No photo of Frank Hoebers

Frank Hoebers

20102019
If you made any changes in Pure these will be visible here soon.

Research Output 2010 2019

2019

Acute Hypoxia Profile is a Stronger Prognostic Factor than Chronic Hypoxia in Advanced Stage Head and Neck Cancer Patients

van der Heijden, M., de Jong, M. C., Verhagen, C. V. M., de Roest, R. H., Sanduleanu, S., Hoebers, F., Leemans, C. R., Brakenhoff, R. H., Vens, C., Verheij, M. & Van Den Brekel, M. W. M., Apr 2019, In : Cancers. 11, 4, 13 p., 583.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Improving decision making in larynx cancer by developing a decision aid: A mixed methods approach

Petersen, J. F., Berlanga, A., Stuiver, M. M., Hamming-Vrieze, O., Hoebers, F., Lambin, P. & van den Brekel, M. W. M., Dec 2019, In : Laryngoscope. 129, 12, p. 2733-2739 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Machine learning algorithms for outcome prediction in (chemo) radiotherapy: An empirical comparison of classifiers (vol 45, pg 3449, 2018)

Deist, T. M., Dankers, F. J. W. M., Valdes, G., Wijsman, R., Hsu, I-C., Oberije, C., Lustberg, T., van Soest, J., Hoebers, F., Jochems, A., El Naqa, I., Wee, L., Morin, O., Raleigh, D. R., Bots, W., Kaanders, J. H., Belderbos, J., Kwint, M., Solberg, T., Monshouwer, R. & 3 others, Bussink, J., Dekker, A. & Lambin, P., Feb 2019, In : Medical Physics. 46, 2, p. 1080-1087 8 p.

Research output: Contribution to journalErratum / corrigendumAcademic

Trends in treatment and overall survival among patients with proximal esophageal cancer

de Vos-Geelen, J., Geurts, S. M. E., van Putten, M., Valkenburg-van Iersel, L. B. J., Grabsch, H. I., Mohammad, N. H., Hoebers, F. J. P., Hoge, C. V., Jeene, P. M., de Jong, E. J. M., van Laarhoven, H. W. M., Rozema, T., Slingerland, M., Tjan-Heijnen, V. C. G., Nieuwenhuijzen, G. A. P. & Lemmens, V. E. P. P., 21 Dec 2019, In : World Journal of Gastroenterology. 25, 47, p. 6835-6846 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Tumor to cervical spinal cord standardized uptake ratio (SUR) improves the reproducibility of F-18-FDG-PET based tumor segmentation in head and neck squamous cell carcinoma in a multicenter setting

van den Bosch, S., Dijkema, T., Philippens, M. E. P., Terhaard, C. H. J., Hoebers, F. J. P., Kaanders, J. H. A. M. & Oyen, W. J. G., Jan 2019, In : Radiotherapy and Oncology. 130, p. 39-45 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

Development and validation of a radiomic signature to predict HPV (p16) status from standard CT imaging: a multicenter study

Leijenaar, R. T. H., Bogowicz, M., Jochems, A., Hoebers, F. J. P., Wesseling, F. W. R., Huang, S. H., Chan, B., Waldron, J. N., O'Sullivan, B., Rietveld, D., Leemans, C. R., Brakenhoff, R. H., Riesterer, O., Tanadini-Lang, S., Guckenberger, M., Ikenberg, K. & Lambin, P., 1 Jan 2018, In : British Journal of Radiology. 91, 1086, 8 p., 2017049811075.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Machine learning algorithms for outcome prediction in (chemo)radiotherapy: An empirical comparison of classifiers

