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Hugo Aerts

20102020

Research output per year

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Research Output

2019

Artificial intelligence for global health

Hosny, A. & Aerts, H. J. W. L., 22 Nov 2019, In : Science. 366, 6468, p. 955-956 2 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Artificial intelligence in cancer imaging: Clinical challenges and applications

Bi, W. L., Hosny, A., Schabath, M. B., Giger, M. L., Birkbak, N. J., Mehrtash, A., Allison, T., Arnaout, O., Abbosh, C., Dunn, I. F., Mak, R. H., Tamimi, R. M., Tempany, C. M., Swanton, C., Hoffmann, U., Schwartz, L. H., Gillies, R. J., Huang, R. Y. & Aerts, H. J. W. L., 2019, In : Ca-A Cancer Journal for Clinicians. 69, 2, p. 127-157 31 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Deep Learning Predicts Lung Cancer Treatment Response from Serial Medical Imaging

Xu, Y., Hosny, A., Zeleznik, R., Parmar, C., Coroller, T., Franco, I., Mak, R. H. & Aerts, H. J. W. L., 1 Jun 2019, In : Clinical Cancer Research. 25, 11, p. 3266-3275 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Density and morphology of coronary artery calcium for the prediction of cardiovascular events: insights from the Framingham Heart Study

Foldyna, B., Eslami, P., Scholtz, J-E., Baltrusaitis, K., Lu, M. T., Massaro, J. M., D'Agostino, R. B., Ferencik, M., Aerts, H. J. W. L., O'Donnell, C. J. & Hoffmann, U., Nov 2019, In : European Radiology. 29, 11, p. 6140-6148 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Distributed radiomics as a signature validation study using the Personal Health Train infrastructure

Shi, Z., Ivan Zhovannik, I., Traverso, A., Dankers, F., Deist, T., Kalendralis, P., Monshouwer, R., Bussink, J., Fijten, R., Aerts, H., Dekker, A. & Wee, L., 22 Oct 2019, In : Scientific data. 6, 8 p., 218.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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81 Downloads (Pure)

Predicting response to cancer immunotherapy using noninvasive radiomic biomarkers

Trebeschi, S., Drago, S. G., Birkbak, N. J., Kurilova, I., Calin, A. M., Pizzi, A. D., Lalezari, F., Lambregts, D. M. J., Rohaan, M. W., Parmar, C., Rozeman, E. A., Hartemink, K. J., Swanton, C., Haanen, J. B. A. G., Blank, C. U., Smit, E. F., Beets-Tan, R. G. H. & Aerts, H. J. W. L., Jun 2019, In : Annals of Oncology. 30, 6, p. 998-1004 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Repeatability of Multiparametric Prostate MRI Radiomics Features

Schwier, M., van Griethuysen, J., Vangel, M. G., Pieper, S., Peled, S., Tempany, C., Aerts, H. J. W. L., Kikinis, R., Fennessy, F. M. & Fedorov, A., 1 Jul 2019, In : Scientific Reports. 9, 16 p., 9441.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

Clinical Outcomes After Lung Stereotactic Body Radiation Therapy in Patients With or Without a Prior Lung Resection

Hou, Y., Hermann, G., Lewis, J. H., Aerts, H. J., Baldini, E. H., Chen, A. B., Colson, Y. L., Hacker, F. L., Killoran, J. H., Kozono, D. E., Wagar, M., Wee, J. O. & Mak, R. H., 1 Jul 2018, In : American Journal of Clinical Oncology-Cancer Clinical Trials. 41, 7, p. 695-701 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

2017

Computational Radiomics System to Decode the Radiographic Phenotype

van Griethuysen, J. J. M., Fedorov, A., Parmar, C., Hosny, A., Aucoin, N., Narayan, V., Beets-Tan, R. G. H., Fillion-Robin, J-C., Pieper, S. & Aerts, H. J. W. L., 1 Nov 2017, In : Cancer Research. 77, 21, p. E104-E107 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Deep Learning for Fully-Automated Localization and Segmentation of Rectal Cancer on Multiparametric MR

Trebeschi, S., van Griethuysen, J. J. M., Lambregts, D. M. J., Lahaye, M. J., Parmer, C., Bakers, F. C. H., Peters, N. H. G. M., Beets-Tan, R. G. H. & Aerts, H. J. W. L., 13 Jul 2017, In : Scientific Reports. 7, 9 p., 5301.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Defining the biological basis of radiomic phenotypes in lung cancer

