
Researcher
Jacobs, H.I.L.
Assistant Professor
View graph of relations
- 2019
- PublishedJacobs, H. I. L. (2019). Focus on the blue locus for learning. Nature human behaviour, 3(11), 1143-1144. https://doi.org/10.1038/s41562-019-0731-2
- PublishedBiddle, K. D., Uquillas, F. DO., Jacobs, H. I. L., Zide, B., Kirn, D. R., Rentz, D. M., ... Donovan, N. J. (2019). Social Engagement and Amyloidb-beta-Related Cognitive Decline in Cognitively Normal Older Adults. American Journal of Geriatric Psychiatry, 27(11), 1247-1256. https://doi.org/10.1016/j.jagp.2019.05.005
- PublishedWolters, A. F., van de Weijer, S. C. F., Leentjens, A. F. G., Duits, A. A., Jacobs, H. I. L., & Kuijf, M. L. (2019). "Resting-state fMRI in Patkinson's disease patients with cognitive Impairment: A meta-analysis": Answer to Wang and colleagues. Parkinsonism & Related Disorders, 66, 253-254. https://doi.org/10.1016/j.parkreldis.2019.07.014
- PublishedBetts, M. J., Kirilina, E., Otaduy, M. C. G., Ivanov, D., Acosta-Cabronero, J., Callaghan, M. F., ... Hämmerer, D. (2019). Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases. Brain, 142(9), 2558–2571. https://doi.org/10.1093/brain/awz193
- PublishedFreeze, W. M., ter Weele, D. N., Palm, W. M., van Hooren, R. W., Hoff, E., Jansen, J. F. A., ... Backes, W. H. (2019). Optimal Detection of Subtle Gadolinium Leakage in CSF with Heavily T2-Weighted Fluid-Attenuated Inversion Recovery Imaging. American Journal of Neuroradiology, 40(9), 1481-1483. https://doi.org/10.3174/ajnr.A6145
- PublishedHanseeuw, B. J., Betensky, R. A., Jacobs, H. I. L., Schultz, A. P., Sepulcre, J., Becker, J. A., ... Johnson, K. (2019). Association of Amyloid and Tau With Cognition in Preclinical Alzheimer Disease: A Longitudinal Study. JAMA Neurology, 76(8), 915-924. https://doi.org/10.1001/jamaneurol.2019.1424
- PublishedBischof, G. N., & Jacobs, H. I. L. (2019). Subthreshold amyloid and its biological and clinical meaning: Long way ahead. Neurology, 93(2), 72-79. https://doi.org/10.1212/WNL.0000000000007747
- PublishedMayrhofer, H. C., Duecker, F., van de Ven, V., Jacobs, H. I. L., & Sack, A. T. (2019). Hemifield-specific Correlations between Cue-related Blood Oxygen Level Dependent Activity in Bilateral Nodes of the Dorsal Attention Network and Attentional Benefits in a Spatial Orienting Paradigm. Journal of Cognitive Neuroscience, 31(5), 625-638. https://doi.org/10.1162/jocn_a_01338
- PublishedWolters, A. F., van de Weijer, S. C. F., Leentjens, A. F. G., Duits, A. A., Jacobs, H. I. L., & Kuijf, M. L. (2019). Resting-state fMRI in Parkinson's disease patients with cognitive impairment: A meta-analysis. Parkinsonism & Related Disorders, 62, 16-27. https://doi.org/10.1016/j.parkreldis.2018.12.016
- PublishedBuckley, R. F., Mormino, E. C., Rabin, J. S., Hohman, T. J., Landau, S., Hanseeuw, B. J., ... Sperling, R. A. (2019). Sex Differences in the Association of Global Amyloid and Regional Tau Deposition Measured by Positron Emission Tomography in Clinically Normal Older Adults. JAMA Neurology, 76(5), 542-551. https://doi.org/10.1001/jamaneurol.2018.4693
- PublishedFreeze, W. M., Bacskai, B. J., Frosch, M. P., Jacobs, H. I. L., Backes, W. H., Greenberg, S. M., & van Veluw, S. J. (2019). Blood-Brain Barrier Leakage and Microvascular Lesions in Cerebral Amyloid Angiopathy. Stroke, 50(2), 328-335. https://doi.org/10.1161/STROKEAHA.118.023788
- PublishedFuller, J. T., Cronin-Golomb, A., Gatchel, J. R., Norton, D. J., Guzman-Velez, E., Jacobs, H. I. L., ... Quiroz, Y. T. (2019). Biological and Cognitive Markers of Presenilin1 E280A Autosomal Dominant Alzheimer's Disease: A Comprehensive Review of the Colombian Kindred. JPAD-Journal of prevention of alzheimers disease, 6(2), 112-120. https://doi.org/10.14283/jpad.2019.6
