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Research Output 2012 2018

2018

The immunocytokine L19-IL2: An interplay between radiotherapy and long-lasting systemic anti-tumour immune responses

Rekers, N. H., Pimentel, V. O., Yaromina, A., Lieuwes, N. G., Biemans, R., Zegers, C. M. L., Germeraad, W. T. V., Van Limbergen, E. J., Neri, D., Dubois, L. J. & Lambin, P., 1 Jan 2018, In : OncoImmunology . 7, 4, 15 p., e1414119.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017
49 Downloads (Pure)

Decision support systems for personalized and participative radiation oncology

Lambin, P., Zindler, J., Vanneste, B. G. L., Van De Voorde, L., Eekers, D., Compter, I., Panth, K. M., Peerlings, J., Larue, R. T. H. M., Deist, T. M., Jochems, A., Lustberg, T., van Soest, J., de Jong, E. E. C., Even, A. J. G., Reymen, B., Rekers, N., van Gisbergen, M., Roelofs, E., Carvalho, S. & 19 others, Leijenaar, R. T. H., Zegers, C. M. L., Jacobs, M., van Timmeren, J., Brouwers, P., Lal, J. A., Dubois, L., Yaromina, A., Van Limbergen, E. J., Berbee, M., van Elmpt, W., Oberije, C., Ramaekers, B., Dekker, A., Boersma, L. J., Hoebers, F., Smits, K. M., Berlanga, A. J. & Walsh, S., 15 Jan 2017, In : Advanced Drug Delivery Reviews. 109, p. 131-153 23 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File

Quantitative assessment of Zirconium-89 labeled cetuximab using PET/CT imaging in patients with advanced head and neck cancer: a theragnostic approach

Even, A. J. G., Hamming-Vrieze, O., van Elmpt, W., Winnepenninckx, V. J. L., Heukelom, J., Tesselaar, M. E. T., Vogel, W. V., Hoeben, A., Zegers, C. M. L., Vugts, D. J., van Dongen, G. A. M. S., Bartelink, H., Mottaghy, F. M., Hoebers, F. & Lambin, P., 17 Jan 2017, In : Oncotarget. 8, 3, p. 3870-3880 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Three-dimensional dose evaluation in breast cancer patients to define decision criteria for adaptive radiotherapy

Zegers, C. M. L., Baeza, J. A., van Elmpt, W., Murrer, L. H. P., Verhoeven, K., Boersma, L., Verhaegen, F. & Nijsten, S. M. J. J. G., Nov 2017, In : Acta Oncologica. 56, 11, p. 1487-1494 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

2016
2 Citations (Scopus)

Evaluation of tumour hypoxia during radiotherapy using [F-18]HX4 PET imaging and blood biomarkers in patients with head and neck cancer

Zegers, K., Hoebers, F. J. P., van Elmpt, W., Bons, J. A., Öllers, M., Troost, E. G. C., Eekers, D., Balmaekers, L., Arts-Pechtold, M., Mottaghy, F. M. & Lambin, P., Nov 2016, In : European Journal of Nuclear Medicine and Molecular Imaging. 43, 12, p. 2139-2146

Research output: Contribution to journalArticleAcademicpeer-review

381 Downloads (Pure)

Imaging of tumor hypoxia with PET: a step towards individualized cancer treatment

Zegers, C. M. L., 1 Jan 2016, Maastricht: Maastricht University. 224 p.

Research output: ThesisDoctoral ThesisExternal prepared

Open Access
File
9 Citations (Scopus)
Open Access

Pharmacokinetic modeling of a novel hypoxia PET tracer [18F]HX4 in patients with non-small cell lung cancer

Verwer, E. E., Zegers, K., van Elmpt, W., Wierts, R., Windhorst, A. D., Mottaghy, F., Lambin, P. & Boellaard, R., 12 Dec 2016, In : EJNMMI Physics. 3, 12 p., 30.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2015
37 Citations (Scopus)

A Comparative Study of the Hypoxia PET Tracers [F-18] HX4, [F-18] FAZA, and [F-18] FMISO in a Preclinical Tumor Model

Peeters, S. G. J. A., Zegers, C. M. L., Lieuwes, N. G., van Elmpt, W., Eriksson, J., van Dongen, G. A. M. S., Dubois, L. & Lambin, P., 1 Feb 2015, In : International Journal of Radiation Oncology Biology Physics. 91, 2, p. 351-359

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Combination of radiotherapy with the immunocytokine L19-IL2: Additive effect in a NK cell dependent tumour model