Grossmann, P., Stringfield, O., El-Hachem, N., Bui, M. M., Velazquez, E. R., Parmar, C., Leijenaar, R. T. H., Haibe-Kains, B., Lambin, P., Gilles, R. J. & Aerts, H. J. W. L., 21 Jul 2017, In : Elife. 6, 22 p., 23421.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Externally validated HPV-based prognostic nomogram for oropharyngeal carcinoma patients yields more accurate predictions than TNM staging (vol 113, pg 324, 2014)

Velazquez, E. R., Hoebers, F., Aerts, H. J. W. L., Rietbergen, M. M., Brakenhoff, R. H., Leemans, R. C., Speel, E-J., Straetmans, J., Kremer, B. & Lambin, P., Aug 2017, In : Radiotherapy and Oncology. 124, 2, p. 337-338 2 p.

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

Imaging biomarker roadmap for cancer studies

O'Connor, J. P. B., Aboagye, E. O., Adams, J. E., Aerts, H. J. W. L., Barrington, S. F., Beer, A. J., Boellaard, R., Bohndiek, S. E., Brady, M., Brown, G., Buckley, D. L., Chenevert, T. L., Clarke, L. P., Collette, S., Cook, G. J., Desouza, N. M., Dickson, J. C., Dive, C., Evelhoch, J. L., Faivre-Finn, C. & 57 others, Gallagher, F. A., Gilbert, F. J., Gillies, R. J., Goh, V., Griffiths, J. R., Groves, A. M., Halligan, S., Harris, A. L., Hawkes, D. J., Hoekstra, O. S., Huang, E. P., Hutton, B. F., Jackson, E. F., Jayson, G. C., Jones, A., Koh, D-M., Lacombe, D., Lambin, P., Lassau, N., Leach, M. O., Lee, T-Y., Leen, E. L., Lewis, J. S., Liu, Y., Lythgoe, M. F., Manoharan, P., Maxwell, R. J., Miles, K. A., Morgan, B., Morris, S., Ng, T., Padhani, A. R., Parker, G. J. M., Partridge, M., Pathak, A. P., Peet, A. C., Punwani, S., Reynolds, A. R., Robinson, S. P., Shankar, L. K., Sharma, R. A., Soloviev, D., Stroobants, S., Sullivan, D. C., Taylor, S. A., Tofts, P. S., Tozer, G. M., van Herk, M., Walker-Samuel, S., Wason, J., Williams, K. J., Workman, P., Yankeelov, T. E., Brindle, K. M., McShane, L. M., Jackson, A. & Waterton, J. C., Mar 2017, In : Nature Reviews Clinical Oncology. 14, 3, p. 169-186 18 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

PET imaging of zirconium-89 labelled cetuximab: A phase I trial in patients with head and neck and lung cancer

van Loon, J., Even, A. J. G., Aerts, H. J. W. L., Ollers, M., Hoebers, F., van Elmpt, W., Dubois, L., Dingemans, A-M. C., Lalisang, R. I., Kempers, P., Brans, B., Winnepenninckx, V., Speel, E-J., Thunnissen, E., Smits, K. M., Boellaard, R., Vugts, D. J., De Ruysscher, D. & Lambin, P., Feb 2017, In : Radiotherapy and Oncology. 122, 2, p. 267-273 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

2016

Exploratory Study to Identify Radiomics Classifiers for Lung Cancer Histology

Wu, W., Parmar, C., Grossmann, P., Quackenbush, J., Lambin, P., Bussink, J., Mak, R. & Aerts, H. J. W. L., 30 Mar 2016, In : Frontiers in Oncology. 6, 71.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
3 Citations (Scopus)
2015

CT-based radiomic signature predicts distant metastasis in lung adenocarcinoma

Coroller, T. P., Grossmann, P., Hou, Y., Velazquez, E. R., Leijenaar, R. T. H., Hermann, G., Lambin, P., Haibe-Kains, B., Mak, R. H. & Aerts, H. J. W. L., Mar 2015, In : Radiotherapy and Oncology. 114, 3, p. 345-350

Research output: Contribution to journalArticleAcademicpeer-review

48 Citations (Scopus)

diXa: a data infrastructure for chemical safety assessment

Hendrickx, D., Aerts, H., Caiment, F., Clark, D., Ebbels, T. M., Evelo, C. T., Gmuender, H., Hebels, D. G., Herwig, R., Hescheler, J., Jennen, D. G., Jetten, M. J., Kanterakis, S., Keun, H. C., Matser, V., Overington, J. P., Pilicheva, E., Sarkans, U., Segura-Lepe, M. P., Sotiriadou, I. & 4 others, Wittenberger, T., Wittwehr, C., Zanzi, A. & Kleinjans, J. C., 1 May 2015, In : Bioinformatics. 31, 9, p. 1505-1507 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