Deist, T. M., Dankers, F. J. W. M., Valdes, G., Wijsman, R., Hsu, I-C., Oberije, C., Lustberg, T., van Soest, J., Hoebers, F., Jochems, A., El Naqa, I., Wee, L., Morin, O., Raleigh, D. R., Bots, W., Kaanders, J. H., Belderbos, J., Kwint, M., Solberg, T., Monshouwer, R. & 3 others, Bussink, J., Dekker, A. & Lambin, P., 1 Jul 2018, In : Medical Physics. 45, 7, p. 3449-3459 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Variation in Integrated Head and Neck Cancer Care: Impact of Patient and Hospital Characteristics

van Overveld, L. F. J., Takes, R. P., Braspenning, J. C. C., de Jong, R. J. B., de Boer, J. P., Brouns, J. J. A., Bun, R. J., Dik, E. A., van Dijk, B. A. C., van Es, R. J. J., Hoebers, F. J. P., Kolenaar, B., Kropveld, A., Langeveld, T. P. M., Verschuur, H. P., de Visscher, J. G. A. M., van Weert, S., Witjes, M. J. H., Smeele, L. E., Merkx, M. A. W. & 1 others, Hermens, R. P. M. G., 1 Dec 2018, In : Journal of the National Comprehensive Cancer Network. 16, 12, p. 1491-1498 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

2017

Cutaan plaveiselcelcarcinoom na irradicale resectie van keratoacanthoom

Maris, M. J. A., Kelleners - Smeets, N. W. J., Baijens - Leurs, L., Hoeberigs, M. C., Hoebers, F., Abdul Hamid, M., Tuinder, S. M. H., Dik, E. A. & Mosterd, K., Oct 2017, In : Nederlands Tijdschrift voor Dermatologie en Venereologie. 27, 10, p. 574-577 4 p.

Research output: Contribution to journalEditorialAcademicpeer-review

49 Downloads (Pure)

Decision support systems for personalized and participative radiation oncology

Lambin, P., Zindler, J., Vanneste, B. G. L., Van De Voorde, L., Eekers, D., Compter, I., Panth, K. M., Peerlings, J., Larue, R. T. H. M., Deist, T. M., Jochems, A., Lustberg, T., van Soest, J., de Jong, E. E. C., Even, A. J. G., Reymen, B., Rekers, N., van Gisbergen, M., Roelofs, E., Carvalho, S. & 19 others, Leijenaar, R. T. H., Zegers, C. M. L., Jacobs, M., van Timmeren, J., Brouwers, P., Lal, J. A., Dubois, L., Yaromina, A., Van Limbergen, E. J., Berbee, M., van Elmpt, W., Oberije, C., Ramaekers, B., Dekker, A., Boersma, L. J., Hoebers, F., Smits, K. M., Berlanga, A. J. & Walsh, S., 15 Jan 2017, In : Advanced Drug Delivery Reviews. 109, p. 131-153 23 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File

Externally validated HPV-based prognostic nomogram for oropharyngeal carcinoma patients yields more accurate predictions than TNM staging (vol 113, pg 324, 2014)

Velazquez, E. R., Hoebers, F., Aerts, H. J. W. L., Rietbergen, M. M., Brakenhoff, R. H., Leemans, R. C., Speel, E-J., Straetmans, J., Kremer, B. & Lambin, P., Aug 2017, In : Radiotherapy and Oncology. 124, 2, p. 337-338 2 p.

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

Feedback preferences of patients, professionals and health insurers in integrated head and neck cancer care

van Overveld, L. F. J., Takes, R. P., Vijn, T. W., Braspenning, J. C. C., de Boer, J. P., Brouns, J. J. A., Bun, R. J., van Dijk, B. A. C., Dortmans, J. A. W. F., Dronkers, E. A. C., van Es, R. J. J., Hoebers, F. J. P., Kropveld, A., Langendijk, J. A., Langeveld, T. P. M., Oosting, S. F., Verschuur, H. P., de Visscher, J. G. A. M., van Weert, S., Merkx, M. A. W. & 2 others, Smeele, L. E. & Hermens, R. P. M. G., Dec 2017, In : Health Expectations. 20, 6, p. 1275-1288 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