- Published
- 2018
- PublishedUquillas, F. DO., Jacobs, H. I. L., Biddle, K. D., Properzi, M., Hanseeuw, B., Schultz, A. P., ... Donovan, N. J. (2018). Regional tau pathology and loneliness in cognitively normal older adults. Translational Psychiatry, 8, [282]. https://doi.org/10.1038/s41398-018-0345-x
- PublishedFreeze, W. M., Jacobs, H. I. L., Schreuder, F. H. B. M., van Oostenbrugge, R. J., Backes, W. H., Verhey, F. R., & Klijn, C. J. M. (2018). Blood-Brain Barrier Dysfunction in Small Vessel Disease Related Intracerebral Hemorrhage. Frontiers in Neurology, 9, [926]. https://doi.org/10.3389/fneur.2018.00926
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- PublishedAlzheimers Dis Neuroimaging Initia; Harvard Aging Brain Study, Hanseeuw, B. J., Betensky, R. A., Mormino, E. C., Schultz, A. P., Sepulcre, J., ... Johnson, K. A. (2018). PET staging of amyloidosis using striatum. Alzheimer's & Dementia, 14(10), 1281-1292. https://doi.org/10.1016/j.jalz.2018.04.011
- PublishedJacobs, H. I. L., & Buckley, R. F. (2018). Where do white matter alterations dovetail with the cascade model of Alzheimer's disease? Brain, 141, 2830-2833. https://doi.org/10.1093/brain/awy243
- PublishedBachmann, C., Jacobs, H. I. L., Mana, P. P., Dillen, K., Richter, N., von Reutern, B., ... Morrison, A. (2018). On the Extraction and Analysis of Graphs From Resting-State fMRI to Support a Correct and Robust Diagnostic Tool for Alzheimer's Disease. Frontiers in Neuroscience, 12, [528]. https://doi.org/10.3389/fnins.2018.00528
- PublishedRosenberg, J., Jacobs, H. I. L., Maximov, I. I., Reske, M., & Shah, N. J. (2018). Chronotype differences in cortical thickness: grey matter reflects when you go to bed. Brain Structure & Function, 223(7), 3411-3421. https://doi.org/10.1007/s00429-018-1697-y
- PublishedCollaborators Alzheimer's Dis Neur; Australian Imaging Biomarker Lifes; Harvard Aging Brain Study, Buckley, R. F., Mormino, E. C., Amariglio, R. E., Properzi, M. J., Rabin, J. S., ... Sperling, R. A. (2018). Sex, amyloid, and APOE ε4 and risk of cognitive decline in preclinical Alzheimer's disease: Findings from three well-characterized cohorts. Alzheimer's & Dementia, 14(9), 1193-1203. https://doi.org/10.1016/j.jalz.2018.04.010
- Published
- PublishedAlzheimer's Dis Neuroimaging Initi, Van Hooren, R. W. E., Riphagen, J. M., & Jacobs, H. I. L. (2018). Inter-network connectivity and amyloid-beta linked to cognitive decline in preclinical Alzheimer's disease: a longitudinal cohort study. Alzheimer's Research & Therapy, 10(88), 1-12. [88]. https://doi.org/10.1186/s13195-018-0420-9
- PublishedRiphagen, J. M., Gronenschild, E. H. B. M., Salat, D. H., Freeze, W. M., Ivanov, D., Clerx, L., ... Jacobs, H. I. L. (2018). Shades of white: diffusion properties of T1- and FLAIR-defined white matter signal abnormalities differ in stages from cognitively normal to dementia. Neurobiology of Aging, 68, 48-58. https://doi.org/10.1016/j.neurobiolaging.2018.03.029
- PublishedBos, I., Verhey, F. R., Ramakers, I. H. G. B., Jacobs, H. I. L., Soininen, H., Freund-Levi, Y., ... Vos, S. J. B. (2018). Correction to: Cerebrovascular and amyloid pathology in predementia stages: the relationship with neurodegeneration and cognitive decline (vol 9, 101, 2017). Alzheimer's Research & Therapy, 10, [56]. https://doi.org/10.1186/s13195-018-0391-x
- PublishedJacobs, H. I. L., Hedden, T., Schultz, A. P., Sepulcre, J., Perea, R. D., Amariglio, R. E., ... Johnson, K. A. (2018). Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals. Nature Neuroscience, 21(3), 424–431 . https://doi.org/10.1038/s41593-018-0070-z
