Jacobs, H.I.L.

Jacobs, H. I. L. (2019). Focus on the blue locus for learning. Nature human behaviour, 3(11), 1143-1144. https://doi.org/10.1038/s41562-019-0731-2

Biddle, K. D., Uquillas, F. DO., Jacobs, H. I. L., Zide, B., Kirn, D. R., Rentz, D. M., ... Donovan, N. J. (2019). Social Engagement and Amyloidb-beta-Related Cognitive Decline in Cognitively Normal Older Adults. American Journal of Geriatric Psychiatry, 27(11), 1247-1256. https://doi.org/10.1016/j.jagp.2019.05.005

Wolters, A. F., van de Weijer, S. C. F., Leentjens, A. F. G., Duits, A. A., Jacobs, H. I. L., & Kuijf, M. L. (2019). "Resting-state fMRI in Patkinson's disease patients with cognitive Impairment: A meta-analysis": Answer to Wang and colleagues. Parkinsonism & Related Disorders, 66, 253-254. https://doi.org/10.1016/j.parkreldis.2019.07.014

Betts, M. J., Kirilina, E., Otaduy, M. C. G., Ivanov, D., Acosta-Cabronero, J., Callaghan, M. F., ... Hämmerer, D. (2019). Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases. Brain, 142(9), 2558–2571. https://doi.org/10.1093/brain/awz193

Freeze, W. M., ter Weele, D. N., Palm, W. M., van Hooren, R. W., Hoff, E., Jansen, J. F. A., ... Backes, W. H. (2019). Optimal Detection of Subtle Gadolinium Leakage in CSF with Heavily T2-Weighted Fluid-Attenuated Inversion Recovery Imaging. American Journal of Neuroradiology, 40(9), 1481-1483. https://doi.org/10.3174/ajnr.A6145

Hanseeuw, B. J., Betensky, R. A., Jacobs, H. I. L., Schultz, A. P., Sepulcre, J., Becker, J. A., ... Johnson, K. (2019). Association of Amyloid and Tau With Cognition in Preclinical Alzheimer Disease: A Longitudinal Study. JAMA Neurology, 76(8), 915-924. https://doi.org/10.1001/jamaneurol.2019.1424

Bischof, G. N., & Jacobs, H. I. L. (2019). Subthreshold amyloid and its biological and clinical meaning: Long way ahead. Neurology, 93(2), 72-79. https://doi.org/10.1212/WNL.0000000000007747

Mayrhofer, H. C., Duecker, F., van de Ven, V., Jacobs, H. I. L., & Sack, A. T. (2019). Hemifield-specific Correlations between Cue-related Blood Oxygen Level Dependent Activity in Bilateral Nodes of the Dorsal Attention Network and Attentional Benefits in a Spatial Orienting Paradigm. Journal of Cognitive Neuroscience, 31(5), 625-638. https://doi.org/10.1162/jocn_a_01338

Wolters, A. F., van de Weijer, S. C. F., Leentjens, A. F. G., Duits, A. A., Jacobs, H. I. L., & Kuijf, M. L. (2019). Resting-state fMRI in Parkinson's disease patients with cognitive impairment: A meta-analysis. Parkinsonism & Related Disorders, 62, 16-27. https://doi.org/10.1016/j.parkreldis.2018.12.016

Buckley, R. F., Mormino, E. C., Rabin, J. S., Hohman, T. J., Landau, S., Hanseeuw, B. J., ... Sperling, R. A. (2019). Sex Differences in the Association of Global Amyloid and Regional Tau Deposition Measured by Positron Emission Tomography in Clinically Normal Older Adults. JAMA Neurology, 76(5), 542-551. https://doi.org/10.1001/jamaneurol.2018.4693

Freeze, W. M., Bacskai, B. J., Frosch, M. P., Jacobs, H. I. L., Backes, W. H., Greenberg, S. M., & van Veluw, S. J. (2019). Blood-Brain Barrier Leakage and Microvascular Lesions in Cerebral Amyloid Angiopathy. Stroke, 50(2), 328-335. https://doi.org/10.1161/STROKEAHA.118.023788

