19942018

Research output per year

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Research Output

  • 64 Article
  • 1 Comment/Letter to the editor
  • 1 Doctoral Thesis
2018

Crystalline silica alters Sulfatase-1 expression in rat lungs which influences hyper-proliferative and fibrogenic effects in human lung epithelial cells

Perkins, T. N., Peeters, P. M., Albrecht, C., Schins, R. P. F., Dentener, M. A., Mossman, B. T., Wouters, E. F. M. & Reynaert, N. L., 1 Jun 2018, In : Toxicology and Applied Pharmacology. 348, p. 43-53 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

2017

Involvement of c-Jun N-Terminal Kinase in TNF-alpha-Driven Remodeling

Eurlings, I. M. J., Reynaert, N. L., van de Wetering, C., Aesif, S. W., Mercken, E. M., de Cabo, R., van der Velden, J. L., Janssen-Heininger, Y. M., Wouters, E. F. M. & Dentener, M. A., Mar 2017, In : American Journal of Respiratory Cell and Molecular Biology. 56, 3, p. 393-401 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2016

Aggravation of Allergic Airway Inflammation by Cigarette Smoke in Mice Is CD44-Dependent

Kumar, S., Lanckacker, E., Dentener, M., Bracke, K., Provoost, S., De Grove, K., Brusselle, G., Wouters, E., Maes, T. & Joos, G., 21 Mar 2016, In : PLOS ONE. 11, 3, e0151113.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Alteration of canonical and non-canonical WNT-signaling by crystalline silica in human lung epithelial cells

Perkins, T. N., Dentener, M. A., Stassen, F. R., Rohde, G. G., Mossman, B. T., Wouters, E. F. M. & Reynaert, N. L., 15 Jun 2016, In : Toxicology and Applied Pharmacology. 301, p. 61-70 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Exposure to common respiratory bacteria alters the airway epithelial response to subsequent viral infection

Bellinghausen, C., Gulraiz, F., Heinzmann, A. C. A., Dentener, M. A., Savelkoul, P. H. M., Wouters, E. F., Rohde, G. G. & Stassen, F. R., 3 Jun 2016, In : Respiratory Research. 17, 68.

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)
2014

A comparative study of matrix remodeling in chronic models for COPD; mechanistic insights into the role of TNF-α

Eurlings, I. M. J., Dentener, M. A., Mercken, E. M., de Cabo, R., Bracke, K. R., Vernooy, J. H. J., Wouters, E. F. M. & Reynaert, N. L., 1 Oct 2014, In : American Journal of Physiology-Lung Cellular and Molecular Physiology. 307, 7, p. L557-L565 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

18 Citations (Scopus)

Cigarette Smoke Extract Induces a Phenotypic Shift in Epithelial Cells; Involvement of HIF1α in Mesenchymal Transition

Eurlings, I. M. J., Reynaert, N. L., van den Beucken, T., Gosker, H. R., de Theije, C. C., Verhamme, F. M., Bracke, K. R., Wouters, E. F. M. & Dentener, M. A., 16 Oct 2014, In : PLOS ONE. 9, 10, 11 p., e107757.

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

Efficacy of IFN-λ1 to protect human airway epithelial cells against human rhinovirus 1B infection.

Gulraiz, F., Bellinghausen, C., Dentener, M. A., Reynaert, N. L., Gaajetaan, G. R., Beuken, E. V., Rohde, G. G., Bruggeman, C. A. & Stassen, F. R., 21 Apr 2014, In : PLOS ONE. 9, 4, 10 p., e95134.

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Similar matrix alterations in alveolar and small airway walls of COPD patients

Eurlings, I. M. J., Dentener, M. A., Cleutjens, J. P. M., Peutz, C. J., Rohde, G. G. U., Wouters, E. F. M. & Reynaert, N. L., 26 May 2014, In : BMC Pulmonary Medicine. 14, 1, 11 p., 90.

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)
2013

Increased glutaredoxin-1 and decreased protein S-glutathionylation in sputum of asthmatics

Kuipers, I., Louis, R., Manise, M., Dentener, M. A., Irvin, C. G., Janssen Heininger, Y. M., Brightling, C. E., Wouters, E. F. M. & Reynaert, N. L., Feb 2013, In : European Respiratory Journal. 41, 2, p. 469-472 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

Interferon-beta induces a long-lasting antiviral state in human respiratory epithelial cells

Gaajetaan, G. R., Geelen, T. H., Vernooy, J. H. J., Dentener, M. A., Reynaert, N. L., Rohde, G. G., Beuken, E. V., Grauls, G. E., Bruggeman, C. A. M. V. A. & Stassen, F. R. M., Feb 2013, In : Journal of Infection. 66, 2, p. 163-169 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)
2012

Decreased plasma sRAGE levels in COPD: influence of oxygen therapy

Gopal, P., Rutten, E. P. A., Dentener, M. A., Wouters, E. F. M. & Reynaert, N. L., Aug 2012, In : European Journal of Clinical Investigation. 42, 8, p. 807-814 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)
2011
25 Citations (Scopus)
2010

Enhanced deposition of low-molecular-weight hyaluronan in lungs of cigarette smoke-exposed mice.