- Published
- PublishedLee, C. M., Jacobs, H. I. L., Marquie, M., Becker, J. A., Andrea, N. V., Jin, D. S., ... Johnson, K. A. (2018). 18F-Flortaucipir Binding in Choroid Plexus: Related to Race and Hippocampus Signal. Journal of Alzheimer's Disease, 62(4), 1691-1702. https://doi.org/10.3233/JAD-170840
- PublishedJacobs, H. I. L., Hopkins, D. A., Mayrhofer, H. C., Bruner, E., van Leeuwen, F. W., Raaijmakers, W., & Schmahmann, J. D. (2018). The cerebellum in Alzheimer's disease: evaluating its role in cognitive decline. Brain, 141, 37-47. https://doi.org/10.1093/brain/awx194
- PublishedAlzheimers Dis Neuroimaging Initia, Muller-Ehrenberg, L., Riphagen, J. M., Verhey, F. R. J., Sack, A. T., & Jacobs, H. I. L. (2018). Alzheimer's Disease Biomarkers Have Distinct Associations with Specific Hippocampal Subfield Volumes. Journal of Alzheimer's Disease, 66(2), 811-823. https://doi.org/10.3233/JAD-180676
- 2017
- PublishedBos, I., Verhey, F. R., Ramakers, I. H. G. B., Jacobs, H. I. L., Soininen, H., Freund-Levi, Y., ... Vos, S. J. B. (2017). Cerebrovascular and amyloid pathology in predementia stages: the relationship with neurodegeneration and cognitive decline. Alzheimer's Research & Therapy, 9, [101]. https://doi.org/10.1186/s13195-017-0328-9
- PublishedJacobs, H. I. L., Hopkins, D. A., Mayrhofer, H. C., Bruner, E., van Leeuwen, F. W., Raaijmakers, W., & Schmahmann, J. D. (2017). CORRIGENDUM: The cerebellum in Alzheimer's disease: evaluating its role in cognitive decline (awx194, 2017). Brain, 140, E77-E77. https://doi.org/10.1093/brain/awx257
- PublishedFreeze, W. M., Jacobs, H. I. L., Gronenschild, E. H., Jansen, J. F. A., Burgmans, S., Aalten, P., ... LeARN Project (2017). White Matter Hyperintensities Potentiate Hippocampal Volume Reduction in Non-Demented Older Individuals with Abnormal Amyloid-beta. Journal of Alzheimer's Disease, 55(1), 333-342. https://doi.org/10.3233/JAD-160474
- PublishedFreeze, W. M., Schnerr, R. S., Palm, W. M., Jansen, J. F., Jacobs, H. I., Hoff, E. I., ... Backes, W. H. (2017). Pericortical Enhancement on Delayed Postgadolinium Fluid-Attenuated Inversion Recovery Images in Normal Aging, Mild Cognitive Impairment, and Alzheimer Disease. American Journal of Neuroradiology, 38(9), 1742-1747. https://doi.org/10.3174/ajnr.A5273
- PublishedDekhtyar, M., Papp, K. V., Buckley, R., Jacobs, H. I. L., Schultz, A. P., Johnson, K. A., ... Rentz, D. M. (2017). Neuroimaging markers associated with maintenance of optimal memory performance in late-life. Neuropsychologia, 100, 164-170. https://doi.org/10.1016/j.neuropsychologia.2017.04.037
- PublishedCleutjens, F. A. H. M., Ponds, R. W. H. M., Spruit, M. A., Burgmans, S., Jacobs, H. I. L., Gronenschild, E. H. B. M., ... Janssen, D. J. A. (2017). The Relationship between Cerebral Small Vessel Disease, Hippocampal Volume and Cognitive Functioning in Patients with COPD: An MRI Study. Frontiers in Aging Neuroscience, 9, [88]. https://doi.org/10.3389/fnagi.2017.00088
- PublishedDillen, K. N. H., Jacobs, H. I. L., Kukolja, J., Richter, N., von Reutern, B., Onur, O. A., ... Fink, G. R. (2017). Functional Disintegration of the Default Mode Network in Prodromal Alzheimer's Disease. Journal of Alzheimer's Disease, 59(1), 169-187. https://doi.org/10.3233/JAD-161120
- 2016
- PublishedDillen, K. N. H., Jacobs, H. I. L., Kukolja, J., von Reutern, B., Richter, N., Onur, O. A., ... Fink, G. R. (2016). Aberrant functional connectivity differentiates retrosplenial cortex from posterior cingulate cortex in prodromal Alzheimer's disease. Neurobiology of Aging, 44, 114-126. https://doi.org/10.1016/j.neurobiolaging.2016.04.010
