The Choroidal Vascularity Index Decreases and Choroidal Thickness Increases in Vogt-Koyanagi-Harada Disease Patients During a Recurrent Anterior Uveitis Attack

Shulin Liu, Liping Du, Qingyun Zhou, Qi Zhang, Ke Hu, Jian Qi, Liang Liang, Chunjiang Zhou, Aize Kijlstra, Peizeng Yang*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

21 Citations (Web of Science)

Abstract

Purpose: To measure changes in the choroidal vascularity index (CVI) in chronic Vogt-Koyanagi-Harada (VKH) disease during a recurrent anterior uveitis attack.

Methods: Forty VKH patients and 40 normal controls were included in this study. Choroidal images were recorded before and during a recurrent anterior uveitis attack, as well as after appropriate treatment. CVI was measured by the binarization technique using ImageJ software (Bethesda, MD).

Results: The CVI was 0.75 +/- 0.09 in quiescent VKH patients, which was significantly higher compared to healthy controls (0.70 +/- 0.05, p <0.0001). The CVI significantly decreased to 0.72 +/- 0.09 when granulomatous anterior uveitis appeared in these patients. However, it returned to 0.75 +/- 0.08 after uveitis resolved.

Conclusions: A significant decrease of the CVI occurred during recurrent anterior uveitis in chronic VKH. CVI may provide a novel parameter to guide the treatment of VKH disease.

Original languageEnglish
Pages (from-to)1237-1243
Number of pages7
JournalOcular Immunology and Inflammation
Volume26
Issue number8
DOIs
Publication statusPublished - 17 Nov 2018

Keywords

  • Binarized image
  • choroidal thickness
  • choroidal vascularity index
  • enhanced depth imaging optical coherence tomography
  • Vogt-Koyanagi-Harada disease
  • OPTICAL COHERENCE TOMOGRAPHY
  • AXIAL LENGTH
  • CLINICAL CHARACTERISTICS
  • INTRAOCULAR-PRESSURE
  • DIURNAL RHYTHMS
  • GROWTH
  • EYES
  • BINARIZATION
  • THERAPY

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