1987 …2019

Research output per year

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Research Output

2019

Airflow Obstruction and Cardio-metabolic Comorbidities

Triest, F. J. J., Studnicka, M., Franssen, F. M. E., Vollmer, W. M., Lamprecht, B., Wouters, E. F. M., Burney, P. G. J. & Vanfleteren, L. E. G. W., 4 Mar 2019, In : Copd-Journal of Chronic Obstructive Pulmonary Disease. 16, 2, p. 109-117 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Artificial intelligence outperforms pulmonologists in the interpretation of pulmonary function tests

Pulm Function Study Investigators, 1 Apr 2019, In : European Respiratory Journal. 53, 4, 11 p., 1801660.

Research output: Contribution to journalArticleAcademicpeer-review

Blood Eosinophil Counts, Withdrawal of Inhaled Corticosteroids and Risk of COPD Exacerbations and Mortality in the Clinical Practice Research Datalink (CPRD)

Oshagbemi, O. A., Franssen, F. M. E., van Kraaij, S., Braeken, D. C. W., Wouters, E. F. M., Maitland-van der Zee, A. H., Driessen, J. H. M. & de Vries, F., 2019, In : COPD. 16, 2, p. 152-159 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Box-Jenkins Transfer Function Modelling for Reliable Determination of VO2 Kinetics in Patients with COPD

Buekers, J., Theunis, J., Fernandez, A. P., Wouters, E. E. M., Spruit, M. A., De Boever, P. & Aerts, J-M., 1 May 2019, In : Applied Sciences. 9, 9, p. 1-13 13 p., 1822.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Chronic Obstructive Pulmonary Disease: Shifting the Paradigm to the Vasculature

Wouters, E. F. M. & Franssen, F. M., 1 Feb 2019, In : American Journal of Respiratory and Critical Care Medicine. 199, 3, p. 258-259 3 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Clustering of 27,525,663 Death Records from the United States Based on Health Conditions Associated with Death: An Example of Big Health Data Exploration

Janssen, D. J. A., Rechberger, S., Wouters, E. F. M., Schols, J. M. G. A., Johnson, M. J., Currow, D. C., Curtis, J. R. & Spruit, M. A., Jul 2019, In : Journal of Clinical Medicine. 8, 7, 15 p., 922.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Cluster-randomised trial of a nurse-led advance care planning session in patients with COPD and their loved ones

Houben, C. H. M., Spruit, M. A., Luyten, H., Pennings, H-J., van den Boogaart, V. E. M., Creemers, J. P. H. M., Wesseling, G., Wouters, E. F. M. & Janssen, D. J. A., Apr 2019, In : Thorax. 74, 4, p. 328-336 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Comprehensive Lung Function Assessment Does not Allow to Infer Response to Pulmonary Rehabilitation in Patients with COPD

Augustin, I. M. L., Wouters, E. E. M., Houben-Wilke, S., Gaffron, S., Janssen, D. J. A., Franssen, F. M. E. & Spruit, M. A., Jan 2019, In : Journal of Clinical Medicine. 8, 1, p. 1-11 11 p., 27.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Disease-Specific Comorbidity Clusters in COPD and Accelerated Aging

Triest, F. J. J., Franssen, F. M. E., Reynaert, N., Gaffron, S., Spruit, M. A., Janssen, D. J. A., Rutten, E. P. A., Wouters, E. F. M. & Vanfleteren, L. E. G. W., Apr 2019, In : Journal of Clinical Medicine. 8, 4, p. 1-18 18 p., 511.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access

Effects of Pulmonary Rehabilitation on Gait Characteristics in Patients with COPD

Liu, W-Y., Meijer, K., Delbressine, J. M., Willems, P. J., Wouters, E. F. M. & Spruit, M. A., Apr 2019, In : Journal of Clinical Medicine. 8, 4, p. 1-14 14 p., 459.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Emphysema: looking beyond alpha-1 antitrypsin deficiency

