Aaron Isaacs

Research output

Research output per year 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2024

• 122 Article
• 5 Comment/Letter to the editor
• 3 Erratum / corrigendum / retractions
• 1 (Systematic) Review article

Research output per year

Research output per year

Search results

• Article

  Genetic Determinants of Electrocardiographic P-Wave Duration and Relation to Atrial Fibrillation

  Weng, L-C., Hall, A. W., Choi, S. H., Jurgens, S. J., Haessler, J., Bihlmeyer, N. A., Grarup, N., Lin, H., Teumer, A., Li-Gao, R., Yao, J., Guo, X., Brody, J. A., Mueller-Nurasyid, M., Schramm, K., Verweij, N., van den Berg, M. E., van Setten, J., Isaacs, A., Ramirez, J., & 40 othersWarren, H. R., Padmanabhan, S., Kors, J. A., de Boer, R. A., van der Meer, P., Sinner, M. F., Waldenberger, M., Psaty, B. M., Taylor, K. D., Voelker, U., Kanters, J. K., Li, M., Alonso, A., Perez, M. V., Vaartjes, I., Bots, M. L., Huang, P. L., Heckbert, S. R., Lin, H. J., Kornej, J., Munroe, P. B., van Duijn, C. M., Asselbergs, F. W., Stricker, B. H., van der Harst, P., Kaeaeb, S., Peters, A., Sotoodehnia, N., Rotter, J. I., Mook-Kanamori, D. O., Doerr, M., Felix, S. B., Linneberg, A., Hansen, T., Arking, D. E., Kooperberg, C., Benjamin, E. J., Lunetta, K. L., Ellinor, P. T. & Lubitz, S. A., Oct 2020, In: Circulation: Genomic and Precision Medicine. 13, 5, p. 387-395 9 p., 002874.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Genetic insights into resting heart rate and its role in cardiovascular disease

  van de Vegte, Y. J., Eppinga, R. N., van der Ende, M. Y., Hagemeijer, Y. P., Mahendran, Y., Salfati, E., Smith, A. V., Tan, V. Y., Arking, D. E., Ntalla, I., Appel, E. V., Schurmann, C., Brody, J. A., Rueedi, R., Polasek, O., Sveinbjornsson, G., Lecoeur, C., Ladenvall, C., Zhao, J. H., Isaacs, A., & 32 othersWang, L., Luan, J., Hwang, S. J., Mononen, N., Auro, K., Jackson, A. U., Bielak, L. F., Zeng, L., Shah, N., Nethander, M., Campbell, A., Rankinen, T., Pechlivanis, S., Qi, L., Zhao, W., Rizzi, F., Tanaka, T., Robino, A., Cocca, M., Lange, L., Müller-Nurasyid, M., Roselli, C., Zhang, W., Kleber, M. E., Guo, X., Lin, H. J., Pavani, F., Galesloot, T. E., Noordam, R., Milaneschi, Y., Van der Harst, P. & The DCCT/EDIC Research Group, 2 Aug 2023, In: Nature Communications. 14, 1, 21 p., 4646.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Genetic loci for coronary calcification and serum lipids relate to aortic and carotid calcification

  Bos, D., Ikram, M. A., Isaacs, A., Verhaaren, B. F. J., Hofman, A., van Duijn, C. M., Witteman, J. C. M., van der Lugt, A. & Vernooij, M. W., Feb 2013, In: Circulation : Cardiovascular Genetics. 6, 1, p. 47-53 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Genetic risk factors for cerebral small-vessel disease in hypertensive patients from a genetically isolated population

  Schuur, M., van Swieten, J. C., Schol-Gelok, S., Ikram, M. A., Vernooij, M. W., Liu, F., Isaacs, A., de Boer, R., de Koning, I., Niessen, W. J., Vrooman, H., Oostra, B. A., van der Lugt, A., Breteler, M. M. B. & van Duijn, C. M., Jan 2011, In: Journal of Neurology Neurosurgery and Psychiatry. 82, 1, p. 41-4 4 p.

  Research output: Contribution to journal › Article › Academic › peer-review

• Genetic studies of body mass index yield new insights for obesity biology

  Locke, A. E., Kahali, B., Berndt, S. I., Justice, A. E., Pers, T. H., Day, F. R., Powell, C., Vedantam, S., Buchkovich, M. L., Yang, J., Croteau-Chonka, D. C., Esko, T., Fall, T., Ferreira, T., Gustafsson, S., Kutalik, Z., Luan, J., Mägi, R., Randall, J. C., Winkler, T. W., & 34 othersWood, A. R., Workalemahu, T., Faul, J. D., Smith, J. A., Zhao, J. H., Zhao, W., Chen, J., Fehrmann, R., Hedman, Å. K., Karjalainen, J., Schmidt, E. M., Absher, D., Amin, N., Anderson, D., Beekman, M., Bolton, J. L., Bragg-Gresham, J. L., Buyske, S., Demirkan, A., Deng, G., Ehret, G. B., Feenstra, B., Feitosa, M. F., Fischer, K., Goel, A., Gong, J., Jackson, A. U., Isaacs, A., Wong, A., Jacobs, K. B., LifeLines Cohort Study, Hirschorn, J. N., Loos, R. J. F. & Speliotes, E. K., 12 Feb 2015, In: Nature. 518, 7538, p. 197-206 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

• Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

  International Consortium for Blood Pressure Genome-Wide Association Studies, 6 Oct 2011, In: Nature. 478, 7367, p. 103-109 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review

• Genetic variants in RBFOX3 are associated with sleep latency

  Amin, N., Allebrandt, K. V., van der Spek, A., Müller-Myhsok, B., Hek, K., Teder-Laving, M., Hayward, C., Esko, T., van Mill, J. G., Mbarek, H., Watson, N. F., Melville, S. A., Del Greco, F. M., Byrne, E. M., Oole, E., Kolcic, I., Chen, T-H., Evans, D. S., Coresh, J., Vogelzangs, N., & 54 othersKarjalainen, J., Willemsen, G., Gharib, S. A., Zgaga, L., Mihailov, E., Stone, K. L., Campbell, H., Brouwer, R. W., Demirkan, A., Isaacs, A., Dogas, Z., Marciante, K. D., Campbell, S., Borovecki, F., Luik, A. I., Li, M., Hottenga, J. J., Huffman, J. E., van den Hout, M. C., Cummings, S. R., Aulchenko, Y. S., Gehrman, P. R., Uitterlinden, A. G., Wichmann, H-E., Müller-Nurasyid, M., Fehrmann, R. S., Montgomery, G. W., Hofman, A., Kao, W. H. L., Oostra, B. A., Wright, A. F., Vink, J. M., Wilson, J. F., Pramstaller, P. P., Hicks, A. A., Polasek, O., Punjabi, N. M., Redline, S., Psaty, B. M., Heath, A. C., Merrow, M., Tranah, G. J., Gottlieb, D. J., Boomsma, D. I., Martin, N. G., Rudan, I., Tiemeier, H., van IJcken, W. F., Penninx, B. W., Metspalu, A., Meitinger, T., Franke, L., Roenneberg, T. & van Duijn, C. M., Oct 2016, In: European Journal of Human Genetics. 24, 10, p. 1488-1495 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Genome of The Netherlands population-specific imputations identify an ABCA6 variant associated with cholesterol levels

  van Leeuwen, E. M., Karssen, L. C., Deelen, J., Isaacs, A., Medina-Gomez, C., Mbarek, H., Kanterakis, A., Trompet, S., Postmus, I., Verweij, N., van Enckevort, D. J., Huffman, J. E., White, C. C., Feitosa, M. F., Bartz, T. M., Manichaikul, A., Joshi, P. K., Peloso, G. M., Deelen, P., van Dijk, F., & 32 othersWillemsen, G., de Geus, E. J., Milaneschi, Y., Penninx, B. W. J. H., Francioli, L. C., Menelaou, A., Pulit, S. L., Rivadeneira, F., Hofman, A., Oostra, B. A., Franco, O. H., Mateo Leach, I., Beekman, M., de Craen, A. J. M., Uh, H-W., Trochet, H., Hocking, L. J., Porteous, D. J., Sattar, N., Packard, C. J., Buckley, B. M., Brody, J. A., Bis, J. C., Rotter, J. I., Mychaleckyj, J. C., Campbell, H., Duan, Q., Lange, L. A., Wilson, J. F., Hayward, C., Genome of the Netherlands Consortium & van Duijn, C., 9 Mar 2015, In: Nature Communications. 6, p. 6065

