Research Output

2020

Adipose tissue in health and disease through the lens of its building blocks

Lenz, M., Arts, I. C. W., Peeters, R. L. M., de Kok, T. M. & Ertaylan, G., 26 Jun 2020, In : Scientific Reports. 10, 1, 14 p., 10433.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

COVID-19 Disease Map, building a computational repository of SARS-CoV-2 virus-host interaction mechanisms

Ostaszewski, M., Mazein, A., Gillespie, M. E., Kuperstein, I., Niarakis, A., Hermjakob, H., Pico, A. R., Willighagen, E. L., Evelo, C. T., Hasenauer, J., Schreiber, F., Dräger, A., Demir, E., Wolkenhauer, O., Furlong, L. I., Barillot, E., Dopazo, J., Orta-resendiz, A., Messina, F., Valencia, A. & 5 others, Funahashi, A., Kitano, H., Auffray, C., Balling, R. & Schneider, R., 5 May 2020, In : Scientific data. 7, 1, 4 p., 136.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Dichotomy between the transcriptomic landscape of naturally versus accelerated aged murine hearts

De Majo, F., Hegenbarth, J-C., Ruehle, F., Baer, C., Thum, T., de Boer, M., Duncker, D. J., Schroen, B., Armand, A-S., Stoll, M. & De Windt, L. J., 18 May 2020, In : Scientific Reports. 10, 1, 14 p., 8136.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Differential effect of lacosamide on Na(v)1.7 varients from responsive and non-responsive patients with small fibre neuropathy

Labau, J. I. R., Estacion, M., Tanaka, B. S., de Greef, B. T. A., Hoeijmakers, J. G. J., Geerts, M., Gerrits, M. M., Smeets, H. J. M., Faber, C. G., Merkies, I. S. J., Lauria, G., Dib-Hajj, S. D. & Waxman, S. G., Mar 2020, In : Brain. 143, p. 771-782 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

EFMviz: A COBRA Toolbox extension to visualize Elementary Flux Modes in Genome-Scale Metabolic Models

Sarathy, C., Kutmon, M., Lenz, M., Adriaens, M. E., Evelo, C. T. & Arts, I. C. W., 12 Feb 2020, In : Metabolites. 10, 2, 14 p., 66.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Fitter Mitochondria Are Associated With Radioresistance in Human Head and Neck SQD9 Cancer Cells

Grasso, D., Medeiros, H. C. D., Zampieri, L. X., Bol, V., Danhier, P., van Gisbergen, M. W., Bouzin, C., Brusa, D., Gregoire, V., Smeets, H., Stassen, A. P. M., Dubois, L. J., Lambin, P., Dutreix, M. & Sonveaux, P., 13 Mar 2020, In : Frontiers in Pharmacology. 11, 16 p., 263.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

GAT-1 (rs2697153) and GAT-3 (rs2272400) polymorphisms are associated with febrile seizures and temporal lobe epilepsy

Schijns, O. E. M. G., Bisschop, J., Rijkers, K., Dings, J., Vanherle, S., Lindsey, P., Smeets, H. J. M. & Hoogland, G., Apr 2020, In : Epileptic Disorders. 22, 2, p. 176-182 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

High-density lipoprotein cholesterol efflux capacity is not associated with atherosclerosis and prevalence of cardiovascular outcome: The CODAM study

Josefs, T., Wouters, K., Tietge, U. J. F., Annema, W., Dullaart, R. P. F., Vaisar, T., Arts, I. C. W., van der Kallen, C. J. H., Stehouwer, C. D. A., Schalkwijk, C. G., Goldberg, I. J., Fisher, E. A. & van Greevenbroek, M. M. J., 2020, In : Journal of Clinical Lipidology. 14, 1, p. 122-132.e4 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Identification of Biological Pathways Contributing to Marbling in Skeletal Muscle to Improve Beef Cattle Breeding

Roudbari, Z., Coort, S. L., Kutmon, M., Eijssen, L., Melius, J., Sadkowski, T. & Evelo, C. T., 7 Feb 2020, In : Frontiers in Genetics. 10, 12 p., 1370.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
88 Downloads (Pure)

Metabolic profiling of tissue-specific insulin resistance in human obesity: results from the Diogenes study and the Maastricht Study

DiOGenes Consortium, Jun 2020, In : International Journal of Obesity. 44, 6, p. 1376-1386 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Metabolomics Profile in Depression: A Pooled Analysis of 230 Metabolic Markers in 5283 Cases With Depression and 10,145 Controls