Janssen, R., Piscaer, I., Franssen, F. M. E. & Wouters, E. F. M., 3 Apr 2019, In : Expert Review of Respiratory Medicine. 13, 4, p. 381-397 17 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Exhaled Volatile Organic Compounds Are Able to Discriminate between Neutrophilic and Eosinophilic Asthma

Schleich, F. N., Zanella, D., Stefanuto, P-H., Bessonov, K., Smolinska, A., Dallinga, J. W., Henket, M., Paulus, V., Guissard, F., Graff, S., Moermans, C., Wouters, E. F. M., Van Steen, K., van Schooten, F-J., Focant, J-F. & Louis, R., 15 Aug 2019, In : American Journal of Respiratory and Critical Care Medicine. 200, 4, p. 444-453 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Fatigue is highly prevalent in patients with COPD and correlates poorly with the degree of airflow limitation

Goertz, Y. M. J., Spruit, M. A., Van't Hul, A. J., Peters, J. B., Van Herck, M., Nakken, N., Djamin, R. S., Burtin, C., Thong, M. S. Y., Coors, A., Meertens-Kerris, Y., Wouters, E. F. M., Prins, J. B., Franssen, F. M. E., Muris, J. W. M., Vanfleteren, L. E. G. W., Sprangers, M. A. G., Janssen, D. J. A. & Vercoulen, J. H., Sep 2019, In : Therapeutic Advances in Respiratory Disease. 13, 13 p., 1753466619878128.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Fentanyl Nasal Spray in a Patient With End-Stage COPD and Severe Chronic Breathlessness

Janssen, D. J. A., van Everdingen - van den Beuken, M., Verberkt, C. A., Creemers, J. P. H. M. & Wouters, E., Sep 2019, In : Breathe. 15, 3, p. 122-125

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations

Sakornsakolpat, P., Prokopenko, D., Lamontagne, M., Reeve, N. F., Guyatt, A. L., Jackson, V. E., Shrine, N., Qiao, D., Bartz, T. M., Kim, D. K., Lee, M. K., Latourelle, J. C., Li, X., Morrow, J. D., Obeidat, M., Wyss, A. B., Bakke, P., Barr, R. G., Beaty, T. H., Belinsky, S. A. & 33 others, Brusselle, G. G., Crapo, J. D., de Jong, K., DeMeo, D. L., Fingerlin, T. E., Gharib, S. A., Gulsvik, A., Hall, I. P., Hokanson, J. E., Kim, W. J., Lomas, D. A., London, S. J., Meyers, D. A., O'Connor, G. T., Rennard, S., Schwartz, D. A., Sliwinski, P., Sparrow, D., Strachan, D. P., Tal-Singer, R., Tesfaigzi, Y., Vestbo, J., Vonk, J. M., Yim, J-J., Zhou, X., Bosse, Y., Manichaikul, A., Gietema, H., ter Riet, G., Wouters, E. F. M., SpiroMeta Consortium, Int COPD Genetics Consortium & Understanding Soc Sci Grp, Mar 2019, In : Nature Genetics. 51, 3, p. 494-+ 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Identifying causes of perceptual differences in problematic activities of daily life between patients with COPD and proxies: A qualitative study

Nakken, N., Spruit, M. A., van den Bogaart, E. H. A., Crutzen, R., Muris, J. W. M., Wouters, E. F. M. & Janssen, D. J. A., Feb 2019, In : Australian Occupational Therapy Journal. 66, 1, p. 44-51 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Impact of pulmonary rehabilitation on activities of daily living in patients with chronic obstructive pulmonary disease

Vaes, A. W., Delbressine, J. M. L., Mesquita, R., Goertz, Y. M. J., Janssen, D. J. A., Nakken, N., Franssen, F. M. E., Vanfleteren, L. E. G. W., Wouters, E. F. M. & Spruit, M. A., Mar 2019, In : Journal of Applied Physiology. 126, 3, p. 607-615 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Integrative Genomics Analysis Identifies ACVR1B as a Candidate Causal Gene of Emphysema Distribution

