@article{2d0548d697b84ee29b61a0f210067f5b,
title = "Research Techniques Made Simple: Lipidomic Analysis in Skin Research",
abstract = "Although lipids are crucial molecules for cell structure, metabolism, and signaling in most organs, they have additional specific functions in the skin. Lipids are required for the maintenance and regulation of the epidermal barrier, physical properties of the skin, and defense against microbes. Analysis of the lipidomeethe totality of lipidseis of similar complexity to those of proteomics or other omics, with lipid structures ranging from simple, linear, to highly complex structures. In addition, the ordering and chemical modifications of lipids have consequences on their biological function, especially in the skin. Recent advances in analytic capability (usually with mass spectrometry), bioinformatic processing, and integration with other dermatological big data have allowed researchers to increasingly understand the roles of specific lipid species in skin biology. In this paper, we review the techniques used to analyze skin lipidomics and epilipidomics.",
keywords = "STRATUM-CORNEUM LIPIDS, SHOTGUN LIPIDOMICS, BARRIER FUNCTION, CERAMIDE, ACID, ORGANIZATION, FILAGGRIN, PROFILE, MS",
author = "M. Sochorova and K. Vavrova and M. Fedorova and Z.X. Ni and D. Slenter and M. Kutmon and E.L. Willighagen and S. Letsiou and D. Torocsik and M. Marchetti-Deschmann and S. Zoratto and C. Kremslehner and F. Gruber",
note = "Funding Information: This publication is based on work from COST Action 19105 EpiLipidNET, supported by European Cooperation in Science and Technology ( www.cost.eu ). FG, MF, SL, DT, DS, MK, and ELW acknowledge the support by European Cooperation in Science and Technology as members of EpiLipidNET (CA19105 – Pan-European Network in Lipidomics and EpiLipidomics), and FG and MMD acknowledge support as members of Correlated Multimodal Imaging in Life Sciences (CA17121). We thank Heidemarie Rossiter for proofreading the manuscript. We gratefully acknowledge the financial support of the Federal Ministry for Digital and Economic Affairs of Austria and the National Foundation for Research, Technology, and Development of Austria and the financial support of CHANEL Parfums et Beaut{\'e} to the Christian Doppler Laboratory for Skin Multimodal Imaging of Aging and Senescence (SKINMAGINE). MMD acknowledges support by the Austrian Bioimaging Initiative for Correlated Multimodal Imaging. Financial support from the German Federal Ministry of Education and Research within the framework of the e:Med research and funding concept for SysMedOS project (to MF) is gratefully acknowledged. SL is now employed at Apivita (Markopoulo Mesogaias, Greece). KV was supported by the Czech Science Foundation (19-09135J) and Efficiency and Safety Improvement of Current Drugs and Nutraceutical (number CZ.02.1.01/0.0/0.0/16_019/0000841 cofunded by European Regional Development Fund). CK, SZ, and DS are PhD student trainees, MS and ZN are postdoctorate trainees. MK and SL are subject-matter experts, and KV, MF, ELW, DT, MMD, and FG are faculty advisors. This work was done primarily in Vienna, Austria . Publisher Copyright: {\textcopyright} 2021 The Authors",
year = "2022",
month = jan,
day = "1",
doi = "10.1016/j.jid.2021.09.017",
language = "English",
volume = "142",
pages = "4--11.e1",
journal = "Journal of Investigative Dermatology",
issn = "0022-202X",
publisher = "Elsevier Science",
number = "1",
}