BBMRI-NL Metabolomics Consortium, 1 Mar 2020, In : Biological Psychiatry. 87, 5, p. 409-418 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

microRNA expression profiles and personal monitoring of exposure to particulate matter

Mancini, F. R., Laine, J. E., Tarallo, S., Vlaanderen, J., Vermeulen, R., van Nunen, E., Hoek, G., Probst-Hensch, N., Imboden, M., Jeong, A., Gulliver, J., Chadeau-Hyam, M., Nieuwenhuijsen, M., de Kok, T. M., Piepers, J., Krauskopf, J., Kleinjans, J. C. S., Vineis, P. & Naccarati, A., Aug 2020, In : Environmental Pollution. 263, 7 p., 114392.

Research output: Contribution to journalArticleAcademicpeer-review

Modelling molecular processes in weight loss: Regulation of metabolic flexibility

Tareen, S. H. K., 2020, Maastricht: Maastricht University. 158 p.

Research output: ThesisDoctoral ThesisInternal

Open Access
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100 Downloads (Pure)
Open Access
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120 Downloads (Pure)
Open Access

TfamKnockdown Results in Reduction of mtDNA Copy Number, OXPHOS Deficiency and Abnormalities in Zebrafish Embryos

Otten, A. B. C., Kamps, R., Lindsey, P., Gerards, M., Pendeville-Samain, H., Muller, M., van Tienen, F. H. J. & Smeets, H. J. M., 12 Jun 2020, In : Frontiers in Cell and Developmental Biology. 8, 11 p., 381.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The molecular processes in the trabecular meshwork after exposure to corticosteroids and in corticosteroid response

Liesenborghs, I., Eijssen, L. M. T., Kutmon, M., Gorgels, T. G. M. F., Evelo, C. T., Beckers, H. J. M., Webers, C. A. B. & Schouten, J. S. A. G., Aug 2020, In : Acta Ophthalmologica. 98, S264, p. 18-18 1 p.

Research output: Contribution to journalConference Abstract/Poster in journalAcademic

Use of deep learning methods to translate drug-induced gene expression changes from rat to human primary hepatocytes

O'Donovan, S. D., Driessens, K., Lopatta, D., Wimmenauer, F., Lukas, A., Neeven, J., Stumm, T., Smirnov, E., Lenz, M., Ertaylan, G., Jennen, D. G. J., van Riel, N. A. W., Cavill, R., Peeters, R. L. M. & de Kok, T. M. C. M., 11 Aug 2020, In : PLOS ONE. 15, 8, 20 p., e0236392.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2019

243rd ENMC international workshop: Developing guidelines for management of reproductive options for families with maternally inherited mtDNA disease, Amsterdam, the Netherlands, 22-24 March 2019

Poulton, J., Steffann, J., Burgstaller, J., McFarland, R., Arbeithuber, B., Bengoa, J., Burgstaller, J., Chan, S., Chiaratti, M., Crouch, M., Dimond, R., Enriques, J. A., Gorman, G., Hyslop, L., Johnston, I., Kitto, J., Maguire, A., McFarland, R., Mitalipov, S., Otterloo, V. & 12 others, Poulton, J., Sallevelt, S., Smeets, H., Spits, C., St John, J., Steffann, J., Stewart, J., Stoneking, M., Thorburn, D., van der Veer, E., Wells, D. & Workshop Participants, Sep 2019, In : Neuromuscular Disorders. 29, 9, p. 725-733 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

A bioinformatics workflow to decipher transcriptomic data from vitamin D studies

Muñoz García, A., Eijssen, L. M., Kutmon, M., Sarathy, C., Cengo, A., Hewison, M., Evelo, C. T., Lenz, M. & Coort, S. L., May 2019, In : Journal of Steroid Biochemistry and Molecular Biology. 189, p. 28-35 8 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

A Co-expression Analysis of the Placental Transcriptome in Association With Maternal Pre-pregnancy BMI and Newborn Birth Weight

Cox, B., Tsamou, M., Vrijens, K., Neven, K. Y., Winckelmans, E., de Kok, T. M., Plusquin, M. & Nawrot, T. S., 29 Apr 2019, In : Frontiers in Genetics. 10, p. 1-13 13 p., 354.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

A computational model of postprandial adipose tissue lipid metabolism derived using human arteriovenous stable isotope tracer data

O'Donovan, S. D., Lenz, M., Vink, R. G., Roumans, N. J. T., de Kok, T. M. C. M., Mariman, E. C. M., Peeters, R. L. M., van Riel, N. A. W., van Baak, M. A. & Arts, I. C. W., Oct 2019, In : PLoS Computational Biology. 15, 10, 23 p., e1007400.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