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Genome-wide analysis of constitutional DNA methylation in familial melanoma

  Salgado, C., Gruis, N., Heijmans, B. T., Oosting, J., van Doorn, R., BIOS Consortium & Isaacs, A., 6 Mar 2020, In: Clinical epigenetics. 12, 1, 7 p., 43.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Genome-wide association analyses identify 18 new loci associated with serum urate concentrations

  Köttgen, A., Albrecht, E., Teumer, A., Vitart, V., Krumsiek, J., Hundertmark, C., Pistis, G., Ruggiero, D., O'Seaghdha, C. M., Haller, T., Yang, Q., Tanaka, T., Johnson, A. D., Kutalik, Z., Smith, A. V., Shi, J., Struchalin, M., Middelberg, R. P. S., Brown, M. J., Gaffo, A. L., & 31 othersPirastu, N., Li, G., Hayward, C., Zemunik, T., Huffman, J., Yengo, L., Zhao, J. H., Demirkan, A., Feitosa, M. F., Liu, X., Malerba, G., Lopez, L. M., van der Harst, P., Li, X., Kleber, M. E., Hicks, A. A., Nolte, I. M., Johansson, A., Murgia, F., Wild, S. H., Bakker, S. J. L., Peden, J. F., Dehghan, A., Steri, M., Tenesa, A., Lagou, V., Salo, P., Mangino, M., Isaacs, A., Wolffenbuttel, B. H. R. & LifeLines Cohort Study, Feb 2013, In: Nature Genetics. 45, 2, p. 145-54 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

• Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM

  Amin, N., Byrne, E., Johnson, J., Chenevix-Trench, G., Walter, S., Nolte, I. M., Vink, J. M., Rawal, R., Mangino, M., Teumer, A., Keers, J. C., Verwoert, G., Baumeister, S., Biffar, R., Petersmann, A., Dahmen, N., Doering, A., Isaacs, A., Broer, L., Wray, N. R., & 32 othersMontgomery, G. W., Levy, D., Psaty, B. M., Gudnason, V., Chakravarti, A., Sulem, P., Gudbjartsson, D. F., Kiemeney, L. A., Thorsteinsdottir, U., Stefansson, K., van Rooij, F. J. A., Aulchenko, Y. S., Hottenga, J. J., Rivadeneira, F. R., Hofman, A., Uitterlinden, A. G., Hammond, C. J., Shin, S-Y., Ikram, A., Witteman, J. C. M., Janssens, A. C. J. W., Snieder, H., Tiemeier, H., Wolfenbuttel, B. H. R., Oostra, B. A., Heath, A. C., Wichmann, E., Spector, T. D., Grabe, H. J., Boomsma, D. I., KConFab Investigators & van Duijn, C. M., Nov 2012, In: Molecular Psychiatry. 17, 11, p. 1116-29 14 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Genome-wide association and functional follow-up reveals new loci for kidney function

  Pattaro, C., Köttgen, A., Teumer, A., Garnaas, M., Böger, C. A., Fuchsberger, C., Olden, M., Chen, M-H., Tin, A., Taliun, D., Li, M., Gao, X., Gorski, M., Yang, Q., Hundertmark, C., Foster, M. C., O'Seaghdha, C. M., Glazer, N., Isaacs, A., Liu, C-T., & 31 othersSmith, A. V., O'Connell, J. R., Struchalin, M., Tanaka, T., Li, G., Johnson, A. D., Gierman, H. J., Feitosa, M., Hwang, S-J., Atkinson, E. J., Lohman, K., Cornelis, M. C., Johansson, Å., Tönjes, A., Dehghan, A., Chouraki, V., Holliday, E. G., Sorice, R., Kutalik, Z., Lehtimäki, T., Esko, T., Deshmukh, H., Ulivi, S., Chu, A. Y., Murgia, F., Trompet, S., Imboden, M., Kollerits, B., Pistis, G., Wang, J. J. & CARDIoGRAM Consortium, 2012, In: Plos Genetics. 8, 3, p. e1002584

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits

  van Setten, J., Verweij, N., Mbarek, H., Niemeijer, M. N., Trompet, S., Arking, D. E., Brody, J. A., Gandin, I., Grarup, N., Hall, L. M., Hemerich, D., Lyytikainen, L-P., Mei, H., Mueller-Nurasyid, M., Prins, B. P., Robino, A., Smith, A. V., Warren, H. R., Asselbergs, F. W., Boomsma, D. I., & 41 othersCaulfield, M. J., Eijgelsheim, M., Ford, I., Hansen, T., Harris, T. B., Heckbert, S. R., Hottenga, J-J., Iorio, A., Kors, J. A., Linneberg, A., MacFarlane, P. W., Meitinger, T., Nelson, C. P., Raitakari, O. T., Aldana, C. T. S., Sinagra, G., Sinner, M., Soliman, E. Z., Stoll, M., Uitterlinden, A., van Duijn, C. M., Waldenberger, M., Alonso, A., Gasparini, P., Gudnason, V., Jamshidi, Y., Kaab, S., Kanters, J. K., Lehtimaki, T., Munroe, P. B., Peters, A., Samani, N. J., Sotoodehnia, N., Ulivi, S., Wilson, J. G., de Geus, E. J. C., Jukema, J. W., Stricker, B., van der Harst, P., de Bakker, P. I. W. & Isaacs, A., Jun 2019, In: European Journal of Human Genetics. 27, 6, p. 952-962 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels

  Draisma, H. H. M., Pool, R., Kobl, M., Jansen, R., Petersen, A-K., Vaarhorst, A. A. M., Yet, I., Haller, T., Demirkan, A., Esko, T., Zhu, G., Böhringer, S., Beekman, M., van Klinken, J. B., Römisch-Margl, W., Prehn, C., Adamski, J., de Craen, A. J. M., van Leeuwen, E. M., Amin, N., & 28 othersDharuri, H., Westra, H-J., Franke, L., de Geus, E. J. C., Hottenga, J. J., Willemsen, G., Henders, A. K., Montgomery, G. W., Nyholt, D. R., Whitfield, J. B., Penninx, B. W., Spector, T. D., Metspalu, A., Slagboom, P. E., van Dijk, K. W., 't Hoen, P. A. C., Strauch, K., Martin, N. G., van Ommen, G-J. B., Illig, T., Bell, J. T., Mangino, M., Suhre, K., McCarthy, M. I., Gieger, C., Isaacs, A., van Duijn, C. M. & Boomsma, D. I., 12 Jun 2015, In: Nature Communications. 6, p. 7208

