Systemic inflammation and skeletal muscle dysfunction in chronic obstructive pulmonary disease: state of the art and novel insights in regulation of muscle plasticity

A.H. Remels; H.R. Gosker; J.L. van der Velden; R.C. Langen; A.M. Schols

doi:10.1016/j.ccm.2007.06.003

Systemic inflammation and skeletal muscle dysfunction in chronic obstructive pulmonary disease: state of the art and novel insights in regulation of muscle plasticity

A.H. Remels, H.R. Gosker, J.L. van der Velden, R.C. Langen, A.M. Schols^*

^*Corresponding author for this work

NUTRIM School of Nutrition and Translational Research in Metabolism

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Systemic inflammation is a recognized hallmark of chronic obstructive pulmonary disease pathogenesis. Although the origin and mechanisms responsible for the persistent chronic inflammatory process remain to be elucidated, it is recognized that it plays an important role in skeletal muscle pathology as observed in chronic obstructive pulmonary disease and several other chronic inflammatory disorders. This article describes state-of-the-art knowledge and novel insights in the role of inflammatory processes on several aspects of inflammation-related skeletal muscle pathology and offers new insights in therapeutic perspectives. AD - Department of Respiratory Medicine, Nutrition and Toxicology Research Institute, University of Maastricht, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands.

Original language	English
Pages (from-to)	537-552
Journal	Clinics in Chest Medicine
Volume	28
Issue number	3
DOIs	https://doi.org/10.1016/j.ccm.2007.06.003
Publication status	Published - 1 Jan 2007

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10.1016/j.ccm.2007.06.003

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Cite this

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title = "Systemic inflammation and skeletal muscle dysfunction in chronic obstructive pulmonary disease: state of the art and novel insights in regulation of muscle plasticity",

abstract = "Systemic inflammation is a recognized hallmark of chronic obstructive pulmonary disease pathogenesis. Although the origin and mechanisms responsible for the persistent chronic inflammatory process remain to be elucidated, it is recognized that it plays an important role in skeletal muscle pathology as observed in chronic obstructive pulmonary disease and several other chronic inflammatory disorders. This article describes state-of-the-art knowledge and novel insights in the role of inflammatory processes on several aspects of inflammation-related skeletal muscle pathology and offers new insights in therapeutic perspectives. AD - Department of Respiratory Medicine, Nutrition and Toxicology Research Institute, University of Maastricht, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands.",

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Systemic inflammation and skeletal muscle dysfunction in chronic obstructive pulmonary disease: state of the art and novel insights in regulation of muscle plasticity. / Remels, A.H.; Gosker, H.R.; van der Velden, J.L. et al.
In: Clinics in Chest Medicine, Vol. 28, No. 3, 01.01.2007, p. 537-552.

Research output: Contribution to journal › Article › Academic › peer-review

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AU - Langen, R.C.

AU - Schols, A.M.

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AB - Systemic inflammation is a recognized hallmark of chronic obstructive pulmonary disease pathogenesis. Although the origin and mechanisms responsible for the persistent chronic inflammatory process remain to be elucidated, it is recognized that it plays an important role in skeletal muscle pathology as observed in chronic obstructive pulmonary disease and several other chronic inflammatory disorders. This article describes state-of-the-art knowledge and novel insights in the role of inflammatory processes on several aspects of inflammation-related skeletal muscle pathology and offers new insights in therapeutic perspectives. AD - Department of Respiratory Medicine, Nutrition and Toxicology Research Institute, University of Maastricht, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands.

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