A gain-of-function sodium channel beta 2-subunit mutation in painful diabetic neuropathy

Alsaloum, M., Estacion, M., Almomani, R., Gerrits, M. M., Boenhof, G. J., Ziegler, D., Malik, R., Ferdousi, M., Lauria, G., Merkies, I. S. J., Faber, C. G., Dib-Hajj, S., Waxman, S. G., de Greef, B., Hoeijmakers, J. G. J., Sopacua, M., Smeets, H. J. M., Vanoevelen, J. M., Eijkenboom, Lindsey, P. & 21 others, Almomani, R., Taiana, M., Marchi, M., Lombardi, R., Cazzato, D., Boneschi, F. M., Zauli, A., Clarelli, F., Santoro, S., Lopez, A. B., Quattrini, A., Cestele, S., Chever, O., Tavakoli, M., Malik, R., Kapetis, D., Xenakis, M. N., Mantegazza, M., Battiato, F., Strom, A. & PROPANE Study Grp, May 2019, In : Molecular Pain. 15, p. 1-14 14 p., 1744806919849802.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Analysis of the genomic architecture of a complex trait locus in hypertensive rat models links Tmem63c to kidney damage

Schulz, A., Mueller, N. V., van de Lest, N. A., Eisenreich, A., Schmidbauer, M., Barysenka, A., Purfuerst, B., Sporbert, A., Lorenzen, T., Meyer, A. M., Herlan, L., Witten, A., Ruehle, F., Zhou, W., de Heer, E., Scharpfenecker, M., Panakova, D., Stoll, M. & Kreutz, R., 22 Mar 2019, In : Elife. 8, 33 p., 42068.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis

Liu, J., Carnero-Montoro, E., van Dongen, J., Lent, S., Nedeljkovic, I., Ligthart, S., Tsai, P-C., Martin, T. C., Mandaviya, P. R., Jansen, R., Peters, M. J., Duijts, L., Jaddoe, V. W. V., Tiemeier, H., Felix, J. F., Willemsen, G., de Geus, E. J. C., Chu, A. Y., Levy, D., Hwang, S-J. & 37 others, Bressler, J., Gondalia, R., Salfati, E. L., Herder, C., Hidalgo, B. A., Tanaka, T., Moore, A. Z., Lemaitre, R. N., Jhun, M. A., Smith, J. A., Sotoodehnia, N., Bandinelli, S., Ferrucci, L., Arnett, D. K., Grallert, H., Assimes, T. L., Hou, L., Baccarelli, A., Whitsel, E. A., van Dijk, K. W., Amin, N., Uitterlinden, A. G., Sijbrands, E. J. G., Franco, O. H., Dehghan, A., Spector, T. D., Dupuis, J., Hivert, M-F., Rotter, J., Meigs, J. B., Pankow, J. S., van Meurs, J. B. J., Isaacs, A., Boomsma, D., Bell, J. T., Demirkan, A. & van Duijn, C. M., 13 Jun 2019, In : Nature Communications. 10, 11 p., 2581.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

A novel mitochondrial m.4414T > C MT-TM gene variant causing progressive external ophthalmoplegia and myopathy

Hellebrekers, D. M. E. I., Blakely, E. L., Hendrickx, A. T. M., Hardy, S. A., Hopton, S., Falkous, G., de Coo, I. F. M., Smeets, H. J. M., van der Beek, N. M. E. & Taylor, R. W., Sep 2019, In : Neuromuscular Disorders. 29, 9, p. 693-697 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

A zebrafish model of small-fiber neuropathy

Eijkenboom, I., 2019, Maastricht: ProefschriftMaken Maastricht. 183 p.

Research output: ThesisDoctoral ThesisInternal

Open Access
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22 Downloads (Pure)

A zebrafish model to study small-fiber neuropathy reveals a potential role for GDAP1

Eijkenboom, I., Vanoevelen, J. M., Hoeijmakers, J. G. J., Wijnen, I., Gerards, M., Faber, C. G. & Smeets, H. J. M., Jul 2019, In : Mitochondrion. 47, p. 273-281 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Beyond Pathway Analysis: Identification of Active Subnetworks in Rett Syndrome

Miller, R. A., Ehrhart, F., Eijssen, L. M. T., Slenter, D. N., Curfs, L. M. G., Evelo, C. T., Willighagen, E. L. & Kutmon, M., 21 Feb 2019, In : Frontiers in Genetics. 10, 10 p., 59.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Cell-free, circulating microRNAs reflect air pollution-induced environmental health risks

Krauskopf, J., van Veldhoven, K., Chadeau-Hyam, M., Vermeulen, R., Carrasco-Turigas, G., Nieuwenhuijsen, M., Vineis, P., de Kok, T. M. & Kleinjans, J. C. S., 15 Oct 2019, In : Toxicology Letters. 314, p. S68-S68 1 p.