Fuller, J. T., Cronin-Golomb, A., Gatchel, J. R., Norton, D. J., Guzman-Velez, E., Jacobs, H. I. L., ... Quiroz, Y. T. (2019). Biological and Cognitive Markers of Presenilin1 E280A Autosomal Dominant Alzheimer's Disease: A Comprehensive Review of the Colombian Kindred. JPAD-Journal of prevention of alzheimers disease, 6(2), 112-120. https://doi.org/10.14283/jpad.2019.6

Priovoulos, N., Poser, B. A., Ivanov, D., Verhey, F. R. J., & Jacobs, H. I. L. (2019). In vivo imaging of the nucleus of the solitary tract with Magnetization Transfer at 7 Tesla. Neuroimage, 201, [116071]. https://doi.org/10.1016/j.neuroimage.2019.116071

Uquillas, F. DO., Jacobs, H. I. L., Biddle, K. D., Properzi, M., Hanseeuw, B., Schultz, A. P., ... Donovan, N. J. (2018). Regional tau pathology and loneliness in cognitively normal older adults. Translational Psychiatry, 8, [282]. https://doi.org/10.1038/s41398-018-0345-x

Freeze, W. M., Jacobs, H. I. L., Schreuder, F. H. B. M., van Oostenbrugge, R. J., Backes, W. H., Verhey, F. R., & Klijn, C. J. M. (2018). Blood-Brain Barrier Dysfunction in Small Vessel Disease Related Intracerebral Hemorrhage. Frontiers in Neurology, 9, [926]. https://doi.org/10.3389/fneur.2018.00926

Rienäcker, F., Jacobs, H. I. L., Van Heugten, C. M., & Van Gerven, P. W. M. (2018). Practice makes perfect: High performance gains in older adults engaged in selective attention within and across sensory modalities. Acta Psychologica, 191, 101-111. https://doi.org/10.1016/j.actpsy.2018.09.005

Alzheimers Dis Neuroimaging Initia; Harvard Aging Brain Study, Hanseeuw, B. J., Betensky, R. A., Mormino, E. C., Schultz, A. P., Sepulcre, J., ... Johnson, K. A. (2018). PET staging of amyloidosis using striatum. Alzheimer's & Dementia, 14(10), 1281-1292. https://doi.org/10.1016/j.jalz.2018.04.011

Jacobs, H. I. L., & Buckley, R. F. (2018). Where do white matter alterations dovetail with the cascade model of Alzheimer's disease? Brain, 141, 2830-2833. https://doi.org/10.1093/brain/awy243

Bachmann, C., Jacobs, H. I. L., Mana, P. P., Dillen, K., Richter, N., von Reutern, B., ... Morrison, A. (2018). On the Extraction and Analysis of Graphs From Resting-State fMRI to Support a Correct and Robust Diagnostic Tool for Alzheimer's Disease. Frontiers in Neuroscience, 12, [528]. https://doi.org/10.3389/fnins.2018.00528

Rosenberg, J., Jacobs, H. I. L., Maximov, I. I., Reske, M., & Shah, N. J. (2018). Chronotype differences in cortical thickness: grey matter reflects when you go to bed. Brain Structure & Function, 223(7), 3411-3421. https://doi.org/10.1007/s00429-018-1697-y

Collaborators Alzheimer's Dis Neur; Australian Imaging Biomarker Lifes; Harvard Aging Brain Study, Buckley, R. F., Mormino, E. C., Amariglio, R. E., Properzi, M. J., Rabin, J. S., ... Sperling, R. A. (2018). Sex, amyloid, and APOE ε4 and risk of cognitive decline in preclinical Alzheimer's disease: Findings from three well-characterized cohorts. Alzheimer's & Dementia, 14(9), 1193-1203. https://doi.org/10.1016/j.jalz.2018.04.010

