Karen Zegers

Research output

Research output per year 2012 2015 2022 2023 2024

• 38 Article
• 3 Conference Abstract/Poster in journal
• 3 (Systematic) Review article
• 1 Chapter
• 2 More
  • 1 Editorial
  • 1 Doctoral Thesis

Research output per year

Research output per year

Search results

• 2024

  Predicting the risk of neurocognitive decline after brain irradiation in adult patients with a primary brain tumor

  Tohidinezhad, F., Zegers, C. M. L., Vaassen, F., Dijkstra, J., Anten, M., Van Elmpt, W., De Ruysscher, D., Dekker, A., Eekers, D. B. P. & Traverso, A., 10 Apr 2024, (E-pub ahead of print) In: Neuro-oncology.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
• 2023

  Anatomical changes in resection cavity during brain radiotherapy

  Willems, Y. C. P., Vaassen, F., Zegers, C. M. L., Postma, A. A., Jaspers, J., Romero, A. M., Unipan, M., Swinnen, A., Anten, M., Teernstra, O., Compter, I., van Elmpt, W. & Eekers, D. B. P., 15 Dec 2023, In: Journal of Neuro-Oncology. 165, 3, p. 479-486 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  1 Downloads (Pure)

• Automatic quality assurance of radiotherapy treatment plans using Bayesian networks: A multi-institutional study

  Kalendralis, P., Luk, S. M. H., Canters, R., Eyssen, D., Vaniqui, A., Wolfs, C., Murrer, L., van Elmpt, W., Kalet, A. M., Dekker, A., van Soest, J., Fijten, R., Zegers, C. M. L. & Bermejo, I., 28 Feb 2023, In: Frontiers in Oncology. 13, 1, 10 p., 1099994.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Clinical Concept-Based Radiology Reports Classification Pipeline for Lung Carcinoma

  Mithun, S., Jha, A. K., Sherkhane, U. B., Jaiswar, V., Purandare, N. C., Dekker, A., Puts, S., Bermejo, I., Rangarajan, V., Zegers, C. M. L. & Wee, L., Jun 2023, In: Journal of Digital Imaging. 36, 3, p. 812-826 15 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Clinical implementation of standardized neurocognitive assessment before and after radiation to the brain

  Zegers, C. M. L., Offermann, C., Dijkstra, J., Compter, I., Hoebers, F. J. P., de Ruysscher, D., Anten, M. M., Broen, M. P. G., Postma, A. A., Hoeben, A., Hovinga, K. E., Van Elmpt, W. & Eekers, D. B. P., 1 Sept 2023, In: Clinical and Translational Radiation Oncology. 42, 1, 8 p., 100664.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Geometric and dosimetric analysis of CT- and MR-based automatic contouring for the EPTN contouring atlas in neuro-oncology

  Vaassen, F., Zegers, C. M. L., Hofstede, D., Wubbels, M., Beurskens, H., Verheesen, L., Canters, R., Looney, P., Battye, M., Gooding, M. J., Compter, I., Eekers, D. B. P. & van Elmpt, W., 1 Oct 2023, In: Physica Medica: European journal of medical physics. 114, 1, 11 p., 103156.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• How Natural Language Processing Can Aid With Pulmonary Oncology Tumor Node Metastasis Staging From Free-Text Radiology Reports: Algorithm Development and Validation

  Puts, S., Nobel, M., Zegers, C., Bermejo, I., Robben, S. & Dekker, A., 2023, In: JMIR Formative Research. 7, 1, 14 p., e38125.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Precisie bestraling voor epilepsie, de PRECISION-trial

  Zegers, K., Swinnen, A., Roumen, C., van Asch, C., Brandts, L., Compter, I., Dieleman, E., Dijkstra, J. B., Hendriks, M., Hofman, P., Houben, R., van Iersel-Vet, M., Ramaekers, B., Ronner, H., Rouhl, R., Van Der Salm, S. M. A., Santegoeds, R., Verhoeff, J., Wagner, L., Zwemmer, J., & 3 othersSchijns, O., Colon, A. & Eekers, D., 2023, In: Epilepsie, periodiek voor professionals. 22, 4

  Research output: Contribution to journal › Article › Academic › peer-review
• 2022

  Automatic dose verification system for breast radiotherapy: Method validation, contour propagation and DVH parameters evaluation

  Baeza, J. A., Zegers, C. M. L., de Groot, N. A., Nijsten, S. M. J. J. G., Murrer, L. H. P., Verhoeven, K., Boersma, L., Verhaegen, F. & van Elmpt, W., May 2022, In: Physica Medica: European journal of medical physics. 97, p. 44-49 6 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Correlation of reduced temporal muscle thickness and systemic muscle loss in newly diagnosed glioblastoma patients

