Advanced glycation endproducts in multiple sclerosis

Research output: ThesisDoctoral ThesisInternal

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Abstract

This thesis investigates the role of saccharified proteins in multiple sclerosis (MS). In MS, the shell of the nerves in the brain is attacked by the immune system. Saccharified proteins can activate specific cells of the immune system. Our research shows that MS patients have high levels of saccharified proteins in their brains. This result has been confirmed with the use of a mouse model. It has also been shown that the consumption of a diet rich in saccharified proteins causes an accumulation of these saccharified proteins in the brain. The effect of lowering saccharified proteins will need to be investigated further.
Original languageEnglish
Awarding Institution
  • Maastricht University
  • Universiteit Hasselt
Supervisors/Advisors
  • Schalkwijk, Casper, Supervisor
  • Hendriks, Jerome J. A., Supervisor, External person
  • Wouters, Kristiaan, Advisor
  • Vanmierlo, T., Advisor, External person
Award date21 Feb 2019
Place of PublicationMaastricht
Publisher
DOIs
Publication statusPublished - 2019

Keywords

  • saccharified proteins
  • Multiple sclerosis
  • Immune system

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