PET imaging of zirconium-89 labelled cetuximab: A phase I trial in patients with head and neck and lung cancer

van Loon, J., Even, A. J. G., Aerts, H. J. W. L., Ollers, M., Hoebers, F., van Elmpt, W., Dubois, L., Dingemans, A-M. C., Lalisang, R. I., Kempers, P., Brans, B., Winnepenninckx, V., Speel, E-J., Thunnissen, E., Smits, K. M., Boellaard, R., Vugts, D. J., De Ruysscher, D. & Lambin, P., Feb 2017, In : Radiotherapy and Oncology. 122, 2, p. 267-273 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Quantitative assessment of Zirconium-89 labeled cetuximab using PET/CT imaging in patients with advanced head and neck cancer: a theragnostic approach

Even, A. J. G., Hamming-Vrieze, O., van Elmpt, W., Winnepenninckx, V. J. L., Heukelom, J., Tesselaar, M. E. T., Vogel, W. V., Hoeben, A., Zegers, C. M. L., Vugts, D. J., van Dongen, G. A. M. S., Bartelink, H., Mottaghy, F. M., Hoebers, F. & Lambin, P., 17 Jan 2017, In : Oncotarget. 8, 3, p. 3870-3880 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The histological and histomorphometric changes in the mandible after radiotherapy: An animal model

Poort, L. J., Ludlage, J. H. B., Lie, N., Bockmann, R. A., Odekerken, J. C. E., Hoebers, F. J. & Kessler, P. A. W. H., May 2017, In : Journal of Cranio-Maxillofacial Surgery. 45, 5, p. 716-721 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Uniform FDG-PET guided GRAdient Dose prEscription to reduce late Radiation Toxicity (UPGRADE-RT): study protocol for a randomized clinical trial with dose reduction to the elective neck in head and neck squamous cell carcinoma

van den Bosch, S., Dijkema, T., Kunze-Busch, M. C., Terhaard, C. H. J., Raaijmakers, C. P. J., Doornaert, P. A. H., Hoebers, F. J. P., Vergeer, M. R., Kreike, B., Wijers, O. B., Oyen, W. J. G. & Kaanders, J. H. A. M., 21 Mar 2017, In : BMC Cancer. 17, 8 p., 208.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2016
1 Citation (Scopus)

Benefit of particle therapy in re-irradiation of head and neck patients. Results of a multicentric in silico ROCOCO trial

Eekers, D. B. P., Roelofs, E., Jelen, U., Kirk, M., Granzier, M., Ammazzalorso, F., Ahn, P. H., Janssens, G. O. R. J., Hoebers, F. J. P., Friedmann, T., Solberg, T., Walsh, S., Troost, E. G. C., Kaanders, J. H. A. M. & Lambin, P., Dec 2016, In : Radiotherapy and Oncology. 121, 3, p. 387-394

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Cervical esophageal cancer: a gap in cancer knowledge

Hoeben, A., Polak, J., van de Voorde, L., Hoebers, F., Grabsch, H. I. & de Vos-Geelen, J., Sep 2016, In : Annals of Oncology. 27, 9, p. 1664-1674 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Development and evaluation of an online three-level proton vs photon decision support prototype for head and neck cancer - Comparison of dose, toxicity and cost-effectiveness

Cheng, Q., Roelofs, E., Ramaekers, B. L. T., Eekers, D., van Soest, J., Lustberg, T., Hendriks, T., Hoebers, F., van der Laan, H. P., Korevaar, E. W., Dekker, A., Langendijk, J. A. & Lambin, P., Feb 2016, In : Radiotherapy and Oncology. 118, 2, p. 281-285

Research output: Contribution to journalArticleAcademicpeer-review

24 Citations (Scopus)

Development and validation of a staging system for HPV-related oropharyngeal cancer by the International Collaboration on Oropharyngeal cancer Network for Staging (ICON-S): a multicentre cohort study

