Rich-Club Connectivity of the Structural Covariance Network Relates to Memory Processes in Mild Cognitive Impairment and Alzheimer's Disease

Gerhard S Drenthen; Walter H Backes; Whitney M Freeze; Heidi I. L. Jacobs; Inge C. M. Verheggen; Martin P. J. van Boxtel; Erik I. Hoff; Frans R. Verhey; Jacobus F A Jansen

doi:10.3233/JAD-220175

Rich-Club Connectivity of the Structural Covariance Network Relates to Memory Processes in Mild Cognitive Impairment and Alzheimer's Disease

Gerhard S Drenthen^*, Walter H Backes, Whitney M Freeze, Heidi I. L. Jacobs, Inge C. M. Verheggen, Martin P. J. van Boxtel, Erik I. Hoff, Frans R. Verhey, Jacobus F A Jansen

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

BACKGROUND: Though mediotemporal lobe volume changes are well-known features of Alzheimer's disease (AD), grey matter volume changes may be distributed throughout the brain. These distributed changes are not independent due to the underlying network structure and can be described in terms of a structural covariance network (SCN).

OBJECTIVE: To investigate how the cortical brain organization is altered in AD we studied the mutual connectivity of hubs in the SCN, i.e., the rich-club.

METHODS: To construct the SCNs, cortical thickness was obtained from structural MRI for 97 participants (normal cognition, n = 37; mild cognitive impairment, n = 41; Alzheimer-type dementia, n = 19). Subsequently, rich-club coefficients were calculated from the SCN, and related to memory performance and hippocampal volume using linear regression.

RESULTS: Lower rich-club connectivity was related to lower memory performance as well as lower hippocampal volume.

CONCLUSION: Therefore, this study provides novel evidence of reduced connectivity in hub areas in relation to AD-related cognitive impairments and atrophy.

Original language	English
Pages (from-to)	209-217
Number of pages	9
Journal	Journal of Alzheimer's Disease
Volume	89
Issue number	1
Early online date	18 Jul 2022
DOIs	https://doi.org/10.3233/JAD-220175
Publication status	Published - 2022

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Drenthen, G. S., Backes, W. H., Freeze, W. M., Jacobs, H. I. L., Verheggen, I. C. M., van Boxtel, M. P. J., Hoff, E. I., Verhey, F. R., & Jansen, J. F. A. (2022). Rich-Club Connectivity of the Structural Covariance Network Relates to Memory Processes in Mild Cognitive Impairment and Alzheimer's Disease. Journal of Alzheimer's Disease, 89(1), 209-217. https://doi.org/10.3233/JAD-220175

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title = "Rich-Club Connectivity of the Structural Covariance Network Relates to Memory Processes in Mild Cognitive Impairment and Alzheimer's Disease",

abstract = "BACKGROUND: Though mediotemporal lobe volume changes are well-known features of Alzheimer's disease (AD), grey matter volume changes may be distributed throughout the brain. These distributed changes are not independent due to the underlying network structure and can be described in terms of a structural covariance network (SCN).OBJECTIVE: To investigate how the cortical brain organization is altered in AD we studied the mutual connectivity of hubs in the SCN, i.e., the rich-club.METHODS: To construct the SCNs, cortical thickness was obtained from structural MRI for 97 participants (normal cognition, n = 37; mild cognitive impairment, n = 41; Alzheimer-type dementia, n = 19). Subsequently, rich-club coefficients were calculated from the SCN, and related to memory performance and hippocampal volume using linear regression.RESULTS: Lower rich-club connectivity was related to lower memory performance as well as lower hippocampal volume.CONCLUSION: Therefore, this study provides novel evidence of reduced connectivity in hub areas in relation to AD-related cognitive impairments and atrophy.",