- 2015
- PublishedJacobs, H. I. L., Riphagen, J. M., Razat, C. M., Wiese, S., & Sack, A. T. (2015). Transcutaneous vagus nerve stimulation boosts associative memory in older individuals. Neurobiology of Aging, 36(5), 1860-1867. https://doi.org/10.1016/j.neurobiolaging.2015.02.023
- PublishedJacobs, H. I. L., Dillen, K. N. H., Risius, O., Goereci, Y., Onur, O. A., Fink, G. R., & Kukolja, J. (2015). Consolidation in older adults depends upon competition between resting-state networks. Frontiers in Aging Neuroscience, 6, [344]. https://doi.org/10.3389/fnagi.2014.00344
- PublishedJacobs, H. I. L., Wiese, S., van de Ven, V., Gronenschild, E. H. B. M., Verhey, F. R. J., & Matthews, P. M. (2015). Relevance of parahippocampal-locus coeruleus connectivity to memory in early dementia. Neurobiology of Aging, 36(2), 618-626. https://doi.org/10.1016/j.neurobiolaging.2014.10.041
- PublishedJacobs, H. I. L., Gronenschild, E. H. B. M., Evers, E. A. T., Ramakers, I. H. G. B., Hofman, P. A. M., Backes, W. H., ... van Boxtel, M. P. J. (2015). Visuospatial processing in early Alzheimer's disease: a multimodal neuroimaging study. Cortex, 64, 394-406. https://doi.org/10.1016/j.cortex.2012.01.005
- PublishedClerx, L., Gronenschild, E. H. B. M., Echavarri, C., Verhey, F., Aalten, P., & Jacobs, H. I. L. (2015). Can FreeSurfer Compete with Manual Volumetric Measurements in Alzheimer's Disease? Current Alzheimer Research, 12(4), 358-367. https://doi.org/10.2174/1567205012666150324174813
- 2014
- PublishedBruner, E., Rangel de Lazaro, G., Manuel de la Cuetara, J., Martin-Loeches, M., Colom, R., & Jacobs, H. I. L. (2014). Midsagittal brain variation and MRI shape analysis of the precuneus in adult individuals. Journal of Anatomy, 224(4), 367-376. https://doi.org/10.1111/joa.12155
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- PublishedJacobs, H. I. L., Clerx, L., Gronenschild, E. H. B. M., Aalten, P., & Verhey, F. R. J. (2014). White Matter Hyperintensities are Positively Associated with Cortical Thickness in Alzheimer's Disease. Journal of Alzheimer's Disease, 39(2), 409-422. https://doi.org/10.3233/JAD-131232
- 2013
- PublishedClerx, L., Jacobs, H. I. L., Burgmans, S., Gronenschild, E. H. B. M., Uylings, H. B. M., Echavarri, C., ... Aalten, P. (2013). Sensitivity of Different MRI-Techniques to Assess Gray Matter Atrophy Patterns in Alzheimer's Disease is Region-Specific. Current Alzheimer Research, 10(9), 940-951. https://doi.org/10.2174/15672050113109990158
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- PublishedMills, J. D., Nalpathamkalam, T., Jacobs, H. I. L., Janitz, C., Merico, D., Hu, P., & Janitz, M. (2013). RNA-Seq analysis of the parietal cortex in Alzheimer's disease reveals alternatively spliced isoforms related to lipid metabolism. Neuroscience Letters, 536, 90-95. https://doi.org/10.1016/j.neulet.2012.12.042
- PublishedJacobs, H. I. L., Leritz, E. C., Williams, V. J., van Boxtel, M. P. J., van der Elst, W., Jolles, J., ... Salat, D. H. (2013). Association between white matter microstructure, executive functions, and processing speed in older adults: The impact of vascular health. Human Brain Mapping, 34(1), 77-95. https://doi.org/10.1002/hbm.21412
- PublishedJacobs, H. I. L., van Boxtel, M. P. J., Gronenschild, E. H. B. M., Uylings, H. B. M., Jolles, J., & Verhey, F. R. J. (2013). Decreased gray matter diffusivity: a potential early Alzheimer's disease biomarker? Alzheimer's & Dementia, 9(1), 93-97. https://doi.org/10.1016/j.jalz.2011.11.004
