Circadian misalignment induces fatty acid metabolism gene profiles and compromises insulin sensitivity in human skeletal muscle

Jakob Wefers, Dirk van Moorsel, Jan Hansen, Niels J. Connell, Bas Havekes, Joris Hoeks, Wouter D. van Marken Lichtenbelt, Helene Duez, Esther Phielix, Andries Kalsbeek, Mark V. Boekschoten, Guido J. Hooiveld, Matthijs K. C. Hesselink, Sander Kersten, Bart Staels, Frank A. J. L. Scheer, Patrick Schrauwen*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)7789-7794
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume115
Issue number30
DOIs
Publication statusPublished - 24 Jul 2018

Keywords

  • circadian misalignment
  • shift work
  • diabetes
  • insulin sensitivity
  • skeletal muscle
  • GLUCOSE-METABOLISM
  • RESONANCE-SPECTROSCOPY
  • OXIDATIVE CAPACITY
  • ENERGY-METABOLISM
  • NIGHT WORK
  • CLOCK
  • TOLERANCE
  • SYSTEM
  • RESISTANCE
  • DISEASE
  • Heart
  • Fatty Acids/blood
  • Humans
  • Male
  • Gene Expression Profiling
  • Adult
  • Diabetes Mellitus, Type 2/blood
  • Insulin Resistance
  • Muscle, Skeletal/metabolism
  • Obesity/blood

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