Frans Ramaekers

Research output

Research output per year 1975 2000 2001 2002 2005 2010 2011 2013 2014 2022 2024

• 88 Article
• 3 Chapter
• 3 (Systematic) Review article
• 1 Inaugural speech
• 1 More
  • 1 Doctoral Thesis

Research output per year

Research output per year

Search results

• 2011

  Deletions of 11q22.3-q25 are associated with atypical lung carcinoids and poor clinical outcome

  Swarts, D. R. A., Claessen, S. M. H., Jonkers, Y. M. H., van Suylen, R-J., Dingemans, A-M. C., de Herder, W. W., de Krijger, R. R., Smit, E. F., Thunnissen, F. B. J. M., Seldenrijk, C. A., Vink, A., Perren, A., Ramaekers, F. C. S. & Speel, E-J. M., Sept 2011, In: American Journal of Pathology. 179, 3, p. 1129-1137 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Reorganization of the nuclear lamina and cytoskeleton in adipogenesis

  Verstraeten, V. L., Renes, J., Ramaekers, F. C. S., Kamps, M., Kuijpers, H. J., Verheyen, F., Wabitsch, M., Steijlen, P. M., van Steensel, M. A. & Broers, J. L., 1 Jan 2011, In: Histochemistry and Cell Biology. 135, 3, p. 251-61

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Repetitive disruptions of the nuclear envelope invoke temporary loss of cellular compartmentalization in laminopathies

  De Vos, W. H., Houben, F., Kamps, M., Malhas, A., Verheyen, F., Cox, J., Manders, E. M. M., Verstraeten, V. L. R. M., van Steensel, M. A. M., Marcelis, C. L. M., van den Wijngaard, A., Vaux, D. J., Ramaekers, F. C. S. & Broers, J. L. V., 1 Nov 2011, In: Human Molecular Genetics. 20, 21, p. 4175-4186

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
• 2012

  Molecular and cellular biology of neuroendocrine lung tumors: Evidence for separate biological entities

  Swarts, D. R. A., Ramaekers, F. C. S. & Speel, E-J. M., Dec 2012, In: Biochimica et Biophysica Acta-reviews on Cancer. 1826, 2, p. 255-271

  Research output: Contribution to journal › Article › Academic › peer-review

• Next-generation treatment strategies for human papillomavirus-related head and neck squamous cell carcinoma: where do we go?

  Olthof, N. C., Straetmans, J. M. J. A. A., Snoeck, R., Ramaekers, F. C. S., Kremer, B. & Speel, E-J. M., Mar 2012, In: Reviews in Medical Virology. 22, 2, p. 88-105

  Research output: Contribution to journal › Article › Academic › peer-review
• 2013

  An exploration of pathways involved in lung carcinoid progression using gene expression profiling

  Swarts, D. R. A., Van Neste, L., Henfling, M. E. R., Eijkenboom, I., Eijk, P. P., van Velthuysen, M-L., Vink, A., Volante, M., Ylstra, B., Van Criekinge, W., van Engeland, M., Ramaekers, F. C. S. & Speel, E-J. M., Dec 2013, In: Carcinogenesis. 34, 12, p. 2726-2737

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• BCL2 and Keratin 5 Define the Uterine-Cervix-Isthmus Junction, a Transition Between Endocervical and Tubal-Like Epithelium

  Hoogduin, K. J., Hopman, A. N. H., Ramaekers, F. C. S., McCluggage, W. G. & Smedts, F., Jan 2013, In: International Journal of Gynecological Pathology. 32, 1, p. 122-130

  Research output: Contribution to journal › Article › Academic › peer-review

• CD44 and OTP Are Strong Prognostic Markers for Pulmonary Carcinoids

  Swarts, D. R. A., Henfling, M. E. R., Van Neste, L., van Suylen, R-J., Dingemans, A-M. C., Dinjens, W. N. M., Haesevoets, A., Rudelius, M., Thunnissen, E., Volante, M., Van Criekinge, W., van Engeland, M., Ramaekers, F. C. S. & Speel, E-J. M., 15 Apr 2013, In: Clinical Cancer Research. 19, 8, p. 2197-2207

  Research output: Contribution to journal › Article › Academic › peer-review

• Chromosome stability in tonsillar squamous cell carcinoma is associated with HPV16 integration and indicates a favorable prognosis

