Total energy expenditure is repeatable in adults but not associated with short-term changes in body composition

Rebecca Rimbach; Yosuke Yamada; Hiroyuki Sagayama; Philip N Ainslie; Lene F Anderson; Liam J Anderson; Lenore Arab; Issaad Baddou; Kweku Bedu-Addo; Ellen E Blaak; Stephane Blanc; Alberto G Bonomi; Carlijn V C Bouten; Pascal Bovet; Maciej S Buchowski; Nancy F Butte; Stefan G J A Camps; Graeme L Close; Jamie A Cooper; Sai Krupa Das; Lara R Dugas; Ulf Ekelund; Sonja Entringer; Terrence Forrester; Barry W Fudge; Annelies H Goris; Michael Gurven; Catherine Hambly; Asmaa El Hamdouchi; Marije B Hoos; Sumei Hu; Noorjehan Joonas; Annemiek M Joosen; Peter Katzmarzyk; Kitty P Kempen; Misaka Kimura; William E Kraus; Robert F Kushner; Estelle V Lambert; William R Leonard; Nader Lessan; Corby K Martin; Anine C Medin; Erwin P Meijer; James C Morehen; James P Morton; Guy Plasqui; Giulio Valenti; Ludovicus van Etten; Edgar A Van Mil; Klaas R Westerterp; IAEA DLW Database Consortium

doi:10.1038/s41467-021-27246-z

Total energy expenditure is repeatable in adults but not associated with short-term changes in body composition

Rebecca Rimbach^*, Yosuke Yamada^*, Hiroyuki Sagayama^*, Philip N Ainslie, Lene F Anderson, Liam J Anderson, Lenore Arab, Issaad Baddou, Kweku Bedu-Addo, Ellen E Blaak, Stephane Blanc, Alberto G Bonomi, Carlijn V C Bouten, Pascal Bovet, Maciej S Buchowski, Nancy F Butte, Stefan G J A Camps, Graeme L Close, Jamie A Cooper, Sai Krupa DasLara R Dugas, Ulf Ekelund, Sonja Entringer, Terrence Forrester, Barry W Fudge, Annelies H Goris, Michael Gurven, Catherine Hambly, Asmaa El Hamdouchi, Marije B Hoos, Sumei Hu, Noorjehan Joonas, Annemiek M Joosen, Peter Katzmarzyk, Kitty P Kempen, Misaka Kimura, William E Kraus, Robert F Kushner, Estelle V Lambert, William R Leonard, Nader Lessan, Corby K Martin, Anine C Medin, Erwin P Meijer, James C Morehen, James P Morton, Guy Plasqui, Giulio Valenti, Ludovicus van Etten, Edgar A Van Mil, Klaas R Westerterp, IAEA DLW Database Consortium

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Low total energy expenditure (TEE, MJ/d) has been a hypothesized risk factor for weight gain, but repeatability of TEE, a critical variable in longitudinal studies of energy balance, is understudied. We examine repeated doubly labeled water (DLW) measurements of TEE in 348 adults and 47 children from the IAEA DLW Database (mean ± SD time interval: 1.9 ± 2.9 y) to assess repeatability of TEE, and to examine if TEE adjusted for age, sex, fat-free mass, and fat mass is associated with changes in weight or body composition. Here, we report that repeatability of TEE is high for adults, but not children. Bivariate Bayesian mixed models show no among or within-individual correlation between body composition (fat mass or percentage) and unadjusted TEE in adults. For adults aged 20-60 y (N = 267; time interval: 7.4 ± 12.2 weeks), increases in adjusted TEE are associated with weight gain but not with changes in body composition; results are similar for subjects with intervals >4 weeks (N = 53; 29.1 ± 12.8 weeks). This suggests low TEE is not a risk factor for, and high TEE is not protective against, weight or body fat gain over the time intervals tested.

Original language	English
Article number	99
Number of pages	8
Journal	Nature Communications
Volume	13
Issue number	1
DOIs	https://doi.org/10.1038/s41467-021-27246-z
Publication status	Published - 10 Jan 2022

Keywords

Adipose Tissue/metabolism
Adult
Bayes Theorem
Body Composition/physiology
Child
Databases, Factual
Energy Metabolism/physiology
Female
Humans
Isotope Labeling
Longitudinal Studies
Male
Middle Aged
Water/metabolism
Weight Gain/physiology