O'Sullivan, B., Huang, S. H., Su, J., Garden, A. S., Sturgis, E. M., Dahlstrom, K., Lee, N., Riaz, N., Pei, X., Koyfman, S. A., Adelstein, D., Burkey, B. B., Friborg, J., Kristensen, C. A., Gothelf, A. B., Hoebers, F., Kremer, B., Speel, E-J., Bowles, D. W., Raben, D. & 3 others, Karam, S. D., Yu, E. & Xu, W., Apr 2016, In : Lancet oncology. 17, 4, p. 440-451

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Evaluation of tumour hypoxia during radiotherapy using [F-18]HX4 PET imaging and blood biomarkers in patients with head and neck cancer

Zegers, K., Hoebers, F. J. P., van Elmpt, W., Bons, J. A., Öllers, M., Troost, E. G. C., Eekers, D., Balmaekers, L., Arts-Pechtold, M., Mottaghy, F. M. & Lambin, P., Nov 2016, In : European Journal of Nuclear Medicine and Molecular Imaging. 43, 12, p. 2139-2146

Research output: Contribution to journalArticleAcademicpeer-review

Implementation of a rapid learning platform: Predicting 2-year survival in laryngeal carcinoma patients in a clinical setting.

Lustberg, T., Bailey, M., Thwaites, D. I., Miller, A., Carolan, M., Holloway, L., Rios Velazquez, E., Hoebers, F. & Dekker, A., 15 Apr 2016, In : OncoTarget. 7, 24, p. 37288-37296

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Intestinal-type sinonasal adenocarcinomas: The road to molecular diagnosis and personalized treatment

Hoeben, A., van de Winkel, L., Hoebers, F., Kross, K., Driessen, C., Slootweg, P., Tjan-Heijnen, V. C. G. & van Herpen, C., Oct 2016, In : Head and Neck-Journal for the Sciences and Specialties of the Head and Neck. 38, p. 1564-1570 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Locally advanced basal cell carcinoma has a distinct methylation and transcriptomic profile

Brinkhuizen, T., van Geel, M., Denil, S. L. I. J., De Meyer, T., Kelleners-Smeets, N. W. J., Lohuis, P. J. F. M., Hoebers, F. J. P., Winnepenninckx, V. J. L., van Steensel, M. A. M. & Mosterd, K., Apr 2016, In : Experimental Dermatology. 25, 4, p. 316-318

Research output: Contribution to journalEditorialAcademicpeer-review

Osseointegration and implant stability of extraoral implants in Gottingen minipigs after irradiation

Poort, L. J., Kiewiet, C. C., Cleutjens, J. P. M., Houben, R., Hoebers, F. J. P. & Kessler, P. A. W. H., Nov 2016, In : Journal of Cranio-Maxillofacial Surgery. 44, 11, p. 1842-1848

Research output: Contribution to journalArticleAcademicpeer-review

2013
35 Citations (Scopus)

Adaptive and innovative Radiation Treatment FOR improving Cancer treatment outcomE (ARTFORCE); a randomized controlled phase II trial for individualized treatment of head and neck cancer

Heukelom, J., Hamming, O., Bartelink, H., Hoebers, F., Giralt, J., Herlestam, T., Verheij, M., van den Brekel, M., Vogel, W., Slevin, N., Deutsch, E., Sonke, J-J., Lambin, P. & Rasch, C., 22 Feb 2013, In : BMC Cancer. 13, 84.

