Imaging Mass Spectrometry

  • Universiteitssingel50, UNS50

    6229 ER Maastricht

    Netherlands

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2019

AntagomiR-103 and-107 Treatment Affects Cardiac Function and Metabolism

Rech, M., Kuhn, A. R., Lumens, J., Carai, P., van Leeuwen, R., Verhesen, W., Verjans, R., Lecomte, J., Liu, Y., Luiken, J. J. F. P., Mohren, R., Cillero-Pastor, B., Heymans, S., Knoops, K., van Bilsen, M. & Schroen, B., 1 Mar 2019, In : Molecular Therapy - Nucleic Acids. 14, p. 424-437 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

A patch-based super resolution algorithm for improving image resolution in clinical mass spectrometry

Scupakova, K., Terzopoulos, V., Jain, S., Smeets, D. & Heeren, R. M. A., 27 Feb 2019, In : Scientific Reports. 9, 11 p., 2915.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Class-specific depletion of lipid ion signals in tissues upon formalin fixation

Vos, D. R. N., Bowman, A. P., Heeren, R. M. A., Balluff, B. & Ellis, S. R., Dec 2019, In : International Journal of Mass Spectrometry. 446, p. 1-9 9 p., 116212.

Research output: Contribution to journalArticleAcademicpeer-review

Deciphering Metabolic Heterogeneity by Single-Cell Analysis

Evers, T. M. J., Hochane, M., Tans, S. J., Heeren, R. M. A., Semrau, S., Nemes, P. & Mashaghi, A., 5 Nov 2019, In : Analytical Chemistry. 91, 21, p. 13314-13323 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Development and evaluation of matrix application techniques for high throughput mass spectrometry imaging of tissues in the clinic

Huizing, L. R. S., Ellis, S. R., Beulen, B. W. A. M. M., Barre, F. P. Y., Kwant, P. B., Vreeken, R. J. & Heeren, R. M. A., Apr 2019, In : Clinical mass spectrometry. 12, p. 7-15 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Distinguishing core from penumbra by lipid profiles using Mass Spectrometry Imaging in a transgenic mouse model of ischemic stroke

Mulder, I. A., Potocnik, N. O., Broos, L. A. M., Prop, A., Wermer, M. J. H., Heeren, R. M. A. & van den Maagdenberg, A. M. J. M., 31 Jan 2019, In : Scientific Reports. 9, p. 1-10 10 p., 1090.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Enhanced Sensitivity Using MALDI Imaging Coupled with Laser Postionization (MALDI-2) for Pharmaceutical Research

Barre, F. P. Y., Paine, M. R. L., Flinders, B., Trevitt, A. J., Kelly, P. D., Ait-Belkacem, R., Garcia, J. P., Creemers, L. B., Stauber, J., Vreeken, R. J., Cillero-Pastor, B., Ellis, S. R. & Heeren, R. M. A., 20 Aug 2019, In : Analytical Chemistry. 91, 16, p. 10840-10848 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Faster raster matrix-assisted laser desorption/ionization mass spectrometry imaging of lipids at high lateral resolution

Barre, F., Rocha, B., Dewez, F., Towers, M., Murray, P., Claude, E., Cillero-Pastor, B., Heeren, R. & Siegel, T. P., Mar 2019, In : International Journal of Mass Spectrometry. 437, p. 38-48 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Imaging Isomers on a Biological Surface: A Review

Claes, B. S. R., Takeo, E., Fukusaki, E., Shimma, S. & Heeren, R. M. A., 2019, In : Mass spectrometry (Tokyo, Japan). 8, 1, p. A0078 19 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Increased throughput and ultra-high mass resolution in DESI FT-ICR MS imaging through new-generation external data acquisition system and advanced data processing approaches

Kooijman, P. C., Nagornov, K. O., Kozhinov, A. N., Kilgour, D. P. A., Tsybin, Y. O., Heeren, R. M. A. & Ellis, S. R., 9 Jan 2019, In : Scientific Reports. 9, p. 1-11 11 p., 8.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Integrative Clustering in Mass Spectrometry Imaging for Enhanced Patient Stratification

