W. H., Senden-Gijsbers, B. L. M. G., Schnijderberg, M. C. A., van Gelder, M., Meek, B., Libon, C., Ferlazzo, G., Germeraad, W. T. V. & Bos, G. M. J., Nov 2010, In: European Journal of Immunology. 40, 11, p. 3138-3149Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Thymic cysts originate from Foxn1 positive thymic medullary epithelium
Vroegindeweij, E., Crobach, S., Itoi, M., Satoh, R., Zuklys, S., Happe, C., Germeraad, W. T. V., Cornelissen, J. J., Cupedo, T., Hollander, G. A., Kawamoto, H. & van Ewijk, W., Feb 2010, In: Molecular Immunology. 47, 5, p. 1106-1113Research output: Contribution to journal › Article › Academic › peer-review
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2008
Increased release of sMD-2 during human endotoxemia and sepsis: a role for endothelial cells.
Wolfs, T. G., Dunn-Siegrist, I., van 't Veer, C., Hodin, C. M., Germeraad, W. T. V., van Zoelen, M., van Suylen, R. J., Peutz-Kootstra, C. J., Elson, G., Pugin, J. & Buurman, W. A., 1 Jan 2008, In: Molecular Immunology. 45, 11, p. 3268-3277Research output: Contribution to journal › Article › Academic › peer-review