  Ten Cate, C., Huijs, S. M. H., Willemsen, A. C. H., Pasmans, R. C. O. S., Eekers, D. B. P., Zegers, C. M. L., Ackermans, L., Beckervordersandforth, J., van Raak, E. P. M., Anten, M. H. M. E., Hoeben, A., Postma, A. A. & Broen, M. P. G., Dec 2022, In: Journal of Neuro-Oncology. 160, 3, p. 611-618 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• External Validation of a Bayesian Network for Error Detection in Radiotherapy Plans

  Kalendralis, P., Eyssen, D., Canters, R., Luk, S. M. H., Kalet, A. M., van Elmpt, W., Fijten, R., Dekker, A., Zegers, C. M. L. & Bermejo, I., 1 Feb 2022, In: IEEE Transactions on Radiation and Plasma Medical Sciences. 6, 2, p. 200-206 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Neurocognition in adults with intracranial tumors: does location really matter?

  Sleurs, C., Zegers, C. M. L., Compter, I., Dijkstra, J., Anten, M. H. M. E., Postma, A. A., Schijns, O. E. M. G., Hoeben, A., Sitskoorn, M. M., De Baene, W., De Roeck, L., Sunaert, S., Van Elmpt, W., Lambrecht, M. & Eekers, D. B. P., Dec 2022, In: Journal of Neuro-Oncology. 160, 3, p. 619-629 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
• 2021

  Current applications of deep-learning in neuro-oncological MRI

  Zegers, C. M. L., Posch, J., Traverso, A., Eekers, D., Postma, A. A., Backes, W., Dekker, A. & van Elmpt, W., 1 Mar 2021, In: Physica Medica: European journal of medical physics. 83, p. 161-173 13 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
• 2020

  Nitroglycerin as a radiosensitizer in non-small cell lung cancer: Results of a prospective imaging-based phase II trial

  Reymen, B. J. T., van Gisbergen, M. W., Even, A. J. G., Zegers, C. M. L., Das, M., Vegt, E., Wildberger, J. E., Mottaghy, F. M., Yaromina, A., Dubois, L. J., van Elmpt, W., De Ruysscher, D. & Lambin, P., Mar 2020, In: Clinical and Translational Radiation Oncology. 21, p. 49-55 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
• 2018

  The immunocytokine L19-IL2: An interplay between radiotherapy and long-lasting systemic anti-tumour immune responses

  Rekers, N. H., Pimentel, V. O., Yaromina, A., Lieuwes, N. G., Biemans, R., Zegers, C. M. L., Germeraad, W. T. V., Van Limbergen, E. J., Neri, D., Dubois, L. J. & Lambin, P., 1 Jan 2018, In: OncoImmunology . 7, 4, 15 p., e1414119.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
• 2017

  Quantitative assessment of Zirconium-89 labeled cetuximab using PET/CT imaging in patients with advanced head and neck cancer: a theragnostic approach

  Even, A. J. G., Hamming-Vrieze, O., van Elmpt, W., Winnepenninckx, V. J. L., Heukelom, J., Tesselaar, M. E. T., Vogel, W. V., Hoeben, A., Zegers, C. M. L., Vugts, D. J., van Dongen, G. A. M. S., Bartelink, H., Mottaghy, F. M., Hoebers, F. & Lambin, P., 17 Jan 2017, In: Oncotarget. 8, 3, p. 3870-3880 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  42 Downloads (Pure)

• Three-dimensional dose evaluation in breast cancer patients to define decision criteria for adaptive radiotherapy

  Zegers, C. M. L., Baeza, J. A., van Elmpt, W., Murrer, L. H. P., Verhoeven, K., Boersma, L., Verhaegen, F. & Nijsten, S. M. J. J. G., Nov 2017, In: Acta Oncologica. 56, 11, p. 1487-1494 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  40 Downloads (Pure)
• 2016

  Evaluation of tumour hypoxia during radiotherapy using [F-18]HX4 PET imaging and blood biomarkers in patients with head and neck cancer

  Zegers, K., Hoebers, F. J. P., van Elmpt, W., Bons, J. A., Öllers, M., Troost, E. G. C., Eekers, D., Balmaekers, L., Arts-Pechtold, M., Mottaghy, F. M. & Lambin, P., Nov 2016, In: European Journal of Nuclear Medicine and Molecular Imaging. 43, 12, p. 2139-2146

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Multiparametric imaging of patient and tumour heterogeneity in non-small-cell lung cancer: quantification of tumour hypoxia, metabolism and perfusion

  van Elmpt, W., Zegers, K., Reymen, B., Even, A. J. G., Dingemans, A-M. C., Öllers, M., Wildberger, J. E., Mottaghy, F. M., Das, M., Troost, E. G. C. & Lambin, P., Feb 2016, In: European Journal of Nuclear Medicine and Molecular Imaging. 43, 2, p. 240-248

