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Research Output 2003 2019

  • 52 Article
  • 1 Comment/Letter to the editor
  • 1 Doctoral Thesis
2019

Effect of l-arginine on energy metabolism, skeletal muscle and brown adipose tissue in South Asian and Europid prediabetic men: a randomised double-blinded crossover study

Boon, M. R., Hanssen, M. J. W., Brans, B., Hulsman, C. J. M., Hoeks, J., Nahon, K. J., Bakker, C., van Klinken, J. B., Havekes, B., Schaart, G., Jazet, I. M., Rensen, P. C. N. & Lichtenbelt, W. D. V. M., Jan 2019, In : Diabetologia. 62, 1, p. 112-122 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

MicroRNA-382 silencing induces a mitonuclear protein imbalance and activates the mitochondrial unfolded protein response in muscle cells

Dahlmans, D., Houzelle, A., Andreux, P., Wang, X., Jorgensen, J. A., Moullan, N., Daemen, S., Kersten, S., Auwerx, J. & Hoeks, J., May 2019, In : Journal of Cellular Physiology. 234, 5, p. 6601-6610 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

Circadian misalignment induces fatty acid metabolism gene profiles and compromises insulin sensitivity in human skeletal muscle

Wefers, J., van Moorsel, D., Hansen, J., Connell, N. J., Havekes, B., Hoeks, J., Lichtenbelt, W. D. V. M., Duez, H., Phielix, E., Kalsbeek, A., Boekschoten, M. V., Hooiveld, G. J., Hesselink, M. K. C., Kersten, S., Staels, B., Scheer, F. A. J. L. & Schrauwen, P., 24 Jul 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 30, p. 7789-7794 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Dissociation of intramyocellular lipid storage and insulin resistance in trained athletes and type 2 diabetes patients; involvement of perilipin 5?

Gemmink, A., Daemen, S., Brouwers, B., Huntjens, P. R., Schaart, G., Moonen-Kornips, E., Jorgensen, J., Hoeks, J., Schrauwen, P. & Hesselink, M. K. C., 1 Mar 2018, In : Journal of Physiology. 596, 5, p. 857-868 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Distinct lipid droplet characteristics and distribution unmask the apparent contradiction of the athlete's paradox

Daemen, S., Gemmink, A., Brouwers, B., Meex, R. C. R., Huntjens, P. R., Schaart, G., Moonen-Komips, E., Jorgensen, J., Hoeks, J., Schrauwen, P. & Hesselink, M. K. C., Nov 2018, In : Molecular Metabolism. 17, p. 71-81 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

An unbiased silencing screen in muscle cells identifies miR-320a, miR-150, miR-196b, and miR-34c as regulators of skeletal muscle mitochondrial metabolism

Dahlmans, D., Houzelle, A., Andreux, P., Jorgensen, J. A., Wang, X., de Windt, L. J., Schrauwen, P., Auwerx, J. & Hoeks, J., Nov 2017, In : Molecular Metabolism. 6, 11, p. 1429-1442 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Cold-Induced Thermogenesis Depends on ATGL-Mediated Lipolysis in Cardiac Muscle, but Not Brown Adipose Tissue

Schreiber, R., Diwoky, C., Schoiswohl, G., Feiler, U., Wongsiriroj, N., Abdellatif, M., Kolb, D., Hoeks, J., Kershaw, E. E., Sedej, S., Schrauwen, P., Haemmerle, G. & Zechner, R., 7 Nov 2017, In : Cell Metabolism. 26, 5, p. 753-763.e7 18 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Evaluation of Muscle microRNA Expression in Relation to Human Peripheral Insulin Sensitivity: A Cross-Sectional Study in Metabolically Distinct Subject Groups

Dahlmans, D., Houzelle, A., Jorgensen, J. A., Phielix, E., Lindeboom, L., Hesselink, M. K. C., Schrauwen, P. & Hoeks, J., 21 Sep 2017, In : Frontiers in physiology. 8, 10 p., 711.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2016