Research output: Contribution to journalConference Abstract/Poster in journalAcademic

Characterization of disease-specific cellular abundance profiles of chronic inflammatory skin conditions from deconvolution of biopsy samples

Garza, Z. C. F., Lenz, M., Liebmann, J., Ertaylan, G., Born, M., Arts, I. C. W., Hilbers, P. A. J. & van Riel, N. A. W., 17 Aug 2019, In : BMC Medical Genomics. 12, 1, 14 p., 121.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen

AstraZeneca-Sanger Drug Combinatio, 17 Jun 2019, In : Nature Communications. 10, 17 p., 2674.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Consumption of Nitrate-Rich Beetroot Juice with or without Vitamin C Supplementation Increases the Excretion of Urinary Nitrate, Nitrite, and N-nitroso Compounds in Humans

Berends, J. E., van den Berg, L. M. M., Guggeis, M. A., Henckens, N. F. T., Hossein, I. J., de Joode, M. E. J. R., Zamani, H., van Pelt, K. A. A. J., Beelen, N. A., Kuhnle, G. G., de Kok, T. M. C. M. & Van Breda, S. G. J., 1 May 2019, In : International Journal of Molecular Sciences. 20, 9, 15 p., 2277.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Correlating Infant Fecal Microbiota Composition and Human Milk Oligosaccharide Consumption by Microbiota of 1-Month-Old Breastfed Infants

Borewicz, K., Gu, F., Saccenti, E., Arts, I. C. W., Penders, J., Thijs, C., van Leeuwen, S. S., Lindner, C., Nauta, A., van Leusen, E., Schols, H. A. & Smidt, H., Jul 2019, In : Molecular Nutrition & Food Research. 63, 13, p. 1-13 13 p., 1801214.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

CyTargetLinker app update: A flexible solution for network extension in Cytoscape

Kutmon, M., Ehrhart, F., Willighagen, E. L., Evelo, C. T. & Coort, S. L., 13 Aug 2019, In : F1000Research. 7, p. 743

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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DNA methylation profiling implicates exposure to PCBs in the pathogenesis of B-cell chronic lymphocytic leukemia

Georgiadis, P., Gavriil, M., Rantakokko, P., Ladoukakis, E., Botsivali, M., Kelly, R. S., Bergdahl, I. A., Kiviranta, H., Vermeulen, R. C. H., Spaeth, F., Hebbels, D. G. A. J., Kleinjans, J. C. S., de Kok, T. M. C. M., Palli, D., Vineis, P., Kyrtopoulos, S. A., Gottschalk, R., van Leeuwen, D., Timmermans, L., Bendinelli, B. & 30 others, Portengen, L., Saberi-Hosnijeh, F., Melin, B., Hallmans, G., Lenner, P., Keun, H. C., Siskos, A., Athersuch, T. J., Kogevinas, M., Stephanou, E. G., Myridakis, A., Fazzo, L., De Santis, M., Comba, P., Airaksinen, R., Ruokojarvi, P., Gilthorpe, M., Fleming, S., Fleming, T., Tu, Y-K., Jonsson, B., Lundh, T., Chen, W. J., Lee, W-C., Hsiao, C. K., Chien, K-L., Kuo, P-H., Hung, H., Liao, S-F. & EnviroGenomarkers Consortium, May 2019, In : Environment International. 126, p. 24-36 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Drug-induced gene expression profile changes in relation to intestinal toxicity: State-of-the-art and new approaches

Rodrigues, D., Souza, T., Jennen, D. G. J., Lemmens, L., Kleinjans, J. C. S. & de Kok, T. M., Jul 2019, In : Cancer Treatment Reviews. 77, p. 57-66 10 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Evolutionary Patterns of Non-Coding RNA in Cardiovascular Biology

Gandhi, S., Ruehle, F. & Stoll, M., 31 Jan 2019, In : Non-coding RNA. 5, 1, 15.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
Open Access
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556 Downloads (Pure)

Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits

van Setten, J., Verweij, N., Mbarek, H., Niemeijer, M. N., Trompet, S., Arking, D. E., Brody, J. A., Gandin, I., Grarup, N., Hall, L. M., Hemerich, D., Lyytikainen, L-P., Mei, H., Mueller-Nurasyid, M., Prins, B. P., Robino, A., Smith, A. V., Warren, H. R., Asselbergs, F. W., Boomsma, D. I. & 41 others, Caulfield, M. J., Eijgelsheim, M., Ford, I., Hansen, T., Harris, T. B., Heckbert, S. R., Hottenga, J-J., Iorio, A., Kors, J. A., Linneberg, A., MacFarlane, P. W., Meitinger, T., Nelson, C. P., Raitakari, O. T., Aldana, C. T. S., Sinagra, G., Sinner, M., Soliman, E. Z., Stoll, M., Uitterlinden, A., van Duijn, C. M., Waldenberger, M., Alonso, A., Gasparini, P., Gudnason, V., Jamshidi, Y., Kaab, S., Kanters, J. K., Lehtimaki, T., Munroe, P. B., Peters, A., Samani, N. J., Sotoodehnia, N., Ulivi, S., Wilson, J. G., de Geus, E. J. C., Jukema, J. W., Stricker, B., van der Harst, P., de Bakker, P. I. W. & Isaacs, A., Jun 2019, In : European Journal of Human Genetics. 27, 6, p. 952-962 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Genome-wide Association Study of Change in Fasting Glucose over time in 13,807 non-diabetic European Ancestry Individuals

Liu, C-T., Merino, J., Rybin, D., DiCorpo, D., Benke, K. S., Bragg-Gresham, J. L., Canouil, M., Corre, T., Grallert, H., Isaacs, A., Kutalik, Z., Lahti, J., Marullo, L., Marzi, C., Rasmussen-Torvik, L. J., Rocheleau, G., Rueedi, R., Scapoli, C., Verweij, N., Vogelzangs, N. & 30 others, Willems, S. M., Yengo, L., Bakker, S. J. L., Beilby, J., Hui, J., Kajantie, E., Müller-Nurasyid, M., Rathmann, W., Balkau, B., Bergmann, S., Eriksson, J. G., Florez, J. C., Froguel, P., Harris, T., Hung, J., James, A. L., Kavousi, M., Miljkovic, I., Musk, A. W., Palmer, L. J., Peters, A., Roussel, R., van der Harst, P., van Duijn, C. M., Vollenweider, P., Barroso, I., Prokopenko, I., Dupuis, J., Meigs, J. B. & Bouatia-Naji, N., 1 Jul 2019, In : Scientific Reports. 9, 1, 8 p., 9439.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Healthy, mtDNA-mutation free mesoangioblasts from mtDNA patients qualify for autologous therapy

van Tienen, F., Zelissen, R., Timmer, E., van Gisbergen, M., Lindsey, P., Quattrocelli, M., Sampaolesi, M., Mulder-den Hartog, E., de Coo, I. & Smeets, H., 21 Dec 2019, In : Stem Cell Research & Therapy. 10, 1, 10 p., 405.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Human 3D multicellular microtissues: An upgraded model for the in vitro mechanistic investigation of inflammation-associated drug toxicity

Jiang, J., Messner, S., Kelm, J. M., van Herwijnen, M., Jennen, D. G. J., Kleinjans, J. C. & de Kok, T. M., 15 Sep 2019, In : Toxicology Letters. 312, p. 34-44 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Identification of Sex-Specific Transcriptome Responses to Polychlorinated Biphenyls (PCBs)

Espin-Perez, A., Hebels, D. G. A. J., Kiviranta, H., Rantakokko, P., Georgiadis, P., Botsivali, M., Bergdahl, I. A., Palli, D., Spath, F., Johansson, A., Chadeau-Hyam, M., Kyrtopoulos, S. A., Kleinjans, J. C. S. & de Kok, T. M. C. M., 24 Jan 2019, In : Scientific Reports. 9, p. 1-12 12 p., 746.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Impact of early events and lifestyle on the gut microbiota and metabolic phenotypes in young school-age children

Zhong, H., Penders, J., Shi, Z., Ren, H., Cai, K., Fang, C., Ding, Q., Thijs, C., Blaak, E. E., Stehouwer, C. D. A., Xu, X., Yang, H., Wang, J., Wang, J., Jonkers, D. M. A. E., Masclee, A. A. M., Brix, S., Li, J., Arts, I. C. W. & Kristiansen, K., 4 Jan 2019, In : Microbiome. 7, 14 p., 2.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access