Jacobs, H. I. L., Müller-Ehrenberg, L., Priovoulos, N., & Roebroeck, A. (2018). Curvilinear locus coeruleus functional connectivity trajectories over the adult lifespan: a 7T MRI study. Neurobiology of Aging, 69, 167-176. https://doi.org/10.1016/j.neurobiolaging.2018.05.021

Alzheimer's Dis Neuroimaging Initi, Van Hooren, R. W. E., Riphagen, J. M., & Jacobs, H. I. L. (2018). Inter-network connectivity and amyloid-beta linked to cognitive decline in preclinical Alzheimer's disease: a longitudinal cohort study. Alzheimer's Research & Therapy, 10(88), 1-12. [88]. https://doi.org/10.1186/s13195-018-0420-9

Riphagen, J. M., Gronenschild, E. H. B. M., Salat, D. H., Freeze, W. M., Ivanov, D., Clerx, L., ... Jacobs, H. I. L. (2018). Shades of white: diffusion properties of T1- and FLAIR-defined white matter signal abnormalities differ in stages from cognitively normal to dementia. Neurobiology of Aging, 68, 48-58. https://doi.org/10.1016/j.neurobiolaging.2018.03.029

Bos, I., Verhey, F. R., Ramakers, I. H. G. B., Jacobs, H. I. L., Soininen, H., Freund-Levi, Y., ... Vos, S. J. B. (2018). Correction to: Cerebrovascular and amyloid pathology in predementia stages: the relationship with neurodegeneration and cognitive decline (vol 9, 101, 2017). Alzheimer's Research & Therapy, 10, [56]. https://doi.org/10.1186/s13195-018-0391-x

Jacobs, H. I. L., Hedden, T., Schultz, A. P., Sepulcre, J., Perea, R. D., Amariglio, R. E., ... Johnson, K. A. (2018). Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals. Nature Neuroscience, 21(3), 424–431 . https://doi.org/10.1038/s41593-018-0070-z

Priovoulos, N., Jacobs, H. I. L., Ivanov, D., Uludag, K., Verhey, F. R. J., & Poser, B. A. (2018). High-resolution in vivo imaging of human locus coeruleus by Magnetization Transfer MRI at 3T and 7T. Neuroimage, 168, 427-436. https://doi.org/10.1016/j.neuroimage.2017.07.045

Lee, C. M., Jacobs, H. I. L., Marquie, M., Becker, J. A., Andrea, N. V., Jin, D. S., ... Johnson, K. A. (2018). 18F-Flortaucipir Binding in Choroid Plexus: Related to Race and Hippocampus Signal. Journal of Alzheimer's Disease, 62(4), 1691-1702. https://doi.org/10.3233/JAD-170840

Jacobs, H. I. L., Hopkins, D. A., Mayrhofer, H. C., Bruner, E., van Leeuwen, F. W., Raaijmakers, W., & Schmahmann, J. D. (2018). The cerebellum in Alzheimer's disease: evaluating its role in cognitive decline. Brain, 141, 37-47. https://doi.org/10.1093/brain/awx194

Alzheimers Dis Neuroimaging Initia, Muller-Ehrenberg, L., Riphagen, J. M., Verhey, F. R. J., Sack, A. T., & Jacobs, H. I. L. (2018). Alzheimer's Disease Biomarkers Have Distinct Associations with Specific Hippocampal Subfield Volumes. Journal of Alzheimer's Disease, 66(2), 811-823. https://doi.org/10.3233/JAD-180676

Bos, I., Verhey, F. R., Ramakers, I. H. G. B., Jacobs, H. I. L., Soininen, H., Freund-Levi, Y., ... Vos, S. J. B. (2017). Cerebrovascular and amyloid pathology in predementia stages: the relationship with neurodegeneration and cognitive decline. Alzheimer's Research & Therapy, 9, [101]. https://doi.org/10.1186/s13195-017-0328-9