A genistein-enriched diet neither improves skeletal muscle oxidative capacity nor prevents the transition towards advanced insulin resistance in ZDF rats

van Bree, B. W. J., Lenaers, E., Nabben, M., Briede, J. J., Jorgensen, J. A., Schaart, G., Schrauwen, P., Hoeks, J. & Hesselink, M. K. C., 14 Mar 2016, In : Scientific Reports. 6, 22854.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
1 Citation (Scopus)

Demonstration of a day-night rhythm in human skeletal muscle oxidative capacity

van Moorsel, D., Hansen, J., Havekes, B., Scheer, F. A. J. L., Jorgensen, J. A., Hoeks, J., Schrauwen-Hinderling, V. B., Duez, H., Lefebvre, P., Schaper, N. C., Hesselink, M. K. C., Staels, B. & Schrauwen, P., Aug 2016, In : Molecular Metabolism. 5, 8, p. 635-645

Research output: Contribution to journalArticleAcademicpeer-review

Mitochondrial dynamics, quality control and miRNA regulation in skeletal muscle: implications for obesity and related metabolic disease

Dahlmans, D., Houzelle, A., Schrauwen, P. & Hoeks, J., 1 Jun 2016, In : Clinical Science. 130, 11, p. 843-852

Research output: Contribution to journalArticleAcademicpeer-review

2015

Effects of high-fat feeding on ectopic fat storage and postprandial lipid metabolism in mouse offspring

van Ewijk, P. A., Paglialunga, S. A., Kooi, M. E., Nunes, P. M., Gemmink, A., Slenter, J., Moonen Kornips, E., Jorgensen, J. A., Hoeks, J., Wildberger, J. E., Hesselink, M. K., Glatz, J. F., Heerschap, A., Kersten, S., Schrauwen, P. & Schrauwen-Hinderling, V. B., 1 Jan 2015, In : Obesity. 23, 11, p. 2242-2250

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)

Glucose uptake in human brown adipose tissue is impaired upon fasting-induced insulin resistance.

Hanssen, M. J., Wierts, R., Hoeks, J., Gemmink, A., Brans, B., Mottaghy, F. M., Schrauwen, P. & van Marken Lichtenbelt, W. D., Mar 2015, In : Diabetologia. 58, 3, p. 586-595 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

20 Citations (Scopus)

Low brown adipose tissue activity in endurance-trained compared with lean sedentary men

Vosselman, M. J., Hoeks, J., Brans, B., Pallubinsky, H., Nascimento, E. B. M., van der Lans, A. A. J., Broeders, E. P., Mottaghy, F. M., Schrauwen, P. & van Marken Lichtenbelt, W. D., Dec 2015, In : International Journal of Obesity. 39, 12, p. 1696-1702 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

40 Citations (Scopus)

Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus

Hanssen, M. J., Hoeks, J., Brans, B., van der Lans, A. A., Schaart, G., van den Driessche, J. J., Jorgensen, J. A., Boekschoten, M. V., Hesselink, M. K., Havekes, B., Kersten, S., Mottaghy, F. M., van Marken Lichtenbelt, W. D. & Schrauwen, P., Aug 2015, In : Nature Medicine. 21, 8, p. 863-865 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

2014
15 Citations (Scopus)

High-Fat Diet-Induced Mitochondrial Biogenesis Is Regulated by Mitochondrial-Derived Reactive Oxygen Species Activation of CaMKII.

Jain, S. S., Paglialunga, S., Vigna, C., Ludzki, A., Herbst, E. A., Lally, J. S., Schrauwen, P., Hoeks, J., Tupling, A. R., Bonen, A. & Holloway, G. P., Jun 2014, In : Diabetes. 63, 6, p. 1907-1913 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Lack of UCP3 does not affect skeletal muscle mitochondrial function under lipid-challenged conditions, but leads to sudden cardiac death.

Nabben, M., van Bree, B. W., Lenaers, E., Hoeks, J., Hesselink, M. K., Schaart, G., Gijbels, M. J., Glatz, J. F., da Silva, G. J., De Windt, L. J., Tian, R., Mike, E., Skapura, D. G., Wehrens, X. H. & Schrauwen, P., Nov 2014, In : Basic Research in Cardiology. 109, 6, 12 p., 447.

