Additional parameters to improve the prognostic value of the 8th edition of the UICC classification for human papillomavirus-related oropharyngeal tumors

Jos M J A A Straetmans; Marijn Stuut; Martin Lacko; Frank Hoebers; Ernst-Jan M Speel; Bernd Kremer

doi:10.1002/hed.27084

Additional parameters to improve the prognostic value of the 8th edition of the UICC classification for human papillomavirus-related oropharyngeal tumors

Jos M J A A Straetmans^*, Marijn Stuut, Martin Lacko, Frank Hoebers, Ernst-Jan M Speel, Bernd Kremer

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: The prognostic reliability of the UICC's TNM classification (8th edition) for human papillomavirus (HPV)-positive tonsillar squamous cell carcinomas (TSCCs) compared to the 7th edition was explored, and its improvement by using additional anatomical and nonanatomical parameters.

METHODS: One hundred and ten HPV-positive and 225 HPV-negative TSCCs were retrospectively analyzed. Survival was correlated with patient and tumor characteristics (7th and 8th edition UICC TNM classification).

RESULTS: In HPV-positive TSCCs, the 8th edition UICC's TNM classification correlated better with prognosis than the 7th edition. Also, smoking status was a stronger prognosticator of survival than UICC staging. Non- or former smokers had a 5-year overall survival of 95.1% regardless of tumor stage. Furthermore, age (>65 years), cN3, and M1 classification were significant prognostic factors.

CONCLUSION: The prognostic value of the 8th edition UICC's TNM classification improved significantly when compared to the 7th edition. Nonetheless, further improvement is possible by adding nonanatomical factors (smoking, age >65 year) and separating N0-N2 from N3.

Original language	English
Pages (from-to)	1799-1815
Number of pages	17
Journal	Head and Neck-Journal for the Sciences and Specialties of the Head and Neck
Volume	44
Issue number	8
Early online date	17 May 2022
DOIs	https://doi.org/10.1002/hed.27084
Publication status	Published - Aug 2022

Keywords

AMERICAN JOINT COMMITTEE
CANCER
EXTERNAL RADIOTHERAPY
HPV
NODAL METASTASIS
RADIATION-THERAPY
RETROSPECTIVE ANALYSIS
SQUAMOUS-CELL CARCINOMA
STAGING SYSTEM
TNM classification
TONSILLAR CARCINOMA
tonsillar carcinoma

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10.1002/hed.27084Licence: CC BY-NC-ND

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Straetmans, J. M. J. A. A., Stuut, M., Lacko, M., Hoebers, F., Speel, E.-J. M., & Kremer, B. (2022). Additional parameters to improve the prognostic value of the 8th edition of the UICC classification for human papillomavirus-related oropharyngeal tumors. Head and Neck-Journal for the Sciences and Specialties of the Head and Neck, 44(8), 1799-1815. https://doi.org/10.1002/hed.27084

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title = "Additional parameters to improve the prognostic value of the 8th edition of the UICC classification for human papillomavirus-related oropharyngeal tumors",

abstract = "BACKGROUND: The prognostic reliability of the UICC's TNM classification (8th edition) for human papillomavirus (HPV)-positive tonsillar squamous cell carcinomas (TSCCs) compared to the 7th edition was explored, and its improvement by using additional anatomical and nonanatomical parameters.METHODS: One hundred and ten HPV-positive and 225 HPV-negative TSCCs were retrospectively analyzed. Survival was correlated with patient and tumor characteristics (7th and 8th edition UICC TNM classification).RESULTS: In HPV-positive TSCCs, the 8th edition UICC's TNM classification correlated better with prognosis than the 7th edition. Also, smoking status was a stronger prognosticator of survival than UICC staging. Non- or former smokers had a 5-year overall survival of 95.1% regardless of tumor stage. Furthermore, age (>65 years), cN3, and M1 classification were significant prognostic factors.CONCLUSION: The prognostic value of the 8th edition UICC's TNM classification improved significantly when compared to the 7th edition. Nonetheless, further improvement is possible by adding nonanatomical factors (smoking, age >65 year) and separating N0-N2 from N3.",

keywords = "AMERICAN JOINT COMMITTEE, CANCER, EXTERNAL RADIOTHERAPY, HPV, NODAL METASTASIS, RADIATION-THERAPY, RETROSPECTIVE ANALYSIS, SQUAMOUS-CELL CARCINOMA, STAGING SYSTEM, TNM classification, TONSILLAR CARCINOMA, tonsillar carcinoma",

author = "Straetmans, {Jos M J A A} and Marijn Stuut and Martin Lacko and Frank Hoebers and Speel, {Ernst-Jan M} and Bernd Kremer",

note = "{\textcopyright} 2022 The Authors. Head & Neck published by Wiley Periodicals LLC.",

