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Researcher

Heijman, J.

Assistant Professor

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  1. 2009
  2. Published
    Decker, K. F., Heijman, J., Silva, J. R., Hund, T. J., & Rudy, Y. (2009). Properties and ionic mechanisms of action potential adaptation, restitution, and accommodation in canine epicardium. American Journal of Physiology-heart and Circulatory Physiology, 296(4), H1017-H1026. https://doi.org/10.1152/ajpheart.01216.2008
  3. 2010
  4. Published
    Johnson, D. M., Heijman, J., Pollard, C. E., Valentin, J. P., Crijns, H. J., Abi-Gerges, N., & Volders, P. G. A. (2010). I(Ks) restricts excessive beat-to-beat variability of repolarization during beta-adrenergic receptor stimulation. Journal of Molecular and Cellular Cardiology, 48(1), 122-130. https://doi.org/10.1016/j.yjmcc.2009.08.033
  5. Published
    Heijman, J., Rudy, Y., Westra, R. L., & Volders, P. G. A. (2010). Computational analysis of the downstream effects of beta-adrenergic stimulation on CaMKII in the canine ventricular myocyte (Abstract). Proc. of Frontiers in CardioVascular Biology, 16-19 Jul. 2010, Berlin, Germany.
  6. 2011
  7. Published
    Heijman, J., Volders, P. G. A., Westra, R. L., & Rudy, Y. (2011). Local control of β-adrenergic stimulation: Effects on ventricular myocyte electrophysiology and Ca2+-transient. Journal of Molecular and Cellular Cardiology, 50(5), 863-871. https://doi.org/10.1016/j.yjmcc.2011.02.007
  8. 2012
  9. Published
    Heijman, J. (2012). Computational analysis of β-adrenergic stimulation and its effects on cardiac ventricular electrophysiology. Maastricht: Maastricht University.
  10. Published
    Heijman, J., Spätjens, R., Seyen, S. R. M., Lentink, V., Kuijpers, H. J. H., Boulet, I. R., ... Volders, P. G. A. (2012). Dominant-Negative Control of cAMP-Dependent I-Ks Upregulation in Human Long-QT Syndrome Type 1. Circulation Research, 110(2), 211-+. https://doi.org/10.1161/CIRCRESAHA.111.249482
  11. 2013
  12. Published
    Johnson, D. M., Heijman, J., Bode, E. F., Greensmith, D. J., van der Linde, H., Abi-Gerges, N., ... Volders, P. G. A. (2013). Diastolic Spontaneous Calcium Release From the Sarcoplasmic Reticulum Increases Beat-to-Beat Variability of Repolarization in Canine Ventricular Myocytes After beta-Adrenergic Stimulation. Circulation Research, 112(2), 246-+. https://doi.org/10.1161/CIRCRESAHA.112.275735
  13. Published
    Heijman, J., Zaza, A., Johnson, D. M., Rudy, Y., Peeters, R. L. M., Volders, P. G. A., & Westra, R. L. (2013). Determinants of Beat-to-Beat Variability of Repolarization Duration in the Canine Ventricular Myocyte: A Computational Analysis. PLoS Computational Biology, 9(8), [e1003202]. https://doi.org/10.1371/journal.pcbi.1003202
  14. 2014
  15. Published
    Spätjens, R., Bebarova, M., Seyen, S. R. M., Lentink, V., Jongbloed, R. J., Arens, Y. H. J. M., ... Volders, P. G. A. (2014). Long-QT mutation p.K557E-Kv7.1: dominant-negative suppression of I-Ks, but preserved cAMP-dependent up-regulation. Cardiovascular Research, 104(1), 216-225. https://doi.org/10.1093/cvr/cvu191
  16. 2015
  17. Published
    Heijman, J., Heusch, G., & Dobrev, D. (2015). Tools to Keep the Clock Ticking: Molecular Approaches to Treat Sinus Node Dysfunction. Cardiology, 132(1), 45-48. https://doi.org/10.1159/000430783
  18. Published
    Voigt, N., Heijman, J., & Dobrev, D. (2015). New antiarrhythmic targets in atrial fibrillation. Future Cardiology, 11(6). https://doi.org/10.2217/fca.15.67
  19. Published