Bracke, K. R., Dentener, M. A., Papakonstantinou, E., Vernooy, J. H., Demoor, T., Pauwels, N. S., Cleutjens, J., van Suylen, R., Joos, G. F., Brusselle, G. G. & Wouters, E. F., Jun 2010, In : American Journal of Respiratory Cell and Molecular Biology. 42, 6, p. 753-761 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

32 Citations (Scopus)
2009

Association of glutathione-S-transferase omega haplotypes with susceptibility to chronic obstructive pulmonary disease.

Yanbaeva, D. G., Wouters, E. F., Dentener, M. A., Spruit, M. A. & Reynaert, N. L., 1 Jan 2009, In : Free Radical Research. 43, 8, p. 738-743

Research output: Contribution to journalArticleAcademicpeer-review

19 Citations (Scopus)

Enhanced pulmonary leptin expression in patients with severe COPD and asymptomatic smokers.

Vernooy, J. H., Drummen, N. E., van Suylen, R. J., Cloots, R. H., Moller, G. M., Bracke, K. R., Zuyderduyn, S., Dentener, M. A., Brusselle, G. G., Hiemstra, P. S. & Wouters, E. F., 1 Jan 2009, In : Thorax. 64, 1, p. 26-32

Research output: Contribution to journalArticleAcademicpeer-review

43 Citations (Scopus)

IL6 and CRP haplotypes are associated with COPD risk and systemic inflammation: a case-control study

Yanbaeva, D. G., Dentener, M. A., Spruit, M. A., Houwing-Doustermaat, J. J., Kotz, D., Lima Passos, V. & Wouters, E. F., 1 Jan 2009, In : BMC Medical Genetics. 10, p. 23

Research output: Contribution to journalArticleAcademicpeer-review

45 Citations (Scopus)
2008

Association between CD14 polymorphisms and serum soluble CD14 levels: effect of atopy and endotoxin inhalation.

Levan, T. D., Michel, O., Dentener, M., Thorn, J., Vertongen, F., Beijer, L. & Martinez, F. D., 1 Jan 2008, In : Journal of Allergy and Clinical Immunology. 121, 2, p. 434-440

Research output: Contribution to journalArticleAcademicpeer-review

32 Citations (Scopus)

Effect of infliximab on local and systemic inflammation in chronic obstructive pulmonary disease: a pilot study

Dentener, M. A., Creutzberg, E. C., Pennings, H. J., Rijkers, G. T., Mercken, E. & Wouters, E. F., 1 Jan 2008, In : Respiration. 76, 3, p. 275-82

Research output: Contribution to journalArticleAcademicpeer-review

47 Citations (Scopus)
2007

Evaluation of oral corticosteroids and phosphodiesterase-4 inhibitor on the acute inflammation induced by inhaled lipopolysaccharide in human.

Michel, O., Dentener, M., Cataldo, D., Cantinieaux, B., Vertongen, F., Delvaux, C. & Murdoch, R. D., 1 Jan 2007, In : Pulmonary Pharmacology & Therapeutics. 20, 6, p. 676-683

Research output: Contribution to journalArticleAcademicpeer-review

23 Citations (Scopus)

Longitudinal follow-up of systemic inflammation after acute exacerbations of COPD

Groenewegen, K. H., Dentener, M. A. & Wouters, E. F., 1 Jan 2007, In : Respiratory Medicine. 101, 11, p. 2409-2415

Research output: Contribution to journalArticleAcademicpeer-review

23 Citations (Scopus)

Systemic effects of smoking

Yanbaeva, D. G., Dentener, M. A., Creutzberg, E. C., Wesseling, G. J. & Wouters, E. F., 1 Jan 2007, In : Chest. 131, 5, p. 1557-1566

Research output: Contribution to journalArticleAcademicpeer-review

472 Citations (Scopus)
80 Citations (Scopus)
2006

Differences in local versus systemic TNFalpha production in COPD: inhibitory effect of hyaluronan on LPS induced blood cell TNFalpha release

Dentener, M. A., Louis, R., Cloots, R. H. E., Henket, M. & Wouters, E. F., 1 Jan 2006, In : Thorax. 61, 6, p. 478-484