  Mooren, J. J., Kremer, B., Claessen, S. M. H., Voogd, A. C., Bot, F. J., Klussmann, J. P., Huebbers, C. U., Hopman, A. H. N., Ramaekers, F. C. S. & Speel, E-J. M., 15 Apr 2013, In: International Journal of Cancer. 132, 8, p. 1781-1789

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Cytoplasmic localization of PML particles in laminopathies

  Houben, F., De Vos, W. H., Krapels, I. P. C., Coorens, M., Kierkels, G. J. J., Kamps, M. A. F., Verstraeten, V. L. R. M., Marcelis, C. L. M., van den Wijngaard, A., Ramaekers, F. C. S. & Broers, J. L. V., Jan 2013, In: Histochemistry and Cell Biology. 139, 1, p. 119-134

  Research output: Contribution to journal › Article › Academic › peer-review

• Human papillomavirus multiplex ligation-dependent probe amplification assay for the assessment of viral load, integration, and gain of telomerase-related genes in cervical malignancies

  Theelen, W., Litjens, R. J. N. T. M., Vinokurova, S., Haesevoets, A., Reijans, M., Simons, G., Smedts, F., Herrington, C. S., Ramaekers, F. C. S., Doeberitz, M. V. K., Speel, E-J. M. & Hopman, A. H. N., Nov 2013, In: Human Pathology. 44, 11, p. 2410-2418

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Serum markers in small cell lung cancer: Opportunities for improvement

  Harmsma, M., Schutte, B. & Ramaekers, F. C. S., Dec 2013, In: Biochimica et Biophysica Acta-reviews on Cancer. 1836, 2, p. 255-272

  Research output: Contribution to journal › Article › Academic › peer-review

• Use of the HPV MLPA assay in cervical cytology for the prediction of high grade lesions

  Litjens, R. J. N. T. M., Theelen, W., van de Pas, Y., Ossel, J., Reijans, M., Simons, G., Speel, E-J. M., Slangen, B. F. M., Ramaekers, F. C. S., Kruitwagen, R. F. P. M. & Hopman, A. H. N., Aug 2013, In: Journal of Medical Virology. 85, 8, p. 1386-1393

  Research output: Contribution to journal › Article › Academic › peer-review
• 2014

  Chromosome instability predicts progression of premalignant lesions of the larynx

  Bergshoeff, V. E., van der Heijden, S. J. A., Haesevoets, A., Litjens, S. G. H., Bot, F. J., Voogd, A. C., Chenault, M. N., Hopman, A. H. N., Schuuring, E., van der Wal, J. M., Manni, J. J., Ramaekers, F. C. S., Kremer, B. & Speel, E. J. M., 1 Jan 2014, In: Pathology. 46, 3, p. 216-224

  Research output: Contribution to journal › Article › Academic › peer-review

• Comprehensive Analysis of HPV16 Integration in OSCC Reveals No Significant Impact of Physical Status on Viral Oncogene and Virally Disrupted Human Gene Expression

  Olthof, N. C., Speel, E-J. M., Kolligs, J., Haesevoets, A., Henfling, M., Ramaekers, F. C. S., Preuss, S. F., Drebber, U., Wieland, U., Silling, S., Lam, W. L., Vucic, E. A., Kremer, B., Klussmann, J-P. & Huebbers, C. U., 24 Feb 2014, In: PLOS ONE. 9, 2, e88718.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Human papillomavirus typing by single tube multiplex amplification in real time (SMART): The Papilloma Finder (R) SMART 20 assay

  Ossel, J., Litjens, R. J., Reijans, M., Brink, A. A. T. P., Ummelen, M., Ramaekers, F. C., Hopman, A. H. N. & Simons, G., Dec 2014, In: Journal of Clinical Virology. 61, 4, p. 540-547

  Research output: Contribution to journal › Article › Academic › peer-review

• Interobserver Variability for the WHO Classification of Pulmonary Carcinoids

  Swarts, D. R. A., van Suylen, R-J., den Bakker, M. A., van Oosterhout, M. F. M., Thunnissen, F. B. J. M., Volante, M., Dingemans, A-M. C., Scheltinga, M. R. M., Bootsma, G. P., Pouwels, H. M. M., van den Borne, B. E. E. M., Ramaekers, F. C. S. & Speel, E-J. M., Oct 2014, In: American Journal of Surgical Pathology. 38, 10, p. 1429-1436

