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Research Output

2020

Associations between pattern separation and hippocampal subfield structure and function vary along the lifespan: A 7 T imaging study

Riphagen, J. M., Schmiedek, L., Gronenschild, E. H. B. M., Yassa, M. A., Priovoulos, N., Sack, A. T., Verhey, F. R. J. & Jacobs, H. I. L., 5 May 2020, In : Scientific Reports. 10, 1, 13 p., 7572.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Associations of Widowhood and beta-Amyloid With Cognitive Decline in Cognitively Unimpaired Older Adults

Biddle, K. D., Jacobs, H. I. L., d'Oleire Uquillas, F., Zide, B. S., Kirn, D. R., Properzi, M. R., Rentz, D. M., Johnson, K. A., Sperling, R. A. & Donovan, N. J., 26 Feb 2020, In : Jama network open. 3, 2, 13 p., e200121.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Contributions of Cerebro-Cerebellar Default Mode Connectivity Patterns to Memory Performance in Mild Cognitive Impairment

Pagen, L. H. G., van de Ven, V. G., Gronenschild, E. H. B. M., Priovoulos, N., Verhey, F. R. J. & Jacobs, H. I. L., 2020, In : Journal of Alzheimer's Disease. 75, 2, p. 633-647 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Linking APOE-epsilon 4, blood-brain barrier dysfunction, and inflammation to Alzheimer's pathology

Riphagen, J. M., Ramakers, I. H. G. M., Freeze, W. M., Pagen, L. H. G., Hanseeuw, B. J., Verbeek, M. M., Verhey, F. R. J. & Jacobs, H. I. L., Jan 2020, In : Neurobiology of Aging. 85, p. 96-103 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The presubiculumlinks incipient amyloid and tau pathology to memory function in older persons

Jacobs, H. I. L., Augustinack, J. C., Schultz, A. P., Hanseeuw, B. J., Locascio, J., Amariglio, R. E., Papp, K., Rentz, D. M., Sperling, R. A. & Johnson, K. A., 5 May 2020, In : Neurology. 94, 18, p. E1916-E1928 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

White matter hyperintensities mediate the association between blood-brain barrier leakage and information processing speed

Freeze, W. M., Jacobs, H. I. L., de Jong, J. J., Verheggen, I. C. M., Gronenschild, E. H. B. M., Palm, W. M., Hoff, E. I., Wardlaw, J. M., Jansen, J. F. A., Verhey, F. R. & Backes, W. H., Jan 2020, In : Neurobiology of Aging. 85, p. 113-122 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

2019

Association of Amyloid and Tau With Cognition in Preclinical Alzheimer Disease: A Longitudinal Study

Hanseeuw, B. J., Betensky, R. A., Jacobs, H. I. L., Schultz, A. P., Sepulcre, J., Becker, J. A., Cosio, D. M. O., Farrell, M., Quiroz, Y. T., Mormino, E. C., Buckley, R. F., Papp, K. V., Amariglio, R. A., Dewachter, I., Ivanoiu, A., Huijbers, W., Hedden, T., Marshall, G. A., Chhatwal, J. P., Rentz, D. M. & 2 others, Sperling, R. A. & Johnson, K., Aug 2019, In : JAMA Neurology. 76, 8, p. 915-924 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Biological and Cognitive Markers of Presenilin1 E280A Autosomal Dominant Alzheimer's Disease: A Comprehensive Review of the Colombian Kindred

Fuller, J. T., Cronin-Golomb, A., Gatchel, J. R., Norton, D. J., Guzman-Velez, E., Jacobs, H. I. L., Hanseeuw, B., Pardilla-Delgado, E., Artola, A., Baena, A., Bocanegra, Y., Kosik, K. S., Chen, K., Tariot, P. N., Johnson, K., Sperling, R. A., Reiman, E. M., Lopera, F. & Quiroz, Y. T., 2019, In : JPAD-Journal of prevention of alzheimers disease. 6, 2, p. 112-120 9 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Blood-Brain Barrier Leakage and Microvascular Lesions in Cerebral Amyloid Angiopathy

Freeze, W. M., Bacskai, B. J., Frosch, M. P., Jacobs, H. I. L., Backes, W. H., Greenberg, S. M. & van Veluw, S. J., Feb 2019, In : Stroke. 50, 2, p. 328-335 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Focus on the blue locus for learning

Jacobs, H. I. L., Nov 2019, In : Nature human behaviour. 3, 11, p. 1143-1144 2 p.