Research output: Contribution to journalArticleAcademicpeer-review

22 Citations (Scopus)

Human bancroftian filariasis: immunological markers of morbidity and infection

Satapathy, A. K., Sartono, E., Sahoo, P. K., Dentener, M. A., Michael, E., Yazdanbakhsh, M. & Ravindran, B., 1 Jan 2006, In : Microbes and Infection. 8, (9-10), p. 2414-2423

Research output: Contribution to journalArticleAcademicpeer-review

21 Citations (Scopus)

Patterns of inflammation and the use of reversibility testing in smokers with airway complaints

Chavannes, N. H., Vernooy, J. H., Schermer, T. R. J., Jacobs, J. A., Dentener, M. A., van Weel, C., van Schayck, C. P. & Wouters, E. F., 1 Jan 2006, In : BMC Pulmonary Medicine. 1, 6, p. 11

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Systemic inflammation in COPD: is genetic susceptibility a key factor?

Yanbaeva, D. G., Dentener, M. A., Creutzberg, E. C. & Wouters, E. F., 1 Jan 2006, In : Copd-Journal of Chronic Obstructive Pulmonary Disease. 3, 1, p. 51-61

Research output: Contribution to journalArticleAcademicpeer-review

37 Citations (Scopus)

Tumor necrosis factor inhibitors for rheumatoid arthritis

Dentener, M. A. & Wouters, E. F., 1 Jan 2006, In : New England Journal of Medicine. 355, 19, p. 2047-2048

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

2005

Enhanced levels of hyaluronan in lungs of patients with COPD: relationship with lung function and local inflammation

Dentener, M. A., Vernooy, J. H. J., Hendriks, S. H. J. & Wouters, E. F. M., 1 Jan 2005, In : Thorax. 60, 2, p. 114-119

Research output: Contribution to journalArticleAcademicpeer-review

62 Citations (Scopus)

Leptin as local inflammatory marker in COPD

Broekhuizen, R., Vernooy, J. H. J., Schols, A. M. W. J., Dentener, M. A. & Wouters, E. F. M., 1 Jan 2005, In : Respiratory Medicine. 99, 1, p. 70-74

Research output: Contribution to journalArticleAcademicpeer-review

49 Citations (Scopus)

Lipopolysaccharide-binding protein is produced in the epididymis and associated with spermatozoa and prostasomes

Malm, J., Nordahl, E. A., Bjartell, A., Sorenson, O. E., Frohm, B., Dentener, M. A. & Egesten, A., 1 Jan 2005, In : Journal of Reproductive Immunology. 66, 1, p. 33-34

Research output: Contribution to journalArticleAcademicpeer-review

20 Citations (Scopus)

Rapid pulmonary expression of acute-phase reactants after local lipopolysaccharide exposure in mice is followed by an interleukin-6 mediated systemic acute-phase response

Vernooy, J. H., Reynaert, N., Wolfs, T. G. A. M., Cloots, R. H. E., Haegens, A., de Vries, B., Dentener, M. A., Buurman, W. A. & Wouters, E. F., 1 Jan 2005, In : Experimental Lung Research. 31, 9-10, p. 855-871

Research output: Contribution to journalArticleAcademicpeer-review

19 Citations (Scopus)
2004

Childhood asthma: exhaled markers of airway inflammation, asthma control score, and lung function tests

Rosias, P. P. R., Dompeling, E. D., Dentener, M. A., Pennings, H. J., Hendriks, H., van Iersel, M. P. & Jöbsis, Q., 1 Jan 2004, In : Pediatric Pulmonology. 38, 2, p. 107-114

Research output: Contribution to journalArticleAcademicpeer-review

106 Citations (Scopus)
2003

Systemic responsiveness to lipopolysaccharide and polymorphisms in the toll-like receptor 4 gene in human beings

Michel, O., Levan, T. D., Stern, D., Dentener, M. A., Thorn, J., Gnat, D., Beijer, M. L., Cochaux, P., Holt, P. G., Martinez, F. D. & Rylander, R., 1 Jan 2003, In : Journal of Allergy and Clinical Immunology. 112, 5, p. 923-929 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

106 Citations (Scopus)
2002

Chronic obstructive pulmonary disease is associated with the -1055 IL-13 promoter polymorphism

van der Pouw-Kraan, T. C., Kucukaycan, M., Bakker, A. M., Dentener, M. A., Baggen, J., Wouters, E. F. M. & van der Zee, J. S., 1 Jan 2002, In : Genes and Immunity. 3, 7, p. 436-439 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

78 Citations (Scopus)

Increased hepatosplanchnic inflammation precedes the development of organ dysfunction after elective high-risk surgery

Poeze, M., Ramsay, G., Buurman, W. A., Greve, J. W. M., Dentener, M. A. & Takala, J., 1 Jan 2002, In : Shock. 17, 6, p. 451-458 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

25 Citations (Scopus)

Local and systemic inflammation in patients with chronic obstructive pulmonary disease: soluble tumor necrosis factor receptors are increased in sputum.

