Abstract
The brain-derived neurotropic growth factor (BDNF) gene has been linked to dementia, inflammation, and Apolipoprotein E (APOE) ɛ4 status. We used cerebrospinal fluid (CSF) amyloid-β (Aβ)42 and phosphorylated tau (p-tau) to investigate associations with BDNF polymorphisms and modifications by APOE ɛ4 or inflammation in a memory clinic population (n = 114; subjective cognitive decline, mild cognitive impairment, Alzheimer's disease). We found distinct pathways to Alzheimer's disease pathology: Val-Met displayed lower CSF-Aβ 42 in APOE ɛ4+ carriers, independent of p-tau, while Val-Val displayed greater p-tau at higher IL-6 and sub-threshold Aβ 42. This may contribute to resolving some inconsistencies in the BDNF literature and provide possible inroads to specific Aβ and tau interventions depending on BDNF polymorphism.
Original language | English |
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Pages (from-to) | 447-453 |
Number of pages | 7 |
Journal | Journal of Alzheimer's Disease |
Volume | 88 |
Issue number | 2 |
Early online date | 28 May 2022 |
DOIs | |
Publication status | Published - 2022 |
Keywords
- APOLIPOPROTEIN-E
- ASSOCIATION
- Alzheimer's disease
- BETA
- COGNITIVE DECLINE
- CYTOKINES
- IMPAIRMENT
- INTERLEUKIN-6
- MECHANISMS
- NEUROINFLAMMATION
- NEUROTROPHIC FACTOR
- amyloid-beta
- brain-derived neurotropic growth factor
- inflammation
- interleukin 6
- phosphorylated tau