Smoothelin in vascular smooth muscle cells

G.J.J.M. van Eys, P.M.G. Niessen, S.S.M. Rensen

Research output: Contribution to journalArticleAcademicpeer-review

49 Citations (Scopus)

Abstract

Smoothelin-A and -B have only been found in fully differentiated contractile smooth muscle cells. They are increasingly used to monitor the smooth muscle cell differentiation process to a contractile or synthetic phenotype. Vascular-specific smoothelin-B is the first smooth muscle cell marker that disappears when vascular tissues are compromised, for example, in atherosclerosis or restenosis. Recently obtained data show that smoothelin deficiency results in a considerable loss of contractile potential and hence in impaired smooth muscle function and suggest that smoothelins are part of the contractile apparatus.
Original languageEnglish
Pages (from-to)26-30
JournalTrends in Cardiovascular Medicine
Volume17 (1)
DOIs
Publication statusPublished - 1 Jan 2007

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