Abstract
Although defined by the presence of airflow obstruction and respiratory symptoms, patients with chronic obstructive pulmonary disease (COPD) are characterized by multimorbidity. Numerous co-occurring conditions and systemic manifestations contribute to the clinical presentation and progression of COPD; however, underlying mechanisms for multimorbidity are currently not fully elucidated. Vitamin A and vitamin D have been related to COPD pathogenesis. Another fat-soluble vitamin, vitamin K, has been put forward to exert protective roles in COPD. Vitamin K is an unequivocal cofactor for the carboxylation of coagulation factors, but also for extra-hepatic proteins including the soft tissue calcification inhibitor matrix Gla-protein and the bone protein osteocalcin. Additionally, vitamin K has been shown to have anti-oxidant and anti-ferroptosis properties. In this review, we discuss the potential role of vitamin K in the systemic manifestations of COPD. We will elaborate on the effect of vitamin K on prevalent co-occurring chronic conditions in COPD including cardiovascular disorders, chronic kidney disease, osteoporosis, and sarcopenia. Finally, we link these conditions to COPD with vitamin K as a connecting factor and provide recommendations for future clinical studies.
Original language | English |
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Article number | 1261 |
Number of pages | 19 |
Journal | Journal of Clinical Medicine |
Volume | 12 |
Issue number | 4 |
DOIs | |
Publication status | Published - 1 Feb 2023 |
Keywords
- chronic obstructive pulmonary disease
- emphysema
- vitamin K
- matrix Gla-protein
- cardiovascular disease
- chronic kidney disease
- osteoporosis
- sarcopenia
- MATRIX GLA-PROTEIN
- BONE-MINERAL DENSITY
- CHRONIC KIDNEY-DISEASE
- SERUM UNDERCARBOXYLATED OSTEOCALCIN
- VASCULAR CALCIFICATION
- ARTERIAL STIFFNESS
- ELASTIN DEGRADATION
- HIP FRACTURE
- DOUBLE-BLIND
- MENAQUINONE-7 SUPPLEMENTATION