Balluff, B., Buck, A., Martin-Lorenzo, M., Dewez, F., Langer, R., McDonnell, L. A., Walch, A. & Heeren, R. M. A., Jan 2019, In : Proteomics Clinical Applications. 13, 1, 5 p., 1800137.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Ion mobility spectrometry combined with multivariate statistical analysis: revealing the effects of a drug candidate for Alzheimer's disease on A beta 1-40 peptide early assembly

Lazzaro, S., Ogrinc, N., Lamont, L., Vecchio, G., Pappalardo, G. & Heeren, R. M. A., Sep 2019, In : Analytical and Bioanalytical Chemistry. 411, 24, p. 6353-6363 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Maintenance of Deep Lung Architecture and Automated Airway Segmentation for 3D Mass Spectrometry Imaging

Scott, A. J., Chandler, C. E., Ellis, S. R., Heeren, R. M. A. & Ernst, R. K., 27 Dec 2019, In : Scientific Reports. 9, p. 1-12 12 p., 20160.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

MALDI-Mass Spectrometry Imaging to Investigate Lipid and Bile Acid Modifications Caused by Lentil Extract Used as a Potential Hypocholesterolemic Treatment

Genangeli, M., Heijens, A. M. M., Rustichelli, A., Schuit, N. D., Di Bonaventura, M. V. M., Cifani, C., Vittori, S., Siegel, T. P. & Heeren, R. M. A., Oct 2019, In : Journal of the American Society for Mass Spectrometry. 30, 10, p. 2041-2050 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Multi-Site Coronary Vein Sampling Study on Cardiac Troponin T Degradation in Non-ST-Segment-Elevation Myocardial Infarction: Toward a More Specific Cardiac Troponin T Assay

Damen, S. A. J., Vroemen, W. H. M., Brouwer, M. A., Mezger, S. T. P., Suryapranata, H., van Royen, N., Bekers, O., Meex, S. J. R., Wodzig, W. K. W. H., Verheugt, F. W. A., de Boer, D., Cramer, G. E. & Mingels, A. M. A., 16 Jul 2019, In : Journal of the American Heart Association. 8, 14, 26 p., 012602.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Precise co-registration of mass spectrometry imaging, histology, and laser microdissection-based omics

Dewez, F., Martin-Lorenzo, M., Herfs, M., Baiwir, D., Mazzucchelli, G., De Pauw, E., Heeren, R. M. A. & Balluff, B., Sep 2019, In : Analytical and Bioanalytical Chemistry. 411, 22, p. 5647-5653 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Protection of the Ovine Fetal Gut against Ureaplasma-Induced Chorioamnionitis: A Potential Role for Plant Sterols

van Gorp, C., de Lange, I. H., Spiller, O. B., Dewez, F., Pastor, B. C., Heeren, R. M. A., Kessels, L., Kloosterboer, N., van Gemert, W. G., Beeton, M. L., Stock, S. J., Jobe, A. H., Payne, M. S., Kemp, M. W., Zimmermann, L. J., Kramer, B. W., Plat, J. & Wolfs, T. G. A. M., May 2019, In : Nutrients. 11, 5, p. 1-21 21 p., 968.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Rapid Identification of Ischemic Injury in Renal Tissue by Mass-Spectrometry Imaging

van Smaalen, T. C., Ellis, S. R., Mascini, N. E., Siegel, T. P., Cillero-Pastor, B., Hillen, L. M., van Heurn, L. W. E., Peutz-Kootstra, C. J. & Heeren, R. M. A., 5 Mar 2019, In : Analytical Chemistry. 91, 5, p. 3575-3581 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Standardized human bone marrow-derived stem cells infusion improves survival and recovery in a rat model of spinal cord injury

de Munter, J. P., Beugels, J., Munter, S., Jansen, L., Cillero-Pastor, B., Moskvin, O., Brook, G., Pavlov, D., Strekalova, T., Kramer, B. W. & Wolters, E. C., 15 Jul 2019, In : Journal of the Neurological Sciences. 402, p. 16-29 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Stigmatic imaging of secondary ions in MeV-SIMS spectrometry by linear Time-of-Flight mass spectrometer and the TimePix detector

