Upregulation of AKR1C1 and AKR1C3 expression in OPSCC with integrated HPV16 and HPV-negative tumors is an indicator of poor prognosis

Christian U. Huebbers*, Femke Verhees, Leonard Poluschkin, Nadine C. Olthof, Jutta Kolligs, Oliver G. Siefer, Mieke Henfling, Frans C. S. Ramaekers, Simon F. Preuss, Dirk Beutner, Julia Seehawer, Uta Drebber, Yueksel Korkmaz, Wan L. Lam, Emily A. Vucic, Bernd Kremer, Jens P. Klussmann, Ernst-Jan M. Speel

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)2465-2477
Number of pages13
JournalInternational Journal of Cancer
Volume144
Issue number10
DOIs
Publication statusPublished - 15 May 2019

Keywords

  • APOT-PCR
  • DIPS-PCR
  • viral integration
  • immunohistochemistry
  • oxidative stress
  • HUMAN-PAPILLOMAVIRUS
  • OXIDATIVE STRESS
  • OROPHARYNGEAL CARCINOMA
  • HEAD
  • CANCER
  • PATHWAY
  • GENOME
  • SURVIVAL

Cite this

Huebbers, C. U., Verhees, F., Poluschkin, L., Olthof, N. C., Kolligs, J., Siefer, O. G., Henfling, M., Ramaekers, F. C. S., Preuss, S. F., Beutner, D., Seehawer, J., Drebber, U., Korkmaz, Y., Lam, W. L., Vucic, E. A., Kremer, B., Klussmann, J. P., & Speel, E-J. M. (2019). Upregulation of AKR1C1 and AKR1C3 expression in OPSCC with integrated HPV16 and HPV-negative tumors is an indicator of poor prognosis. International Journal of Cancer, 144(10), 2465-2477. https://doi.org/10.1002/ijc.31954