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations

  Demirkan, A., van Duijn, C. M., Ugocsai, P., Isaacs, A., Pramstaller, P. P., Liebisch, G., Wilson, J. F., Johansson, Å., Rudan, I., Aulchenko, Y. S., Kirichenko, A. V., Janssens, A. C. J. W., Jansen, R. C., Gnewuch, C., Domingues, F. S., Pattaro, C., Wild, S. H., Jonasson, I., Polasek, O., Zorkoltseva, I. V., & 31 othersHofman, A., Karssen, L. C., Struchalin, M., Floyd, J., Igl, W., Biloglav, Z., Broer, L., Pfeufer, A., Pichler, I., Campbell, S., Zaboli, G., Kolcic, I., Rivadeneira, F., Huffman, J., Hastie, N. D., Uitterlinden, A., Franke, L., Franklin, C. S., Vitart, V., Nelson, C. P., Preuss, M., Bis, J. C., O'Donnell, C. J., Franceschini, N., Witteman, J. C. M., Axenovich, T., Oostra, B. A., Meitinger, T., Hicks, A. A., Hayward, C. & DIAGRAM Consortium, 2012, In: Plos Genetics. 8, 2, p. e1002490

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Genome-wide Association Study of Change in Fasting Glucose over time in 13,807 non-diabetic European Ancestry Individuals

  Liu, C-T., Merino, J., Rybin, D., DiCorpo, D., Benke, K. S., Bragg-Gresham, J. L., Canouil, M., Corre, T., Grallert, H., Isaacs, A., Kutalik, Z., Lahti, J., Marullo, L., Marzi, C., Rasmussen-Torvik, L. J., Rocheleau, G., Rueedi, R., Scapoli, C., Verweij, N., Vogelzangs, N., & 30 othersWillems, S. M., Yengo, L., Bakker, S. J. L., Beilby, J., Hui, J., Kajantie, E., Müller-Nurasyid, M., Rathmann, W., Balkau, B., Bergmann, S., Eriksson, J. G., Florez, J. C., Froguel, P., Harris, T., Hung, J., James, A. L., Kavousi, M., Miljkovic, I., Musk, A. W., Palmer, L. J., Peters, A., Roussel, R., van der Harst, P., van Duijn, C. M., Vollenweider, P., Barroso, I., Prokopenko, I., Dupuis, J., Meigs, J. B. & Bouatia-Naji, N., 1 Jul 2019, In: Scientific Reports. 9, 1, 8 p., 9439.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits

  Teumer, A., Qi, Q., Nethander, M., Aschard, H., Bandinelli, S., Beekman, M., Berndt, S. I., Bidlingmaier, M., Broer, L., Cappola, A., Ceda, G. P., Chanock, S., Chen, M-H., Chen, T. C., Chen, Y-D. I., Chung, J., Miglianico, F. D. G., Eriksson, J., Ferrucci, L., Friedrich, N., & 66 othersGnewuch, C., Goodarzi, M. O., Grarup, N., Guo, T., Hammer, E., Hayes, R. B., Hicks, A. A., Hofman, A., Houwing-Duistermaat, J. J., Hu, F., Hunter, D. J., Husemoen, L. L., Isaacs, A., Jacobs, K. B., Janssen, J. A. M. J. L., Jansson, J-O., Jehmlich, N., Johnson, S., Juul, A., Karlsson, M., Kilpelainen, T. O., Kovacs, P., Kraft, P., Li, C., Linneberg, A., Liu, Y., Loos, R. J. F., Lorentzon, M., Lu, Y., Maggio, M., Magi, R., Meigs, J., Mellstrom, D., Nauck, M., Newman, A. B., Pollak, M. N., Pramstaller, P. P., Prokopenko, I., Psaty, B. M., Reincke, M., Rimm, E. B., Rotter, J. I., Saint Pierre, A., Schurmann, C., Seshadri, S., Sjogren, K., Slagboom, P. E., Strickler, H. D., Stumvoll, M., Suh, Y., Sun, Q., Zhang, C., Svensson, J., Tanaka, T., Tare, A., Toenjes, A., Uh, H-W., van Duijn, C. M., van Heemst, D., Vandenput, L., Vasan, R. S., Voelker, U., Willems, S. M., Ohlsson, C., Wallaschofski, H. & Kaplan, R. C., Oct 2016, In: Aging Cell. 15, 5, p. 811-824

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels

  Kilpelainen, T. O., Carli, J. F. M., Skowronski, A. A., Sun, Q., Kriebel, J., Feitosa, M. F., Hedman, A. K., Drong, A. W., Hayes, J. E., Zhao, J., Pers, T. H., Schick, U., Grarup, N., Kutalik, Z., Trompet, S., Mangino, M., Kristiansson, K., Beekman, M., Lyytikainen, L-P., Eriksson, J., & 157 othersHenneman, P., Lahti, J., Tanaka, T., Luan, J., Del Greco M, F., Pasko, D., Renstrom, F., Willems, S. M., Mahajan, A., Rose, L. M., Guo, X., Liu, Y., Kleber, M. E., Perusse, L., Gaunt, T., Ahluwalia, T. S., Sung, Y. J., Ramos, Y. F., Amin, N., Amuzu, A., Barroso, I., Bellis, C., Blangero, J., Buckley, B. M., Bohringer, S., Chen, Y-D. I., de Craen, A. J. N., Crosslin, D. R., Dale, C. E., Dastani, Z., Day, F. R., Deelen, J., Delgado, G. E., Demirkan, A., Finucane, F. M., Ford, I., Garcia, M. E., Gieger, C., Gustafsson, S., Hallmans, G., Hankinson, S. E., Havulinna, A. S., Herder, C., Hernandez, D., Hicks, A. A., Hunter, D. J., Illig, T., Ingelsson, E., Ioan-Facsinay, A., Jansson, J-O., Jenny, N. S., Jorgensen, M. E., Jorgensen, T., Karlsson, M., Koenig, W., Kraft, P., Kwekkeboom, J., Laatikainen, T., Ladwig, K-H., LeDuc, C. A., Lowe, G., Lu, Y., Marques-Vidal, P., Meisinger, C., Menni, C., Morris, A. P., Myers, R. H., Mannisto, S., Nalls, M. A., Paternoster, L., Peters, A., Pradhan, A. D., Rankinen, T., Rasmussen-Torvik, L. J., Rathmann, W., Rice, T. K., Richards, J. B., Ridker, P. M., Sattar, N., Savage, D. B., Soderberg, S., Timpson, N. J., Vandenput, L., van Heemst, D., Uh, H-W., Vohl, M-C., Walker, M., Wichmann, H-E., Widen, E., Wood, A. R., Yao, J., Zeller, T., Zhang, Y., Meulenbelt, I., Kloppenburg, M., Astrup, A., Sorensen, T. I. A., Sarzynski, M. A., Rao, D. C., Jousilahti, P., Vartiainen, E., Hofman, A., Rivadeneira, F., Uitterlinden, A. G., Kajantie, E., Osmond, C., Palotie, A., Eriksson, J. G., Heliovaara, M., Knekt, P. B., Koskinen, S., Jula, A., Perola, M., Huupponen, R. K., Viikari, J. S., Kahonen, M., Lehtimaki, T., Raitakari, O. T., Mellstrom, D., Lorentzon, M., Casas, J. P., Bandinelli, S., Maerz, W., Isaacs, A., van Dijk, K. W., van Duijn, C. M., Harris, T. B., Bouchard, C., Allison, M. A., Chasman, D. I., Ohlsson, C., Lind, L., Scott, R. A., Langenberg, C., Wareham, N. J., Ferrucci, L., Frayling, T. M., Pramstaller, P. P., Borecki, I. B., Waterworth, D. M., Bergmann, S., Waeber, G., Vollenweider, P., Vestergaard, H., Hansen, T., Pedersen, O., Hu, F. B., Slagboom, P. E., Grallert, H., Spector, T. D., Jukema, J. W., Klein, R. J., Schadt, E. E., Franks, P. W., Lindgren, C. M., Leibel, R. L. & Loos, R. J. F., Feb 2016, In: Nature Communications. 7, 10494.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes

  Franceschini, N., Giambartolomei, C., de Vries, P. S., Finan, C., Bis, J. C., Huntley, R. P., Lovering, R. C., Tajuddin, S. M., Winkler, T. W., Graff, M., Kavousi, M., Dale, C., Smith, A. V., Hofer, E., van Leeuwen, E. M., Nolte, I. M., Lu, L., Scholz, M., Sargurupremraj, M., Pitkanen, N., & 44 othersFranzen, O., Joshi, P. K., Noordam, R., Marioni, R. E., Hwang, S-J., Musani, S. K., Schminke, U., Palmas, W., Isaacs, A., Correa, A., Zonderman, A. B., Hofman, A., Teumer, A., Cox, A. J., Uitterlinden, A. G., Wong, A., Smit, A. J., Newman, A. B., Britton, A., Ruusalepp, A., Sennblad, B., Hedblad, B., Pasaniuc, B., Penninx, B. W., Langefeld, C. D., Wassel, C. L., Tzourio, C., Fava, C., Baldassarre, D., O'Leary, D. H., Teupser, D., Kuh, D., Tremoli, E., Mannarino, E., Grossi, D., Boerwinkle, E., Schadt, E. E., Ingelsson, E., Veglia, F., Rivadeneira, F., Beutner, F., MEGASTROKE Consortium, Bjorkegren, J. L. M. & O'Donnell, C. J., 3 Dec 2018, In: Nature Communications. 9, 14 p., 5141.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification

  Lagou, V., Jiang, L., Ulrich, A., Zudina, L., González, K. S. G., Balkhiyarova, Z., Faggian, A., Maina, J. G., Chen, S., Todorov, P. V., Sharapov, S., David, A., Marullo, L., Mägi, R., Rujan, R. M., Ahlqvist, E., Thorleifsson, G., Gao, H., ?vangelou, ., Benyamin, B., & 35 othersScott, R. A., Isaacs, A., Zhao, J. H., Willems, S. M., Johnson, T., Gieger, C., Grallert, H., Meisinger, C., Müller-Nurasyid, M., Strawbridge, R. J., Goel, A., Rybin, D., Albrecht, E., Jackson, A. U., Stringham, H. M., Corrêa, I. R., Farber-Eger, E., Steinthorsdottir, V., Uitterlinden, A. G., Munroe, P. B., Brown, M. J., Schmidberger, J., Holmen, O., Thorand, B., Hveem, K., Wilsgaard, T., Mohlke, K. L., Wang, Z., den Hoed, M., Shmeliov, A., Kaakinen, M., Jones, B., Prokopenko, I., Et al. & Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC), Sept 2023, In: Nature Genetics. 55, 9, p. 1448-1461 14 p.

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• Heart Failure, Female Sex, and Atrial Fibrillation Are the Main Drivers of Human Atrial Cardiomyopathy: Results From the CATCH ME Consortium

  Winters, J., Isaacs, A., Zeemering, S., Kawczynski, M., Maesen, B., Maessen, J., Bidar, E., Boukens, B., Hermans, B., van Hunnik, A., Casadei, B., Fabritz, L., Chua, W., Sommerfeld, L., Guasch, E., Mont, L., Batlle, M., Hatem, S., Kirchhof, P., Wakili, R., & 5 othersSinner, M., Stoll, M., Goette, A., Verheule, S. & Schotten, U., 21 Nov 2023, In: Journal of the American Heart Association. 12, 22, 15 p., e031220.

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• Heritabilities, proportions of heritabilities explained by GWAS findings, and implications of cross-phenotype effects on PR interval

  Silva, C. T., Kors, J. A., Amin, N., Dehghan, A., Witteman, J. C. M., Willemsen, R., Oostra, B. A., van Duijn, C. M. & Isaacs, A., Nov 2015, In: Human Genetics. 134, 11-12, p. 1211-1219 9 p.

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• Heritability in a SCN5A-mutation founder population with increased female susceptibility to non-nocturnal ventricular tachyarrhythmia and sudden cardiac death

  ter Bekke, R. M. A., Isaacs, A., Barysenka, A., Hoos, M. B., Jongbloed, J. D. H., Hoorntje, J. C. A., Patelski, A. S. M., Helderman-van den Enden, A. T. J. M., van den Wijngaard, A., Stoll, M. & Volders, P. G. A., Dec 2017, In: Heart Rhythm. 14, 12, p. 1873-1881 9 p.

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• Identification of context-dependent expression quantitative trait loci in whole blood

  Zhernakova, D. V., Deelen, P., Vermaat, M., van Iterson, M., van Galen, M., Arindrarto, W., van 't Hof, P., Mei, H., van Dijk, F., Westra, H-J., Bonder, M. J., van Rooij, J., Verkerk, M., Jhamai, P. M., Moed, M., Kielbasa, S. M., Bot, J., Nooren, I., Pool, R., van Dongen, J., & 27 othersHottenga, J. J., Stehouwer, C. D. A., van der Kallen, C. J. H., Schalkwijk, C. G., Zhernakova, A., Li, Y., Tigchelaar, E. F., de Klein, N., Beekman, M., Deelen, J., van Heemst, D., van den Berg, L. H., Hofman, A., Uitterlinden, A. G., van Greevenbroek, M. M. J., Veldink, J. H., Boomsma, D. I., van Duijn, C. M., Wijmenga, C., Slagboom, P. E., Swertz, M. A., Isaacs, A., van Meurs, J. B. J., Jansen, R., Heijmans, B. T., 't Hoen, P. A. C. & Franke, L., Jan 2017, In: Nature Genetics. 49, 1, p. 139-145 7 p.

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• Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders

  den Hoed, M., Eijgelsheim, M., Esko, T., Brundel, B. J. J. M., Peal, D. S., Evans, D. M., Nolte, I. M., Segrè, A. V., Holm, H., Handsaker, R. E., Westra, H-J., Johnson, T., Isaacs, A., Yang, J., Lundby, A., Zhao, J. H., Kim, Y. J., Go, M. J., Almgren, P., Bochud, M., & 32 othersBoucher, G., Cornelis, M. C., Gudbjartsson, D., Hadley, D., van der Harst, P., Hayward, C., den Heijer, M., Igl, W., Jackson, A. U., Kutalik, Z., Luan, J., Kemp, J. P., Kristiansson, K., Ladenvall, C., Lorentzon, M., Montasser, M. E., Njajou, O. T., O'Reilly, P. F., Padmanabhan, S., St Pourcain, B., Rankinen, T., Salo, P., Tanaka, T., Timpson, N. J., Vitart, V., Waite, L., Wheeler, W., Zhang, W., Draisma, H. H. M., Wong, A., Global BPgen Consortium & Loos, R. J. F., Jun 2013, In: Nature Genetics. 45, 6, p. 621-31 11 p.