Research output: Contribution to journalEditorialAcademicpeer-review

In vivo imaging of the nucleus of the solitary tract with Magnetization Transfer at 7 Tesla

Priovoulos, N., Poser, B. A., Ivanov, D., Verhey, F. R. J. & Jacobs, H. I. L., 2019, In : Neuroimage. 201, 7 p., 116071.

Research output: Contribution to journalArticleAcademicpeer-review

Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases

Betts, M. J., Kirilina, E., Otaduy, M. C. G., Ivanov, D., Acosta-Cabronero, J., Callaghan, M. F., Lambert, C., Cardenas-Blanco, A., Pine, K., Passamonti, L., Loane, C., Keuken, M. C., Trujillo, P., Lüsebrink, F., Mattern, H., Liu, K. Y., Priovoulos, N., Fliessbach, K., Dahl, M. J., Maaß, A. & 22 others, Madelung, C. F., Meder, D., Ehrenberg, A. J., Speck, O., Weiskopf, N., Dolan, R., Inglis, B., Tosun, D., Morawski, M., Zucca, F. A., Siebner, H. R., Mather, M., Uludag, K., Heinsen, H., Poser, B. A., Howard, R., Zecca, L., Rowe, J. B., Grinberg, L. T., Jacobs, H. I. L., Düzel, E. & Hämmerer, D., Sep 2019, In : Brain. 142, 9, p. 2558–2571 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

No effect of cold pressor test-induced arousal on attentional benefits and costs in an endogenous spatial orienting paradigm

Duecker, F., Mayrhofer, H. C., Jacobs, H. I. L. & Sack, A. T., Dec 2019, In : Neuropsychologia. 135, 15 p., 107250.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Resting-state fMRI in Parkinson's disease patients with cognitive impairment: A meta-analysis

Wolters, A. F., van de Weijer, S. C. F., Leentjens, A. F. G., Duits, A. A., Jacobs, H. I. L. & Kuijf, M. L., May 2019, In : Parkinsonism & Related Disorders. 62, p. 16-27 12 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Resting-state fMRI in Patkinson's disease patients with cognitive Impairment: A meta-analysis: Answer to Wang and colleagues

Wolters, A. F., van de Weijer, S. C. F., Leentjens, A. F. G., Duits, A. A., Jacobs, H. I. L. & Kuijf, M. L., Sep 2019, In : Parkinsonism & Related Disorders. 66, p. 253-254 2 p.

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

Sex Differences in the Association of Global Amyloid and Regional Tau Deposition Measured by Positron Emission Tomography in Clinically Normal Older Adults

Buckley, R. F., Mormino, E. C., Rabin, J. S., Hohman, T. J., Landau, S., Hanseeuw, B. J., Jacobs, H. I. L., Papp, K. V., Amariglio, R. E., Properzi, M. J., Schultz, A. P., Kirn, D., Scott, M. R., Hedden, T., Farrell, M., Price, J., Chhatwal, J., Rentz, D. M., Villemagne, V. L., Johnson, K. A. & 1 others, Sperling, R. A., May 2019, In : JAMA Neurology. 76, 5, p. 542-551 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Social Engagement and Amyloidb-beta-Related Cognitive Decline in Cognitively Normal Older Adults

Biddle, K. D., Uquillas, F. DO., Jacobs, H. I. L., Zide, B., Kirn, D. R., Rentz, D. M., Johnson, K. A., Sperling, R. A. & Donovan, N. J., Nov 2019, In : American Journal of Geriatric Psychiatry. 27, 11, p. 1247-1256 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Spatial distributions of cholinergic impairment and neuronal hypometabolism differ in MCI due to AD