Jencic, B., Sepec, L., Vavpetic, P., Kelemen, M., Rupnik, Z., Vencelj, M., Vogel-Mikus, K., Potocnik, N. O., Ellis, S. R., Heeren, R. & Pelicon, P., 1 Aug 2019, In : Nuclear Instruments & Methods in Physics Research Section B-Beam Interactions with Materials and Atoms. 452, p. 1-6 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Strategies for managing multi-patient 3D mass spectrometry imaging data

Vos, D. R. N., Jansen, R. L., Lucas, M., Paine, M. R. L., de Boer, O. J., Meijer, S. L., Savci-Heijink, C. D., Marquering, H. A., de Bruin, D. M., Heeren, R. M. A., Ellis, S. R. & Balluff, B., 20 Feb 2019, In : Journal of Proteomics. 193, p. 184-191 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Synthesis and Catalytic Application of Knolker-Type Iron Complexes with a Novel Asymmetric Cyclopentadienone Ligand Design

van Slagmaat, C. A. M. R., Chou, K. C., Morick, L., Hadavi, D., Blom, B. & De Wildeman, S. M. A., Oct 2019, In : Catalysts. 9, 10, 24 p., 790.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The Crystalline Sponge Method in Water

de Poel, W., Tinnemans, P., Duchateau, A. L. L., Honing, M., Rutjes, F. P. J. T., Vlieg, E. & de Gelder, R., 22 Nov 2019, In : Chemistry: a European journal. 25, 65, p. 14999-15003 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Three-Dimensional Mass Spectrometry Imaging Identifies Lipid Markers of Medulloblastoma Metastasis

Paine, M. R. L., Liu, J., Huang, D., Ellis, S. R., Trede, D., Kobarg, J. H., Heeren, R. M. A., Fernandez, F. M. & MacDonald, T. J., 18 Feb 2019, In : Scientific Reports. 9, p. 1-10 10 p., 2205.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Trends in mass spectrometry imaging for cardiovascular diseases

Mezger, S. T. P., Mingels, A. M. A., Bekers, O., Cillero-Pastor, B. & Heeren, R. M. A., Jul 2019, In : Analytical and Bioanalytical Chemistry. 411, 17, p. 3709-3720 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

Adduct-ion formation in trapped ion mobility spectrometry as a potential tool for studying molecular structures and conformations

Zietek, B. M., Mengerink, Y., Jordens, J., Somsen, G. W., Kool, J. & Honing, M., Jun 2018, In : International Journal for Ion Mobility Spectrometry. 21, 1-2, p. 19-32 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Automated, parallel mass spectrometry imaging and structural identification of lipids

Ellis, S. R., Paine, M. R. L., Eijkel, G. B., Pauling, J. K., Husen, P., Jervelund, M. W., Hermansson, M., Ejsing, C. S. & Heeren, R. M. A., Jul 2018, In : Nature Methods. 15, 7, p. 515–518 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Cross-Species Molecular Imaging of Bile Salts and Lipids in Liver: Identification of Molecular Structural Markers in Health and Disease

Flinders, B., Huizing, L. R. S., van Heerden, M., Cuyckens, F., Neumann, U. P., van der Laan, L. J. W., Damink, S. W. M. O., Heeren, R. M. A., Schaap, F. G. & Vreeken, R. J., 16 Oct 2018, In : Analytical Chemistry. 90, 20, p. 11835-11846 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Digestion-Free Analysis of Peptides from 30-year-old Formalin-Fixed, Paraffin-Embedded Tissue by Mass Spectrometry Imaging