Jacobs, H. I. L., Hopkins, D. A., Mayrhofer, H. C., Bruner, E., van Leeuwen, F. W., Raaijmakers, W., & Schmahmann, J. D. (2017). CORRIGENDUM: The cerebellum in Alzheimer's disease: evaluating its role in cognitive decline (awx194, 2017). Brain, 140, E77-E77. https://doi.org/10.1093/brain/awx257

Freeze, W. M., Jacobs, H. I. L., Gronenschild, E. H., Jansen, J. F. A., Burgmans, S., Aalten, P., ... LeARN Project (2017). White Matter Hyperintensities Potentiate Hippocampal Volume Reduction in Non-Demented Older Individuals with Abnormal Amyloid-beta. Journal of Alzheimer's Disease, 55(1), 333-342. https://doi.org/10.3233/JAD-160474

Freeze, W. M., Schnerr, R. S., Palm, W. M., Jansen, J. F., Jacobs, H. I., Hoff, E. I., ... Backes, W. H. (2017). Pericortical Enhancement on Delayed Postgadolinium Fluid-Attenuated Inversion Recovery Images in Normal Aging, Mild Cognitive Impairment, and Alzheimer Disease. American Journal of Neuroradiology, 38(9), 1742-1747. https://doi.org/10.3174/ajnr.A5273

Dekhtyar, M., Papp, K. V., Buckley, R., Jacobs, H. I. L., Schultz, A. P., Johnson, K. A., ... Rentz, D. M. (2017). Neuroimaging markers associated with maintenance of optimal memory performance in late-life. Neuropsychologia, 100, 164-170. https://doi.org/10.1016/j.neuropsychologia.2017.04.037

Cleutjens, F. A. H. M., Ponds, R. W. H. M., Spruit, M. A., Burgmans, S., Jacobs, H. I. L., Gronenschild, E. H. B. M., ... Janssen, D. J. A. (2017). The Relationship between Cerebral Small Vessel Disease, Hippocampal Volume and Cognitive Functioning in Patients with COPD: An MRI Study. Frontiers in Aging Neuroscience, 9, [88]. https://doi.org/10.3389/fnagi.2017.00088

Dillen, K. N. H., Jacobs, H. I. L., Kukolja, J., Richter, N., von Reutern, B., Onur, O. A., ... Fink, G. R. (2017). Functional Disintegration of the Default Mode Network in Prodromal Alzheimer's Disease. Journal of Alzheimer's Disease, 59(1), 169-187. https://doi.org/10.3233/JAD-161120

Dillen, K. N. H., Jacobs, H. I. L., Kukolja, J., von Reutern, B., Richter, N., Onur, O. A., ... Fink, G. R. (2016). Aberrant functional connectivity differentiates retrosplenial cortex from posterior cingulate cortex in prodromal Alzheimer's disease. Neurobiology of Aging, 44, 114-126. https://doi.org/10.1016/j.neurobiolaging.2016.04.010

Jacobs, H. I. L., Riphagen, J. M., Razat, C. M., Wiese, S., & Sack, A. T. (2015). Transcutaneous vagus nerve stimulation boosts associative memory in older individuals. Neurobiology of Aging, 36(5), 1860-1867. https://doi.org/10.1016/j.neurobiolaging.2015.02.023

Jacobs, H. I. L., Dillen, K. N. H., Risius, O., Goereci, Y., Onur, O. A., Fink, G. R., & Kukolja, J. (2015). Consolidation in older adults depends upon competition between resting-state networks. Frontiers in Aging Neuroscience, 6, [344]. https://doi.org/10.3389/fnagi.2014.00344

Jacobs, H. I. L., Wiese, S., van de Ven, V., Gronenschild, E. H. B. M., Verhey, F. R. J., & Matthews, P. M. (2015). Relevance of parahippocampal-locus coeruleus connectivity to memory in early dementia. Neurobiology of Aging, 36(2), 618-626. https://doi.org/10.1016/j.neurobiolaging.2014.10.041

