Abstract
Objectives. To prospectively investigate whether hip shape variants at baseline are associated with the need for future total hip replacement ( THR) in women and to validate the resulting associated shape variants of the Cohort Hip and Cohort Knee ( CHECK) cohort and the Chingford cohort. Methods. Female participants from the CHECK cohort without radiographic OA ( Kellgren - Lawrence score <2) at baseline were included ( 1100 hips); 22 hips had a THR within 5 years of follow- up. For the Chingford cohort, with only female participants, hips without radiographic OA at baseline were selected and a nested case - control design was used, with 19 THR cases within 19 years of follow- up and 95 controls matched 5 to 1 for age and BMI. Hip shape on baseline anteroposterior pelvic radiographs was assessed by statistical shape modelling ( SSM) using the same model for both cohorts. Results. In the CHECK and Chingford cohorts, the respective mean age was 55.8 ( S. D. 5.1) and 53.6 ( S. D. 5.4) and the BMI was 26.14 ( S. D. 4.3) and 25.7 ( S. D. 3.3), respectively. Multiple shape variants of the hip were significantly ( P<0.05) associated with future THR in both the CHECK ( modes 4, 11, 15, 17 and 22) and Chingford ( modes 2 and 17) cohorts. Mode 17 [ odds ratio ( OR) 0.51 ( 95% CI 0.33, 0.80) in the CHECK cohort], representing a flattened head - neck junction and flat greater trochanter, could be confirmed in the Chingford cohort [ OR 0.41 ( 95% CI 0.23, 0.82)]. Modes 4 and 15 of the CHECK cohort also showed non- significant trends in the Chingford cohort. Conclusion. Several baseline shape variants are associated with the future need for THR within a cohort. Despite differences in participant characteristics, radiographic protocol and follow- up time, we could validate at least one shape variant, suggesting that SSM is reasonably transferable between cohorts.
Original language | English |
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Pages (from-to) | 2033-2041 |
Number of pages | 9 |
Journal | Rheumatology |
Volume | 54 |
Issue number | 11 |
DOIs | |
Publication status | Published - Nov 2015 |
Keywords
- hip shape
- morphology
- osteoarthritis
- total hip replacement
- validation
- radiography
- epidemiology
- statistical shape modelling
- active shape modelling
- NATIONWIDE PROSPECTIVE COHORT
- MALE SOCCER PLAYERS
- CAM-TYPE DEFORMITY
- ACETABULAR DYSPLASIA
- PROXIMAL FEMUR
- IMPINGEMENT
- RISK
- ASSOCIATION
- BURDEN
- CHECK