    Heijman, J., & Dobrev, D. (2015). Irregular rhythm and atrial metabolism are key for the evolution of proarrhythmic atrial remodeling in atrial fibrillation. Basic Research in Cardiology, 110(4), [41]. https://doi.org/10.1007/s00395-015-0498-1
  20. Published
    Schmidt, C., Wiedmann, F., Voigt, N., Zhou, X-B., Heijman, J., Lang, S., ... Thomas, D. (2015). Upregulation of K(2P)3.1 K+ Current Causes Action Potential Shortening in Patients With Chronic Atrial Fibrillation. Circulation, 132(2), 82-92. https://doi.org/10.1161/CIRCULATIONAHA.114.012657
  21. Published
    Heijman, J., & Crijns, H. J. G. M. (2015). T-wave Right Slope Provides a New Angle in the Prediction of Drug-Induced Ventricular Arrhythmias. Cardiovascular Drugs and Therapy, 29(5), 411-413. https://doi.org/10.1007/s10557-015-6620-7
  22. Published
    Heijman, J., Voigt, N., Ghezelbash, S., Schirmer, I., & Dobrev, D. (2015). Calcium Handling Abnormalities as a Target for Atrial Fibrillation Therapeutics: How Close to Clinical Implementation? Journal of Cardiovascular Pharmacology, 66(6), 515-522. https://doi.org/10.1097/FJC.0000000000000253
  23. 2016
  24. Published
    Molina, C. E., Heijman, J., & Dobrev, D. (2016). Differences in Left Versus Right Ventricular Electrophysiological Properties in Cardiac Dysfunction and Arrhythmogenesis. Arrhythmia & Electrophysiology Review, 5(1), 14-9. https://doi.org/10.15420/AER.2016.8.2
  25. Published
    Heijman, J., Abdoust, P. E., Voigt, N., Nattel, S., & Dobrev, D. (2016). Computational models of atrial cellular electrophysiology and calcium handling, and their role in atrial fibrillation. Journal of Physiology, 594(3), 537-553. https://doi.org/10.1113/JP271404
  26. Published
    Schmidt, C., Wiedmann, F., Voigt, N., Zhou, X-B., Heijman, J., Lang, S., ... Thomas, D. (2016). Response to Letter Regarding Article, "Upregulation of K 2P 3.1 K+ Current Causes Action Potential Shortening in Patients With Chronic Atrial Fibrillation". Circulation, 133(11), E440-E441. https://doi.org/10.1161/CIRCULATIONAHA.115.020662
  27. Published
    Heijman, J., Algalarrondo, V., Voigt, N., Melka, J., Wehrens, X. H. T., Dobrev, D., & Nattel, S. (2016). The value of basic research insights into atrial fibrillation mechanisms as a guide to therapeutic innovation: a critical analysis. Cardiovascular Research, 109(4), 467-479. https://doi.org/10.1093/cvr/cvv275
  28. Published
    Heijman, J., & Dobrev, D. (2016). Challenges to the translation of basic science findings to atrial fibrillation therapies. Future Cardiology, 12(3), 251-254. https://doi.org/10.2217/fca-2016-0007
  29. Published
    Heijman, J., Schirmer, I., & Dobrev, D. (2016). The multiple proarrhythmic roles of cardiac calcium-handling abnormalities: triggered activity, conduction abnormalities, beat-to-beat variability, and adverse remodelling. EP Europace, 18(10), 1452-1454. https://doi.org/10.1093/europace/euv417
  30. 2017
  31. Published
    Heijman, J., Ghezelbash, S., & Dobrev, D. (2017). Investigational antiarrhythmic agents: promising drugs in early clinical development. Expert Opinion on Investigational Drugs, 26(8), 897-907. https://doi.org/10.1080/13543784.2017.1353601
  32. Published
    Heijman, J., Ghezelbash, S., Wehrens, X. H. T., & Dobrev, D. (2017). Serine/Threonine Phosphatases in Atrial Fibrillation. Journal of Molecular and Cellular Cardiology, 103, 110-120. https://doi.org/10.1016/j.yjmcc.2016.12.009
  33. Published
    Grandi, E., Sanguinetti, M. C., Bartos, D. C., Bers, D. M., Ye Chen-Izu, Chiamvimonvat, N., ... Yarov-Yarovoy, V. (2017). Potassium channels in the heart: structure, function and regulation. Journal of Physiology, 595(7), 2209-2228. https://doi.org/10.1113/JP272864
