Automated multiscale vessel analysis for the quantification of MR angiography of peripheral arteriogenesis

Karolien Jaspers, Jos M. G. M. Slenter, Tim Leiner, Allard Wagenaar, Mark J. Post, Walter H. Backes*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Web of Science)


Purpose: To automatically analyze the time course of collateralization in a rat hindlimb ischemia model based on signal intensity distribution (SID). Materials and Methods: Time-of-flight magnetic resonance angiograms (TOF-MRA) were acquired in eight rats at 2, 7, and 21 days after unilateral femoral artery ligation. Analysis was performed on maximum intensity projections filtered with multiscale vessel enhancement filter. Differences in SID between ligated limb and a reference region were monitored over time and compared to manual collateral artery identification. Results: The differences in SID correlated well with the number of collateral arteries found with manual quantification. The time courses of ultrasmall (diameter
Original languageEnglish
Pages (from-to)379-386
JournalJournal of Magnetic Resonance Imaging
Issue number2
Publication statusPublished - Feb 2012


  • image filtering
  • collateral arteries
  • histogram analysis

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