Healthy aging and muscle function are positively associated with NAD(+) abundance in humans

G.E. Janssens, L. Grevendonk, R.Z. Perez, B.V. Schomakers, J. de Vogel-van den Bosch, J.M.W. Geurts, M. van Weeghel, P. Schrauwen, R.H. Houtkooper*, J. Hoeks*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Skeletal muscle is greatly affected by aging, resulting in a loss of metabolic and physical function. However, the underlying molecular processes and how (lack of) physical activity is involved in age-related metabolic decline in muscle function in humans is largely unknown. Here, we compared, in a cross-sectional study, the muscle metabolome from young to older adults, whereby the older adults were exercise trained, had normal physical activity levels or were physically impaired. Nicotinamide adenine dinucleotide (NAD(+)) was one of the most prominent metabolites that was lower in older adults, in line with preclinical models. This lower level was even more pronounced in impaired older individuals, and conversely, exercise-trained older individuals had NAD(+) levels that were more similar to those found in younger individuals. NAD(+) abundance positively correlated with average number of steps per day and mitochondrial and muscle functioning. Our work suggests that a clear association exists between NAD(+) and health status in human aging.
Original languageEnglish
Pages (from-to)254–263
Number of pages19
JournalNature aging
Volume2
Issue number3
DOIs
Publication statusPublished - 1 Mar 2022

Keywords

  • HUMAN SKELETAL-MUSCLE
  • NICOTINAMIDE MONONUCLEOTIDE
  • MITOCHONDRIAL RESPIRATION
  • MICRORNA EXPRESSION
  • KYNURENIC ACID
  • EXERCISE
  • LONGEVITY
  • DIET
  • DYSFUNCTION
  • PERFORMANCE

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