External validation of a prognostic CT-based radiomic signature in oropharyngeal squamous cell carcinoma

Leijenaar, R. T. H., Carvalho, S., Hoebers, F. J. P., Aerts, H. J. W. L., Van Elmpt, W. J. C., Huang, S. H., Chan, B., Waldron, J. N., O'Sullivan, B. & Lambin, P., 21 Oct 2015, In : Acta Oncologica. 54, 9, p. 1423-1429

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

Machine Learning methods for Quantitative Radiomic Biomarkers

Parmar, C., Grossmann, P., Bussink, J., Lambin, P. & Aerts, H. J. W. L., 17 Aug 2015, In : Scientific Reports. 5, 13087.

Research output: Contribution to journalArticleAcademicpeer-review

32 Citations (Scopus)

Quantitative Computed Tomographic Descriptors Associate Tumor Shape Complexity and Intratumor Heterogeneity with Prognosis in Lung Adenocarcinoma

Grove, O., Berglund, A. E., Schabath, M. B., Aerts, H. J. W. L., Dekker, A., Wang, H., Velazquez, E. R., Lambin, P., Gu, Y., Balagurunathan, Y., Eikman, E., Gatenby, R. A., Eschrich, S. & Gillies, R. J., 4 Mar 2015, In : PLOS ONE. 10, 3, e0118261.

Research output: Contribution to journalArticleAcademicpeer-review

24 Citations (Scopus)

Radiomic feature clusters and Prognostic Signatures specific for Lung and Head & Neck cancer

Parmar, C., Leijenaar, R. T. H., Grossmann, P., Velazquez, E. R., Bussink, J., Rietveld, D., Rietbergen, M. M., Haibe-Kains, B., Lambin, P. & Aerts, H. J. W. L., 5 Jun 2015, In : Scientific Reports. 5, 11044.

Research output: Contribution to journalArticleAcademicpeer-review

43 Citations (Scopus)

Radiomic Machine-Learning Classifiers for Prognostic Biomarkers of Head and Neck Cancer

Parmar, C., Grossmann, P., Rietveld, D., Rietbergen, M. M., Lambin, P. & Aerts, H. J. W. L., 3 Dec 2015, In : Frontiers in Oncology. 5, 272.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
12 Citations (Scopus)

The effect of SUV discretization in quantitative FDG-PET Radiomics: the need for standardized methodology in tumor texture analysis

Leijenaar, R. T. H., Nalbantov, G., Carvalho, S., van Elmpt, W. J. C., Troost, E. G. C., Boellaard, R., Aerts, H. J. W. L., Gillies, R. J. & Lambin, P., 5 Aug 2015, In : Scientific Reports. 5, 11075.

Research output: Contribution to journalArticleAcademicpeer-review

36 Citations (Scopus)
2014

Decoding tumour phenotype by noninvasive imaging using a quantitative radiomics approach

Aerts, H. J. W. L., Velazquez, E. R., Leijenaar, R. T. H., Parmar, C., Grossmann, P., Cavalho, S., Bussink, J., Monshouwer, R., Haibe-Kains, B., Rietveld, D., Hoebers, F., Rietbergen, M. M., Leemans, C. R., Dekker, A., Quackenbush, J., Gillies, R. J. & Lambin, P., Jun 2014, In : Nature Communications. 5, 4006.

Research output: Contribution to journalArticleAcademicpeer-review

261 Citations (Scopus)

Evaluation of database-derived pathway development for enabling biomarker discovery for hepatotoxicity

Hebels, D. G. A., Jetten, M. J. A., Aerts, H. J. W., Herwig, R., Theunissen, D. H. J., Gaj, S., van Delft, J. H. & Kleinjans, J. C. S., Feb 2014, In : Biomarkers in Medicine. 8, 2, p. 185-200

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Externally validated HPV-based prognostic nomogram for oropharyngeal carcinoma patients yields more accurate predictions than TNM staging

Rios Velazquez, E., Hoebers, F., Aerts, H. J. W. L., Rietbergen, M. M., Brakenhoff, R. H., Leemans, R. C., Speel, E-J., Straetmans, J., Kremer, B. & Lambin, P., Dec 2014, In : Radiotherapy and Oncology. 113, 3, p. 324-30 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

18 Citations (Scopus)

Importance of collection in gene set enrichment analysis of drug response in cancer cell lines

Bateman, A. R., El-Hachem, N., Beck, A. H., Aerts, H. J. W. L. & Haibe-Kains, B., 13 Feb 2014, In : Scientific Reports. 4, 4092.

