Downregulation of DUOX1 function contributes to aging-related impairment of innate airway injury responses and accelerated senile emphysema

Caspar Schiffers, Lennart K. A. Lundblad, Milena Hristova, Aida Habibovic, Christopher M. Dustin, Nirav Daphtary, Minara Aliyeva, David J. Seward, Yvonne M. W. Janssen-Heininger, Emiel F. M. Wouters, Niki L. Reynaert, Albert van der Vliet*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)L144-L158
Number of pages15
JournalAmerican Journal of Physiology-Lung Cellular and Molecular Physiology
Volume321
Issue number1
DOIs
Publication statusPublished - Jul 2021

Keywords

  • allergen
  • epithelium
  • NADPH oxidase
  • NNT
  • type 2 cytokines
  • EPITHELIAL-CELL MIGRATION
  • NADPH OXIDASES
  • LIFE-SPAN
  • PROMOTER HYPERMETHYLATION
  • OXIDATIVE STRESS
  • IL-33 PROMOTES
  • NOX ENZYMES
  • LUNG HEALTH
  • MITOCHONDRIAL
  • EXPRESSION

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