Imaging techniques for tumour delineation and heterogeneity quantification of lung cancer: overview of current possibilities

Wouter van Elmpt*, Catharina M. L. Zegers, Marco Das, Dirk De Ruysscher

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Imaging techniques for the characterization and delineation of primary lung tumours and lymph nodes are a prerequisite for adequate radiotherapy. Numerous imaging modalities have been proposed for this purpose, but only computed tomography (CT) and FDG-PET have been implemented in clinical routine. Hypoxia PET, dynamic contrast-enhanced CT (DCE-CT), dual energy CT (DECT) and (functional) magnetic resonance imaging (MRI) hold promise for the future. Besides information on the primary tumour, these techniques can be used for quantification of tissue heterogeneity and response. In the future, treatment strategies may be designed which are based on imaging techniques to optimize individual treatment.
Original languageEnglish
Pages (from-to)319-327
JournalJournal of Thoracic Disease
Issue number4
Publication statusPublished - Apr 2014


  • Lung cancer
  • imaging
  • tumour delineation
  • heterogeneity

Cite this