Richter, N., Nellessen, N., Dronse, J., Dillen, K., Jacobs, H. I. L., Langen, K-J., Dietlein, M., Kracht, L., Neumaier, B., Fink, G. R., Kukolja, J. & Onur, O. A., 2019, In : NeuroImage: Clinical. 24, 7 p., 101978.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Subthreshold amyloid and its biological and clinical meaning: Long way ahead

Bischof, G. N. & Jacobs, H. I. L., 9 Jul 2019, In : Neurology. 93, 2, p. 72-79 8 p.

Research output: Contribution to journalReview articleAcademicpeer-review

2018

18F-Flortaucipir Binding in Choroid Plexus: Related to Race and Hippocampus Signal

Lee, C. M., Jacobs, H. I. L., Marquie, M., Becker, J. A., Andrea, N. V., Jin, D. S., Schultz, A. P., Frosch, M. P., Gomez-Isla, T., Sperling, R. A. & Johnson, K. A., 1 Jan 2018, In : Journal of Alzheimer's Disease. 62, 4, p. 1691-1702 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Alzheimer's Disease Biomarkers Have Distinct Associations with Specific Hippocampal Subfield Volumes

Muller-Ehrenberg, L., Riphagen, J. M., Verhey, F. R. J., Sack, A. T., Jacobs, H. I. L. & Alzheimer's Disease Neuroimaging Initiative, 2018, In : Journal of Alzheimer's Disease. 66, 2, p. 811-823 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Blood-Brain Barrier Dysfunction in Small Vessel Disease Related Intracerebral Hemorrhage

Freeze, W. M., Jacobs, H. I. L., Schreuder, F. H. B. M., van Oostenbrugge, R. J., Backes, W. H., Verhey, F. R. & Klijn, C. J. M., 12 Nov 2018, In : Frontiers in Neurology. 9, 11 p., 926.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Chronotype differences in cortical thickness: grey matter reflects when you go to bed

Rosenberg, J., Jacobs, H. I. L., Maximov, I. I., Reske, M. & Shah, N. J., 1 Sep 2018, In : Brain Structure & Function. 223, 7, p. 3411-3421 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Correction to: Cerebrovascular and amyloid pathology in predementia stages: the relationship with neurodegeneration and cognitive decline (vol 9, 101, 2017)

Bos, I., Verhey, F. R., Ramakers, I. H. G. B., Jacobs, H. I. L., Soininen, H., Freund-Levi, Y., Hampel, H., Tsolaki, M., Wallin, A. K., van Buchem, M. A., Oleksik, A., Verbeek, M. M., Rikkert, M. O., van der Flier, W. M., Scheltens, P., Aalten, P., Visser, P. J. & Vos, S. J. B., 20 Jun 2018, In : Alzheimer's Research & Therapy. 10, 3 p., 56.

Research output: Contribution to journalErratum / corrigendumAcademic

Open Access

High-resolution in vivo imaging of human locus coeruleus by Magnetization Transfer MRI at 3T and 7T

Priovoulos, N., Jacobs, H. I. L., Ivanov, D., Uludag, K., Verhey, F. R. J. & Poser, B. A., Mar 2018, In : Neuroimage. 168, p. 427-436 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Inter-network connectivity and amyloid-beta linked to cognitive decline in preclinical Alzheimer's disease: a longitudinal cohort study

Van Hooren, R. W. E., Riphagen, J. M., Jacobs, H. I. L. & Alzheimer's Disease Neuroimaging Initiative, 28 Aug 2018, In : Alzheimer's Research & Therapy. 10, 88, p. 1-12 12 p., 88.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

On the Extraction and Analysis of Graphs From Resting-State fMRI to Support a Correct and Robust Diagnostic Tool for Alzheimer's Disease