Access to Document

10.1038/s41467-021-27246-zLicence: CC BY

Cite this

Rimbach, R., Yamada, Y., Sagayama, H., Ainslie, P. N., Anderson, L. F., Anderson, L. J., Arab, L., Baddou, I., Bedu-Addo, K., Blaak, E. E., Blanc, S., Bonomi, A. G., Bouten, C. V. C., Bovet, P., Buchowski, M. S., Butte, N. F., Camps, S. G. J. A., Close, G. L., Cooper, J. A., ... IAEA DLW Database Consortium (2022). Total energy expenditure is repeatable in adults but not associated with short-term changes in body composition. Nature Communications, 13(1), Article 99. https://doi.org/10.1038/s41467-021-27246-z

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abstract = "Low total energy expenditure (TEE, MJ/d) has been a hypothesized risk factor for weight gain, but repeatability of TEE, a critical variable in longitudinal studies of energy balance, is understudied. We examine repeated doubly labeled water (DLW) measurements of TEE in 348 adults and 47 children from the IAEA DLW Database (mean ± SD time interval: 1.9 ± 2.9 y) to assess repeatability of TEE, and to examine if TEE adjusted for age, sex, fat-free mass, and fat mass is associated with changes in weight or body composition. Here, we report that repeatability of TEE is high for adults, but not children. Bivariate Bayesian mixed models show no among or within-individual correlation between body composition (fat mass or percentage) and unadjusted TEE in adults. For adults aged 20-60 y (N = 267; time interval: 7.4 ± 12.2 weeks), increases in adjusted TEE are associated with weight gain but not with changes in body composition; results are similar for subjects with intervals >4 weeks (N = 53; 29.1 ± 12.8 weeks). This suggests low TEE is not a risk factor for, and high TEE is not protective against, weight or body fat gain over the time intervals tested.",

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author = "Rebecca Rimbach and Yosuke Yamada and Hiroyuki Sagayama and Ainslie, {Philip N} and Anderson, {Lene F} and Anderson, {Liam J} and Lenore Arab and Issaad Baddou and Kweku Bedu-Addo and Blaak, {Ellen E} and Stephane Blanc and Bonomi, {Alberto G} and Bouten, {Carlijn V C} and Pascal Bovet and Buchowski, {Maciej S} and Butte, {Nancy F} and Camps, {Stefan G J A} and Close, {Graeme L} and Cooper, {Jamie A} and Das, {Sai Krupa} and Dugas, {Lara R} and Ulf Ekelund and Sonja Entringer and Terrence Forrester and Fudge, {Barry W} and Goris, {Annelies H} and Michael Gurven and Catherine Hambly and {El Hamdouchi}, Asmaa and Hoos, {Marije B} and Sumei Hu and Noorjehan Joonas and Joosen, {Annemiek M} and Peter Katzmarzyk and Kempen, {Kitty P} and Misaka Kimura and Kraus, {William E} and Kushner, {Robert F} and Lambert, {Estelle V} and Leonard, {William R} and Nader Lessan and Martin, {Corby K} and Medin, {Anine C} and Meijer, {Erwin P} and Morehen, {James C} and Morton, {James P} and Guy Plasqui and Giulio Valenti and {van Etten}, Ludovicus and {Van Mil}, {Edgar A} and Westerterp, {Klaas R} and {IAEA DLW Database Consortium}",

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Rimbach, R, Yamada, Y, Sagayama, H, Ainslie, PN, Anderson, LF, Anderson, LJ, Arab, L, Baddou, I, Bedu-Addo, K, Blaak, EE, Blanc, S, Bonomi, AG, Bouten, CVC, Bovet, P, Buchowski, MS, Butte, NF, Camps, SGJA, Close, GL, Cooper, JA, Das, SK, Dugas, LR, Ekelund, U, Entringer, S, Forrester, T, Fudge, BW, Goris, AH, Gurven, M, Hambly, C, El Hamdouchi, A, Hoos, MB, Hu, S, Joonas, N, Joosen, AM, Katzmarzyk, P, Kempen, KP, Kimura, M, Kraus, WE, Kushner, RF, Lambert, EV, Leonard, WR, Lessan, N, Martin, CK, Medin, AC, Meijer, EP, Morehen, JC, Morton, JP, Plasqui, G, Valenti, G, van Etten, L, Van Mil, EA, Westerterp, KR & IAEA DLW Database Consortium 2022, 'Total energy expenditure is repeatable in adults but not associated with short-term changes in body composition', Nature Communications, vol. 13, no. 1, 99. https://doi.org/10.1038/s41467-021-27246-z

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T1 - Total energy expenditure is repeatable in adults but not associated with short-term changes in body composition

