Chronic obstructive pulmonary disease is associated with the -1055 IL-13 promoter polymorphism

T.C. van der Pouw-Kraan, M. Kucukaycan, A.M. Bakker, M.A. Dentener, J. Baggen, E.F.M. Wouters, J.S. van der Zee

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Abstract

Chronic obstructive pulmonary disease is associated with the -1055 IL-13 promoter polymorphism.

Van Der Pouw Kraan TC, Kucukaycan M, Bakker AM, Baggen JM, Van Der Zee JS, Dentener MA, Wouters EF, Verweij CL.

Department of Molecular Cell Biology, Free University, Amsterdam, The Netherlands.

IL-13 is strongly implicated in the development of asthma and chronic obstructive polymonary disease (COPD). We previously identified an IL-13 promoter polymorphism (-1055 C to T) that is associated with allergic asthma. We now report an increased frequency of the -1055 T allele in COPD patients compared to healthy controls (P=0.002) and compared to a second control group consisting of smoking individuals with normal lung function (P=0.01). A closely linked IL-13 exon polymorphism is present at normal allelic frequencies (P=0.3 and 0.4, respectively). In addition, we observed a normal distribution of two IL-4 polymorphisms at positions -590 and +33 (P=0.2 and 0.9, respectively). These results could implicate a functional role for the IL-13 promoter polymorphism in the enhanced risk to develop COPD. doi: 10.1038/sj.gene.6363896
Original languageEnglish
Pages (from-to)436-439
Number of pages4
JournalGenes and Immunity
Volume3
Issue number7
DOIs
Publication statusPublished - 1 Jan 2002

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