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Pharmacokinetic modeling of a novel hypoxia PET tracer [18F]HX4 in patients with non-small cell lung cancer

  Verwer, E. E., Zegers, K., van Elmpt, W., Wierts, R., Windhorst, A. D., Mottaghy, F., Lambin, P. & Boellaard, R., 12 Dec 2016, In: EJNMMI Physics. 3, 12 p., 30.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
• 2015

  A Comparative Study of the Hypoxia PET Tracers [F-18] HX4, [F-18] FAZA, and [F-18] FMISO in a Preclinical Tumor Model

  Peeters, S. G. J. A., Zegers, C. M. L., Lieuwes, N. G., van Elmpt, W., Eriksson, J., van Dongen, G. A. M. S., Dubois, L. & Lambin, P., 1 Feb 2015, In: International Journal of Radiation Oncology Biology Physics. 91, 2, p. 351-359

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Combination of radiotherapy with the immunocytokine L19-IL2: Additive effect in a NK cell dependent tumour model

  Rekers, N. H., Zegers, C. M. L., Yaromina, A., Lieuwes, N. G., Biemans, R., Senden-Gijsbers, B. L. M. G., Losen, M., Van Limbergen, E. J., Germeraad, W. T. V., Neri, D., Dubois, L. & Lambin, P., Sept 2015, In: Radiotherapy and Oncology. 116, 3, p. 438-442

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Comparison of [18F]-FMISO, [18F]-FAZA and [18F]-HX4 for PET imaging of hypoxia - a simulation study

  Wack, L. J., Moennich, D., Van Elmpt, W., Zegers, C. M. L., Troost, E. G. C., Zips, D. & Thorwarth, D., 21 Oct 2015, In: Acta Oncologica. 54, 9, p. 1370-1377

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Imaging of tumour hypoxia and metabolism in patients with head and neck squamous cell carcinoma

  Zegers, C. M. L., Van Elmpt, W., Hoebers, F. J. P., Troost, E. G. C., Ollers, M. C., Mottaghy, F. M. & Lambin, P., 21 Oct 2015, In: Acta Oncologica. 54, 9, p. 1378-1384

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  40 Downloads (Pure)

• Modern clinical research: How rapid learning health care and cohort multiple randomised clinical trials complement traditional evidence based medicine

  Lambin, P., Zindler, J., Vanneste, B., Van De Voorde, L., Jacobs, M., Eekers, D., Peerlings, J., Reymen, B., Larue, R. T. H. M., Deist, T. M., De Jong, E. E. C., Even, A. J. G., Berlanga, A. J., Roelofs, E., Cheng, Q., Carvalho, S., Leijenaar, R. T. H., Zegers, C. M. L., Van Limbergen, E., Berbee, M., & 10 othersVan Elmpt, W., Oberije, C., Houben, R., Dekker, A., Boersma, L., Verhaegen, F., Bosmans, G., Hoebers, F., Smits, K. & Walsh, S., 21 Oct 2015, In: Acta Oncologica. 54, 9, p. 1289-1300

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  41 Downloads (Pure)

• New ways to image and target tumour hypoxia and its molecular responses

  Dubois, L. J., Niemans, R., van Kuijk, S. J. A., Panth, K. M., Parvathaneni, N-K., Peeters, S. G. J. A., Zegers, C. M. L., Rekers, N. H., van Gisbergen, M. W., Biemans, R., Lieuwes, N. G., Spiegelberg, L., Yaromina, A., Winum, J-Y., Vooijs, M. & Lambin, P., Sept 2015, In: Radiotherapy and Oncology. 116, 3, p. 352-357

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• PET-based dose painting in non-small cell lung cancer: Comparing uniform dose escalation with boosting hypoxic and metabolically active sub-volumes

  Even, A. J. G., van der Stoep, J., Zegers, C. M. L., Reymen, B., Troost, E. G. C., Lambin, P. & van Elmpt, W., Aug 2015, In: Radiotherapy and Oncology. 116, 2, p. 281-286

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Radiotherapy Combined with the Immunocytokine L19-IL2 Provides Long-lasting Antitumor Effects

  Zegers, C. M. L., Rekers, N. H., Quaden, D. H. F., Lieuwes, N. G., Yaromina, A., Germeraad, W. T. V., Wieten, L., Biessen, E. A. L., Boon, L., Neri, D., Troost, E. G. C., Dubois, L. J. & Lambin, P., Mar 2015, In: Clinical Cancer Research. 21, 5, p. 1151-1160

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  59 Downloads (Pure)

• Repeatability of hypoxia PET imaging using [F-18]HX4 in lung and head and neck cancer patients: a prospective multicenter trial