Jacobs, H. I. L., Gronenschild, E. H. B. M., Evers, E. A. T., Ramakers, I. H. G. B., Hofman, P. A. M., Backes, W. H., ... van Boxtel, M. P. J. (2015). Visuospatial processing in early Alzheimer's disease: a multimodal neuroimaging study. Cortex, 64, 394-406. https://doi.org/10.1016/j.cortex.2012.01.005

Clerx, L., Gronenschild, E. H. B. M., Echavarri, C., Verhey, F., Aalten, P., & Jacobs, H. I. L. (2015). Can FreeSurfer Compete with Manual Volumetric Measurements in Alzheimer's Disease? Current Alzheimer Research, 12(4), 358-367. https://doi.org/10.2174/1567205012666150324174813

Bruner, E., Rangel de Lazaro, G., Manuel de la Cuetara, J., Martin-Loeches, M., Colom, R., & Jacobs, H. I. L. (2014). Midsagittal brain variation and MRI shape analysis of the precuneus in adult individuals. Journal of Anatomy, 224(4), 367-376. https://doi.org/10.1111/joa.12155

Lückmann, H. C., Jacobs, H. I. L., & Sack, A. T. (2014). The cross-functional role of frontoparietal regions in cognition : Internal attention as the overarching mechanism. Progress in Neurobiology, 116, 66-86. https://doi.org/10.1016/j.pneurobio.2014.02.002

Jacobs, H. I. L., Clerx, L., Gronenschild, E. H. B. M., Aalten, P., & Verhey, F. R. J. (2014). White Matter Hyperintensities are Positively Associated with Cortical Thickness in Alzheimer's Disease. Journal of Alzheimer's Disease, 39(2), 409-422. https://doi.org/10.3233/JAD-131232

Clerx, L., Jacobs, H. I. L., Burgmans, S., Gronenschild, E. H. B. M., Uylings, H. B. M., Echavarri, C., ... Aalten, P. (2013). Sensitivity of Different MRI-Techniques to Assess Gray Matter Atrophy Patterns in Alzheimer's Disease is Region-Specific. Current Alzheimer Research, 10(9), 940-951. https://doi.org/10.2174/15672050113109990158

Jacobs, H. I. L., Radua, J., Lückmann, H. C., & Sack, A. T. (2013). Meta-analysis of functional network alterations in Alzheimer's disease: Toward a network biomarker. Neuroscience and Biobehavioral Reviews, 37(5), 753-765. https://doi.org/10.1016/j.neubiorev.2013.03.009

Mills, J. D., Nalpathamkalam, T., Jacobs, H. I. L., Janitz, C., Merico, D., Hu, P., & Janitz, M. (2013). RNA-Seq analysis of the parietal cortex in Alzheimer's disease reveals alternatively spliced isoforms related to lipid metabolism. Neuroscience Letters, 536, 90-95. https://doi.org/10.1016/j.neulet.2012.12.042

Jacobs, H. I. L., Leritz, E. C., Williams, V. J., van Boxtel, M. P. J., van der Elst, W., Jolles, J., ... Salat, D. H. (2013). Association between white matter microstructure, executive functions, and processing speed in older adults: The impact of vascular health. Human Brain Mapping, 34(1), 77-95. https://doi.org/10.1002/hbm.21412

Jacobs, H. I. L., van Boxtel, M. P. J., Gronenschild, E. H. B. M., Uylings, H. B. M., Jolles, J., & Verhey, F. R. J. (2013). Decreased gray matter diffusivity: a potential early Alzheimer's disease biomarker? Alzheimer's & Dementia, 9(1), 93-97. https://doi.org/10.1016/j.jalz.2011.11.004

Bruner, E., & Jacobs, H. I. L. (2013). Alzheimer's Disease: The Downside of a Highly Evolved Parietal Lobe? Journal of Alzheimer's Disease, 35(2), 227-240. https://doi.org/10.3233/JAD-122299