Rekers, N. H., Zegers, C. M. L., Yaromina, A., Lieuwes, N. G., Biemans, R., Senden-Gijsbers, B. L. M. G., Losen, M., Van Limbergen, E. J., Germeraad, W. T. V., Neri, D., Dubois, L. & Lambin, P., Sep 2015, In : Radiotherapy and Oncology. 116, 3, p. 438-442

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Comparison of [18F]-FMISO, [18F]-FAZA and [18F]-HX4 for PET imaging of hypoxia - a simulation study

Wack, L. J., Moennich, D., Van Elmpt, W., Zegers, C. M. L., Troost, E. G. C., Zips, D. & Thorwarth, D., 21 Oct 2015, In : Acta Oncologica. 54, 9, p. 1370-1377

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)

Current preclinical and clinical applications of hypoxia PET imaging using 2-nitroimidazoles

Peeters, S. G. J. A., Zegers, C. M. L., Yaromina, A., Van Elmpt, W., Dubois, L. & Lambin, P., Mar 2015, In : Quarterly Journal of Nuclear Medicine and Molecular Imaging. 59, 1, p. 39-57

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Imaging of tumour hypoxia and metabolism in patients with head and neck squamous cell carcinoma

Zegers, C. M. L., Van Elmpt, W., Hoebers, F. J. P., Troost, E. G. C., Ollers, M. C., Mottaghy, F. M. & Lambin, P., 21 Oct 2015, In : Acta Oncologica. 54, 9, p. 1378-1384

Research output: Contribution to journalArticleAcademicpeer-review

Long-lasting antitumor effects provided by radiotherapy combined with the immunocytokine L19-IL2

Rekers, N. H., Zegers, C. M. L., Germeraad, W. T., Dubois, L. & Lambin, P., Aug 2015, In : OncoImmunology . 4, 8, p. e1021541

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)

Modern clinical research: How rapid learning health care and cohort multiple randomised clinical trials complement traditional evidence based medicine

Lambin, P., Zindler, J., Vanneste, B., Van De Voorde, L., Jacobs, M., Eekers, D., Peerlings, J., Reymen, B., Larue, R. T. H. M., Deist, T. M., De Jong, E. E. C., Even, A. J. G., Berlanga, A. J., Roelofs, E., Cheng, Q., Carvalho, S., Leijenaar, R. T. H., Zegers, C. M. L., Van Limbergen, E., Berbee, M. & 10 others, Van Elmpt, W., Oberije, C., Houben, R., Dekker, A., Boersma, L., Verhaegen, F., Bosmans, G., Hoebers, F., Smits, K. & Walsh, S., 21 Oct 2015, In : Acta Oncologica. 54, 9, p. 1289-1300

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

New ways to image and target tumour hypoxia and its molecular responses

Dubois, L. J., Niemans, R., van Kuijk, S. J. A., Panth, K. M., Parvathaneni, N-K., Peeters, S. G. J. A., Zegers, C. M. L., Rekers, N. H., van Gisbergen, M. W., Biemans, R., Lieuwes, N. G., Spiegelberg, L., Yaromina, A., Winum, J-Y., Vooijs, M. & Lambin, P., Sep 2015, In : Radiotherapy and Oncology. 116, 3, p. 352-357

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

PET-based dose painting in non-small cell lung cancer: Comparing uniform dose escalation with boosting hypoxic and metabolically active sub-volumes

Even, A. J. G., van der Stoep, J., Zegers, C. M. L., Reymen, B., Troost, E. G. C., Lambin, P. & van Elmpt, W., Aug 2015, In : Radiotherapy and Oncology. 116, 2, p. 281-286

Research output: Contribution to journalArticleAcademicpeer-review

21 Citations (Scopus)

Radiotherapy Combined with the Immunocytokine L19-IL2 Provides Long-lasting Antitumor Effects

Zegers, C. M. L., Rekers, N. H., Quaden, D. H. F., Lieuwes, N. G., Yaromina, A., Germeraad, W. T. V., Wieten, L., Biessen, E. A. L., Boon, L., Neri, D., Troost, E. G. C., Dubois, L. J. & Lambin, P., Mar 2015, In : Clinical Cancer Research. 21, 5, p. 1151-1160

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

Repeatability of hypoxia PET imaging using [F-18]HX4 in lung and head and neck cancer patients: a prospective multicenter trial

Zegers, C. M. L., van Elmpt, W., Szardenings, K., Kolb, H., Waxman, A., Subramaniam, R. M., Moon, D. H., Brunetti, J. C., Srinivas, S. M., Lambin, P. & Chien, D., Nov 2015, In : European Journal of Nuclear Medicine and Molecular Imaging. 42, 12, p. 1840-1849

Research output: Contribution to journalArticleAcademicpeer-review

20 Citations (Scopus)

TH-302 in Combination with Radiotherapy Enhances the Therapeutic Outcome and Is Associated with Pretreatment [F-18]HX4 Hypoxia PET Imaging

