Development of the Uterine Cervix and Its Implications for the Pathogenesis of Cervical Cancer

Anton H. N. Hopman, Frans C. S. Ramaekers

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic


Normal development of the uterine cervix has been widely studied and the origin of both the columnar and squamous epithelia, as well as the molecular basis of their differentiation, has been established. The process of early carcinogenesis in the uterine cervix has also been described extensively, in particular with respect to the role of human papillomavirus (HPV) infection. However, questions remain about the progenitor cell(s) that play(s) a role in normal (embryonic and fetal) development, as well as in the oncogenic processes that take place in the transformation zone of the uterine cervix. This chapter describes the development of the human lower female reproductive tract, in particular the cervical squamocolumnar junction, and its implications for the pathogenesis of cervical cancer.
Original languageEnglish
Title of host publicationPathology of the Cervix
EditorsC. Simon Herrington
Number of pages20
ISBN (Electronic)978-3-319-51257-0
ISBN (Print)978-3-319-51255-6
Publication statusPublished - 10 Sep 2017

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