Paine, M. R. L., Ellis, S. R., Maloney, D., Heeren, R. M. A. & Verhaert, P. D. E. M., 7 Aug 2018, In : Analytical Chemistry. 90, 15, p. 9272-9280 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Evaluation of Thin-Layer Chromatography-Laser Desorption Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometric Imaging for Visualization of Crude Oil Interactions

Zahraei, A., Arisz, P. W. F., van Bawl, A. P. & Heeren, R. M. A., Jul 2018, In : Energy & Fuels. 32, 7, p. 7347-7357 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Identification and High-Resolution Imaging of alpha-Tocopherol from Human Cells to Whole Animals by TOF-SIMS Tandem Mass Spectrometry

Bruinen, A. L., Fisher, G. L., Balez, R., van der Sar, A. M., Ooi, L. & Heeren, R. M. A., Aug 2018, In : Journal of the American Society for Mass Spectrometry. 29, 8, p. 1571-1581 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Ionisation efficiencies can be predicted in complicated biological matrices: A proof of concept

Liigand, P., Liigand, J., Cuyckens, F., Vreeken, R. J. & Kruve, A., 22 Nov 2018, In : Analytica Chimica Acta. 1032, p. 68-74 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Lipid surface modifications increase mesoporous silica nanoparticle labeling properties in mesenchymal stem cells

Rosenbrand, R., Barata, D., Sutthavas, P., Mohren, R., Cillero-Pastor, B., Habibovic, P. & van Rijt, S., 2018, In : International Journal of Nanomedicine. 13, p. 7711-7725 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Mass Spectrometry Imaging with Isomeric Resolution Enabled by Ozone-Induced Dissociation

Paine, M. R. L., Poad, B. L. J., Eijkel, G. B., Marshall, D. L., Blanksby, S. J., Heeren, R. M. A. & Ellis, S. R., 13 Aug 2018, In : Angewandte Chemie-International Edition. 57, 33, p. 10530-10534 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

NF-kappa B-mediated metabolic remodelling in the inflamed heart in acute viral myocarditis

Remels, A. H. V., Derks, W. J. A., Cillero-Pastor, B., Verhees, K. J. P., Kelders, M. C., Heggermont, W., Carai, P., Summer, G., Ellis, S. R., de Theije, C. C., Heeren, R. M. A., Heymans, S., Papageorgiou, A. P. & van Bilsen, M., Aug 2018, In : Biochimica et Biophysica Acta-Molecular Basis of Disease. 1864, 8, p. 2579-2589 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Quality-In(Process)Line (QuIProLi) process intensification for a micro-flow UV-photo synthesis enabled by online UHPLC analysis

Escriba-Gelonch, M., Shahbazali, E., Honing, M. & Hessel, V., 21 Jun 2018, In : Tetrahedron. 74, 25, p. 3143-3151 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Robotic Surface Analysis Mass Spectrometry (RoSA-MS) of Three-Dimensional Objects

Li, A., Paine, M. R. L., Zambrzycki, S., Stryffeler, R. B., Wu, J., Bouza, M., Huckaby, J., Chang, C-Y., Kumar, M., Mukhija, P. & Fernandez, F. M., 20 Mar 2018, In : Analytical Chemistry. 90, 6, p. 3981-3986 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Round robin study of formalin-fixed paraffin-embedded tissues in mass spectrometry imaging

Buck, A., Heijs, B., Beine, B., Schepers, J., Cassese, A., Heeren, R. M. A., McDonnell, L. A., Henkel, C., Walch, A. & Balluff, B., Sep 2018, In : Analytical and Bioanalytical Chemistry. 410, 23, p. 5969–5980 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Simultaneous lipidomic and transcriptomic profiling in mouse brain punches of acute epileptic seizure model compared to controls

Lerner, R., Post, J. M., Ellis, S. R., Vos, D. R. N., Heeren, R. M. A., Lutz, B. & Bindila, L., Feb 2018, In : Journal of Lipid Research. 59, 2, p. 283-297 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Solvent effects on differentiation of mouse brain tissue using laser microdissection 'cut and drop' sampling with direct mass spectral analysis

