Contribution of extracerebral tracer retention and partial volume effects to sex differences in Flortaucipir-PET signal

Matthew R Scott, Natalie C Edwards, Michael J Properzi, Heidi Il Jacobs, Julie C Price, Cristina Lois, Michelle E Farrell, Bernard J Hanseeuw, Emma G Thibault, Dorene M Rentz, Keith A Johnson, Reisa A Sperling, Aaron P Schultz, Rachel F Buckley*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Clinically normal females exhibit higher F-flortaucipir (FTP)-PET signal than males across the cortex. However, these sex differences may be explained by neuroimaging idiosyncrasies such as off-target extracerebral tracer retention or partial volume effects (PVEs). 343 clinically normal participants (female?=?58%; mean[SD]=73.8[8.5] years) and 55 patients with mild cognitive impairment (female?=?38%; mean[SD]?=?76.9[7.3] years) underwent cross-sectional FTP-PET. We parcellated extracerebral FreeSurfer areas based on proximity to cortical ROIs. Sex differences in cortical tau were then estimated after accounting for local extracerebral retention. We simulated PVE by convolving group-level standardized uptake value ratio means in each ROI with 6?mm Gaussian kernels and compared the sexes across ROIs post-smoothing. Widespread sex differences in extracerebral retention were observed. Although attenuating sex differences in cortical tau-PET signal, covarying for extracerebral retention did not impact the largest sex differences in tau-PET signal. Differences in PVE were observed in both female and male directions with no clear sex-specific bias. Our findings suggest that sex differences in FTP are not solely attributed to off-target extracerebral retention or PVE, consistent with the notion that sex differences in medial temporal and neocortical tau are biologically driven. Future work should investigate sex differences in regional cerebral blood flow kinetics and longitudinal tau-PET.
Original languageEnglish
Pages (from-to)131–141
Number of pages11
JournalJournal of Cerebral Blood Flow and Metabolism
Volume44
Issue number1
Early online date20 Sept 2023
DOIs
Publication statusPublished - 2024

Keywords

  • Extracerebral
  • PET
  • flortaucipir
  • partial volume effects
  • sex

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