  Zegers, C. M. L., van Elmpt, W., Szardenings, K., Kolb, H., Waxman, A., Subramaniam, R. M., Moon, D. H., Brunetti, J. C., Srinivas, S. M., Lambin, P. & Chien, D., Nov 2015, In: European Journal of Nuclear Medicine and Molecular Imaging. 42, 12, p. 1840-1849

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• TH-302 in Combination with Radiotherapy Enhances the Therapeutic Outcome and Is Associated with Pretreatment [F-18]HX4 Hypoxia PET Imaging

  Peeters, S. G. J. A., Zegers, C. M. L., Biemans, R., Lieuwes, N. G., van Stiphout, R. G. P. M., Yaromina, A., Sun, J. D., Hart, C. P., Windhorst, A. D., van Elmpt, W., Dubois, L. J. & Lambin, P., 1 Jul 2015, In: Clinical Cancer Research. 21, 13, p. 2984-2992

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  52 Downloads (Pure)
• 2014

  Imaging techniques for tumour delineation and heterogeneity quantification of lung cancer: overview of current possibilities

  van Elmpt, W., Zegers, C. M. L., Das, M. & De Ruysscher, D., Apr 2014, In: Journal of Thoracic Disease. 6, 4, p. 319-327

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• In vivo quantification of hypoxic and metabolic status of NSCLC tumors using [18f]hx4 and [18f]fdg-pet/ct imaging

  Zegers, C. M. L., Van Elmpt, W., Reymen, B., Even, A. J. G., Troost, E. G. C., Oelers, M. C., Hoebers, F. J. P., Houben, R., Eriksson, J., Windhorst, A. D., Mottaghy, F. M., De Ruysscher, D. & Lambin, P., 15 Dec 2014, In: Clinical Cancer Research. 20, 24, p. 6389-6397 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  39 Downloads (Pure)

• Stereotactic ablative body radiotherapy combined with immunotherapy: Present status and future perspectives

  Rekers, N. H., Troost, E. G. C., Zegers, C. M. L., Germeraad, W. T. V., Dubois, L. J. & Lambin, P., Oct 2014, In: Cancer Radiotherapie. 18, 5-6, p. 391-395

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  57 Downloads (Pure)
• 2013

  Characterization of tumor heterogeneity using dynamic contrast enhanced CT and FDG-PET in non-small cell lung cancer

  van Elmpt, W., Das, M., Huellner, M., Sharifi, H., Zegers, C. M. L., Reymen, B., Lambin, P., Wildberger, J. E., Troost, E. G. C., Veit-Haibach, P. & De Ruysscher, D., Oct 2013, In: Radiotherapy and Oncology. 109, 1, p. 65-70

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  31 Downloads (Pure)

• Hypoxia imaging with [¹⁸F]HX4 PET in NSCLC patients: Defining optimal imaging parameters☆

  Zegers, C. M., van Elmpt, W., Wierts, R., Reymen, B., Sharifi, H., Ollers, M. C., Hoebers, F., Troost, E. G., Wanders, R., van Baardwijk, A., Brans, B., Eriksson, J., Windhorst, B., Mottaghy, F. M., De Ruysscher, D. & Lambin, P., Oct 2013, In: Radiotherapy and Oncology. 109, 1, p. 58-64 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  30 Downloads (Pure)

• 'Rapid Learning health care in oncology' - An approach towards decision support systems enabling customised radiotherapy

  Lambin, P., Roelofs, E., Reymen, B., Velazquez, E. R., Buijsen, J., Zegers, C. M. L., Carvalho, S., Leijenaar, R. T. H., Nalbantov, G., Oberije, C., Scott Marshall, M., Hoebers, F., Troost, E. G. C., van Stiphout, R., Van Elmpt, W., Van Der Weijden, T., Boersma, L., Valentini, V. & Dekker, A., Oct 2013, In: Radiotherapy and Oncology. 109, 1, p. 159-164 6 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
• 2012

  Dosimetric Analysis of Lu-177-cG250 Radioimmunotherapy in Renal Cell Carcinoma Patients: Correlation with Myelotoxicity and Pretherapeutic Absorbed Dose Predictions Based on In-111-cG250 Imaging

  Stillebroer, A. B., Zegers, C. M., Boerman, O. C., Oosterwijk, E., Mulders, P. F. A., O'Donoghue, J. A., Visser, E. P. & Oyen, W. J. G., Jan 2012, In: Journal of Nuclear Medicine. 53, 1, p. 82-89 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Radiomics: Extracting more information from medical images using advanced feature analysis

  Lambin, P., Rios-Velazquez, E., Leijenaar, R., Carvalho, S., van Stiphout, R. G. P. M., Granton, P., Zegers, C. M. L., Gillies, R., Boellard, R., Dekker, A. & Aerts, H. J. W. L., Mar 2012, In: European Journal of Cancer. 48, 4, p. 441-446 6 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
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