Specific amino acid supplementation rescues the heart from lipid overload-induced insulin resistance and contractile dysfunction by targeting the endosomal mTOR-v-ATPase axis

S.J. Wang, F. Schianchi, D. Neumann, L.Y. Wong, A.M. Sun, F.A. van Nieuwenhoven, M.P. Zeegers, A. Strzelecka, U. Col, J.F.C. Glatz, M. Nabben, J.J.F.P. Luiken*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Article number101293
Number of pages14
JournalMolecular Metabolism
Volume53
DOIs
Publication statusPublished - 1 Nov 2021

Keywords

  • Vacuolar H plus -ATPase
  • Endosomal CD36
  • mTORC1
  • Lipid-induced insulin resistance
  • Contractile function
  • Diabetic heart
  • INHIBITION
  • METABOLISM
  • CD36
  • ACCUMULATION
  • TRANSLOCATION
  • TRANSPORTERS
  • PALMITATE
  • COMPLEX
  • GLUT4

Cite this