ECLIPSE Investigators & Wouters, E., Apr 2019, In : American Journal of Respiratory Cell and Molecular Biology. 60, 4, p. 388-398 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

It's more than low BMI: prevalence of cachexia and associated mortality in COPD

McDonald, M-L. N., Wouters, E. F. M., Rutten, E., Casaburi, R., Rennard, S., Lomas, D. A., Bamman, M., Celli, B., Agusti, A., Tal-Singer, R., Hersh, C. P., Dransfield, M. & Silverman, E. K., 22 May 2019, In : Respiratory Research. 20, 9 p., 100.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Low Vitamin K Status Is Associated with Increased Elastin Degradation in Chronic Obstructive Pulmonary Disease

Piscaer, I., van den Ouweland, J. M. W., Vermeersch, K., Reynaert, N. L., Franssen, F. M. E., Keene, S., Wouters, E. F. M., Janssens, W., Vermeer, C. & Janssen, R., Aug 2019, In : Journal of Clinical Medicine. 8, 8, 14 p., 1116.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Organizational aspects of pulmonary rehabilitation in chronic respiratory diseases

Spruit, M. A. & Wouters, E. F. M., Sep 2019, In : Respirology. 24, 9, p. 838-843 6 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Overdiagnosis of COPD in Subjects With Unobstructed Spirometry A BOLD Analysis

Sator, L., Horner, A., Studnicka, M., Lamprecht, B., Kaiser, B., McBurnie, M. A., Buist, A. S., Gnatiuc, L., Mannino, D. M., Janson, C., Bateman, E. D., Burney, P., Zhong, N., Liu, S., Lu, J., Ran, P., Wang, D., Zheng, J., Zhou, Y., Kocabas, A. & 31 others, Hancioglu, A., Hanta, I., Kuleci, S., Turkyilmaz, A. S., Umut, S., Unalan, T., Dawes, T., Bateman, E., Jithoo, A., Adams, D., Barnes, E., Freeman, J., Hayes, A., Hlengwa, S., Johannisen, C., Koopman, M., Louw, I., Ludick, I., Olckers, A., Ryck, J., Storbeck, J., Gislason, T., Benedikdtsdottir, B., Jorundsdottir, K., Gudmundsdottir, L., Gudmundsdottir, S., Gundmundsson, G., Nizankowska-Mogilnicka, E., Wouters, E. F. M., Wesseling, G. J. & BOLD Collaborative Res Grp, Aug 2019, In : Chest. 156, 2, p. 277-288 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Personalized medicine for patients with COPD: where are we?

Franssen, F. M. E., Alter, P., Bar, N., Benedikter, B. J., Iurato, S., Maier, D., Maxheim, M., Roessler, F. K., Spruit, M. A., Vogelmeier, C. F., Wouters, E. F. M., Schmeck, B. & SysMed-COPD Consortium, 2019, In : International journal of chronic obstructive pulmonary disease. 14, p. 1465-1484 20 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Pulmonary rehabilitation, physical activity, respiratory failure and palliative respiratory care

Spruit, M. A., Rochester, C. L., Pitta, F., Kenn, K., Schols, A. M. W. J., Hart, N., Wouters, E. F. M., Nava, S., Dreher, M., Janssen, D. J. A., Johnson, M. J., Curtis, R. J., Sastry, M. & Franssen, F. M. E., Jul 2019, In : Thorax. 74, 7, p. 693-699 7 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Revealing Methodological Challenges in Chronic Obstructive Pulmonary Disease Studies Assessing Comorbidities: A Narrative Review

Houben-Wilke, S., Triest, F. J. J., Franssen, F. M. E., Janssen, D. J. A., Wouters, E. F. M. & Vanfleteren, L. E. G. W., Apr 2019, In : Chronic Obstructive Pulmonary Diseases : Journal of the COPD Foundation. 6, 2, p. 166-177 12 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Risk stratification for short-term mortality at hospital admission for acute exacerbations of COPD

