TY - JOUR
T1 - Oropharyngeal dysphagia and cachexia
T2 - Intertwined in head and neck cancer
AU - Willemsen, Anna C H
AU - Pilz, Walmari
AU - Hoeben, Ann
AU - Hoebers, Frank J P
AU - Schols, Annemie M W J
AU - Baijens, Laura W J
N1 - Funding Information:
Anna C. H. Willemsen was funded by the Nutrim Graduate Programme, 2018 laureate.
Publisher Copyright:
© 2022 The Authors. Head & Neck published by Wiley Periodicals LLC.
PY - 2023/4
Y1 - 2023/4
N2 - BACKGROUND: This study aims to investigate the relationship between cancer cachexia and oropharyngeal dysphagia (OD) in patients with head and neck cancer (HNC) prior to chemoradiotherapy or bioradiotherapy (CRT/BRT).METHODS: A prospective cohort study with patients with HNC undergoing CRT/BRT (2018-2021) was conducted. Body composition and skeletal muscle function were evaluated using bioelectrical impedance analysis, handgrip strength, and the short physical performance battery (SPPB). The M. D. Anderson Dysphagia Inventory (MDADI), Eating Assessment Tool (EAT)-10 questionnaire, and patient characteristics were collected. A standardized videofluoroscopic swallowing study was offered to patients.RESULTS: Sixty-six patients were included. Twenty-six patients scored EAT-10 ≥ 3 and seventeen were cachectic. ACE-27 score >1, cachexia, abnormal SPPB-derived repeated chair-stand test, lower MDADI scores, and higher overall stage grouping showed potential predictive value (p ≤ 0.10) for EAT-10 ≥ 3. Using multivariable regression analysis, only cachexia remained a significant predictor of EAT-10 ≥ 3 (HR 9.000 [95%CI 2.483-32.619], p = 0.001).CONCLUSION: Cachexia independently predicted the presence of patient-reported OD.
AB - BACKGROUND: This study aims to investigate the relationship between cancer cachexia and oropharyngeal dysphagia (OD) in patients with head and neck cancer (HNC) prior to chemoradiotherapy or bioradiotherapy (CRT/BRT).METHODS: A prospective cohort study with patients with HNC undergoing CRT/BRT (2018-2021) was conducted. Body composition and skeletal muscle function were evaluated using bioelectrical impedance analysis, handgrip strength, and the short physical performance battery (SPPB). The M. D. Anderson Dysphagia Inventory (MDADI), Eating Assessment Tool (EAT)-10 questionnaire, and patient characteristics were collected. A standardized videofluoroscopic swallowing study was offered to patients.RESULTS: Sixty-six patients were included. Twenty-six patients scored EAT-10 ≥ 3 and seventeen were cachectic. ACE-27 score >1, cachexia, abnormal SPPB-derived repeated chair-stand test, lower MDADI scores, and higher overall stage grouping showed potential predictive value (p ≤ 0.10) for EAT-10 ≥ 3. Using multivariable regression analysis, only cachexia remained a significant predictor of EAT-10 ≥ 3 (HR 9.000 [95%CI 2.483-32.619], p = 0.001).CONCLUSION: Cachexia independently predicted the presence of patient-reported OD.
KW - Cancer cachexia
KW - Chemoradiotherapy
KW - Head and neck cancer
KW - Oropharyngeal dysphagia
KW - Videofluoroscopic swallowing study
U2 - 10.1002/hed.27288
DO - 10.1002/hed.27288
M3 - Article
C2 - 36583567
SN - 1043-3074
VL - 45
SP - 783
EP - 797
JO - Head and Neck-Journal for the Sciences and Specialties of the Head and Neck
JF - Head and Neck-Journal for the Sciences and Specialties of the Head and Neck
IS - 4
ER -