TY - JOUR
T1 - Characterization of tumor heterogeneity using dynamic contrast enhanced CT and FDG-PET in non-small cell lung cancer
AU - van Elmpt, Wouter
AU - Das, Marco
AU - Huellner, Martin
AU - Sharifi, Hoda
AU - Zegers, Catharina M. L.
AU - Reymen, Bart
AU - Lambin, Philippe
AU - Wildberger, Joachim E.
AU - Troost, Esther G. C.
AU - Veit-Haibach, Patrick
AU - De Ruysscher, Dirk
PY - 2013/10
Y1 - 2013/10
N2 - Purpose: Dynamic contrast-enhanced CT (DCE-CT) quantifies vasculature properties of tumors, whereas static FDG-PET/CT defines metabolic activity. Both imaging modalities are capable of showing intra-tumor heterogeneity. We investigated differences in vasculature properties within primary non-small cell lung cancer (NSCLC) tumors measured by DCE-CT and metabolic activity from FDG-PET/CT. Methods: Thirty three NSCLC patients were analyzed prior to treatment. FDG-PET/CT and DCE-CT were co-registered. The tumor was delineated and metabolic activity was segmented on the FDG-PET/CT in two regions: low (= 50% maximum SUV) metabolic uptake. Blood flow, blood volume and permeability were calculated using a maximum slope, deconvolution algorithm and a Patlak model. Correlations were assessed between perfusion parameters for the regions of interest. Results: DCE-CT provided additional information on vasculature and tumor heterogeneity that was not correlated to metabolic tumor activity. There was no significant difference between low and high metabolic active regions for any of the DCE-CT parameters. Furthermore, only moderate correlations between maximum Shy and DCE-CT parameters were observed. Conclusions: No direct correlation was observed between FOG-uptake and parameters extracted from DCE-CT. DCE-CT may provide complementary information to the characterization of primary NSCLC tumors over FDG-PET/CT imaging.
AB - Purpose: Dynamic contrast-enhanced CT (DCE-CT) quantifies vasculature properties of tumors, whereas static FDG-PET/CT defines metabolic activity. Both imaging modalities are capable of showing intra-tumor heterogeneity. We investigated differences in vasculature properties within primary non-small cell lung cancer (NSCLC) tumors measured by DCE-CT and metabolic activity from FDG-PET/CT. Methods: Thirty three NSCLC patients were analyzed prior to treatment. FDG-PET/CT and DCE-CT were co-registered. The tumor was delineated and metabolic activity was segmented on the FDG-PET/CT in two regions: low (= 50% maximum SUV) metabolic uptake. Blood flow, blood volume and permeability were calculated using a maximum slope, deconvolution algorithm and a Patlak model. Correlations were assessed between perfusion parameters for the regions of interest. Results: DCE-CT provided additional information on vasculature and tumor heterogeneity that was not correlated to metabolic tumor activity. There was no significant difference between low and high metabolic active regions for any of the DCE-CT parameters. Furthermore, only moderate correlations between maximum Shy and DCE-CT parameters were observed. Conclusions: No direct correlation was observed between FOG-uptake and parameters extracted from DCE-CT. DCE-CT may provide complementary information to the characterization of primary NSCLC tumors over FDG-PET/CT imaging.
KW - Dynamic contrast enhanced (DCE) CT
KW - Perfusion CT imaging
KW - FDG-PET
KW - NSCLC
KW - Image analysis
U2 - 10.1016/j.radonc.2013.08.032
DO - 10.1016/j.radonc.2013.08.032
M3 - Article
C2 - 24044795
SN - 0167-8140
VL - 109
SP - 65
EP - 70
JO - Radiotherapy and Oncology
JF - Radiotherapy and Oncology
IS - 1
ER -