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Robust Radiomics Feature Quantification Using Semiautomatic Volumetric Segmentation

Parmar, C., Velazquez, E. R., Leijenaar, R., Jermoumi, M., Carvalho, S., Mak, R. H., Mitra, S., Shankar, B. U., Kikinis, R., Haibe-Kains, B., Lambin, P. & Aerts, H. J. W. L., 15 Jul 2014, In : PLOS ONE. 9, 7

Research output: Contribution to journalArticleAcademicpeer-review

47 Citations (Scopus)
2013

Automated delineation of lung tumors from CT images using a single click ensemble segmentation approach

Gu, Y., Kumar, V., Hall, L. O., Goldgof, D. B., Li, C-Y., Korn, R., Bendtsen, C., Velazquez, E. R., Dekker, A., Aerts, H., Lambin, P., Li, X., Tian, J., Gatenby, R. A. & Gillies, R. J., Mar 2013, In : Pattern Recognition. 46, 3, p. 692-702

Research output: Contribution to journalArticleAcademicpeer-review

41 Citations (Scopus)

Comparison and validation of genomic predictors for anticancer drug sensitivity

Papillon-Cavanagh, S., De Jay, N., El-Hachem, N., Olsen, C., Bontempi, G., Aerts, H. J. W. L., Quackenbush, J. & Haibe-Kains, B., Jul 2013, In : Journal of the American Medical Informatics Association. 20, 4, p. 597-602

Research output: Contribution to journalArticleAcademicpeer-review

Inconsistency in large pharmacogenomic studies

Haibe-Kains, B., El-Hachem, N., Birkbak, N. J., Jin, A. C., Beck, A. H., Aerts, H. J. W. L. & Quackenbush, J., 19 Dec 2013, In : Nature. 504, 7480, p. 389-+

Research output: Contribution to journalArticleAcademicpeer-review

136 Citations (Scopus)

Predicting outcomes in radiation oncology-multifactorial decision support systems

Lambin, P., van Stiphout, R., Starmans, M. H. W., Rios-Velazquez, E., Nalbantov, G., Aerts, H. J. W. L., Roelofs, E., van Elmpt, W., Boutros, P. C., Granone, P., Valentini, V., Begg, A. C., De Ruysscher, D. & Dekker, A., Jan 2013, In : Nature Reviews Clinical Oncology. 10, 1, p. 27-40

Research output: Contribution to journalArticleAcademicpeer-review

Prognostic value of metabolic metrics extracted from baseline positron emission tomography images in non-small cell lung cancer.

Carvalho, S., Leijenaar, R. T. H., Velazquez, E. R., Oberije, C., Parmar, C., van Elmpt, W., Reymen, B., Troost, E. G. C., Oellers, M., Dekker, A., Gillies, R., Aerts, H. J. W. L. & Lambin, P., 2013, In : Acta Oncologica. 52, 7, p. 1398-404 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)

Stability of FDG-PET Radiomics features: an integrated analysis of test-retest and inter-observer variability.

Leijenaar, R. T. H., Carvalho, S., Velazquez, E. R., van Elmpt, W. J. C., Parmar, C., Hoekstra, O. S., Hoekstra, C. J., Boellaard, R., Dekker, A., Gillies, R. J., Aerts, H. J. W. L. & Lambin, P., 2013, In : Acta oncologica. 52, 7, p. 1391-1397 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

67 Citations (Scopus)

Volumetric CT-based segmentation of NSCLC using 3D-Slicer

Velazquez, E. R., Parmar, C., Jermoumi, M., Mak, R. H., van Baardwijk, A., Fennessy, F. M., Lewis, J. H., De Ruysscher, D., Kikinis, R., Lambin, P. & Aerts, H. J. W. L., 18 Dec 2013, In : Scientific Reports. 3, 3529.