Sprooten, R. T. M., Rohde, G. G. U., Lawyer, G., Leijte, W. T., Wouters, E. F. M. & Franssen, F. M. E., Aug 2019, In : Respirology. 24, 8, p. 765-776 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

The LEAD (Lung, Heart, Social, Body) Study: Objectives, Methodology, and External Validity of the Population-Based Cohort Study

Breyer-Kohansal, R., Hartl, S., Burghuber, O. C., Urban, M., Schrott, A., Agusti, A., Sigsgaard, T., Vogelmeier, C., Wouters, E., Studnicka, M. & Breyer, M-K., Aug 2019, In : Journal of Epidemiology. 29, 8, p. 315-324 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The Medusa faces of dyspnoea in COPD

Wouters, E. F. M., 1 Apr 2019, In : European Respiratory Journal. 53, 4, 3 p., 1900487.

Research output: Contribution to journalEditorialAcademicpeer-review

The superexacerbator phenotype in patients with COPD: a descriptive analysis

Vanfleteren, L. E. G. W., Boonen, L. M. C., Spruit, M. A., Janssen, D. J. A., Wouters, E. F. M. & Franssen, F. M. E., 1 Apr 2019, In : ERJ Open Research. 5, 2, 4 p., 00235-2018.

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

Open Access
Open Access

Understanding changes and stability in the long-term use of technologies by seniors who are aging in place: a dynamical framework

Peek, S. T. M., Luijkx, K. G., Vrijhoef, H. J. M., Nieboer, M. E., Aarts, S., van der Voort, C. S., Rijnaard, M. D. & Wouters, E. J. M., 28 Aug 2019, In : BMC Geriatrics. 19, 1, 13 p., 236.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Wearable Finger Pulse Oximetry for Continuous Oxygen Saturation Measurements During Daily Home Routines of Patients With Chronic Obstructive Pulmonary Disease (COPD) Over One Week: Observational Study

Buekers, J., Theunis, J., De Boever, P., Vaes, A. W., Koopman, M., Janssen, E. V. M., Wouters, E. F. M., Spruit, M. A. & Aerts, J-M., 11 Jun 2019, In : JMIR mHealth and uHealth. 7, 6, 14 p., 12866.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

Adverse respiratory effects of opioids for chronic breathlessness: to what extent can we learn lessons from chronic pain?

Verberkt, C. A., van den Beuken-van Everdingen, M. H. J., Schols, J. M. G. A., Datla, S., Dirksen, C. D., Johnson, M. J., van Kuijk, S. M. J., Wouters, E. F. M. & Janssen, D. J. A., 1 Jul 2018, In : European Respiratory Journal. 52, 1, 3 p., 1800882.

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

Airflow Obstruction and Use of Solid Fuels for Cooking or Heating BOLD (Burden of Obstructive Lung Disease) Results

Amaral, A. F. S., Patel, J., Kato, B. S., Obaseki, D. O., Lawin, H., Tan, W. C., Juvekar, S. K., Harrabi, I., Studnicka, M., Wouters, E. F. M., Loh, L-C., Bateman, E. D., Mortimer, K., Buist, A. S., Burney, P. G. J. & Burden Obstructive Lung Dis BOLD, 1 Mar 2018, In : American Journal of Respiratory and Critical Care Medicine. 197, 5, p. 595-610 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Blood eosinophil count thresholds and exacerbations in patients with chronic obstructive pulmonary disease

Yun, J. H., Lamb, A., Chase, R., Singh, D., Parker, M. M., Saferali, A., Vestbo, J., Tal-Singer, R., Castaldi, P. J., Silverman, E. K., Hersh, C. P., COPDGene Investigator, ECLIPSE Investigators & Wouters, E., Jun 2018, In : Journal of Allergy and Clinical Immunology. 141, 6, p. 2037-2047 21 p.

