Abstract
Introduction Cortical thinning is a marker of neurodegeneration in Alzheimer's disease (AD). We investigated the age-related trajectory of cortical thickness across the lifespan (9-59 years) in a Colombian kindred with autosomal dominant AD (ADAD). Methods Two hundred eleven participants (105 presenilin-1 [PSEN1] E280A mutation carriers, 16 with cognitive impairment; 106 non-carriers) underwent magnetic resonance imaging. A piecewise linear regression identified change-points in the age-related trajectory of cortical thickness in carriers and non-carriers. Results Unimpaired carriers exhibited elevated cortical thickness compared to non-carriers, and thickness more negatively correlated with age and cognition in carriers relative to non-carriers. We found increased cortical thickness in child carriers, after which thickness steadied compared to non-carriers prior to a rapid reduction in the decade leading up to the expected age at cognitive impairment in carriers. Discussion Findings suggest that cortical thickness may fluctuate across the ADAD lifespan, from early-life increased thickness to atrophy proximal to clinical onset.
Original language | English |
---|---|
Article number | e12233 |
Number of pages | 11 |
Journal | Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring |
Volume | 13 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2021 |
Keywords
- age-related
- cortical thickness
- familial Alzheimer's disease
- lifespan
- presenilin1
- trajectory
- VOLUME
- MUTATION
- CERAD
- MRI
- ASSOCIATION
- RELIABILITY
- SIGNATURE
- ATROPHY
- CORTEX
- RISK