  Research output: Contribution to journal › Article › Academic › peer-review

• MEN1 Gene Mutation and Reduced Expression Are Associated With Poor Prognosis in Pulmonary Carcinoids

  Swarts, D. R. A., Scarpa, A., Corbo, V., van Criekinge, W., van Engeland, M., Gatti, G., Henfling, M. E. R., Papotti, M., Perren, A., Ramaekers, F. C. S., Speel, E-J. M. & Volante, M., Feb 2014, In: Journal of Clinical Endocrinology & Metabolism. 99, 2, p. E374-E378

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• P16(INK4A) immunostaining is a strong indicator for high-risk-HPV-associated oropharyngeal carcinomas and dysplasias, but is unreliable to predict low-risk-HPV-infection in head and neck papillomas and laryngeal dysplasias

  Mooren, J. J., Gultekin, S. E., Straetmans, J. M. J. A. A., Haesevoets, A., Peutz-Kootstra, C. J., Huebbers, C. U., Dienes, H. P., Wieland, U., Ramaekers, F. C. S., Kremer, B., Speel, E-J. M. & Klussmann, J. P., 1 May 2014, In: International Journal of Cancer. 134, 9, p. 2108-2117

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• The role of the nuclear lamina in cancer and apoptosis

  Broers, J. & Ramaekers, F., 2014, Cancer Biology and the nuclear envelope. Advances in experimental medicine and biology .

  Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic
• 2015

  Gene expression profiling of pulmonary neuroendocrine neoplasms: a comprehensive overview

  Swarts, D., Ramaekers, F. & Speel, E., 2015, In: Cancer Treatment Communications. 4, p. 148-160

  Research output: Contribution to journal › Article › Academic › peer-review

• Sustained accumulation of prelamin A and depletion of lamin A/C both cause oxidative stress and mitochondrial dysfunction but induce different cell fates

  Sieprath, T., Corne, T. D. J., Nooteboom, M., Grootaert, C., Rajkovic, A., Buysschaert, B., Robijns, J., Broers, J. L. V., Ramaekers, F. C. S., Koopman, W. J. H., Willems, P. H. G. M. & De Vos, W. H., 2015, In: Nucleus-austin. 6, 3, p. 236-246

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Viral load, gene expression and mapping of viral integration sites in HPV16-associated HNSCC cell lines

  Olthof, N. C., Huebbers, C. U., Kolligs, J., Henfling, M., Ramaekers, F. C. S., Cornet, I., van Lent-Albrechts, J. A., Stegmann, A. P. A., Silling, S., Wieland, U., Carey, T. E., Walline, H. M., Gollin, S. M., Hoffmann, T. K., de Winter, J., Kremer, B., Klussmann, J. P. & Speel, E-J. M., 1 Mar 2015, In: International Journal of Cancer. 136, 5, p. E207-E218

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
• 2017

  Development of the Uterine Cervix and Its Implications for the Pathogenesis of Cervical Cancer

  Hopman, A. H. N. & Ramaekers, F. C. S., 10 Sept 2017, Pathology of the Cervix. Herrington, C. S. (ed.). 1 ed. Springer, Vol. 3. p. 1-20 20 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic

• Investigating the race for the surface and skin integration in clinically retrieved abutments with two-photon microscopy

  Kapsokalyvas, D., van Hoof, M., Wigren, S., Chimhanda, T., Kuijpers, H. J., Ramaekers, F. C. S., Stokroos, R. J. & van Zandvoort, M. A. M. J., 1 Nov 2017, In: Colloids and Surfaces B-Biointerfaces. 159, p. 97-107 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Limited additive value of the Ki-67 proliferative index on patient survival in World Health Organization-classified pulmonary carcinoids

  Swarts, D. R. A., Rudelius, M., Claessen, S. M. H., Cleutjens, J. P., Seidl, S., Volante, M., Ramaekers, F. C. S. & Speel, E. J. M., Feb 2017, In: Histopathology. 70, 3, p. 412-422 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review
• 2018

  Determination of the proliferative fractions in differentiating hematopoietic cell lineages of normal bone marrow

  Nies, K. P. H., Kraaijvanger, R., Lindelauf, K. H. K., Drent, R. J. M. R., Rutten, R. M. J., Ramaekers, F. C. S. & Leers, M. P. G., Nov 2018, In: Cytometry Part A. 93A, 11, p. 1097-1105 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• The IGF pathway is activated in insulinomas but downregulated in metastatic disease