Peeters, S. G. J. A., Zegers, C. M. L., Biemans, R., Lieuwes, N. G., van Stiphout, R. G. P. M., Yaromina, A., Sun, J. D., Hart, C. P., Windhorst, A. D., van Elmpt, W., Dubois, L. J. & Lambin, P., 1 Jul 2015, In : Clinical Cancer Research. 21, 13, p. 2984-2992

Research output: Contribution to journalArticleAcademicpeer-review

2014
8 Citations (Scopus)

Imaging techniques for tumour delineation and heterogeneity quantification of lung cancer: overview of current possibilities

van Elmpt, W., Zegers, C. M. L., Das, M. & De Ruysscher, D., Apr 2014, In : Journal of Thoracic Disease. 6, 4, p. 319-327

Research output: Contribution to journalArticleAcademicpeer-review

31 Citations (Scopus)

In vivo quantification of hypoxic and metabolic status of NSCLC tumors using [18f]hx4 and [18f]fdg-pet/ct imaging

Zegers, C. M. L., Van Elmpt, W., Reymen, B., Even, A. J. G., Troost, E. G. C., Oelers, M. C., Hoebers, F. J. P., Houben, R., Eriksson, J., Windhorst, A. D., Mottaghy, F. M., De Ruysscher, D. & Lambin, P., 15 Dec 2014, In : Clinical Cancer Research. 20, 24, p. 6389-6397 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Stereotactic ablative body radiotherapy combined with immunotherapy: Present status and future perspectives

Rekers, N. H., Troost, E. G. C., Zegers, C. M. L., Germeraad, W. T. V., Dubois, L. J. & Lambin, P., Oct 2014, In : Cancer Radiotherapie. 18, 5-6, p. 391-395

Research output: Contribution to journalArticleAcademicpeer-review

2013

Characterization of tumor heterogeneity using dynamic contrast enhanced CT and FDG-PET in non-small cell lung cancer

van Elmpt, W., Das, M., Huellner, M., Sharifi, H., Zegers, C. M. L., Reymen, B., Lambin, P., Wildberger, J. E., Troost, E. G. C., Veit-Haibach, P. & De Ruysscher, D., Oct 2013, In : Radiotherapy and Oncology. 109, 1, p. 65-70

Research output: Contribution to journalArticleAcademicpeer-review

38 Citations (Scopus)

Hypoxia imaging with [18F]HX4 PET in NSCLC patients: Defining optimal imaging parameters☆

Zegers, C. M., van Elmpt, W., Wierts, R., Reymen, B., Sharifi, H., Ollers, M. C., Hoebers, F., Troost, E. G., Wanders, R., van Baardwijk, A., Brans, B., Eriksson, J., Windhorst, B., Mottaghy, F. M., De Ruysscher, D. & Lambin, P., Oct 2013, In : Radiotherapy and Oncology. 109, 1, p. 58-64 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

50 Citations (Scopus)

'Rapid Learning health care in oncology' - An approach towards decision support systems enabling customised radiotherapy

Lambin, P., Roelofs, E., Reymen, B., Velazquez, E. R., Buijsen, J., Zegers, C. M. L., Carvalho, S., Leijenaar, R. T. H., Nalbantov, G., Oberije, C., Scott Marshall, M., Hoebers, F., Troost, E. G. C., van Stiphout, R., Van Elmpt, W., Van Der Weijden, T., Boersma, L., Valentini, V. & Dekker, A., Oct 2013, In : Radiotherapy and Oncology. 109, 1, p. 159-164 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

2012

Dosimetric Analysis of Lu-177-cG250 Radioimmunotherapy in Renal Cell Carcinoma Patients: Correlation with Myelotoxicity and Pretherapeutic Absorbed Dose Predictions Based on In-111-cG250 Imaging

Stillebroer, A. B., Zegers, C. M., Boerman, O. C., Oosterwijk, E., Mulders, P. F. A., O'Donoghue, J. A., Visser, E. P. & Oyen, W. J. G., Jan 2012, In : Journal of Nuclear Medicine. 53, 1, p. 82-89 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

230 Citations (Scopus)

Radiomics: Extracting more information from medical images using advanced feature analysis

Lambin, P., Rios-Velazquez, E., Leijenaar, R., Carvalho, S., van Stiphout, R. G. P. M., Granton, P., Zegers, C. M. L., Gillies, R., Boellard, R., Dekker, A. & Aerts, H. J. W. L., Mar 2012, In : European Journal of Cancer. 48, 4, p. 441-446 6 p.

Research output: Contribution to journalArticleAcademicpeer-review