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• In situ lipid-loading activates peripheral dendritic cell subsets characterized by cellular ROS accumulation but compromises their capacity to prime naïve T cells

  Christ, A., Maas, S. L., Jin, H., Lu, C., Legein, B., Wijnands, E., Temmerman, L., Otten, J., Isaacs, A., Zenke, M., Stoll, M., Biessen, E. A. L. & van der Vorst, E. P. C., 5 Jan 2024, In: Free Radical Biology and Medicine. 210, p. 406-415 10 p.

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• Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function

  Chasman, D. I., Fuchsberger, C., Pattaro, C., Teumer, A., Böger, C. A., Endlich, K., Olden, M., Chen, M-H., Tin, A., Taliun, D., Li, M., Gao, X., Gorski, M., Yang, Q., Hundertmark, C., Foster, M. C., O'Seaghdha, C. M., Glazer, N., Isaacs, A., Liu, C-T., & 31 othersSmith, A. V., O'Connell, J. R., Struchalin, M., Tanaka, T., Li, G., Johnson, A. D., Gierman, H. J., Feitosa, M. F., Hwang, S-J., Atkinson, E. J., Lohman, K., Cornelis, M. C., Johansson, A., Tönjes, A., Dehghan, A., Lambert, J-C., Holliday, E. G., Sorice, R., Kutalik, Z., Lehtimäki, T., Esko, T., Deshmukh, H., Ulivi, S., Chu, A. Y., Murgia, F., Trompet, S., Imboden, M., Coassin, S., Pistis, G., Wang, J. J. & CARDIoGRAM Consortium, 15 Dec 2012, In: Human Molecular Genetics. 21, 24, p. 5329-43 15 p.

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• JavaCyte, a novel open-source tool for automated quantification of key hallmarks of cardiac structural remodeling

  Winters, J., von Braunmuhl, M. E., Zeemering, S., Gilbers, M., Ten Brink, T., Scaf, B., Guasch, E., Mont, L., Batlle, M., Sinner, M., Hatem, S., Mansour, M. K., Fabritz, L., Sommerfeld, L. C., Kirchhof, P., Isaacs, A., Stoll, M., Schotten, U. & Verheule, S., 18 Nov 2020, In: Scientific Reports. 10, 1, 15 p., 20074.

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  Open Access

• Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

  Scott, R. A., Lagou, V., Welch, R. P., Wheeler, E., Montasser, M. E., Luan, J., Mägi, R., Strawbridge, R. J., Rehnberg, E., Gustafsson, S., Kanoni, S., Rasmussen-Torvik, L. J., Yengo, L., Lecoeur, C., Shungin, D., Sanna, S., Sidore, C., Johnson, P. C. D., Jukema, J. W., Johnson, T., & 36 othersMahajan, A., Verweij, N., Thorleifsson, G., Hottenga, J-J., Shah, S., Smith, A. V., Sennblad, B., Gieger, C., Salo, P., Perola, M., Timpson, N. J., Evans, D. M., Pourcain, B. S., Wu, Y., Andrews, J. S., Hui, J., Bielak, L. F., Zhao, W., Horikoshi, M., Navarro, P., Isaacs, A., O'Connell, J. R., Stirrups, K., Vitart, V., Hayward, C., Esko, T., Mihailov, E., Fraser, R. M., Fall, T., Voight, B. F., DIAbetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium, Florez, J. C., Langenberg, C., Ingelsson, E., Prokopenko, I. & Barroso, I., Sept 2012, In: Nature Genetics. 44, 9, p. 991-1005 15 p.

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• Linkage analysis for plasma amyloid beta levels in persons with hypertension implicates Aβ-40 levels to presenilin 2

  Ibrahim-Verbaas, C. A., Zorkoltseva, I. V., Amin, N., Schuur, M., Coppus, A. M. W., Isaacs, A., Aulchenko, Y. S., Breteler, M. M. B., Ikram, M. A., Axenovich, T. I., Verbeek, M. M., van Swieten, J. C., Oostra, B. A. & van Duijn, C. M., Dec 2012, In: Human Genetics. 131, 12, p. 1869-76 8 p.

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• Loci influencing blood pressure identified using a cardiovascular gene-centric array

  CARDIOGRAM, METASTROKE, Keating, B. J. & Asselbergs, F. W., 15 Apr 2013, In: Human Molecular Genetics. 22, 8, p. 1663-78 16 p.

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• Low Density Lipoprotein Exposure of Plasmacytoid Dendritic Cells Blunts Toll-like Receptor 7/9 Signaling via NUR77

  Christ, A., Goossens, P. G., Wijnands, E., Jin, H., Legein, B., Oth, T., Isaacs, A., Stoll, M., Vanderlocht, J., Lutgens, E., Daemen, M. J. A. P., Zenke, M. & Biessen, E. A. L., 17 May 2022, In: Biomedicines. 10, 5, 17 p., 1152.

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• Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility

  Wessel, J., Chu, A. Y., Willems, S. M., Wang, S., Yaghootkar, H., Brody, J. A., Dauriz, M., Hivert, M-F., Raghavan, S., Lipovich, L., Hidalgo, B., Fox, K., Huffman, J. E., An, P., Lu, Y., Rasmussen-Torvik, L. J., Grarup, N., Ehm, M. G., Li, L., Baldridge, A. S., & 31 othersStančáková, A., Abrol, R., Besse, C., Boland, A., Bork-Jensen, J., Fornage, M., Freitag, D. F., Garcia, M. E., Guo, X., Hara, K., Isaacs, A., Jakobsdottir, J., Lange, L. A., Layton, J. C., Li, M., Hua Zhao, J., Meidtner, K., Morrison, A. C., Nalls, M. A., Peters, M. J., Sabater-Lleal, M., Schurmann, C., Silveira, A., Smith, A. V., Southam, L., Stoiber, M. H., Strawbridge, R. J., Taylor, K. D., Varga, T. V., Allin, K. H. & EPIC-InterAct Consortium, 29 Jan 2015, In: Nature Communications. 6, p. 5897

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• Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits

  Porcu, E., Rueger, S., Lepik, K., Agbessi, M., Ahsan, H., Alves, I., Andiappan, A., Arindrarto, W., Awadalla, P., Battle, A., Beutner, F., Bonder, M. J., Boomsma, D., Christiansen, M., Claringbould, A., Deelen, P., Esko, T., Fave, M-J., Franke, L., Frayling, T., & 32 othersGharib, S. A., Gibson, G., Heijmans, B. T., Hemani, G., Jansen, R., Kahonen, M., Kalnapenkis, A., Kasela, S., Kettunen, J., Kim, Y., Kirsten, H., Kovacs, P., Krohn, K., Kronberg-Guzman, J., Kukushkina, V., Lee, B., Lehtimaki, T., Loeffler, M., Marigorta, U. M., Mei, H., Milani, L., Montgomery, G. W., Mueler-Nurasyid, M., Nauck, M., Stehouwer, C. D. A., Isaacs, A., Schalkwijk, C. G., van der Kallen, C. J. H., van Greevenbroek, M. M. J., eQTLgen Consortium, BIOS Consortium & Kutalik, Z., 24 Jul 2019, In: Nature Communications. 10, 12 p., 3300.

