Skeletal muscle mitochondrial network dynamics in metabolic disorders and aging

C.E. Fealy, L. Grevendonk, J. Hoeks, M.K.C. Hesselink*

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

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Abstract

With global demographics trending towards an aging population, the numbers of individuals with an age-associated loss of independence is increasing. A key contributing factor is loss of skeletal muscle mitochondrial, metabolic, and contractile function. Recent advances in imaging technologies have demonstrated the importance of mitochondrial morphology and dynamics in the pathogenesis of disease. In this review, we examine the evidence for altered mitochondrial dynamics as a mechanism in age and obesity-associated loss of skeletal muscle function, with a particular focus on the available human data. We highlight some of the areas where more data are needed to identify the specific mechanisms connecting mitochondrial morphology and skeletal muscle dysfunction.
Original languageEnglish
Pages (from-to)1033-1044
Number of pages12
JournalTrends in Molecular Medicine
Volume27
Issue number11
DOIs
Publication statusPublished - 1 Nov 2021

Keywords

  • MITOFUSIN 2
  • INSULIN-RESISTANCE
  • SARCOPENIC OBESITY
  • QUALITY-CONTROL
  • PROTEIN
  • FISSION
  • EXERCISE
  • MFN2
  • AGE
  • EXPRESSION

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