Beral, V., Bull, D., Pirie, K., Reeves, G., Peto, R., Skegg, D., ... Fukao, A. (2012). Menarche, menopause, and breast cancer risk: individual participant meta-analysis, including 118 964 women with breast cancer from 117 epidemiological studies. Lancet oncology, 13(11), 1141-1151. https://doi.org/10.1016/S1470-2045(12)70425-4

Jacobs, H. I. L., van Boxtel, M. P. J., Gronenschild, E. H. B. M., Williams, V. J., Burgmans, S., Uylings, H. B. M., ... Verhey, F. R. J. (2012). Patterns of Gray and White Matter Changes in Individuals at Risk for Alzheimer's Disease. Current Alzheimer Research, 9(9), 1097-1105. https://doi.org/10.2174/156720512803568993

Gronenschild, E. H. B. M., Habets, P., Jacobs, H. I. L., Mengelers, R., Rozendaal, N., van Os, J., & Marcelis, M. (2012). The Effects of FreeSurfer Version, Workstation Type, and Macintosh Operating System Version on Anatomical Volume and Cortical Thickness Measurements. PLOS ONE, 7(6), [e38234]. https://doi.org/10.1371/journal.pone.0038234

Jacobs, H. I. L., van Boxtel, M. P. J., Heinecke, A., Gronenschild, E. H. B. M., Backes, W. H., Ramakers, I. H. G. B., ... Verhey, F. R. J. (2012). Functional integration of parietal lobe activity in early Alzheimer disease. Neurology, 78(5), 352-360. https://doi.org/10.1212/WNL.0b013e318245287d

Jacobs, H. I. L., van Boxtel, M. P. J., Jolles, J., Verhey, F. R. J., & Uylings, H. B. M. (2012). Parietal cortex matters in alzheimer's disease: An overview of structural, functional and metabolic findings. Neuroscience and Biobehavioral Reviews, 36(1), 297-309. https://doi.org/10.1016/j.neubiorev.2011.06.009

Jacobs, H. I. L., Visser, P. J., van Boxtel, M. P. J., Frisoni, G. B., Tsolaki, M., Papapostolou, P., ... Verhey, F. R. J. (2012). The association between white matter hyperintensities and executive decline in mild cognitive impairment is network dependent. Neurobiology of Aging, 33(1), 201.e1-201.e8. [ARTN 201.e1]. https://doi.org/10.1016/j.neurobiolaging.2010.07.015

Burgmans, S., van Boxtel, M. P. J., Berg, K. E. M., Gronenschild, E. H. B. M., Jacobs, H. I. L., Jolles, J., & Uylings, H. B. M. (2011). The posterior parahippocampal gyrus is preferentially affected in age-related memory decline. Neurobiology of Aging, 32(9), 1572-1578. https://doi.org/10.1016/j.neurobiolaging.2009.09.008

Jacobs, H. I. L., van Boxtel, M. P. J., Uylings, H. B. M., Gronenschild, E. H. B., Verhey, F. R., & Jolles, J. (2011). Atrophy of the parietal lobe in preclinical dementia. Brain and Cognition, 75(2), 154-163. https://doi.org/10.1016/j.bandc.2010.11.003

Jacobs, H. I. L., van Boxtel, M. P. J., van der Elst, W., Burgmans, S., Smeets, F. G. B., Gronenschild, E. H. B. M., ... Jolles, J. (2011). Increasing the diagnostic accuracy of medial temporal lobe atrophy in Alzheimer's disease. Journal of Alzheimer's Disease, 25(3), 477-490. https://doi.org/10.3233/JAD-2011-102043

Echavarri, C., Aalten, P., Uylings, H. B. M., Jacobs, H. I. L., Visser, P. J., Gronenschild, E. H. B. M., ... Burgmans, S. (2011). Atrophy in the parahippocampal gyrus as an early biomarker of Alzheimer's disease. Brain Structure & Function, 215(3-4), 265-271. https://doi.org/10.1007/s00429-010-0283-8