Bachmann, C., Jacobs, H. I. L., Mana, P. P., Dillen, K., Richter, N., von Reutern, B., Dronse, J., Onur, O. A., Langen, K-J., Fink, G. R., Kukolja, J. & Morrison, A., 28 Sep 2018, In : Frontiers in Neuroscience. 12, 24 p., 528.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

PET staging of amyloidosis using striatum

Hanseeuw, B. J., Betensky, R. A., Mormino, E. C., Schultz, A. P., Sepulcre, J., Becker, J. A., Jacobs, H. I. L., Buckley, R. F., LaPoint, M. R., Vannini, P., Donovan, N. J., Chhatwal, J. P., Marshall, G. A., Papp, K., Amariglio, R. E., Rentz, D. M., Sperling, R. A., Johnson, K. A. & Alzheimers Dis Neuroimaging Initia; Harvard Aging Brain Study, 1 Oct 2018, In : Alzheimer's & Dementia. 14, 10, p. 1281-1292 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Regional tau pathology and loneliness in cognitively normal older adults

Uquillas, F. DO., Jacobs, H. I. L., Biddle, K. D., Properzi, M., Hanseeuw, B., Schultz, A. P., Rentz, D. M., Johnson, K. A., Sperling, R. A. & Donovan, N. J., 18 Dec 2018, In : Translational Psychiatry. 8, 9 p., 282.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Sex, amyloid, and APOE ε4 and risk of cognitive decline in preclinical Alzheimer's disease: Findings from three well-characterized cohorts

Buckley, R. F., Mormino, E. C., Amariglio, R. E., Properzi, M. J., Rabin, J. S., Lim, Y. Y., Papp, K. V., Jacobs, H. I. L., Burnham, S., Hanseeuw, B. J., Dore, V., Dobson, A., Masters, C. L., Waller, M., Rowe, C. C., Maruff, P., Donohue, M. C., Rentz, D. M., Kirn, D., Hedden, T. & 6 others, Chhatwal, J., Schultz, A. P., Johnson, K. A., Villemagne, V. L., Sperling, R. A. & Collaborators Alzheimer's Dis Neur; Australian Imaging Biomarker Lifes; Harvard Aging Brain Study, 1 Sep 2018, In : Alzheimer's & Dementia. 14, 9, p. 1193-1203 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Shades of white: diffusion properties of T1- and FLAIR-defined white matter signal abnormalities differ in stages from cognitively normal to dementia

Riphagen, J. M., Gronenschild, E. H. B. M., Salat, D. H., Freeze, W. M., Ivanov, D., Clerx, L., Verhey, F. R. J., Aalten, P. & Jacobs, H. I. L., Aug 2018, In : Neurobiology of Aging. 68, p. 48-58 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals

Jacobs, H. I. L., Hedden, T., Schultz, A. P., Sepulcre, J., Perea, R. D., Amariglio, R. E., Papp, K. V., Rentz, D. M., Sperling, R. A. & Johnson, K. A., 1 Mar 2018, In : Nature Neuroscience. 21, 3, p. 424–431 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

The cerebellum in Alzheimer's disease: evaluating its role in cognitive decline

Jacobs, H. I. L., Hopkins, D. A., Mayrhofer, H. C., Bruner, E., van Leeuwen, F. W., Raaijmakers, W. & Schmahmann, J. D., 1 Jan 2018, In : Brain. 141, p. 37-47 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Where do white matter alterations dovetail with the cascade model of Alzheimer's disease?

Jacobs, H. I. L. & Buckley, R. F., Oct 2018, In : Brain. 141, p. 2830-2833 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

2017

Cerebrovascular and amyloid pathology in predementia stages: the relationship with neurodegeneration and cognitive decline

Bos, I., Verhey, F. R., Ramakers, I. H. G. B., Jacobs, H. I. L., Soininen, H., Freund-Levi, Y., Hampel, H., Tsolaki, M., Wallin, A. K., van Buchem, M. A., Oleksik, A., Verbeek, M. M., Rikkert, M. O., van der Flier, W. M., Scheltens, P., Aalten, P., Visser, P. J. & Vos, S. J. B., 29 Dec 2017, In : Alzheimer's Research & Therapy. 9, 10 p., 101.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

CORRIGENDUM: The cerebellum in Alzheimer's disease: evaluating its role in cognitive decline (awx194, 2017)

Jacobs, H. I. L., Hopkins, D. A., Mayrhofer, H. C., Bruner, E., van Leeuwen, F. W., Raaijmakers, W. & Schmahmann, J. D., Dec 2017, In : Brain. 140, p. E77-E77 1 p.