AU - Rimbach, Rebecca

AU - Yamada, Yosuke

AU - Sagayama, Hiroyuki

AU - Ainslie, Philip N

AU - Anderson, Lene F

AU - Anderson, Liam J

AU - Arab, Lenore

AU - Baddou, Issaad

AU - Bedu-Addo, Kweku

AU - Blaak, Ellen E

AU - Blanc, Stephane

AU - Bonomi, Alberto G

AU - Bouten, Carlijn V C

AU - Bovet, Pascal

AU - Buchowski, Maciej S

AU - Butte, Nancy F

AU - Camps, Stefan G J A

AU - Close, Graeme L

AU - Cooper, Jamie A

AU - Das, Sai Krupa

AU - Dugas, Lara R

AU - Ekelund, Ulf

AU - Entringer, Sonja

AU - Forrester, Terrence

AU - Fudge, Barry W

AU - Goris, Annelies H

AU - Gurven, Michael

AU - Hambly, Catherine

AU - El Hamdouchi, Asmaa

AU - Hoos, Marije B

AU - Hu, Sumei

AU - Joonas, Noorjehan

AU - Joosen, Annemiek M

AU - Katzmarzyk, Peter

AU - Kempen, Kitty P

AU - Kimura, Misaka

AU - Kraus, William E

AU - Kushner, Robert F

AU - Lambert, Estelle V

AU - Leonard, William R

AU - Lessan, Nader

AU - Martin, Corby K

AU - Medin, Anine C

AU - Meijer, Erwin P

AU - Morehen, James C

AU - Morton, James P

AU - Plasqui, Guy

AU - Valenti, Giulio

AU - van Etten, Ludovicus

AU - Van Mil, Edgar A

AU - Westerterp, Klaas R

AU - IAEA DLW Database Consortium

PY - 2022/1/10

Y1 - 2022/1/10

N2 - Low total energy expenditure (TEE, MJ/d) has been a hypothesized risk factor for weight gain, but repeatability of TEE, a critical variable in longitudinal studies of energy balance, is understudied. We examine repeated doubly labeled water (DLW) measurements of TEE in 348 adults and 47 children from the IAEA DLW Database (mean ± SD time interval: 1.9 ± 2.9 y) to assess repeatability of TEE, and to examine if TEE adjusted for age, sex, fat-free mass, and fat mass is associated with changes in weight or body composition. Here, we report that repeatability of TEE is high for adults, but not children. Bivariate Bayesian mixed models show no among or within-individual correlation between body composition (fat mass or percentage) and unadjusted TEE in adults. For adults aged 20-60 y (N = 267; time interval: 7.4 ± 12.2 weeks), increases in adjusted TEE are associated with weight gain but not with changes in body composition; results are similar for subjects with intervals >4 weeks (N = 53; 29.1 ± 12.8 weeks). This suggests low TEE is not a risk factor for, and high TEE is not protective against, weight or body fat gain over the time intervals tested.

AB - Low total energy expenditure (TEE, MJ/d) has been a hypothesized risk factor for weight gain, but repeatability of TEE, a critical variable in longitudinal studies of energy balance, is understudied. We examine repeated doubly labeled water (DLW) measurements of TEE in 348 adults and 47 children from the IAEA DLW Database (mean ± SD time interval: 1.9 ± 2.9 y) to assess repeatability of TEE, and to examine if TEE adjusted for age, sex, fat-free mass, and fat mass is associated with changes in weight or body composition. Here, we report that repeatability of TEE is high for adults, but not children. Bivariate Bayesian mixed models show no among or within-individual correlation between body composition (fat mass or percentage) and unadjusted TEE in adults. For adults aged 20-60 y (N = 267; time interval: 7.4 ± 12.2 weeks), increases in adjusted TEE are associated with weight gain but not with changes in body composition; results are similar for subjects with intervals >4 weeks (N = 53; 29.1 ± 12.8 weeks). This suggests low TEE is not a risk factor for, and high TEE is not protective against, weight or body fat gain over the time intervals tested.

KW - Adipose Tissue/metabolism

KW - Adult

KW - Bayes Theorem

KW - Body Composition/physiology

KW - Child

KW - Databases, Factual

KW - Energy Metabolism/physiology

KW - Female

KW - Humans

KW - Isotope Labeling

KW - Longitudinal Studies

KW - Male

KW - Middle Aged

KW - Water/metabolism

KW - Weight Gain/physiology

U2 - 10.1038/s41467-021-27246-z

DO - 10.1038/s41467-021-27246-z

M3 - Article

C2 - 35013190

SN - 2041-1723

VL - 13

JO - Nature Communications

JF - Nature Communications

IS - 1

M1 - 99

ER -