The Choroidal Vascularity Index Decreases and Choroidal Thickness Increases in Vogt-Koyanagi-Harada Disease Patients During a Recurrent Anterior Uveitis Attack

Shulin Liu; Liping Du; Qingyun Zhou; Qi Zhang; Ke Hu; Jian Qi; Liang Liang; Chunjiang Zhou; Aize Kijlstra; Peizeng Yang

doi:10.1080/09273948.2017.1343357

The Choroidal Vascularity Index Decreases and Choroidal Thickness Increases in Vogt-Koyanagi-Harada Disease Patients During a Recurrent Anterior Uveitis Attack

Shulin Liu, Liping Du, Qingyun Zhou, Qi Zhang, Ke Hu, Jian Qi, Liang Liang, Chunjiang Zhou, Aize Kijlstra, Peizeng Yang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Purpose: To measure changes in the choroidal vascularity index (CVI) in chronic Vogt-Koyanagi-Harada (VKH) disease during a recurrent anterior uveitis attack.

Methods: Forty VKH patients and 40 normal controls were included in this study. Choroidal images were recorded before and during a recurrent anterior uveitis attack, as well as after appropriate treatment. CVI was measured by the binarization technique using ImageJ software (Bethesda, MD).

Results: The CVI was 0.75 +/- 0.09 in quiescent VKH patients, which was significantly higher compared to healthy controls (0.70 +/- 0.05, p <0.0001). The CVI significantly decreased to 0.72 +/- 0.09 when granulomatous anterior uveitis appeared in these patients. However, it returned to 0.75 +/- 0.08 after uveitis resolved.

Conclusions: A significant decrease of the CVI occurred during recurrent anterior uveitis in chronic VKH. CVI may provide a novel parameter to guide the treatment of VKH disease.

Original language	English
Pages (from-to)	1237-1243
Number of pages	7
Journal	Ocular Immunology and Inflammation
Volume	26
Issue number	8
DOIs	https://doi.org/10.1080/09273948.2017.1343357
Publication status	Published - 17 Nov 2018

Keywords

Binarized image
choroidal thickness
choroidal vascularity index
enhanced depth imaging optical coherence tomography
Vogt-Koyanagi-Harada disease
OPTICAL COHERENCE TOMOGRAPHY
AXIAL LENGTH
CLINICAL CHARACTERISTICS
INTRAOCULAR-PRESSURE
DIURNAL RHYTHMS
GROWTH
EYES
BINARIZATION
THERAPY

Access to Document

10.1080/09273948.2017.1343357

Cite this

@article{998796fbe22f496e947db4e97e7abb5b,

title = "The Choroidal Vascularity Index Decreases and Choroidal Thickness Increases in Vogt-Koyanagi-Harada Disease Patients During a Recurrent Anterior Uveitis Attack",

abstract = "Purpose: To measure changes in the choroidal vascularity index (CVI) in chronic Vogt-Koyanagi-Harada (VKH) disease during a recurrent anterior uveitis attack.Methods: Forty VKH patients and 40 normal controls were included in this study. Choroidal images were recorded before and during a recurrent anterior uveitis attack, as well as after appropriate treatment. CVI was measured by the binarization technique using ImageJ software (Bethesda, MD).Results: The CVI was 0.75 +/- 0.09 in quiescent VKH patients, which was significantly higher compared to healthy controls (0.70 +/- 0.05, p <0.0001). The CVI significantly decreased to 0.72 +/- 0.09 when granulomatous anterior uveitis appeared in these patients. However, it returned to 0.75 +/- 0.08 after uveitis resolved.Conclusions: A significant decrease of the CVI occurred during recurrent anterior uveitis in chronic VKH. CVI may provide a novel parameter to guide the treatment of VKH disease.",

keywords = "Binarized image, choroidal thickness, choroidal vascularity index, enhanced depth imaging optical coherence tomography, Vogt-Koyanagi-Harada disease, OPTICAL COHERENCE TOMOGRAPHY, AXIAL LENGTH, CLINICAL CHARACTERISTICS, INTRAOCULAR-PRESSURE, DIURNAL RHYTHMS, GROWTH, EYES, BINARIZATION, THERAPY",

author = "Shulin Liu and Liping Du and Qingyun Zhou and Qi Zhang and Ke Hu and Jian Qi and Liang Liang and Chunjiang Zhou and Aize Kijlstra and Peizeng Yang",