Vernooy, J. H. J., Kucukaycan, M., Jacobs, J. A., Chavannes, N. H., Buurman, W. A., Dentener, M. A. & Wouters, E. F. M., 1 Jan 2002, In : American Journal of Respiratory and Critical Care Medicine. 166, 9, p. 1218-1224 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

291 Citations (Scopus)

Long-term intratracheal lipopolysaccharide exposure in mice results in chronic lung inflammation and persistent pathology

Vernooy, J. H. J., Dentener, M. A., van Suylen, R. J., Buurman, W. A. & Wouters, E. F. M., 1 Jan 2002, In : American Journal of Respiratory Cell and Molecular Biology. 26, 1, p. 152-159 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

155 Citations (Scopus)

Tumor Necrosis Factor-alpha +489G/A gene polymorphism is associated with chronic obstructive pulmonary disease

Kucukaycan, M., van Krugten, M., Pennings, H. J., Huizinga, T. W. J., Buurman, W. A., Dentener, M. A. & Wouters, E. F. M., 1 Jan 2002, In : Respiratory Research. 29, 3, 29.

Research output: Contribution to journalArticleAcademicpeer-review

2001

Healthy subjects express differences in clinical responses to inhaled lipopolysaccharide that are related with inflammation and with atopy

Michel, O., Dentener, M. A., Corazza, F., Buurman, W. A. & Rylander, R., 1 Jan 2001, In : Journal of Allergy and Clinical Immunology. 107, 5, p. 797-804 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

70 Citations (Scopus)

Systemic anti-inflammatory mediators in COPD: increase in soluble interleukin 1 receptor II during treatment of exacerbations

Dentener, M. A., Creutzberg, E. C., Schols, A. M. W. J., Mantovani, A., van 't Veer, C., Buurman, W. A. & Wouters, E. F. M., 1 Jan 2001, In : Thorax. 56, 9, p. 721-726 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

107 Citations (Scopus)
2000

Disturbances in leptin metabolism are related to energy imbalance during acute exacerbations of chronic obstructive pulmonary disease

Creutzberg, E. C., Wouters, E. F. M., Vanderhoven-Augustin, I., Dentener, M. A. & Schols, A. M. W. J., 1 Jan 2000, In : American Journal of Respiratory and Critical Care Medicine. 162, 4 (Pt 1), p. 1239-1245 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

101 Citations (Scopus)
121 Citations (Scopus)

Release of endotoxin-binding proteins during major elective surgery: role of soluble CD14 in phagocytic activation

Hiki, N., Berger, D., Mimura, Y., Frick, J., Dentener, M. A., Buurman, W. A., Seidelmann, M., Kaminishi, M. & Beger, H. G., 1 Jan 2000, In : World Journal of Surgery. 24, p. 499-506 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

22 Citations (Scopus)

Strong association of interleukin-6 and lipopolysaccharide-binding protein with severity of adverse reactions after diethylcarbamazine treatment of microfilaremic patients

Haarbrink, M., Abadi, G. K., Buurman, W. A., Dentener, M. A., Terhell, A. J. & Yazdanbakhsh, M. J., 1 Jan 2000, In : Journal of Infectious Diseases. 182, p. 564-569 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

30 Citations (Scopus)
1999

Changes in endotoxin-binding proteins during major elective surgery: important role for soluble CD14 in regulation of biological activity of systemic endotoxin.

Hiki, N., Berger, D., Dentener, M. A., Mimura, Y., Buurman, W. A., Prigl, C., Seidelmann, M., Tsuji, E., Kaminishi, M. & Beger, H. G., 1 Jan 1999, In : Clinical and Diagnostic Laboratory Immunology. 6, 6, p. 844-850 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

21 Citations (Scopus)

Impact of blood transfusions on inflammatory mediator release in patients undergoing cardiac surgery.

Fransen, E. J., Maessen, J. G., Dentener, M. A., Senden, N. & Buurman, W. A., 1 Jan 1999, In : Chest. 116, 5, p. 1233-1239 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

259 Citations (Scopus)

Lipopolysaccharide binding protein and serum amyloid A secretion by human intestinal epithelial cells during the acute phase response.

Vreugdenhil, A. C. E., Dentener, M. A., Snoek, A. M. P., Greve, J. W. M. & Buurman, W. A., 1 Jan 1999, In : Journal of Immunology. 163, 5, p. 2792-2798 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

106 Citations (Scopus)