Upregulation of AKR1C1 and AKR1C3 expression in OPSCC with integrated HPV16 and HPV-negative tumors is an indicator of poor prognosis

Christian U. Huebbers*, Femke Verhees, Leonard Poluschkin, Nadine C. Olthof, Jutta Kolligs, Oliver G. Siefer, Mieke Henfling, Frans C. S. Ramaekers, Simon F. Preuss, Dirk Beutner, Julia Seehawer, Uta Drebber, Yueksel Korkmaz, Wan L. Lam, Emily A. Vucic, Bernd Kremer, Jens P. Klussmann, Ernst-Jan M. Speel

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)2465-2477
Number of pages13
JournalInternational Journal of Cancer
Volume144
Issue number10
DOIs
Publication statusPublished - 15 May 2019

Keywords

  • APOT-PCR
  • DIPS-PCR
  • viral integration
  • immunohistochemistry
  • oxidative stress
  • HUMAN-PAPILLOMAVIRUS
  • OXIDATIVE STRESS
  • OROPHARYNGEAL CARCINOMA
  • HEAD
  • CANCER
  • PATHWAY
  • GENOME
  • SURVIVAL

Cite this

Huebbers, Christian U. ; Verhees, Femke ; Poluschkin, Leonard ; Olthof, Nadine C. ; Kolligs, Jutta ; Siefer, Oliver G. ; Henfling, Mieke ; Ramaekers, Frans C. S. ; Preuss, Simon F. ; Beutner, Dirk ; Seehawer, Julia ; Drebber, Uta ; Korkmaz, Yueksel ; Lam, Wan L. ; Vucic, Emily A. ; Kremer, Bernd ; Klussmann, Jens P. ; Speel, Ernst-Jan M. / Upregulation of AKR1C1 and AKR1C3 expression in OPSCC with integrated HPV16 and HPV-negative tumors is an indicator of poor prognosis. In: International Journal of Cancer. 2019 ; Vol. 144, No. 10. pp. 2465-2477.
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title = "Upregulation of AKR1C1 and AKR1C3 expression in OPSCC with integrated HPV16 and HPV-negative tumors is an indicator of poor prognosis",
keywords = "APOT-PCR, DIPS-PCR, viral integration, immunohistochemistry, oxidative stress, HUMAN-PAPILLOMAVIRUS, OXIDATIVE STRESS, OROPHARYNGEAL CARCINOMA, HEAD, CANCER, PATHWAY, GENOME, SURVIVAL",
author = "Huebbers, {Christian U.} and Femke Verhees and Leonard Poluschkin and Olthof, {Nadine C.} and Jutta Kolligs and Siefer, {Oliver G.} and Mieke Henfling and Ramaekers, {Frans C. S.} and Preuss, {Simon F.} and Dirk Beutner and Julia Seehawer and Uta Drebber and Yueksel Korkmaz and Lam, {Wan L.} and Vucic, {Emily A.} and Bernd Kremer and Klussmann, {Jens P.} and Speel, {Ernst-Jan M.}",
year = "2019",
month = "5",
day = "15",
doi = "10.1002/ijc.31954",
language = "English",
volume = "144",
pages = "2465--2477",
journal = "International Journal of Cancer",
issn = "0020-7136",
publisher = "Wiley",
number = "10",

}

Huebbers, CU, Verhees, F, Poluschkin, L, Olthof, NC, Kolligs, J, Siefer, OG, Henfling, M, Ramaekers, FCS, Preuss, SF, Beutner, D, Seehawer, J, Drebber, U, Korkmaz, Y, Lam, WL, Vucic, EA, Kremer, B, Klussmann, JP & Speel, E-JM 2019, 'Upregulation of AKR1C1 and AKR1C3 expression in OPSCC with integrated HPV16 and HPV-negative tumors is an indicator of poor prognosis', International Journal of Cancer, vol. 144, no. 10, pp. 2465-2477. https://doi.org/10.1002/ijc.31954

Upregulation of AKR1C1 and AKR1C3 expression in OPSCC with integrated HPV16 and HPV-negative tumors is an indicator of poor prognosis. / Huebbers, Christian U.; Verhees, Femke; Poluschkin, Leonard; Olthof, Nadine C.; Kolligs, Jutta; Siefer, Oliver G.; Henfling, Mieke; Ramaekers, Frans C. S.; Preuss, Simon F.; Beutner, Dirk; Seehawer, Julia; Drebber, Uta; Korkmaz, Yueksel; Lam, Wan L.; Vucic, Emily A.; Kremer, Bernd; Klussmann, Jens P.; Speel, Ernst-Jan M.

In: International Journal of Cancer, Vol. 144, No. 10, 15.05.2019, p. 2465-2477.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Upregulation of AKR1C1 and AKR1C3 expression in OPSCC with integrated HPV16 and HPV-negative tumors is an indicator of poor prognosis

AU - Huebbers, Christian U.

AU - Verhees, Femke

AU - Poluschkin, Leonard

AU - Olthof, Nadine C.

AU - Kolligs, Jutta

AU - Siefer, Oliver G.

AU - Henfling, Mieke

AU - Ramaekers, Frans C. S.

AU - Preuss, Simon F.

AU - Beutner, Dirk

AU - Seehawer, Julia

AU - Drebber, Uta

AU - Korkmaz, Yueksel

AU - Lam, Wan L.

AU - Vucic, Emily A.

AU - Kremer, Bernd

AU - Klussmann, Jens P.

AU - Speel, Ernst-Jan M.

PY - 2019/5/15

Y1 - 2019/5/15

KW - APOT-PCR

KW - DIPS-PCR

KW - viral integration

KW - immunohistochemistry

KW - oxidative stress

KW - HUMAN-PAPILLOMAVIRUS

KW - OXIDATIVE STRESS

KW - OROPHARYNGEAL CARCINOMA

KW - HEAD

KW - CANCER

KW - PATHWAY

KW - GENOME

KW - SURVIVAL

U2 - 10.1002/ijc.31954

DO - 10.1002/ijc.31954

M3 - Article

VL - 144

SP - 2465

EP - 2477

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

IS - 10

ER -