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Long-echo time MR spectroscopy for skeletal muscle acetylcarnitine detection

Lindeboom, L., Nabuurs, C. I., Hoeks, J., Brouwers, B., Phielix, E., Kooi, M. E., Hesselink, M. K., Wildberger, J. E., Stevens, R. D., Koves, T., Muoio, D. M., Schrauwen, P. & Schrauwen-Hinderling, V. B., Nov 2014, In : Journal of Clinical Investigation. 124, 11, p. 4915-4925 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

2013
222 Citations (Scopus)

Cold acclimation recruits human brown fat and increases nonshivering thermogenesis

van der Lans, A. A., Hoeks, J., Brans, B., Vijgen, G. H. E. J., Visser, M. G., Vosselman, M. J., Hansen, J., Jorgensen, J. A., Wu, J., Mottaghy, F. M., Schrauwen, P. & van Marken Lichtenbelt, W. D., Aug 2013, In : Journal of Clinical Investigation. 123, 8, p. 3395-3403 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

17 Citations (Scopus)

Effects of Bezafibrate Treatment in a Patient and a Carrier With Mutations in the PNPLA2 Gene, Causing Neutral Lipid Storage Disease With Myopathy

van de Weijer, T., Havekes, B., Bilet, L., Hoeks, J., Sparks, L., Bosma, M., Paglialunga, S., Jorgensen, J., Janssen, M. C., Schaart, G., Sauerwein, H. P., Smeets, J. L., Wildberger, J. E., Zechner, R., Schrauwen-Hinderling, V. B., Hesselink, M. K. C. & Schrauwen, P., 1 Jan 2013, In : Circulation Research. 112, 5, p. e51-54

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

9 Citations (Scopus)

Impaired skeletal muscle mitochondrial function in morbidly obese patients is normalized one year after bariatric surgery.

Vijgen, G. H. E. J., Bouvy, N. D., Hoeks, J., Wijers, S., Schrauwen, P. & van Marken Lichtenbelt, W. D., 1 Jan 2013, In : Surgery for Obesity and Related Diseases. 9, 6, p. 936-941 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

Increased Oxygen Consumption in Human Adipose Tissue From the "Brown Adipose Tissue" Region

Vijgen, G. H. E. J., Sparks, L. M., Bouvy, N. D., Schaart, G., Hoeks, J., van Marken Lichtenbelt, W. D. & Schrauwen, P., Jul 2013, In : Journal of Clinical Endocrinology & Metabolism. 98, 7, p. E1230-E1234 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Relationship of C5L2 receptor to skeletal muscle substrate utilization

Roy, C., Paglialunga, S., Schaart, G., Moonen-Kornips, E., Meex, R. C., Phielix, E., Hoeks, J., Hesselink, M. K., Cianflone, K. & Schrauwen, P., 27 Feb 2013, In : PLOS ONE. 8, 2, 8 p., 57494.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
59 Citations (Scopus)

The Hypoxia-Inducible MicroRNA Cluster miR-199a similar to 214 Targets Myocardial PPAR delta and Impairs Mitochondrial Fatty Acid Oxidation

El Azzouzi, H., Leptidis, S., Dirkx, E., Hoeks, J., van Bree, B., van de Brand, K., McClellan, E. A., Poels, E., Sluimer, J. C., van den Hoogenhof, M. M., Armand, A. S., Yin, X., Langley, S., Bourajjaj, M., Olieslagers, S., Krishnan, J., Vooijs, M., Kurihara, H., Stubbs, A., Pinto, Y. M. & 5 others, Krek, W., Mayr, M., da Costa Martins, P. A., Schrauwen, P. & De Windt, L. J., 3 Sep 2013, In : Cell Metabolism. 18, 3, p. 341-354 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

2012
878 Citations (Scopus)

Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human.

Wu, J., Bostrom, P., Sparks, L. M., Ye, L., Choi, J. H., Giang, A. H., Khandekar, M., Virtanen, K. A., Nuutila, P., Schaart, G., Huang, K., Tu, H., van Marken Lichtenbelt, W. D., Hoeks, J., Enerback, S., Schrauwen, P. & Spiegelman, B. M., 20 Jul 2012, In : Cell. 150, 2, p. 366-376 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)
27 Citations (Scopus)

High oxidative capacity due to chronic exercise training attenuates lipid-induced insulin resistance.

