Research Techniques Made Simple: Lipidomic Analysis in Skin Research

M. Sochorova, K. Vavrova, M. Fedorova, Z.X. Ni, D. Slenter, M. Kutmon, E.L. Willighagen, S. Letsiou, D. Torocsik, M. Marchetti-Deschmann, S. Zoratto, C. Kremslehner, F. Gruber*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Although lipids are crucial molecules for cell structure, metabolism, and signaling in most organs, they have additional specific functions in the skin. Lipids are required for the maintenance and regulation of the epidermal barrier, physical properties of the skin, and defense against microbes. Analysis of the lipidomeethe totality of lipidseis of similar complexity to those of proteomics or other omics, with lipid structures ranging from simple, linear, to highly complex structures. In addition, the ordering and chemical modifications of lipids have consequences on their biological function, especially in the skin. Recent advances in analytic capability (usually with mass spectrometry), bioinformatic processing, and integration with other dermatological big data have allowed researchers to increasingly understand the roles of specific lipid species in skin biology. In this paper, we review the techniques used to analyze skin lipidomics and epilipidomics.
Original languageEnglish
Pages (from-to)4-11.e1
Number of pages9
JournalJournal of Investigative Dermatology
Volume142
Issue number1
DOIs
Publication statusPublished - 1 Jan 2022

Keywords

  • STRATUM-CORNEUM LIPIDS
  • SHOTGUN LIPIDOMICS
  • BARRIER FUNCTION
  • CERAMIDE
  • ACID
  • ORGANIZATION
  • FILAGGRIN
  • PROFILE
  • MS

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