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• Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels

  van Leeuwen, E. M., Sabo, A., Bis, J. C., Huffman, J. E., Manichaikul, A., Smith, A. V., Feitosa, M. F., Demissie, S., Joshi, P. K., Duan, Q., Marten, J., van Klinken, J. B., Surakka, I., Nolte, I. M., Zhang, W., Mbarek, H., Li-Gao, R., Trompet, S., Verweij, N., Evangelou, E., & 78 othersLyytikainen, L-P., Tayo, B. O., Deelen, J., van der Most, P. J., van der Laan, S. W., Arking, D. E., Morrison, A., Dehghan, A., Franco, O. H., Hofman, A., Rivadeneira, F., Sijbrands, E. J., Uitterlinden, A. G., Mychaleckyj, J. C., Campbell, A., Hocking, L. J., Padmanabhan, S., Brody, J. A., Rice, K. M., White, C. C., Harris, T., Isaacs, A., Campbell, H., Lange, L. A., Rudan, I., Kolcic, I., Navarro, P., Zemunik, T., Salomaa, V., Kooner, A. S., Kooner, J. S., Lehne, B., Scott, W. R., Tan, S-T., de Geus, E. J., Milaneschi, Y., Penninx, B. W. J. H., Willemsen, G., de Mutsert, R., Ford, I., Gansevoort, R. T., Segura-Lepe, M. P., Raitakari, O. T., Viikari, J. S., Nikus, K., Forrester, T., McKenzie, C. A., de Craen, A. J. M., de Ruijter, H. M., Pasterkamp, G., Snieder, H., Oldehinkel, A. J., Slagboom, P. E., Cooper, R. S., Kahonen, M., Lehtimaki, T., Elliott, P., van der Harst, P., Jukema, J. W., Mook-Kanamori, D. O., Boomsma, D. I., Chambers, J. C., Swertz, M., Ripatti, S., van Dijk, K. W., Vitart, V., Polasek, O., Hayward, C., Wilson, J. G., Wilson, J. F., Gudnason, V., Rich, S. S., Psaty, B. M., Borecki, I. B., Boerwinkle, E., Rotter, J. I., Cupples, L. A. & van Duijn, C. M., Jul 2016, In: Journal of Medical Genetics. 53, 7, p. 441-449

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• Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque

  Bis, J. C., Kavousi, M., Franceschini, N., Isaacs, A., Abecasis, G. R., Schminke, U., Post, W. S., Smith, A. V., Cupples, L. A., Markus, H. S., Schmidt, R., Huffman, J. E., Lehtimäki, T., Baumert, J., Münzel, T., Heckbert, S. R., Dehghan, A., North, K., Oostra, B., Bevan, S., & 31 othersStoegerer, E-M., Hayward, C., Raitakari, O., Meisinger, C., Schillert, A., Sanna, S., Völzke, H., Cheng, Y-C., Thorsson, B., Fox, C. S., Rice, K., Rivadeneira, F., Nambi, V., Halperin, E., Petrovic, K. E., Peltonen, L., Wichmann, H. E., Schnabel, R. B., Dörr, M., Parsa, A., Aspelund, T., Demissie, S., Kathiresan, S., Reilly, M. P., Taylor, K., Uitterlinden, A., Couper, D. J., Sitzer, M., Kähönen, M., Illig, T. & CARDIoGRAM Consortium, 11 Sept 2011, In: Nature Genetics. 43, 10, p. 940-7 8 p.

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• Meta-analysis of telomere length in 19,713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect

  Broer, L., Codd, V., Nyholt, D. R., Deelen, J., Mangino, M., Willemsen, G., Albrecht, E., Amin, N., Beekman, M., de Geus, E. J. C., Henders, A., Nelson, C. P., Steves, C. J., Wright, M. J., de Craen, A. J. M., Isaacs, A., Matthews, M., Moayyeri, A., Montgomery, G. W., Oostra, B. A., & 7 othersVink, J. M., Spector, T. D., Slagboom, P. E., Martin, N. G., Samani, N. J., van Duijn, C. M. & Boomsma, D. I., Oct 2013, In: European Journal of Human Genetics. 21, 10, p. 1163-8 6 p.

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• Metabolomics reveals a link between homocysteine and lipid metabolism and leukocyte telomere length: the ENGAGE consortium

  van der Spek, A., Broer, L., Draisma, H. H. M., Pool, R., Albrecht, E., Beekman, M., Mangino, M., Raag, M., Nyholt, D. R., Dharuri, H. K., Codd, V., Amin, N., de Geus, E. J. C., Deelen, J., Demirkan, A., Yet, I., Fischer, K., Haller, T., Henders, A. K., Isaacs, A., & 19 othersMedland, S. E., Montgomery, G. W., Mooijaart, S. P., Strauch, K., Suchiman, H. E. D., Vaarhorst, A. A. M., van Heemst, D., Wang-Sattler, R., Whitfield, J. B., Willemsen, G., Wright, M. J., Martin, N. G., Samani, N. J., Metspalu, A., Slagboom, P. E., Spector, T. D., Boomsma, D., van Duijn, C. M. & Gieger, C., 12 Aug 2019, In: Scientific Reports. 9, 12 p., 11623.

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• Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction

  Ntalla, I., Weng, L-C., Cartwright, J. H., Hall, A. W., Sveinbjornsson, G., Tucker, N. R., Choi, S. H., Chaffin, M. D., Roselli, C., Barnes, M. R., Mifsud, B., Warren, H. R., Hayward, C., Marten, J., Cranley, J. J., Concas, M. P., Gasparini, P., Boutin, T., Kolcic, I., Polasek, O., & 167 othersRudan, I., Araujo, N. M., Lima-Costa, M. F., Ribeiro, A. L. P., Souza, R. P., Tarazona-Santos, E., Giedraitis, V., Ingelsson, E., Mahajan, A., Morris, A. P., Del Greco, F. M., Foco, L., Gogele, M., Hicks, A. A., Cook, J. P., Lind, L., Lindgren, C. M., Sundstrom, J., Nelson, C. P., Riaz, M. B., Samani, N. J., Sinagra, G., Ulivi, S., Kahonen, M., Mishra, P. P., Mononen, N., Nikus, K., Caulfield, M. J., Dominiczak, A., Padmanabhan, S., Montasser, M. E., O'Connell, J. R., Ryan, K., Shuldiner, A. R., Aeschbacher, S., Conen, D., Risch, L., Theriault, S., Hutri-Kahonen, N., Lehtimaki, T., Lyytikainen, L-P., Raitakari, O. T., Barnes, C. L. K., Campbell, H., Joshi, P. K., Wilson, J. F., Isaacs, A., Kors, J. A., van Duijn, C. M., Huang, P. L., Gudnason, V., Harris, T. B., Launer, L. J., Smith, A., Bottinger, E. P., Loos, R. J. F., Nadkarni, G. N., Preuss, M. H., Correa, A., Mei, H., Wilson, J., Meitinger, T., Mueller-Nurasyid, M., Peters, A., Waldenberger, M., Mangino, M., Spector, T. D., Rienstra, M., van de Vegte, Y. J., van der Harst, P., Verweij, N., Kaab, S., Schramm, K., Sinner, M. F., Strauch, K., Cutler, M. J., Fatkin, D., London, B., Olesen, M., Roden, D. M., Shoemaker, M. B., Smith, J. G., Biggs, M. L., Bis, J. C., Brody, J. A., Psaty, B. M., Rice, K., Sotoodehnia, N., De Grandi, A., Fuchsberger, C., Pattaro, C., Pramstaller, P. P., Ford, I., Jukema, J. W., Macfarlane, P. W., Trompet, S., Doerr, M., Felix, S. B., Voelker, U., Weiss, S., Havulinna, A. S., Jula, A., Saaksjarvi, K., Salomaa, V., Guo, X., Heckbert, S. R., Lin, H. J., Rotter, J., Taylor, K. D., Yao, J., de Mutsert, R., Maan, A. C., Mook-Kanamori, D. O., Noordam, R., Cucca, F., Ding, J., Lakatta, E. G., Qian, Y., Tarasov, K., Levy, D., Lin, H., Newton-Cheh, C. H., Lunetta, K. L., Murray, A. D., Porteous, D. J., Smith, B. H., Stricker, B. H., Uitterlinden, A., van den Berg, M. E., Haessler, J., Jackson, R. D., Kooperberg, C., Peters, U., Reiner, A. P., Whitsel, E. A., Alonso, A., Arking, D. E., Boerwinkle, E., Ehret, G. B., Soliman, E. Z., Avery, C. L., Gogarten, S. M., Kerr, K. F., Laurie, C. C., Seyerle, A. A., Stilp, A., Assa, S., Said, M. A., van der Ende, M. Y., Lambiase, P. D., Orini, M., Ramirez, J., Van Duijvenboden, S., Arnar, D. O., Gudbjartsson, D. F., Holm, H., Sulem, P., Thorleifsson, G., Thorolfsdottir, R. B., Thorsteinsdottir, U., Benjamin, E. J., Tinker, A., Stefansson, K., Ellinor, P. T., Jamshidi, Y., Lubitz, S. A. & Munroe, P. B., 21 May 2020, In: Nature Communications. 11, 1, 12 p., 2542.

