Abstract
BACKGROUND: The prognostic reliability of the UICC's TNM classification (8th edition) for human papillomavirus (HPV)-positive tonsillar squamous cell carcinomas (TSCCs) compared to the 7th edition was explored, and its improvement by using additional anatomical and nonanatomical parameters.
METHODS: One hundred and ten HPV-positive and 225 HPV-negative TSCCs were retrospectively analyzed. Survival was correlated with patient and tumor characteristics (7th and 8th edition UICC TNM classification).
RESULTS: In HPV-positive TSCCs, the 8th edition UICC's TNM classification correlated better with prognosis than the 7th edition. Also, smoking status was a stronger prognosticator of survival than UICC staging. Non- or former smokers had a 5-year overall survival of 95.1% regardless of tumor stage. Furthermore, age (>65 years), cN3, and M1 classification were significant prognostic factors.
CONCLUSION: The prognostic value of the 8th edition UICC's TNM classification improved significantly when compared to the 7th edition. Nonetheless, further improvement is possible by adding nonanatomical factors (smoking, age >65 year) and separating N0-N2 from N3.
| Original language | English |
|---|---|
| Pages (from-to) | 1799-1815 |
| Number of pages | 17 |
| Journal | Head and Neck-Journal for the Sciences and Specialties of the Head and Neck |
| Volume | 44 |
| Issue number | 8 |
| Early online date | 17 May 2022 |
| DOIs | |
| Publication status | Published - Aug 2022 |
Keywords
- AMERICAN JOINT COMMITTEE
- CANCER
- EXTERNAL RADIOTHERAPY
- HPV
- NODAL METASTASIS
- RADIATION-THERAPY
- RETROSPECTIVE ANALYSIS
- SQUAMOUS-CELL CARCINOMA
- STAGING SYSTEM
- TNM classification
- TONSILLAR CARCINOMA
- tonsillar carcinoma