Defucosylation of Tumor-Specific Humanized Anti-MUC1 Monoclonal Antibody Enhances NK Cell-Mediated Anti-Tumor Cell Cytotoxicity

Ying Gong, Roel G. J. Klein Wolterink, Valeriia Gulaia, Silvie Cloosen, Femke A. I. Ehlers, Lotte Wieten, Yvo F. Graus, Gerard M. J. Bos, Wilfred T. V. Germeraad*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Article number2579
Number of pages19
JournalCancers
Volume13
Issue number11
DOIs
Publication statusPublished - Jun 2021

Keywords

  • antibody therapy
  • natural killer cells
  • MUC1
  • antibody-dependent cellular cytotoxicity
  • breast cancer
  • NATURAL-KILLER-CELLS
  • T-CELLS
  • DOWN-MODULATION
  • MEMBRANE
  • CD16
  • GLYCOSYLATION
  • ENDOCYTOSIS
  • EXPRESSION
  • RECEPTORS

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