Phielix, E., Meex, R., Ouwens, DM., Sparks, L. M., Hoeks, J., Schaart, G., Kornips, C. F. P., Hesselink, M. K. C. & Schrauwen, P., Oct 2012, In : Diabetes. 61, 10, p. 2472-2478 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

93 Citations (Scopus)

Increase in brown adipose tissue activity after weight loss in morbidly obese subjects.

Vijgen, G. H. E. J., Bouvy, N. D., Teule, G. J. J., Brans, B., Hoeks, J., Schrauwen, P. & van Marken Lichtenbelt, W. D., Jul 2012, In : Journal of Clinical Endocrinology & Metabolism. 97, 7, p. E1229-E1233 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)
39 Citations (Scopus)

Muscle mitochondria and insulin resistance: a human perspective.

Hoeks, J. & Schrauwen, P., Sep 2012, In : Trends in Endocrinology and Metabolism. 23, 9, p. 444-450 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

17 Citations (Scopus)

Targeting of mitochondrial reactive oxygen species production does not avert lipid-induced insulin resistance in muscle tissue from mice.

Paglialunga, S., van Bree, B. W., Bosma, M., Valdecantos, M. P., Amengual Cladera, E., Jorgensen, J. A., Van Beurden, D., den Hartog, G. J. M., Ouwens, DM., Briedé, J. J., Schrauwen, P. & Hoeks, J., Oct 2012, In : Diabetologia. 55, 10, p. 2759-2768 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

2011

Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans

Timmers, S., Konings, E., Bilet, L., Houtkooper, R. H., van de Weijer, T., Goossens, G. H., Hoeks, J., van der Krieken, S., Ryu, D., Kersten, S., Kornips, C. F. P., Hesselink, M. K. C., Kunz, I., Schrauwen-Hinderling, V., Blaak, E. E., Auwerx, J. & Schrauwen, P., 1 Jan 2011, In : Cell Metabolism. 14, 5, p. 612-22

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

High fat diet-induced changes in mouse muscle mitochondrial phospholipids do not impair mitochondrial respiration despite insulin resistance

Hoeks, J., de Wilde, J., Hulshof, M. F., van den Berg, S. A., Schaart, G., van Dijk, K. W., Smit, E. & Mariman, E. C., 28 Nov 2011, In : PLOS ONE. 6, 11, 10 p., 27274.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
13 Citations (Scopus)

High-fat diets rich in medium- versus long-chain fatty acids induce distinct patterns of tissue specific insulin resistance.

de Vogel-van den Bosch, J., van den Berg, S. A., Bijland, S., Voshol, P. J., Havekes, L. M., Romijn, H. A., Hoeks, J., Van Beurden, D., Hesselink, M. K. C., Schrauwen, P. & van Dijk, K. W., Apr 2011, In : Journal of Nutritional Biochemistry. 22, 4, p. 366-371 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

Short-term increase of plasma free fatty acids does not interfere with intrinsic mitochondrial function in healthy young men.

Brands, M., Hoeks, J., Sauerwein, H. P., Ackermans, M. T., Ouwens, M., Lammers, N. M., van der Plas, M. N., Schrauwen, P., Groen, A. K. & Serlie, M. J., 1 Jan 2011, In : Metabolism-Clinical and Experimental. 60, 10, p. 1398-1405 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

Significance of uncoupling protein 3 in mitochondrial function upon mid- and long-term dietary high-fat exposure

Nabben, M., Hoeks, J., Kornips, C. F. P., Van Beurden, D., Briedé, J. J., Hesselink, M. K. C., Glatz, J. F. & Schrauwen, P., 15 Dec 2011, In : Febs Letters. 585, 24, p. 4010-4017 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

The effects of long- or medium-chain fat diets on glucose tolerance and myocellular content of lipid intermediates in rats.

de Vogel-van den Bosch, J., Hoeks, J., Timmers, S., Houten, S. M., van Dijk, P. J., Boon, W., Van Beurden, D., Schaart, G., Kersten, S., Voshol, P. J., Wanders, R. J., Hesselink, M. K. C. & Schrauwen, P., Apr 2011, In : Obesity. 19, 4, p. 792-799 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

23 Citations (Scopus)

Uncoupled respiration, ROS production, acute lipotoxicity and oxidative damage in isolated skeletal muscle mitochondria from UCP3-ablated mice.

