Cortical thickness across the lifespan in a Colombian cohort with autosomal-dominant Alzheimer's disease: A cross-sectional study

J.T. Fox-Fuller, H. Torrico-Teave, F.D. Uquillas, K.W. Chen, Y. Su*, Y.H. Chen, M. Brickhouse, J.S. Sanchez, C. Aguero, H.I.L. Jacobs, O. Hampton, E. Guzman-Velez, C. Vila-Castelar, D.C. Aguirre-Acevedo, A. Baena, A. Artola, J. Martinez, C.F. Pluim, S. Alvarez, M. Ochoa-EscuderoE.M. Reiman, R.A. Sperling, F. Lopera, K.A. Johnson, B.C. Dickerson, Y.T. Quiroz*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Web of Science)

Abstract

Introduction Cortical thinning is a marker of neurodegeneration in Alzheimer's disease (AD). We investigated the age-related trajectory of cortical thickness across the lifespan (9-59 years) in a Colombian kindred with autosomal dominant AD (ADAD). Methods Two hundred eleven participants (105 presenilin-1 [PSEN1] E280A mutation carriers, 16 with cognitive impairment; 106 non-carriers) underwent magnetic resonance imaging. A piecewise linear regression identified change-points in the age-related trajectory of cortical thickness in carriers and non-carriers. Results Unimpaired carriers exhibited elevated cortical thickness compared to non-carriers, and thickness more negatively correlated with age and cognition in carriers relative to non-carriers. We found increased cortical thickness in child carriers, after which thickness steadied compared to non-carriers prior to a rapid reduction in the decade leading up to the expected age at cognitive impairment in carriers. Discussion Findings suggest that cortical thickness may fluctuate across the ADAD lifespan, from early-life increased thickness to atrophy proximal to clinical onset.
Original languageEnglish
Article numbere12233
Number of pages11
JournalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume13
Issue number1
DOIs
Publication statusPublished - 2021

Keywords

  • age-related
  • cortical thickness
  • familial Alzheimer's disease
  • lifespan
  • presenilin1
  • trajectory
  • VOLUME
  • MUTATION
  • CERAD
  • MRI
  • ASSOCIATION
  • RELIABILITY
  • SIGNATURE
  • ATROPHY
  • CORTEX
  • RISK

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