Research output: Contribution to journalErratum / corrigendumAcademic

Open Access

Functional Disintegration of the Default Mode Network in Prodromal Alzheimer's Disease

Dillen, K. N. H., Jacobs, H. I. L., Kukolja, J., Richter, N., von Reutern, B., Onur, O. A., Langen, K-J. & Fink, G. R., 2017, In : Journal of Alzheimer's Disease. 59, 1, p. 169-187 19 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Neuroimaging markers associated with maintenance of optimal memory performance in late-life

Dekhtyar, M., Papp, K. V., Buckley, R., Jacobs, H. I. L., Schultz, A. P., Johnson, K. A., Sperling, R. A. & Rentz, D. M., Jun 2017, In : Neuropsychologia. 100, p. 164-170 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

The Relationship between Cerebral Small Vessel Disease, Hippocampal Volume and Cognitive Functioning in Patients with COPD: An MRI Study

Cleutjens, F. A. H. M., Ponds, R. W. H. M., Spruit, M. A., Burgmans, S., Jacobs, H. I. L., Gronenschild, E. H. B. M., Staals, J., Franssen, F. M. E., Dijkstra, J. B., Vanfleteren, L. E. G. W., Hofman, P. A., Wouters, E. F. M. & Janssen, D. J. A., 29 Mar 2017, In : Frontiers in Aging Neuroscience. 9, 9 p., 88.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

White Matter Hyperintensities Potentiate Hippocampal Volume Reduction in Non-Demented Older Individuals with Abnormal Amyloid-beta

Freeze, W. M., Jacobs, H. I. L., Gronenschild, E. H., Jansen, J. F. A., Burgmans, S., Aalten, P., Clerx, L., Vos, S. J., van Buchem, M. A., Barkhof, F., van der Flier, W. M., Verbeek, M. M., Rikkert, M. O., Backes, W. H., Verhey, F. R. & LeARN Project, 1 Nov 2017, In : Journal of Alzheimer's Disease. 55, 1, p. 333-342 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

2016

Aberrant functional connectivity differentiates retrosplenial cortex from posterior cingulate cortex in prodromal Alzheimer's disease

Dillen, K. N. H., Jacobs, H. I. L., Kukolja, J., von Reutern, B., Richter, N., Onur, O. A., Dronse, J., Langen, K-J. & Fink, G. R., Aug 2016, In : Neurobiology of Aging. 44, p. 114-126

Research output: Contribution to journalArticleAcademicpeer-review

2015

Can FreeSurfer Compete with Manual Volumetric Measurements in Alzheimer's Disease?

Clerx, L., Gronenschild, E. H. B. M., Echavarri, C., Verhey, F., Aalten, P. & Jacobs, H. I. L., 2015, In : Current Alzheimer Research. 12, 4, p. 358-367

Research output: Contribution to journalArticleAcademicpeer-review

Consolidation in older adults depends upon competition between resting-state networks

Jacobs, H. I. L., Dillen, K. N. H., Risius, O., Goereci, Y., Onur, O. A., Fink, G. R. & Kukolja, J., 9 Jan 2015, In : Frontiers in Aging Neuroscience. 6, 344.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
3 Citations (Scopus)

Relevance of parahippocampal-locus coeruleus connectivity to memory in early dementia

Jacobs, H. I. L., Wiese, S., van de Ven, V., Gronenschild, E. H. B. M., Verhey, F. R. J. & Matthews, P. M., 1 Jan 2015, In : Neurobiology of Aging. 36, 2, p. 618-626

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)