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• Multiethnic Exome-Wide Association Study of Subclinical Atherosclerosis

  Natarajan, P., Bis, J. C., Bielak, L. F., Cox, A. J., Dorr, M., Feitosa, M. F., Franceschini, N., Guo, X., Hwang, S-J., Isaacs, A., Jhun, M. A., Kavousi, M., Li-Gao, R., Lyytikainen, L-P., Marioni, R. E., Schminke, U., Stitziel, N. O., Tada, H., van Setten, J., Smith, A. V., & 80 othersVojinovic, D., Yanek, L. R., Yao, J., Yerges-Armstrong, L. M., Amin, N., Baber, U., Borecki, I. B., Carr, J. J., Chen, Y-D. I., Cupples, L. A., de Jong, P. A., de Koning, H., de Vos, B. D., Demirkan, A., Fuster, V., Franco, O. H., Goodarzi, M. O., Harris, T. B., Heckbert, S. R., Heiss, G., Hoffmann, U., Hofman, A., Isgum, I., Jukema, J. W., Kahonen, M., Kardia, S. L. R., Kral, B. G., Launer, L. J., Massaro, J., Mehran, R., Mitchell, B. D., Jr, T. H. M., de Mutsert, R., Newman, A. B., Nguyen, K., North, K. E., O'Connell, J. R., Oudkerk, M., Pankow, J. S., Peloso, G. M., Post, W., Province, M. A., Raffield, L. M., Raitakari, O. T., Reilly, D. F., Rivadeneira, F., Rosendaal, F., Sartori, S., Taylor, K. D., Teumer, A., Trompet, S., Turner, S. T., Uitterlinden, A. G., Vaidya, D., van der Lugt, A., Volker, U., Wardlaw, J. M., Wassel, C. L., Weiss, S., Wojczynski, M. K., Becker, D. M., Becker, L. C., Boerwinkle, E., Bowden, D. W., Deary, I. J., Dehghan, A., Felix, S. B., Gudnason, V., Lehtimaki, T., Mathias, R., Mook-Kanamori, D. O., Psaty, B. M., Rader, D. J., Rotter, J. I., Wilson, J. G., van Duijn, C. M., Volzke, H., Kathiresan, S., Peyser, P. A. & O'Donnell, C. J., Dec 2016, In: Circulation : Cardiovascular Genetics. 9, 6, p. 511-520

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  Open Access

• New genetic loci link adipose and insulin biology to body fat distribution

  Shungin, D., Winkler, T. W., Croteau-Chonka, D. C., Ferreira, T., Locke, A. E., Mägi, R., Strawbridge, R. J., Pers, T. H., Fischer, K., Justice, A. E., Workalemahu, T., Wu, J. M. W., Buchkovich, M. L., Heard-Costa, N. L., Roman, T. S., Drong, A. W., Song, C., Gustafsson, S., Day, F. R., Esko, T., & 33 othersFall, T., Kutalik, Z., Luan, J., Randall, J. C., Scherag, A., Vedantam, S., Wood, A. R., Chen, J., Fehrmann, R., Karjalainen, J., Kahali, B., Liu, C-T., Schmidt, E. M., Absher, D., Amin, N., Anderson, D., Beekman, M., Bragg-Gresham, J. L., Buyske, S., Demirkan, A., Ehret, G. B., Feitosa, M. F., Goel, A., Jackson, A. U., Johnson, T., Kleber, M. E., Kristiansson, K., Isaacs, A., Wong, A., Staessen, J. A., ADIPOGen Consortium, Lindgren, C. M. & Mohlke, K. L., 12 Feb 2015, In: Nature. 518, 7538, p. 187-196 10 p.

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• New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism

  Horikoshi, M., Yaghootkar, H., Mook-Kanamori, D. O., Sovio, U., Taal, H. R., Hennig, B. J., Bradfield, J. P., St Pourcain, B., Evans, D. M., Charoen, P., Kaakinen, M., Cousminer, D. L., Lehtimäki, T., Kreiner-Møller, E., Warrington, N. M., Bustamante, M., Feenstra, B., Berry, D. J., Thiering, E., Pfab, T., & 37 othersBarton, S. J., Shields, B. M., Kerkhof, M., van Leeuwen, E. M., Fulford, A. J., Kutalik, Z., Zhao, J. H., den Hoed, M., Mahajan, A., Lindi, V., Goh, L-K., Hottenga, J-J., Wu, Y., Raitakari, O. T., Harder, M. N., Meirhaeghe, A., Ntalla, I., Salem, R. M., Jameson, K. A., Zhou, K., Monies, D. M., Lagou, V., Kirin, M., Heikkinen, J., Adair, L. S., Alkuraya, F. S., Al-Odaib, A., Amouyel, P., Andersson, E. A., Isaacs, A., Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC), McCarthy, M. I., Jaddoe, V. W., Jarvelin, M-R., Timpson, N. J., Prokopenko, I. & Freathy, R., Jan 2013, In: Nature Genetics. 45, 1, p. 76-82 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review

• Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis

  Benyamin, B., Esko, T., Ried, J. S., Radhakrishnan, A., Vermeulen, S. H., Traglia, M., Gögele, M., Anderson, D., Broer, L., Podmore, C., Luan, J., Kutalik, Z., Sanna, S., van der Meer, P., Tanaka, T., Wang, F., Westra, H-J., Franke, L., Mihailov, E., Milani, L., & 32 othersHälldin, J., Häldin, J., Winkelmann, J., Meitinger, T., Thiery, J., Peters, A., Waldenberger, M., Rendon, A., Jolley, J., Sambrook, J., Kiemeney, L. A., Sweep, F. C., Sala, C. F., Schwienbacher, C., Pichler, I., Hui, J., Demirkan, A., Isaacs, A., Amin, N., Steri, M., Waeber, G., Verweij, N., Powell, J. E., Nyholt, D. R., Heath, A. C., Madden, P. A. F., Visscher, P. M., Wright, M. J., Montgomery, G. W., Martin, N. G., InterAct Consortium & Whitfield, J. B., 29 Oct 2014, In: Nature Communications. 5, p. 4926

