Chronic obstructive pulmonary disease is associated with the -1055 IL-13 promoter polymorphism

T.C. van der Pouw-Kraan; M. Kucukaycan; A.M. Bakker; M.A. Dentener; J. Baggen; E.F.M. Wouters; J.S. van der Zee

doi:10.1038/sj.gene.6363896

Chronic obstructive pulmonary disease is associated with the -1055 IL-13 promoter polymorphism

T.C. van der Pouw-Kraan^*, M. Kucukaycan, A.M. Bakker, M.A. Dentener, J. Baggen, E.F.M. Wouters, J.S. van der Zee

^*Corresponding author for this work

NUTRIM - Institute of Nutrition and Translational Research in Metabolism

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Chronic obstructive pulmonary disease is associated with the -1055 IL-13 promoter polymorphism.

Van Der Pouw Kraan TC, Kucukaycan M, Bakker AM, Baggen JM, Van Der Zee JS, Dentener MA, Wouters EF, Verweij CL.

Department of Molecular Cell Biology, Free University, Amsterdam, The Netherlands.

IL-13 is strongly implicated in the development of asthma and chronic obstructive polymonary disease (COPD). We previously identified an IL-13 promoter polymorphism (-1055 C to T) that is associated with allergic asthma. We now report an increased frequency of the -1055 T allele in COPD patients compared to healthy controls (P=0.002) and compared to a second control group consisting of smoking individuals with normal lung function (P=0.01). A closely linked IL-13 exon polymorphism is present at normal allelic frequencies (P=0.3 and 0.4, respectively). In addition, we observed a normal distribution of two IL-4 polymorphisms at positions -590 and +33 (P=0.2 and 0.9, respectively). These results could implicate a functional role for the IL-13 promoter polymorphism in the enhanced risk to develop COPD. doi: 10.1038/sj.gene.6363896

Original language	English
Pages (from-to)	436-439
Number of pages	4
Journal	Genes and Immunity
Volume	3
Issue number	7
DOIs	https://doi.org/10.1038/sj.gene.6363896
Publication status	Published - 1 Jan 2002

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@article{ea83b8d95fcf43eeb3428317d3fef244,

title = "Chronic obstructive pulmonary disease is associated with the -1055 IL-13 promoter polymorphism",

abstract = "Chronic obstructive pulmonary disease is associated with the -1055 IL-13 promoter polymorphism.Van Der Pouw Kraan TC, Kucukaycan M, Bakker AM, Baggen JM, Van Der Zee JS, Dentener MA, Wouters EF, Verweij CL.Department of Molecular Cell Biology, Free University, Amsterdam, The Netherlands.IL-13 is strongly implicated in the development of asthma and chronic obstructive polymonary disease (COPD). We previously identified an IL-13 promoter polymorphism (-1055 C to T) that is associated with allergic asthma. We now report an increased frequency of the -1055 T allele in COPD patients compared to healthy controls (P=0.002) and compared to a second control group consisting of smoking individuals with normal lung function (P=0.01). A closely linked IL-13 exon polymorphism is present at normal allelic frequencies (P=0.3 and 0.4, respectively). In addition, we observed a normal distribution of two IL-4 polymorphisms at positions -590 and +33 (P=0.2 and 0.9, respectively). These results could implicate a functional role for the IL-13 promoter polymorphism in the enhanced risk to develop COPD. doi: 10.1038/sj.gene.6363896",

author = "{van der Pouw-Kraan}, T.C. and M. Kucukaycan and A.M. Bakker and M.A. Dentener and J. Baggen and E.F.M. Wouters and {van der Zee}, J.S.",

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T1 - Chronic obstructive pulmonary disease is associated with the -1055 IL-13 promoter polymorphism

AU - van der Pouw-Kraan, T.C.

AU - Kucukaycan, M.

AU - Bakker, A.M.

AU - Dentener, M.A.

AU - Baggen, J.

AU - Wouters, E.F.M.

AU - van der Zee, J.S.

PY - 2002/1/1

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N2 - Chronic obstructive pulmonary disease is associated with the -1055 IL-13 promoter polymorphism.Van Der Pouw Kraan TC, Kucukaycan M, Bakker AM, Baggen JM, Van Der Zee JS, Dentener MA, Wouters EF, Verweij CL.Department of Molecular Cell Biology, Free University, Amsterdam, The Netherlands.IL-13 is strongly implicated in the development of asthma and chronic obstructive polymonary disease (COPD). We previously identified an IL-13 promoter polymorphism (-1055 C to T) that is associated with allergic asthma. We now report an increased frequency of the -1055 T allele in COPD patients compared to healthy controls (P=0.002) and compared to a second control group consisting of smoking individuals with normal lung function (P=0.01). A closely linked IL-13 exon polymorphism is present at normal allelic frequencies (P=0.3 and 0.4, respectively). In addition, we observed a normal distribution of two IL-4 polymorphisms at positions -590 and +33 (P=0.2 and 0.9, respectively). These results could implicate a functional role for the IL-13 promoter polymorphism in the enhanced risk to develop COPD. doi: 10.1038/sj.gene.6363896

AB - Chronic obstructive pulmonary disease is associated with the -1055 IL-13 promoter polymorphism.Van Der Pouw Kraan TC, Kucukaycan M, Bakker AM, Baggen JM, Van Der Zee JS, Dentener MA, Wouters EF, Verweij CL.Department of Molecular Cell Biology, Free University, Amsterdam, The Netherlands.IL-13 is strongly implicated in the development of asthma and chronic obstructive polymonary disease (COPD). We previously identified an IL-13 promoter polymorphism (-1055 C to T) that is associated with allergic asthma. We now report an increased frequency of the -1055 T allele in COPD patients compared to healthy controls (P=0.002) and compared to a second control group consisting of smoking individuals with normal lung function (P=0.01). A closely linked IL-13 exon polymorphism is present at normal allelic frequencies (P=0.3 and 0.4, respectively). In addition, we observed a normal distribution of two IL-4 polymorphisms at positions -590 and +33 (P=0.2 and 0.9, respectively). These results could implicate a functional role for the IL-13 promoter polymorphism in the enhanced risk to develop COPD. doi: 10.1038/sj.gene.6363896

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DO - 10.1038/sj.gene.6363896

M3 - Article

C2 - 12424628

SN - 1466-4879

VL - 3

SP - 436

EP - 439

JO - Genes and Immunity

JF - Genes and Immunity

IS - 7

ER -

Chronic obstructive pulmonary disease is associated with the -1055 IL-13 promoter polymorphism

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