New ways to image and target tumour hypoxia and its molecular responses

Ludwig J. Dubois; Raymon Niemans; Simon J. A. van Kuijk; Kranthi M. Panth; Nanda-Kumar Parvathaneni; Sarah G. J. A. Peeters; Catharina M. L. Zegers; Nicolle H. Rekers; Marike W. van Gisbergen; Rianne Biemans; Natasja G. Lieuwes; Linda Spiegelberg; Ala Yaromina; Jean-Yves Winum; Marc Vooijs; Philippe Lambin

doi:10.1016/j.radonc.2015.08.022

New ways to image and target tumour hypoxia and its molecular responses

Ludwig J. Dubois^*, Raymon Niemans, Simon J. A. van Kuijk, Kranthi M. Panth, Nanda-Kumar Parvathaneni, Sarah G. J. A. Peeters, Catharina M. L. Zegers, Nicolle H. Rekers, Marike W. van Gisbergen, Rianne Biemans, Natasja G. Lieuwes, Linda Spiegelberg, Ala Yaromina, Jean-Yves Winum, Marc Vooijs, Philippe Lambin

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Tumour hypoxia and its molecular responses have been shown to be associated with poor prognosis. Detection of hypoxia, preferably in a non-invasive manner, could therefore predict treatment outcome and serve as a tool to individualize treatment. This review gives an overview of recent literature on hypoxia imaging markers currently used in clinical trials. Furthermore, recent progress made in targeting hypoxia (hypoxia-activated prodrugs) or hypoxia response (carbonic anhydrase IX inhibitors) is summarized. Last, window-of-opportunity trials implementing non-invasive imaging are proposed as an important tool to prove anti-tumour efficacy of experimental drugs early during drug development.

Original language	English
Pages (from-to)	352-357
Journal	Radiotherapy and Oncology
Volume	116
Issue number	3
DOIs	https://doi.org/10.1016/j.radonc.2015.08.022
Publication status	Published - Sept 2015

Keywords

Hypoxia
Imaging
Carbonic anhydrase IX
Therapy
Window-of-opportunity trial

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Dubois, L. J., Niemans, R., van Kuijk, S. J. A., Panth, K. M., Parvathaneni, N.-K., Peeters, S. G. J. A., Zegers, C. M. L., Rekers, N. H., van Gisbergen, M. W., Biemans, R., Lieuwes, N. G., Spiegelberg, L., Yaromina, A., Winum, J.-Y., Vooijs, M., & Lambin, P. (2015). New ways to image and target tumour hypoxia and its molecular responses. Radiotherapy and Oncology, 116(3), 352-357. https://doi.org/10.1016/j.radonc.2015.08.022

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title = "New ways to image and target tumour hypoxia and its molecular responses",

abstract = "Tumour hypoxia and its molecular responses have been shown to be associated with poor prognosis. Detection of hypoxia, preferably in a non-invasive manner, could therefore predict treatment outcome and serve as a tool to individualize treatment. This review gives an overview of recent literature on hypoxia imaging markers currently used in clinical trials. Furthermore, recent progress made in targeting hypoxia (hypoxia-activated prodrugs) or hypoxia response (carbonic anhydrase IX inhibitors) is summarized. Last, window-of-opportunity trials implementing non-invasive imaging are proposed as an important tool to prove anti-tumour efficacy of experimental drugs early during drug development.",

keywords = "Hypoxia, Imaging, Carbonic anhydrase IX, Therapy, Window-of-opportunity trial",

author = "Dubois, {Ludwig J.} and Raymon Niemans and {van Kuijk}, {Simon J. A.} and Panth, {Kranthi M.} and Nanda-Kumar Parvathaneni and Peeters, {Sarah G. J. A.} and Zegers, {Catharina M. L.} and Rekers, {Nicolle H.} and {van Gisbergen}, {Marike W.} and Rianne Biemans and Lieuwes, {Natasja G.} and Linda Spiegelberg and Ala Yaromina and Jean-Yves Winum and Marc Vooijs and Philippe Lambin",

year = "2015",

month = sep,

doi = "10.1016/j.radonc.2015.08.022",

language = "English",

volume = "116",

pages = "352--357",

journal = "Radiotherapy and Oncology",

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Dubois, LJ, Niemans, R, van Kuijk, SJA, Panth, KM, Parvathaneni, N-K, Peeters, SGJA, Zegers, CML, Rekers, NH, van Gisbergen, MW, Biemans, R, Lieuwes, NG, Spiegelberg, L, Yaromina, A, Winum, J-Y, Vooijs, M & Lambin, P 2015, 'New ways to image and target tumour hypoxia and its molecular responses', Radiotherapy and Oncology, vol. 116, no. 3, pp. 352-357. https://doi.org/10.1016/j.radonc.2015.08.022

TY - JOUR

T1 - New ways to image and target tumour hypoxia and its molecular responses

AU - Dubois, Ludwig J.

AU - Niemans, Raymon

AU - van Kuijk, Simon J. A.

AU - Panth, Kranthi M.

AU - Parvathaneni, Nanda-Kumar

AU - Peeters, Sarah G. J. A.

AU - Zegers, Catharina M. L.

AU - Rekers, Nicolle H.

AU - van Gisbergen, Marike W.

AU - Biemans, Rianne

AU - Lieuwes, Natasja G.

AU - Spiegelberg, Linda

AU - Yaromina, Ala

AU - Winum, Jean-Yves

AU - Vooijs, Marc

AU - Lambin, Philippe

PY - 2015/9

Y1 - 2015/9

N2 - Tumour hypoxia and its molecular responses have been shown to be associated with poor prognosis. Detection of hypoxia, preferably in a non-invasive manner, could therefore predict treatment outcome and serve as a tool to individualize treatment. This review gives an overview of recent literature on hypoxia imaging markers currently used in clinical trials. Furthermore, recent progress made in targeting hypoxia (hypoxia-activated prodrugs) or hypoxia response (carbonic anhydrase IX inhibitors) is summarized. Last, window-of-opportunity trials implementing non-invasive imaging are proposed as an important tool to prove anti-tumour efficacy of experimental drugs early during drug development.

AB - Tumour hypoxia and its molecular responses have been shown to be associated with poor prognosis. Detection of hypoxia, preferably in a non-invasive manner, could therefore predict treatment outcome and serve as a tool to individualize treatment. This review gives an overview of recent literature on hypoxia imaging markers currently used in clinical trials. Furthermore, recent progress made in targeting hypoxia (hypoxia-activated prodrugs) or hypoxia response (carbonic anhydrase IX inhibitors) is summarized. Last, window-of-opportunity trials implementing non-invasive imaging are proposed as an important tool to prove anti-tumour efficacy of experimental drugs early during drug development.

KW - Hypoxia

KW - Imaging

KW - Carbonic anhydrase IX

KW - Therapy

KW - Window-of-opportunity trial

U2 - 10.1016/j.radonc.2015.08.022

DO - 10.1016/j.radonc.2015.08.022

M3 - Article

C2 - 26324018

SN - 0167-8140

VL - 116

SP - 352

EP - 357

JO - Radiotherapy and Oncology

JF - Radiotherapy and Oncology

IS - 3

ER -

New ways to image and target tumour hypoxia and its molecular responses

Abstract

Keywords

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