Research output: Contribution to journalArticleAcademicpeer-review

2012

A semiautomatic CT-based ensemble segmentation of lung tumors: Comparison with oncologists' delineations and with the surgical specimen

Velazquez, E. R., Aerts, H. J. W. L., Gu, Y., Goldgof, D. B., De Ruysscher, D., Dekker, A., Korn, R., Gillies, R. J. & Lambin, P., Nov 2012, In : Radiotherapy and Oncology. 105, 2, p. 167-173

Research output: Contribution to journalArticleAcademicpeer-review

Identification of residual metabolic-active areas within NSCLC tumours using a pre-radiotherapy FDG-PET-CT scan: A prospective validation

Aerts, H. J. W. L., Bussink, J., Oyen, W. J. G., van Elmpt, W., Folgering, A. M., Emans, D., Velders, M., Lambin, P. & De Ruysscher, D., Jan 2012, In : Lung Cancer. 75, 1, p. 73-76

Research output: Contribution to journalArticleAcademicpeer-review

46 Citations (Scopus)

Radiomics: Extracting more information from medical images using advanced feature analysis

Lambin, P., Rios-Velazquez, E., Leijenaar, R., Carvalho, S., van Stiphout, R. G. P. M., Granton, P., Zegers, C. M. L., Gillies, R., Boellard, R., Dekker, A. & Aerts, H. J. W. L., Mar 2012, In : European Journal of Cancer. 48, 4, p. 441-446 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

230 Citations (Scopus)
5 Citations (Scopus)

Quantitative Imaging Test Approval and Biomarker Qualification: Interrelated but Distinct Activities

Genetic Risk and Outcome of Psychosis (GROUP) Investigators & Aerts, H., Jun 2011, In : Radiology. 259, 3, p. 875-884

Research output: Contribution to journalArticleAcademicpeer-review

2010

Accurate Prediction of Pathological Rectal Tumor Response after Two Weeks of Preoperative Radiochemotherapy Using 18F-Fluorodeoxyglucose-Positron Emission Tomography-Computed Tomography Imaging

Janssen, M. H. M., Öllers, M. C., Riedl, R. G., van den Bogaard, J., Buijsen, J., van Stiphout, R. G. P. M., Aerts, H. J. W. L., Lambin, P. & Lammering, G., 1 Jun 2010, In : International Journal of Radiation Oncology Biology Physics. 77, 2, p. 392-399 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

COMPARISON BETWEEN PERFUSION COMPUTED TOMOGRAPHY AND DYNAMIC CONTRAST-ENHANCED MAGNETIC RESONANCE IMAGING IN RECTAL CANCER

Kierkels, R. G. J., Backes, W. H., Janssen, M. H. M., Buijsen, J., Beets-Tan, R. G. H., Lambin, P., Lammerng, G., Oellers, M. C. & Aerts, H. J. W. L., 1 Jun 2010, In : International Journal of Radiation Oncology Biology Physics. 77, 2, p. 400-408

Research output: Contribution to journalArticleAcademicpeer-review

Effectiveness of surgery and individualized high-dose hyperfractionated accelerated radiotherapy on survival in clinical stage I non-small cell lung cancer. A propensity score matched analysis

Jimenez, M. F., van Baardwijk, A., Aerts, H. J. W. L., De Ruysscher, D., Novoa, N. M., Varela, G. & Lambin, P., Dec 2010, In : Radiotherapy and Oncology. 97, 3, p. 413-417

Research output: Contribution to journalArticleAcademicpeer-review

122 Downloads (Pure)

PET imaging of hypoxia using [F-18]HX4: a phase I trial

van Loon, J., Janssen, M. H. M., Ollers, M., Aerts, H. J. W. L., Dubois, L., Hochstenbag, M., Dingemans, A-M. C., Lalisang, R., Brans, B., Windhorst, B., van Dongen, G. A. M. S., Kolb, H., Zhang, J., De Ruysscher, D. & Lambin, P., Aug 2010, In : European Journal of Nuclear Medicine and Molecular Imaging. 37, 9, p. 1663-1668

Research output: Contribution to journalArticleAcademicpeer-review

Prediction of residual metabolic activity after treatment in NSCLC patients

Velazquez, E. R., Aerts, H. J. W. L., Oberije, C., De Ruysscher, D. & Lambin, P., Oct 2010, In : Acta Oncologica. 49, 7, p. 1033-1039

Research output: Contribution to journalArticleAcademicpeer-review

The ESTRO Breur Lecture 2009. From population to voxel-based radiotherapy: Exploiting intra-tumour and intra-organ heterogeneity for advanced treatment of non-small cell lung cancer

Lambin, P., Petit, S. F., Aerts, H. J. W. L., van Elmpt, W. J. C., Oberije, C. J. G., Starmans, M. H. W., van Stiphout, R. G. P. M., van Dongen, G. A. M. S., Muylle, K., Flamen, P., Dekker, A. L. A. J. & De Ruysscher, D., Aug 2010, In : Radiotherapy and Oncology. 96, 2, p. 145-152 8 p.

Research output: Contribution to journalArticleAcademicpeer-review