- PublishedBruner, E., & Jacobs, H. I. L. (2013). Alzheimer's Disease: The Downside of a Highly Evolved Parietal Lobe? Journal of Alzheimer's Disease, 35(2), 227-240. https://doi.org/10.3233/JAD-122299
- 2012
- PublishedBeral, V., Bull, D., Pirie, K., Reeves, G., Peto, R., Skegg, D., ... Fukao, A. (2012). Menarche, menopause, and breast cancer risk: individual participant meta-analysis, including 118 964 women with breast cancer from 117 epidemiological studies. Lancet oncology, 13(11), 1141-1151. https://doi.org/10.1016/S1470-2045(12)70425-4
- PublishedJacobs, H. I. L., van Boxtel, M. P. J., Gronenschild, E. H. B. M., Williams, V. J., Burgmans, S., Uylings, H. B. M., ... Verhey, F. R. J. (2012). Patterns of Gray and White Matter Changes in Individuals at Risk for Alzheimer's Disease. Current Alzheimer Research, 9(9), 1097-1105. https://doi.org/10.2174/156720512803568993
- PublishedGronenschild, E. H. B. M., Habets, P., Jacobs, H. I. L., Mengelers, R., Rozendaal, N., van Os, J., & Marcelis, M. (2012). The Effects of FreeSurfer Version, Workstation Type, and Macintosh Operating System Version on Anatomical Volume and Cortical Thickness Measurements. PLOS ONE, 7(6), [e38234]. https://doi.org/10.1371/journal.pone.0038234
- PublishedJacobs, H. I. L., van Boxtel, M. P. J., Heinecke, A., Gronenschild, E. H. B. M., Backes, W. H., Ramakers, I. H. G. B., ... Verhey, F. R. J. (2012). Functional integration of parietal lobe activity in early Alzheimer disease. Neurology, 78(5), 352-360. https://doi.org/10.1212/WNL.0b013e318245287d
- PublishedJacobs, H. I. L., van Boxtel, M. P. J., Jolles, J., Verhey, F. R. J., & Uylings, H. B. M. (2012). Parietal cortex matters in alzheimer's disease: An overview of structural, functional and metabolic findings. Neuroscience and Biobehavioral Reviews, 36(1), 297-309. https://doi.org/10.1016/j.neubiorev.2011.06.009
- PublishedJacobs, H. I. L., Visser, P. J., van Boxtel, M. P. J., Frisoni, G. B., Tsolaki, M., Papapostolou, P., ... Verhey, F. R. J. (2012). The association between white matter hyperintensities and executive decline in mild cognitive impairment is network dependent. Neurobiology of Aging, 33(1), 201.e1-201.e8. [ARTN 201.e1]. https://doi.org/10.1016/j.neurobiolaging.2010.07.015
- 2011
- PublishedBurgmans, S., van Boxtel, M. P. J., Berg, K. E. M., Gronenschild, E. H. B. M., Jacobs, H. I. L., Jolles, J., & Uylings, H. B. M. (2011). The posterior parahippocampal gyrus is preferentially affected in age-related memory decline. Neurobiology of Aging, 32(9), 1572-1578. https://doi.org/10.1016/j.neurobiolaging.2009.09.008
- PublishedJacobs, H. I. L., van Boxtel, M. P. J., Uylings, H. B. M., Gronenschild, E. H. B., Verhey, F. R., & Jolles, J. (2011). Atrophy of the parietal lobe in preclinical dementia. Brain and Cognition, 75(2), 154-163. https://doi.org/10.1016/j.bandc.2010.11.003
- PublishedJacobs, H. I. L., van Boxtel, M. P. J., van der Elst, W., Burgmans, S., Smeets, F. G. B., Gronenschild, E. H. B. M., ... Jolles, J. (2011). Increasing the diagnostic accuracy of medial temporal lobe atrophy in Alzheimer's disease. Journal of Alzheimer's Disease, 25(3), 477-490. https://doi.org/10.3233/JAD-2011-102043
- PublishedJacobs, H. I. L. (2011). Parietal matters in early Alzheimer's disease : evidence from structural and functional MRI. Maastricht: NeuroPsych Publishers.
- PublishedEchavarri, C., Aalten, P., Uylings, H. B. M., Jacobs, H. I. L., Visser, P. J., Gronenschild, E. H. B. M., ... Burgmans, S. (2011). Atrophy in the parahippocampal gyrus as an early biomarker of Alzheimer's disease. Brain Structure & Function, 215(3-4), 265-271. https://doi.org/10.1007/s00429-010-0283-8