  34. Published
    Chiamvimonvat, N., Ye Chen-Izu, U., Clancy, C. E., Deschenes, I., Dobrev, D., Heijman, J., ... Nerbonne, J. M. (2017). Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics. Journal of Physiology, 595(7), 2229-2252. https://doi.org/10.1113/JP272883
  35. Published
    Schmidt, C., Wiedmann, F., Zhou, X-B., Heijman, J., Voigt, N., Ratte, A., ... Thomas, D. (2017). Inverse remodelling of K(2P)3.1 K(+) channel expression and action potential duration in left ventricular dysfunction and atrial fibrillation: implications for patient-specific antiarrhythmic drug therapy. European Heart Journal, 38(22), 1764-1774. https://doi.org/10.1093/eurheartj/ehw559
  36. Published
    Tomek, J., Rodriguez, B., Bub, G., & Heijman, J. (2017). beta-Adrenergic receptor stimulation inhibits proarrhythmic alternans in postinfarction border zone cardiomyocytes: a computational analysis. American Journal of Physiology-heart and Circulatory Physiology, 313(2), H338-H353. https://doi.org/10.1152/ajpheart.00094.2017
  37. Published
    Neef, S., Heijman, J., Otte, K., Dewenter, M., Saadatmand, A. R., Meyer-Roxlau, S., ... El-Armouche, A. (2017). Chronic loss of inhibitor-1 diminishes cardiac RyR2 phosphorylation despite exaggerated CaMKII activity. Naunyn-Schmiedebergs Archives of Pharmacology, 390(8), 857-862. https://doi.org/10.1007/s00210-017-1376-1
  38. Published
    Heijman, J., & Dobrev, D. (2017). Inhibition of Small-Conductance Ca2+-Activated K+ Channels The Long-Awaited Breakthrough for Antiarrhythmic Drug Therapy of Atrial Fibrillation? Circulation-Arrhythmia and Electrophysiology, 10(10), [e005776]. https://doi.org/10.1161/CIRCEP.117.005776
  39. Published
    Heijman, J., Dobrev, D., & Crijns, H. J. G. M. (2017). Targeting supraventricular ectopic complexes: Which approach should be used and how does it affect atrial fibrillation? International Journal of Cardiology, 244, 202-203. https://doi.org/10.1016/j.ijcard.2017.06.013
  40. 2018
  41. Published
    Abu-Taha, I. H., Heijman, J., Feng, Y., Vettel, C., Dobrev, D., & Wieland, T. (2018). Regulation of heterotrimeric G-protein signaling by NDPK/NME proteins and caveolins: an update. Laboratory Investigation, 98(2), 190-197. https://doi.org/10.1038/labinvest.2017.103
  42. Published
    Heijman, J., & Dobrev, D. (2018). Ion channels as part of macromolecular multiprotein complexes: Clinical significance. Herzschrittmachertherapie und Elektrophysiologie, 29(1), 30-35. https://doi.org/10.1007/s00399-017-0542-y
  43. Published
    Heijman, J., Guichard, J-B., Dobrev, D., & Nattel, S. (2018). Translational Challenges in Atrial Fibrillation. Circulation Research, 122(5), 752-773. https://doi.org/10.1161/CIRCRESAHA.117.311081
  44. Published
    Heijman, J., Kirchner, D., Kunze, F., Chretien, E. M., Michel-Reher, M. B., Voigt, N., ... Dobrev, D. (2018). Muscarinic type-1 receptors contribute to I-K,I-ACh in human atrial cardiomyocytes and are upregulated in patients with chronic atrial fibrillation. International Journal of Cardiology, 255, 61-68. https://doi.org/10.1016/j.ijcard.2017.12.050
  45. Published
    Sutanto, H., van Sloun, B., Schönleitner, P., van Zandvoort, M. A. M. J., Antoons, G., & Heijman, J. (2018). The Subcellular Distribution of Ryanodine Receptors and L-Type Ca2+ Channels Modulates Ca2+-Transient Properties and Spontaneous Ca2+-Release Events in Atrial Cardiomyocytes. Frontiers in physiology, 9, [1108]. https://doi.org/10.3389/fphys.2018.01108
  46. Published
    Clerx, M., Heijman, J., Collins, P., & Volders, P. G. A. (2018). Predicting changes to I-Na from missense mutations in human SCN5A. Scientific Reports, 8(1), [12797]. https://doi.org/10.1038/s41598-018-30577-5