Cahill, J. F., Kertesz, V., Porta, T., LeBlanc, J. C. Y., Heeren, R. M. A. & Van Berkel, G. J., 15 Mar 2018, In : Rapid Communications in Mass Spectrometry. 32, 5, p. 414-422 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Spatial Systems Lipidomics Reveals Nonalcoholic Fatty Liver Disease Heterogeneity

Scupakova, K., Soons, Z., Ertaylan, G., Pierzchalski, K. A., Eijkel, G. B., Ellis, S. R., Greve, J. W., Driessen, A., Verheij, J., De Kok, T. M., Damink, S. W. M. O., Rensen, S. S. & Heeren, R. M. A., 17 Apr 2018, In : Analytical Chemistry. 90, 8, p. 5130-5138 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Specific Lipid and Metabolic Profiles of R-CHOP-Resistant Diffuse Large B-Cell Lymphoma Elucidated by Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Imaging and in Vivo Imaging

Barre, F. P. Y., Claes, B. S. R., Dewez, F., Peutz-Kootstra, C., Munch-Petersen, H. F., Gronbaek, K., Lund, A. H., Heeren, R. M. A., Come, C. & Cillero-Pastor, B., 18 Dec 2018, In : Analytical Chemistry. 90, 24, p. 14198-14206 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Targeted Drug and Metabolite Imaging: Desorption Electrospray Ionization Combined with Triple Quadrupole Mass Spectrometry

Lamont, L., Eijkel, G. B., Jones, E. A., Flinders, B., Ellis, S. R., Porta Siegel, T., Heeren, R. M. A. & Vreeken, R. J., 20 Nov 2018, In : Analytical Chemistry. 90, 22, p. 13229-13235 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The deep-subsurface sulfate reducer Desulfotomaculum kuznetsovii employs two methanol-degrading pathways

Sousa, D. Z., Visser, M., van Gelder, A. H., Boeren, S., Pieterse, M. M., Pinkse, M. W. H., Verhaert, P. D. E. M., Vogt, C., Franke, S., Kummel, S. & Stams, A. J. M., 16 Jan 2018, In : Nature Communications. 9, 9 p., 239.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Tumor classification with MALDI-MSI data of tissue microarrays: A case study

Mascini, N. E., Teunissen, J., Noorlag, R., Willems, S. M. & Heeren, R. M. A., 1 Dec 2018, In : Methods. 151, p. 21-27 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Understanding Detrimental and Beneficial Grain Boundary Effects in Halide Perovskites

Adhyaksa, G. W. P., Brittman, S., Abolins, H., Lof, A., Li, X., Keelor, J. D., Luo, Y., Duevski, T., Heeren, R. M. A., Ellis, S. R., Fenning, D. P. & Garnett, E. C., 27 Dec 2018, In : Advanced Materials. 30, 52, 9 p., 1804792.

Research output: Contribution to journalArticleAcademicpeer-review

2017

An experimental guideline for the analysis of histologically heterogeneous tumors by MALDI-TOF mass spectrometry imaging

Lou, S., Balluff, B., Cleven, A. H. G., Bovee, J. V. M. G. & McDonnell, L. A., Jul 2017, In : Biochimica et Biophysica Acta-Proteins and Proteomics. 1865, 7, p. 957-966 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Combining Time-of-Flight Secondary Ion Mass Spectrometry Imaging Mass Spectrometry and CARS Microspectroscopy Reveals Lipid Patterns Reminiscent of Gene Expression Patterns in the Wing Imaginal Disc of Drosophila melanogaster

Marty, F., Rago, G., Smith, D. F., Gao, X., Eijkel, G. B., MacAleese, L., Bonn, M., Brunner, E., Basler, K. & Heeren, R. M. A., 19 Sep 2017, In : Analytical Chemistry. 89, 18, p. 9664-9670 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access