Research output: Contribution to journalArticleAcademicpeer-review

A Pragmatic Contouring Guideline for Salivary Gland Structures in Head and Neck Radiation Oncology The MOIST Target

Hoebers, F., Yu, E., Eisbruch, A., Thorstad, W., O'Sullivan, B., Dawson, L. A. & Hope, A., Feb 2013, In : American Journal of Clinical Oncology-Cancer Clinical Trials. 36, 1, p. 70-76

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Definitive radiation therapy for treatment of laryngeal carcinoma Impact of local relapse on outcome and implications for treatment strategies

Hoebers, F., Rios, E., Troost, E., van den Ende, P., Kross, K., Lacko, M., Lalisang, R., Kremer, B. & de Jong, J., Oct 2013, In : Strahlentherapie Und onkologie. 189, 10, p. 834-841

Research output: Contribution to journalArticleAcademicpeer-review

50 Citations (Scopus)

'Rapid Learning health care in oncology' - An approach towards decision support systems enabling customised radiotherapy

Lambin, P., Roelofs, E., Reymen, B., Velazquez, E. R., Buijsen, J., Zegers, C. M. L., Carvalho, S., Leijenaar, R. T. H., Nalbantov, G., Oberije, C., Scott Marshall, M., Hoebers, F., Troost, E. G. C., van Stiphout, R., Van Elmpt, W., Van Der Weijden, T., Boersma, L., Valentini, V. & Dekker, A., Oct 2013, In : Radiotherapy and Oncology. 109, 1, p. 159-164 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

State of the Art Radiation Therapy for Lung Cancer 2012: A Glimpse of the Future

De Ruysscher, D., Belderbos, J., Reymen, B., van Elmpt, W., van Baardwijk, A., Wanders, R., Hoebers, F., Vooijs, M., Oellers, M. & Lambin, P., Mar 2013, In : Clinical Lung Cancer. 14, 2, p. 89-95

Research output: Contribution to journalArticleAcademicpeer-review

2011

Development and validation of a nomogram for prediction of survival and local control in laryngeal carcinoma patients treated with radiotherapy alone: A cohort study based on 994 patients

Egelmeer, A. G. T. M., Velazquez, E. R., de Jong, J. M. A., Oberije, C., Geussens, Y., Nuyts, S., Kremer, B., Rietveld, D., Leemans, C. R., de Jong, M. C., Rasch, C. R., Hoebers, F., Homer, J., Slevin, N., West, C. M. & Lambin, P., Jul 2011, In : Radiotherapy and Oncology. 100, 1, p. 108-115

Research output: Contribution to journalArticleAcademicpeer-review

REIRRADIATION FOR HEAD-AND-NECK CANCER: DELICATE BALANCE BETWEEN EFFECTIVENESS AND TOXICITY

Hoebers, F., Heemsbergen, W., Moor, S., Lopez-Yurda, M., Klop, M., Tesselaar, M. E. T. & Rasch, C. R., 1 Nov 2011, In : International Journal of Radiation Oncology Biology Physics. 81, 3, p. E111-E118

Research output: Contribution to journalArticleAcademicpeer-review

Semi-automatic delitneation using weighted CT-MRI registered images for radiotherapy of nasopharyngeal cancer

Fitton, I., Cornelissen, S. A. P., Duppen, J. C., Steenbakkers, R. J. H. M., Peeters, S. T. H., Hoebers, F. J. P., Kaanders, J. H. A. M., Nowak, P. J. C. M., Rasch, C. R. N. & van Herk, M., Aug 2011, In : Medical Physics. 38, 8, p. 4662-4666

Research output: Contribution to journalArticleAcademicpeer-review

2010

CD44 Expression Predicts Local Recurrence after Radiotherapy in Larynx Cancer

de Jong, M. C., Pramana, J., van der Wal, J. E., Lacko, M., Peutz-Kootstra, C. J., de Jong, J. M., Takes, R. P., Kaanders, J. H. A. M., van der Laan, B. F., Wachters, J., Jansen, J. C., Rasch, C. R., van Velthuysen, M-L. F., Grenman, R., Hoebers, F. J., Schuuring, E., van den Brekel, M. W. M. & Begg, A. C., 1 Nov 2010, In : Clinical Cancer Research. 16, 21, p. 5329-5338

Research output: Contribution to journalArticleAcademicpeer-review