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  Open Access

• Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

  Dastani, Z., Hivert, M-F., Timpson, N., Perry, J. R. B., Yuan, X., Scott, R. A., Henneman, P., Heid, I. M., Kizer, J. R., Lyytikäinen, L-P., Fuchsberger, C., Tanaka, T., Morris, A. P., Small, K., Isaacs, A., Beekman, M., Coassin, S., Lohman, K., Qi, L., Kanoni, S., & 31 othersPankow, J. S., Uh, H-W., Wu, Y., Bidulescu, A., Rasmussen-Torvik, L. J., Greenwood, C. M. T., Ladouceur, M., Grimsby, J., Manning, A. K., Liu, C-T., Kooner, J., Mooser, V. E., Vollenweider, P., Kapur, K. A., Chambers, J., Wareham, N. J., Langenberg, C., Frants, R., Willems-Vandijk, K., Oostra, B. A., Willems, S. M., Lamina, C., Winkler, T. W., Psaty, B. M., Tracy, R. P., Brody, J., Chen, I., Viikari, J., Kähönen, M., Vogelzangs, N. & DIAGRAM+ Consortium, 2012, In: Plos Genetics. 8, 3, p. e1002607

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  Open Access

• Nucleotide excision DNA repair is associated with age-related vascular dysfunction

  Durik, M., Kavousi, M., van der Pluijm, I., Isaacs, A., Cheng, C., Verdonk, K., Loot, A. E., Oeseburg, H., Bhaggoe, U. M., Leijten, F., van Veghel, R., de Vries, R., Rudez, G., Brandt, R., Ridwan, Y. R., van Deel, E. D., de Boer, M., Tempel, D., Fleming, I., Mitchell, G. F., & 12 othersVerwoert, G. C., Tarasov, K. V., Uitterlinden, A. G., Hofman, A., Duckers, H. J., van Duijn, C. M., Oostra, B. A., Witteman, J. C. M., Duncker, D. J., Danser, A. H. J., Hoeijmakers, J. H. & Roks, A. J. M., 24 Jul 2012, In: Circulation. 126, 4, p. 468-78 11 p.

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  Open Access

• Occupational exposure to gases/fumes and mineral dust affect DNA methylation levels of genes regulating expression

  van Der Plaat, D., Vonk, J. M., Terzikhan, N., de Jong, K., de Vries, M., La Bastide-van Gemert, S., van Diemen, C. C., Lahousse, L., Brusselle, G., Nedeljkovic, I., Amin, N., Kromhout, H., Vermeulen, R. C. H., Postma, D. S., van Duijn, C. M., Boezen, H. M., Heijmans, B. T., Hoen, P. A. C. T., van Meurs, J., Isaacs, A., & 31 othersJansen, R., Franke, L., Boomsma, D., Pool, R., van Dongen, J., Hottenga, J. J., van Greevenbroek, M. M. J., Stehouwer, C. D. A., van Der Kallen, C. J. H., Schalkwijk, C. G., Wijmenga, C., Zhernakova, S., Tigchelaar, E. E., Slagboom, P. E., Beekman, M., Deelen, J., van Heemst, D., Veldink, J. H., van den Berg, L. H., Hofman, B. A., Uitterlinden, A. G., Jhamai, P. M., Verbiest, M., Suchiman, H. E. D., Verkerk, M., van Der Breggen, R., van Rooij, J., Lakenberg, N., Mei, H., van Iterson, M. & BIOS Consortium, 1 Aug 2019, In: Human Molecular Genetics. 28, 15, p. 2477-2485 9 p.

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  Open Access

• Pharmacogenomics study of thiazide diuretics and QT interval in multi-ethnic populations: the cohorts for heart and aging research in genomic epidemiology

  Seyerle, A. A., Sitlani, C. M., Noordam, R., Gogarten, S. M., Li, J., Li, X., Evans, D. S., Sun, F., Laaksonen, M. A., Isaacs, A., Kristiansson, K., Highland, H. M., Stewart, J. D., Harris, T. B., Trompet, S., Bis, J. C., Peloso, G. M., Brody, J. A., Broer, L., Busch, E. L., & 54 othersDuan, Q., Stilp, A. M., O'Donnell, C. J., Macfarlane, P. W., Floyd, J. S., Kors, J. A., Lin, H. J., Li-Gao, R., Sofer, T., Mendez-Giraldez, R., Cummings, S. R., Heckbert, S. R., Hofman, A., Ford, I., Li, Y., Launer, L. J., Porthan, K., Newton-Cheh, C., Napier, M. D., Kerr, K. F., Reiner, A. P., Rice, K. M., Roach, J., Buckley, B. M., Soliman, E. Z., de Mutsert, R., Sotoodehnia, N., Uitterlinden, A. G., North, K. E., Lee, C. R., Gudnason, V., Sturmer, T., Rosendaal, F. R., Taylor, K. D., Wiggins, K. L., Wilson, J. G., Chen, Y-D., Kaplan, R. C., Wilhelmsen, K., Cupples, L. A., Salomaa, V., van Duijn, C., Jukema, J. W., Liu, Y., Mook-Kanamori, D. O., Lange, L. A., Vasan, R. S., Smith, A., Stricker, B. H., Laurie, C. C., Rotter, J., Whitsel, E. A., Psaty, B. M. & Avery, C. L., 1 Mar 2018, In: Pharmacogenomics Journal. 18, 2, p. 215-226 12 p.

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• Plasma phosphatidylcholine and sphingomyelin concentrations are associated with depression and anxiety symptoms in a Dutch family-based lipidomics study

  Demirkan, A., Isaacs, A., Ugocsai, P., Liebisch, G., Struchalin, M., Rudan, I., Wilson, J. F., Pramstaller, P. P., Gyllensten, U., Campbell, H., Schmitz, G., Oostra, B. A. & van Duijn, C. M., Mar 2013, In: Journal of Psychiatric Research. 47, 3, p. 357-62 6 p.

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• Plasma proprotein convertase subtilisin kexin type 9 levels are related to markers of cholesterol synthesis in familial combined hyperlipidemia

  Brouwers, M. C. G. J., Konrad, R. J., van Himbergen, T. M., Isaacs, A., Otokozawa, S., Troutt, J. S., Schaefer, E. J., van Greevenbroek, M. M. J., Stalenhoef, A. F. H. & de Graaf, J., Nov 2013, In: Nutrition Metabolism and Cardiovascular Diseases. 23, 11, p. 1115-1121

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• Preoperative P-wave parameters and risk of atrial fibrillation after cardiac surgery: a meta-analysis of 20,201 patients

  Kawczynski, M. J., Van De Walle, S., Maesen, B., Isaacs, A., Zeemering, S., Hermans, B., Vernooy, K., Maessen, J. G., Schotten, U. & Bidar, E., 1 Oct 2022, In: Interactive Cardiovascular and Thoracic Surgery. 35, 4, 12 p., ivac220.

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  Open Access