  47. Published
    Heijman, J., Dobrev, D., & Crijns, H. J. G. M. (2018). Electrocardiographic characteristics associated with atrial fibrillation - What do they tell us? International Journal of Cardiology, 266, 143-144. https://doi.org/10.1016/j.ijcard.2018.04.071
  48. Published
    Molina, C. E., Abu-Taha, I. H., Wang, Q., Rosello-Diez, E., Kamler, M., Nattel, S., ... Dobrev, D. (2018). Profibrotic, Electrical, and Calcium-Handling Remodeling of the Atria in Heart Failure Patients With and Without Atrial Fibrillation. Frontiers in physiology, 9, [1383]. https://doi.org/10.3389/fphys.2018.01383
  49. Published
    Uyen Chau Nguyen, N. V., Potse, M., Vernooy, K., Mafi-Rad, M., Heijman, J., Caputo, M. L., ... Maffessanti, F. (2018). A left bundle branch block activation sequence and ventricular pacing influence voltage amplitudes: an in vivo and in silico study. EP Europace, 20, 77-86. https://doi.org/10.1093/europace/euy233
  50. Published
    Sutanto, H., Dobrev, D., & Heijman, J. (2018). Resveratrol: an effective pharmacological agent to prevent inflammation-induced atrial fibrillation? Naunyn-Schmiedebergs Archives of Pharmacology, 391(11), 1163-1167. https://doi.org/10.1007/s00210-018-1566-5
  51. 2019
  52. Published
    van Mourik, M. J. W., Zaar, D. V. J., Smulders, M. W., Heijman, J., Lumens, J., Dokter, J. E., ... Bekkers, S. C. A. M. (2019). Adding Speckle-Tracking Echocardiography to Visual Assessment of Systolic Wall Motion Abnormalities Improves the Detection of Myocardial Infarction. Journal of the American Society of Echocardiography, 32(1), 65-73. https://doi.org/10.1016/j.echo.2018.09.007
  53. Published
    Heijman, J., & Dobrev, D. (2019). Bayesian network analyses in atrial fibrillation - A path to better therapies? IJC Heart and Vasculature, 22, 210-211. https://doi.org/10.1016/j.ijcha.2019.02.009
  54. Published
    Sutanto, H., & Heijman, J. (2019). The Role of Calcium in the Human Heart: With Great Power Comes Great Responsibility. Frontiers for Young Minds, 7(65). https://doi.org/10.3389/frym.2019.00065
  55. Published
    Thomas, D., Christ, T., Fabritz, L., Goette, A., Hammwoehner, M., Heijman, J., ... Voigt, N. (2019). German Cardiac Society Working Group on Cellular Electrophysiology state-of-the-art paper: impact of molecular mechanisms on clinical arrhythmia management. Clinical research in cardiology, 108(6), 577-599. https://doi.org/10.1007/s00392-018-1377-1
  56. Published
    Dobrev, D., Aguilar, M., Heijman, J., Guichard, J-B., & Nattel, S. (2019). Postoperative atrial fibrillation: mechanisms, manifestations and management. Nature Reviews Cardiology, 16(7), 417-436. https://doi.org/10.1038/s41569-019-0166-5
  57. Published
    Grandi, E., Dobrev, D., & Heijman, J. (2019). Computational modeling: What does it tell us about atrial fibrillation therapy? International Journal of Cardiology, 287, 155-161. https://doi.org/10.1016/j.ijcard.2019.01.077
  58. Published
    Sutanto, H., Dobrev, D., & Heijman, J. (2019). Genome-wide association studies of atrial fibrillation: Finding meaning in the life of risk loci. IJC Heart and Vasculature, 24, 100397. https://doi.org/10.1016/j.ijcha.2019.100397
  59. Published
    Sutanto, H., Laudy, L., Clerx, M., Dobrev, D., Crijns, H. J. G. M., & Heijman, J. (2019). Maastricht antiarrhythmic drug evaluator (MANTA): a computational tool for better understanding of antiarrhythmic drugs. Pharmacological Research, 148, 104444. [104444]. https://doi.org/10.1016/j.phrs.2019.104444

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