  Henfling, M. E. R., Perren, A. A., Schmitt, A. M., Saddig, C. M., Starke, A. A., Riedl, R. G., Versleijen-Jonkers, Y. M. H., Sprij-Mooij, D. M., Ramaekers, F. C. S., Hofland, L. J. & Speel, E-J. M., Dec 2018, In: Endocrine-Related Cancer. 25, 12, p. 1005-1018 14 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
• 2019

  Assessment of fibroblast nuclear morphology aids interpretation of LMNA variants

  van Tienen, F., Lindsey, P., Kamps, M., Krapels, I., Ramaekers, F., Brunner, H., van den Wijngaard, A. & Broers, J., Mar 2019, In: European Journal of Human Genetics. 27, 3, p. 389–399 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Upregulation of AKR1C1 and AKR1C3 expression in OPSCC with integrated HPV16 and HPV-negative tumors is an indicator of poor prognosis

  Huebbers, C. U., Verhees, F., Poluschkin, L., Olthof, N. C., Kolligs, J., Siefer, O. G., Henfling, M., Ramaekers, F. C. S., Preuss, S. F., Beutner, D., Seehawer, J., Drebber, U., Korkmaz, Y., Lam, W. L., Vucic, E. A., Kremer, B., Klussmann, J. P. & Speel, E-J. M., 15 May 2019, In: International Journal of Cancer. 144, 10, p. 2465-2477 13 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
• 2020

  SOX17 expression and its down-regulation by promoter methylation in cervical adenocarcinoma in situ and adenocarcinoma

  Hopman, A. N. H., Moshi, J. M., Hoogduin, K. J., Ummelen, M., Henfling, M. E. R., van Engeland, M., Wouters, K. A. D., Stoop, H., Looijenga, L. H. J. & Ramaekers, F. C. S., Feb 2020, In: Histopathology. 76, 3, p. 383-393 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Structural and Mechanical Aberrations of the Nuclear Lamina in Disease

  Stiekema, M., van Zandvoort, M. A. M. J., Ramaekers, F. C. S. & Broers, J. L., Aug 2020, In: Cells. 9, 8, 22 p., 1884.

  Research output: Contribution to journal › (Systematic) Review article › peer-review

  Open Access

• Switches of SOX17 and SOX2 expression in the development of squamous metaplasia and squamous intraepithelial lesions of the uterine cervix

  Moshi, J. M., Hoogduin, K. J., Ummelen, M., Henfling, M. E. R., van Engeland, M., Wouters, K. A. D., Stoop, H., Demers, I., Looijenga, L. H. J., Ramaekers, F. C. S. & Hopman, A. N. H., Sept 2020, In: Cancer Medicine. 9, 17, p. 6330-6343 14 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
• 2021

  Proliferative activity is disturbed in myeloproliferative neoplasms (MPN), myelodysplastic syndrome (MDS), andMDS/MPNdiseases. Differences betweenMDSandMDS/MPN

  Mestrum, S. G. C., de Wit, N. C. J., Drent, R. J. M., Hopman, A. H. N., Ramaekers, F. C. S. & Leers, M. P. G., May 2021, In: Cytometry Part B-clinical Cytometry. 100, 3, p. 322-330 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Super-Resolution Imaging of the A- and B-Type Lamin Networks: A Comparative Study of Different Fluorescence Labeling Procedures

  Stiekema, M., Ramaekers, F. C. S., Kapsokalyvas, D., van Zandvoort, M. A. M. J., Veltrop, R. J. A. & Broers, J. L. V., 1 Oct 2021, In: International Journal of Molecular Sciences. 22, 19, 20 p., 10194.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• The potential of proliferative and apoptotic parameters in clinical flow cytometry of myeloid malignancies

  Mestrum, S. G. C., Hopman, A. H. N., Ramaekers, F. C. S. & Leers, M. P. G., 13 Apr 2021, In: Blood advances. 5, 7, p. 2040-2052 13 p.