year = "2022",

month = aug,

doi = "10.1002/hed.27084",

language = "English",

volume = "44",

pages = "1799--1815",

journal = "Head and Neck-Journal for the Sciences and Specialties of the Head and Neck",

issn = "1043-3074",

publisher = "John Wiley & Sons Inc.",

number = "8",

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Straetmans, JMJAA, Stuut, M, Lacko, M , Hoebers, F , Speel, E-JM & Kremer, B 2022, 'Additional parameters to improve the prognostic value of the 8th edition of the UICC classification for human papillomavirus-related oropharyngeal tumors', Head and Neck-Journal for the Sciences and Specialties of the Head and Neck, vol. 44, no. 8, pp. 1799-1815. https://doi.org/10.1002/hed.27084

Additional parameters to improve the prognostic value of the 8th edition of the UICC classification for human papillomavirus-related oropharyngeal tumors. / Straetmans, Jos M J A A; Stuut, Marijn; Lacko, Martin et al.
In: Head and Neck-Journal for the Sciences and Specialties of the Head and Neck, Vol. 44, No. 8, 08.2022, p. 1799-1815.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Additional parameters to improve the prognostic value of the 8th edition of the UICC classification for human papillomavirus-related oropharyngeal tumors

AU - Straetmans, Jos M J A A

AU - Stuut, Marijn

AU - Lacko, Martin

AU - Hoebers, Frank

AU - Speel, Ernst-Jan M

AU - Kremer, Bernd

PY - 2022/8

Y1 - 2022/8

N2 - BACKGROUND: The prognostic reliability of the UICC's TNM classification (8th edition) for human papillomavirus (HPV)-positive tonsillar squamous cell carcinomas (TSCCs) compared to the 7th edition was explored, and its improvement by using additional anatomical and nonanatomical parameters.METHODS: One hundred and ten HPV-positive and 225 HPV-negative TSCCs were retrospectively analyzed. Survival was correlated with patient and tumor characteristics (7th and 8th edition UICC TNM classification).RESULTS: In HPV-positive TSCCs, the 8th edition UICC's TNM classification correlated better with prognosis than the 7th edition. Also, smoking status was a stronger prognosticator of survival than UICC staging. Non- or former smokers had a 5-year overall survival of 95.1% regardless of tumor stage. Furthermore, age (>65 years), cN3, and M1 classification were significant prognostic factors.CONCLUSION: The prognostic value of the 8th edition UICC's TNM classification improved significantly when compared to the 7th edition. Nonetheless, further improvement is possible by adding nonanatomical factors (smoking, age >65 year) and separating N0-N2 from N3.

AB - BACKGROUND: The prognostic reliability of the UICC's TNM classification (8th edition) for human papillomavirus (HPV)-positive tonsillar squamous cell carcinomas (TSCCs) compared to the 7th edition was explored, and its improvement by using additional anatomical and nonanatomical parameters.METHODS: One hundred and ten HPV-positive and 225 HPV-negative TSCCs were retrospectively analyzed. Survival was correlated with patient and tumor characteristics (7th and 8th edition UICC TNM classification).RESULTS: In HPV-positive TSCCs, the 8th edition UICC's TNM classification correlated better with prognosis than the 7th edition. Also, smoking status was a stronger prognosticator of survival than UICC staging. Non- or former smokers had a 5-year overall survival of 95.1% regardless of tumor stage. Furthermore, age (>65 years), cN3, and M1 classification were significant prognostic factors.CONCLUSION: The prognostic value of the 8th edition UICC's TNM classification improved significantly when compared to the 7th edition. Nonetheless, further improvement is possible by adding nonanatomical factors (smoking, age >65 year) and separating N0-N2 from N3.

KW - AMERICAN JOINT COMMITTEE

KW - CANCER

KW - EXTERNAL RADIOTHERAPY

KW - HPV

KW - NODAL METASTASIS

KW - RADIATION-THERAPY

KW - RETROSPECTIVE ANALYSIS

KW - SQUAMOUS-CELL CARCINOMA

KW - STAGING SYSTEM

KW - TNM classification

KW - TONSILLAR CARCINOMA

KW - tonsillar carcinoma

U2 - 10.1002/hed.27084

DO - 10.1002/hed.27084

M3 - Article

C2 - 35579041

SN - 1043-3074

VL - 44

SP - 1799

EP - 1815

JO - Head and Neck-Journal for the Sciences and Specialties of the Head and Neck

JF - Head and Neck-Journal for the Sciences and Specialties of the Head and Neck

IS - 8

ER -

Additional parameters to improve the prognostic value of the 8th edition of the UICC classification for human papillomavirus-related oropharyngeal tumors

Abstract

Keywords

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