Research output: Contribution to journalArticleAcademicpeer-review

Blood eosinophilia, use of inhaled corticosteroids, and risk of COPD exacerbations and mortality

Oshagbemi, O. A., Franssen, F. M. E., Braeken, D. C. W., Henskens, Y., Wouters, E. F. M., Maitland-van der Zee, A-H., Burden, A. M. & de Vries, F., Nov 2018, In : Pharmacoepidemiology and Drug Safety. 27, 11, p. 1191-1199 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Cognitive impairment and clinical characteristics in patients with chronic obstructive pulmonary disease

Cleutjens, F. A. H. M., Spruit, M. A., Ponds, R. W. H. M., Vanfleteren, L. E. G. W., Franssen, F. M. E., Gijsen, C., Dijkstra, J. B., Wouters, E. F. M. & Janssen, D. J. A., May 2018, In : Chronic respiratory disease. 15, 2, p. 91-102 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Collagen Degradation and Formation Are Elevated in Exacerbated COPD Compared With Stable Disease

Schumann, D. M., Leeming, D., Papakonstantinou, E., Blasi, F., Kostikas, K., Boersma, W., Louis, R., Milenkovic, B., Aerts, J., Sand, J. M. B., Wouters, E. F. M., Rohde, G., Prat, C., Torres, A., Welte, T., Tamm, M., Karsdal, M. & Stolz, D., 1 Oct 2018, In : Chest. 154, 4, p. 798-807 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Contribution of individual COPD assessment test (CAT) items to CAT total score and effects of pulmonary rehabilitation on CAT scores

Houben-Wilke, S., Janssen, D. J. A., Franssen, F. M. E., Vanfleteren, L. E. G. W., Wouters, E. F. M. & Spruit, M. A., 30 Oct 2018, In : Health and Quality of Life Outcomes. 16, 8 p., 205.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

COPD patient education and support - Achieving patient-centredness

Stoilkova-Hartmann, A., Franssen, F. M. E., Augustin, I. M. L., Wouters, E. F. M. & Barnard, K. D., 1 Nov 2018, In : Patient Education and Counseling. 101, 11, p. 2031-2036 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

COPD stands for complex obstructive pulmonary disease

Houben-Wilke, S., Augustin, I. M., Vercoulen, J. H., van Ranst, D., de Vaate, E. B., Wempe, J. B., Spruit, M. A., Wouters, E. F. M. & Franssen, F. M. E., 30 Jun 2018, In : European Respiratory Review. 27, 148, p. 1-12 12 p., 180027.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Copper as the most likely pathogenic divergence factor between lung fibrosis and emphysema

Janssen, R., de Brouwer, B., von der Thusen, J. H. & Wouters, E. F. M., 1 Nov 2018, In : Medical Hypotheses. 120, p. 49-54 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Crystalline silica alters Sulfatase-1 expression in rat lungs which influences hyper-proliferative and fibrogenic effects in human lung epithelial cells

Perkins, T. N., Peeters, P. M., Albrecht, C., Schins, R. P. F., Dentener, M. A., Mossman, B. T., Wouters, E. F. M. & Reynaert, N. L., 1 Jun 2018, In : Toxicology and Applied Pharmacology. 348, p. 43-53 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Determinants of functional, peak and endurance exercise capacity in people with chronic obstructive pulmonary disease

McNamara, R. J., Houben-Wilke, S., Franssen, F. M. E., Smid, D. E., Vanfleteren, L. E. G. W., Groenen, M. T. J., Uszko-Lencer, N. H. M. K., Wouters, E. F. M., Alison, J. A. & Spruit, M. A., May 2018, In : Respiratory Medicine. 138, p. 81-87 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Diagnosis of vertebral deformities on chest CT and DXA compared to routine lateral thoracic spine X-ray

van Dort, M. J., Romme, E. A. P. M., Smeenk, F. W. J. M., Geusens, P. P. P. M., Wouters, E. F. M. & van den Bergh, J. P., Jun 2018, In : Osteoporosis International. 29, 6, p. 1285-1293 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access