  Research output: Contribution to journal › (Systematic) Review article › peer-review

  Open Access
• 2022

  Evaluation Criteria for Chromosome Instability Detection by FISH to Predict Malignant Progression in Premalignant Glottic Laryngeal Lesions

  Bergshoeff, V. E., Balkenhol, M. C. A., Haesevoets, A., Ruland, A., Chenault, M. N., Nelissen, R. C., Peutz, C. J., Clarijs, R., Van der Laak, J. A. W. M., Takes, R. P., Van den Brekel, M. W., Van Velthuysen, M-L. F., Ramaekers, F. C. S., Kremer, B. & Speel, E-J. M., 3 Jul 2022, In: Cancers. 14, 13, 15 p., 3260.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Integration of the Ki-67 proliferation index into the Ogata score improves its diagnostic sensitivity for low-grade myelodysplastic syndromes

  Mestrum, S. G. C., Cremers, E. M. P., de Wit, N. C. J., Drent, R. J. M., Ramaekers, F. C. S., Hopman, A. H. N. & Leers, M. P. G., Feb 2022, In: Leukemia Research. 113, 8 p., 106789.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Optimized gating strategy and supporting flow cytometry data for the determination of the Ki-67 proliferation index in the diagnosis of myelodysplastic syndrome

  Mestrum, S. G. C., Cremers, E. M. P., de Wit, N. C. J., Drent, R. J. M., Ramaekers, F. C. S., Hopman, A. H. N. & Leers, M. P. G., Apr 2022, In: Data in brief. 41, 12 p., 107976.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Proliferative and anti-apoptotic fractions in maturing hematopoietic cell lineages and their role in homeostasis of normal bone marrow

  Mestrum, S. G. C., Vanblarcum, R. B. Y., Drent, R. J. M., Boonen, B. T., van Hemert, W. L. W., Ramaekers, F. C. S., Hopman, A. H. N. & Leers, M. P. G., Jul 2022, In: Cytometry Part A. 101, 7, p. 552-563 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• SOX2 expression in the pathogenesis of premalignant lesions of the uterine cervix: its histo-topographical distribution distinguishes between low- and high-grade CIN

  Moshi, J. M., Ummelen, M., Broers, J. L. V., Smedts, F., Van de Vijver, K. K., Cleutjens, J. P. M., Litjens, R. J. N. T. M., Ramaekers, F. C. S. & Hopman, A. H. N., Dec 2022, In: Histochemistry and Cell Biology. 158, 6, p. 545-559 15 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• The Proliferation Index of Erythroid Cells Predicts the Development of Transfusion-dependence in Myelodysplastic Syndrome Patients With Mildly Reduced Hemoglobin Levels at Initial Diagnosis

  Mestrum, S. G. C., de Wit, N. C. J., Cremers, E. M. P., Drent, R. J. M., Ramaekers, F. C. S., Hopman, A. H. N. & Leers, M. P. G., 9 Dec 2022, In: HemaSphere. 6, 12, 4 p., e804.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• The Role of Lamins in the Nucleoplasmic Reticulum, a Pleiomorphic Organelle That Enhances Nucleo-Cytoplasmic Interplay

  Stiekema, M., Houben, F., Verheyen, F., Borgers, M., Menzel, J., Meschkat, M., van Zandvoort, M. A. M. J., Ramaekers, F. C. S. & Broers, J. L. V., 16 Jun 2022, In: Frontiers in Cell and Developmental Biology. 10, 17 p., 914286.

  Research output: Contribution to journal › (Systematic) Review article › peer-review

  Open Access
• 2023

  Impact of antigen retrieval protocols on the immunohistochemical detection of epigenetic DNA modifications

  Moshi, J. M., Ummelen, M., Broers, J. L. V., Ramaekers, F. C. S. & Hopman, A. H. N., Jun 2023, In: Histochemistry and Cell Biology. 159, 6, p. 513-526 14 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Impact of the gating strategy for Ki-67 and Bcl-2 on the determination of proliferation and anti-apoptosis data by flow cytometry in non-malignant bone marrow aspirates and aspirates from patients with myeloid malignancies

  Mestrum, S. G. C., Vanblarcum, R., de Wit, N. C. J., Drent, R. J. M., Boonen, B. T., van Hemert, W. L. W., Hopman, A. H. N., Ramaekers, F. C. S. & Leers, M. P. G., 1 Aug 2023, In: Data in brief. 49, 1, 14 p., 109284.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
• 2024

  Inhibition of cytosine 5-hydroxymethylation during progression of cancer precursor lesions in the uterine cervix

  Moshi, J. M., Ummelen, M., Smedts, F., Ramaekers, F. C. S. & Hopman, A. H. N., 1 Apr 2024, In: PLOS ONE. 19, 4, 23 p., e0297008.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access