Lipoproteins and lipids in cardiovascular disease: from mechanistic insights to therapeutic targeting

Josefin Soppert, Michael Lehrke, Nikolaus Marx, Joachim Jankowski, Heidi Noels*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

36 Citations (Web of Science)

Abstract

With cardiovascular disease being the leading cause of morbidity and mortality worldwide, effective and costefficient therapies to reduce cardiovascular risk are highly needed. Lipids and lipoprotein particles crucially contribute to atherosclerosis as underlying pathology of cardiovascular disease and influence inflammatory processes as well as function of leukocytes, vascular and cardiac cells, thereby impacting on vessels and heart. Statins form the first-line therapy with the aim to block cholesterol synthesis, but additional lipid-lowering drugs are sometimes needed to achieve low-density lipoprotein (LDL) cholesterol target values. Furthermore, beyond LDL cholesterol, also other lipid mediators contribute to cardiovascular risk. This review comprehensively discusses low- and high-density lipoprotein cholesterol, lipoprotein (a), triglycerides as well as fatty acids and derivatives in the context of cardiovascular disease, providing mechanistic insights into their role in pathological processes impacting on cardiovascular disease. Also, an overview of applied as well as emerging therapeutic strategies to reduce lipid-induced cardiovascular burden is provided. (C) 2020 The Author(s). Published by Elsevier B.V.

Original languageEnglish
Pages (from-to)4-33
Number of pages30
JournalAdvanced Drug Delivery Reviews
Volume159
DOIs
Publication statusPublished - 2020

Keywords

  • Cardiovascular disease
  • atherosclerosis
  • myocardial infarction
  • lipid
  • HDL
  • LDL
  • triglyceride
  • fatty acid
  • lipoprotein(a)
  • lipid-lowering therapy
  • HIGH-DENSITY-LIPOPROTEIN
  • CORONARY-HEART-DISEASE
  • APOLIPOPROTEIN-A-I
  • SERUM-AMYLOID-A
  • HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA
  • NITRIC-OXIDE SYNTHASE
  • PLATELET-ACTIVATING-FACTOR
  • LECITHIN-CHOLESTEROL ACYLTRANSFERASE
  • TRIGLYCERIDE-TRANSFER PROTEIN
  • EXTENDED-RELEASE NIACIN

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