Nabben, M., Shabalina, I. G., Kornips, C. F. P., Van Beurden, D., Cannon, B., Schrauwen, P., Nedergaard, J. & Hoeks, J., 1 Jan 2011, In : Biochimica et Biophysica Acta-bioenergetics. 1807, 9, p. 1095-1105

Research output: Contribution to journalArticleAcademicpeer-review

2010
18 Citations (Scopus)

Adaptations in mitochondrial function parallel, but fail to rescue, the transition to severe hyperglycemia and hyperinsulinemia: a study in Zucker diabetic fatty rats.

Lenaers, E., Feyter, H. M., Hoeks, J., Schrauwen, P., Schaart, G., Nabben, M., Nicolay, K., Prompers, J. J. & Hesselink, M. K., 1 Jan 2010, In : Obesity. 18, 6, p. 1100-1107

Research output: Contribution to journalArticleAcademicpeer-review

35 Citations (Scopus)
9 Citations (Scopus)

High levels of whole-body energy expenditure are associated with a lower coupling of skeletal muscle mitochondria in C57B1/6 mice

van den Berg, S. A., Nabben, M., Bijland, S., Voshol, P. J., van Klinken, J. B., Havekes, L. M., Romijn, H. A., Hoeks, J., Hesselink, M. K., Schrauwen, P. & van Dijk, K. W., Nov 2010, In : Metabolism-Clinical and Experimental. 59, 11, p. 1612-1618 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

97 Citations (Scopus)

Mitochondrial dysfunction and lipotoxicity.

Schrauwen, P., Schrauwen-Hinderling, V. B., Hoeks, J. & Hesselink, M. K., Mar 2010, In : Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids. 1801, 3, p. 266-271 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

71 Citations (Scopus)

Prolonged fasting identifies skeletal muscle mitochondrial dysfunction as consequence rather than cause of human insulin resistance.

Hoeks, J., van Herpen, N. A., Mensink, M. R., Kornips, C. F. P., Van Beurden, D., Hesselink, M. K. C. & Schrauwen, P., Sep 2010, In : Diabetes. 59, 9, p. 2117-2125 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

2008
151 Citations (Scopus)

Lower intrinsic ADP-stimulated mitochondrial respiration underlies in vivo mitochondrial dysfunction in muscle of male type 2 diabetic patients.

Phielix, E., Schrauwen-Hinderling, V., Mensink, M., Lenaers, E., Meex, R. C., Hoeks, J., Kooi, M. E., Kornips, E., Sels, J. P., Hesselink, M. K. & Schrauwen, P., 1 Jan 2008, In : Diabetes. 57, 11, p. 2943-2949

Research output: Contribution to journalArticleAcademicpeer-review

43 Citations (Scopus)

Mitochondrial function, content and ROS production in rat skeletal muscle: effect of high-fat feeding

Hoeks, J., Briede, J. J., de Vogel, J., Schaart, G., Nabben, M., Kornips, E., Hesselink, M. K. & Schrauwen, P., 1 Jan 2008, In : Febs Letters. 582, 4, p. 510-6

Research output: Contribution to journalArticleAcademicpeer-review

50 Citations (Scopus)
2006
23 Citations (Scopus)

Involvement of UCP3 in mild uncoupling and lipotoxicity

Hoeks, J., Hesselink, M. K. & Schrauwen, P., 1 Jan 2006, In : Experimental Gerontology. 41, 7, p. 658-826

Research output: Contribution to journalArticleAcademicpeer-review

47 Citations (Scopus)

Peroxisome proliferator-activated receptor-gamma coactivator-1 and insulin resistance: acute effect of fatty acids

Hoeks, J., Hesselink, M. K., Russell, A. P., Mensink, M., Saris, W. H., Mensink, R. P. & Schrauwen, P., 1 Jan 2006, In : Diabetologia. 49, 10, p. 2419-2426

Research output: Contribution to journalArticleAcademicpeer-review

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Open Access
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62 Citations (Scopus)