year = "2018",

month = nov,

day = "17",

doi = "10.1080/09273948.2017.1343357",

language = "English",

volume = "26",

pages = "1237--1243",

journal = "Ocular Immunology and Inflammation",

issn = "0927-3948",

publisher = "Routledge/Taylor & Francis Group",

number = "8",

}

Liu, S, Du, L, Zhou, Q, Zhang, Q, Hu, K, Qi, J, Liang, L, Zhou, C, Kijlstra, A & Yang, P 2018, 'The Choroidal Vascularity Index Decreases and Choroidal Thickness Increases in Vogt-Koyanagi-Harada Disease Patients During a Recurrent Anterior Uveitis Attack', Ocular Immunology and Inflammation, vol. 26, no. 8, pp. 1237-1243. https://doi.org/10.1080/09273948.2017.1343357

The Choroidal Vascularity Index Decreases and Choroidal Thickness Increases in Vogt-Koyanagi-Harada Disease Patients During a Recurrent Anterior Uveitis Attack. / Liu, Shulin; Du, Liping; Zhou, Qingyun et al.
In: Ocular Immunology and Inflammation, Vol. 26, No. 8, 17.11.2018, p. 1237-1243.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - The Choroidal Vascularity Index Decreases and Choroidal Thickness Increases in Vogt-Koyanagi-Harada Disease Patients During a Recurrent Anterior Uveitis Attack

AU - Liu, Shulin

AU - Du, Liping

AU - Zhou, Qingyun

AU - Zhang, Qi

AU - Hu, Ke

AU - Qi, Jian

AU - Liang, Liang

AU - Zhou, Chunjiang

AU - Kijlstra, Aize

AU - Yang, Peizeng

PY - 2018/11/17

Y1 - 2018/11/17

N2 - Purpose: To measure changes in the choroidal vascularity index (CVI) in chronic Vogt-Koyanagi-Harada (VKH) disease during a recurrent anterior uveitis attack.Methods: Forty VKH patients and 40 normal controls were included in this study. Choroidal images were recorded before and during a recurrent anterior uveitis attack, as well as after appropriate treatment. CVI was measured by the binarization technique using ImageJ software (Bethesda, MD).Results: The CVI was 0.75 +/- 0.09 in quiescent VKH patients, which was significantly higher compared to healthy controls (0.70 +/- 0.05, p <0.0001). The CVI significantly decreased to 0.72 +/- 0.09 when granulomatous anterior uveitis appeared in these patients. However, it returned to 0.75 +/- 0.08 after uveitis resolved.Conclusions: A significant decrease of the CVI occurred during recurrent anterior uveitis in chronic VKH. CVI may provide a novel parameter to guide the treatment of VKH disease.

AB - Purpose: To measure changes in the choroidal vascularity index (CVI) in chronic Vogt-Koyanagi-Harada (VKH) disease during a recurrent anterior uveitis attack.Methods: Forty VKH patients and 40 normal controls were included in this study. Choroidal images were recorded before and during a recurrent anterior uveitis attack, as well as after appropriate treatment. CVI was measured by the binarization technique using ImageJ software (Bethesda, MD).Results: The CVI was 0.75 +/- 0.09 in quiescent VKH patients, which was significantly higher compared to healthy controls (0.70 +/- 0.05, p <0.0001). The CVI significantly decreased to 0.72 +/- 0.09 when granulomatous anterior uveitis appeared in these patients. However, it returned to 0.75 +/- 0.08 after uveitis resolved.Conclusions: A significant decrease of the CVI occurred during recurrent anterior uveitis in chronic VKH. CVI may provide a novel parameter to guide the treatment of VKH disease.

KW - Binarized image

KW - choroidal thickness

KW - choroidal vascularity index

KW - enhanced depth imaging optical coherence tomography

KW - Vogt-Koyanagi-Harada disease

KW - OPTICAL COHERENCE TOMOGRAPHY

KW - AXIAL LENGTH

KW - CLINICAL CHARACTERISTICS

KW - INTRAOCULAR-PRESSURE

KW - DIURNAL RHYTHMS

KW - GROWTH

KW - EYES

KW - BINARIZATION

KW - THERAPY

U2 - 10.1080/09273948.2017.1343357

DO - 10.1080/09273948.2017.1343357

M3 - Article

C2 - 28914578

SN - 0927-3948

VL - 26

SP - 1237

EP - 1243

JO - Ocular Immunology and Inflammation

JF - Ocular Immunology and Inflammation

IS - 8

ER -