Sustained accumulation of prelamin A and depletion of lamin A/C both cause oxidative stress and mitochondrial dysfunction but induce different cell fates

Tom Sieprath, Tobias D. J. Corne, Marco Nooteboom, Charlotte Grootaert, Andreja Rajkovic, Benjamin Buysschaert, Joke Robijns, Jos L. V. Broers, Frans C. S. Ramaekers, Werner J. H. Koopman, Peter H. G. M. Willems, Winnok H. De Vos*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)236-246
JournalNucleus-austin
Volume6
Issue number3
DOIs
Publication statusPublished - 2015

Keywords

  • apoptosis
  • high-content microscopy
  • lamin A
  • C
  • laminopathies
  • mitochondria
  • mitochondrial dysfunction
  • oxidative stress
  • prelamin A
  • senescence
  • ZMPSTE24

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