author = "Drenthen, {Gerhard S} and Backes, {Walter H} and Freeze, {Whitney M} and Jacobs, {Heidi I. L.} and Verheggen, {Inge C. M.} and {van Boxtel}, {Martin P. J.} and Hoff, {Erik I.} and Verhey, {Frans R.} and Jansen, {Jacobus F A}",

note = "Funding Information: W.M. Freeze reports support from Alzheimer Nederland [grant WE.03-2018-13]. Heidi I.L. Jacobs reports support from Alzheimer Nederland [grant WE.09-2019-02] and the NIH-NIA R01AG06255. I.C.M. Verheggen reports support from the Dutch Research Council (NWO) [grant 406-15-031]. Publisher Copyright: {\textcopyright} 2022 - The authors. Published by IOS Press.",

year = "2022",

doi = "10.3233/JAD-220175",

language = "English",

volume = "89",

pages = "209--217",

journal = "Journal of Alzheimer's Disease",

issn = "1387-2877",

publisher = "IOS Press",

number = "1",

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TY - JOUR

T1 - Rich-Club Connectivity of the Structural Covariance Network Relates to Memory Processes in Mild Cognitive Impairment and Alzheimer's Disease

AU - Drenthen, Gerhard S

AU - Backes, Walter H

AU - Freeze, Whitney M

AU - Jacobs, Heidi I. L.

AU - Verheggen, Inge C. M.

AU - van Boxtel, Martin P. J.

AU - Hoff, Erik I.

AU - Verhey, Frans R.

AU - Jansen, Jacobus F A

N1 - Funding Information: W.M. Freeze reports support from Alzheimer Nederland [grant WE.03-2018-13]. Heidi I.L. Jacobs reports support from Alzheimer Nederland [grant WE.09-2019-02] and the NIH-NIA R01AG06255. I.C.M. Verheggen reports support from the Dutch Research Council (NWO) [grant 406-15-031]. Publisher Copyright: © 2022 - The authors. Published by IOS Press.

PY - 2022

Y1 - 2022

N2 - BACKGROUND: Though mediotemporal lobe volume changes are well-known features of Alzheimer's disease (AD), grey matter volume changes may be distributed throughout the brain. These distributed changes are not independent due to the underlying network structure and can be described in terms of a structural covariance network (SCN).OBJECTIVE: To investigate how the cortical brain organization is altered in AD we studied the mutual connectivity of hubs in the SCN, i.e., the rich-club.METHODS: To construct the SCNs, cortical thickness was obtained from structural MRI for 97 participants (normal cognition, n = 37; mild cognitive impairment, n = 41; Alzheimer-type dementia, n = 19). Subsequently, rich-club coefficients were calculated from the SCN, and related to memory performance and hippocampal volume using linear regression.RESULTS: Lower rich-club connectivity was related to lower memory performance as well as lower hippocampal volume.CONCLUSION: Therefore, this study provides novel evidence of reduced connectivity in hub areas in relation to AD-related cognitive impairments and atrophy.

AB - BACKGROUND: Though mediotemporal lobe volume changes are well-known features of Alzheimer's disease (AD), grey matter volume changes may be distributed throughout the brain. These distributed changes are not independent due to the underlying network structure and can be described in terms of a structural covariance network (SCN).OBJECTIVE: To investigate how the cortical brain organization is altered in AD we studied the mutual connectivity of hubs in the SCN, i.e., the rich-club.METHODS: To construct the SCNs, cortical thickness was obtained from structural MRI for 97 participants (normal cognition, n = 37; mild cognitive impairment, n = 41; Alzheimer-type dementia, n = 19). Subsequently, rich-club coefficients were calculated from the SCN, and related to memory performance and hippocampal volume using linear regression.RESULTS: Lower rich-club connectivity was related to lower memory performance as well as lower hippocampal volume.CONCLUSION: Therefore, this study provides novel evidence of reduced connectivity in hub areas in relation to AD-related cognitive impairments and atrophy.

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DO - 10.3233/JAD-220175

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JO - Journal of Alzheimer's Disease

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