Soluble receptors for tumor necrosis factor alpha (TNF-R p55 and TNF-R p75) in familial combined hyperlipidemia

M.M.J. van Greevenbroek; C.J.H. van der Kallen; J.M.W. Geurts; R.G.J.H. Janssen; W.A. Buurman; T.W.A. de Bruin

doi:10.1016/S0021-9150(00)00375-0

Soluble receptors for tumor necrosis factor alpha (TNF-R p55 and TNF-R p75) in familial combined hyperlipidemia

M.M.J. van Greevenbroek^*, C.J.H. van der Kallen, J.M.W. Geurts, R.G.J.H. Janssen, W.A. Buurman, T.W.A. de Bruin

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

We investigated the potential role of the 75 kD receptor for tumor necrosis factor-alpha (TNF-alpha) (TNFRSF1B, located on chromosome 1 band p36.2) as a modifier gene in familial combined hyperlipidemia (FCH), based on previous linkage and association data. Age-corrected values for the soluble (s) extracellular domain of TNF-R p75 were lower in 156 well-characterized hyperlipidemic (HL) FCH relatives than in 168 normolipidemic (NL) relatives (P ( 0.01). Plasma concentrations of the soluble domain of the 55 kD receptor (sTNF-R p55, the other TNF-alpha receptor) did not differ between HL and NL relatives. In conditional logistic regression analysis, plasma sTNF-R p75 concentration was the only non-lipid variable that contributed significantly to prediction of affected FCH status (regression coefficient = -0.413, P=0.01). The present findings have potentially important diagnostic and therapeutic implications in FCH.

Original language	English
Pages (from-to)	1-8
Number of pages	8
Journal	Atherosclerosis
Volume	153
Issue number	1
DOIs	https://doi.org/10.1016/S0021-9150(00)00375-0
Publication status	Published - 1 Jan 2000

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10.1016/S0021-9150(00)00375-0

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@article{bd5daa13947b47f2a2811ba1b7f8ba8e,

title = "Soluble receptors for tumor necrosis factor alpha (TNF-R p55 and TNF-R p75) in familial combined hyperlipidemia",

abstract = "We investigated the potential role of the 75 kD receptor for tumor necrosis factor-alpha (TNF-alpha) (TNFRSF1B, located on chromosome 1 band p36.2) as a modifier gene in familial combined hyperlipidemia (FCH), based on previous linkage and association data. Age-corrected values for the soluble (s) extracellular domain of TNF-R p75 were lower in 156 well-characterized hyperlipidemic (HL) FCH relatives than in 168 normolipidemic (NL) relatives (P ( 0.01). Plasma concentrations of the soluble domain of the 55 kD receptor (sTNF-R p55, the other TNF-alpha receptor) did not differ between HL and NL relatives. In conditional logistic regression analysis, plasma sTNF-R p75 concentration was the only non-lipid variable that contributed significantly to prediction of affected FCH status (regression coefficient = -0.413, P=0.01). The present findings have potentially important diagnostic and therapeutic implications in FCH. ",

author = "{van Greevenbroek}, M.M.J. and {van der Kallen}, C.J.H. and J.M.W. Geurts and R.G.J.H. Janssen and W.A. Buurman and {de Bruin}, T.W.A.",

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T1 - Soluble receptors for tumor necrosis factor alpha (TNF-R p55 and TNF-R p75) in familial combined hyperlipidemia

AU - van Greevenbroek, M.M.J.

AU - van der Kallen, C.J.H.

AU - Geurts, J.M.W.

AU - Janssen, R.G.J.H.

AU - Buurman, W.A.

AU - de Bruin, T.W.A.

PY - 2000/1/1

Y1 - 2000/1/1

N2 - We investigated the potential role of the 75 kD receptor for tumor necrosis factor-alpha (TNF-alpha) (TNFRSF1B, located on chromosome 1 band p36.2) as a modifier gene in familial combined hyperlipidemia (FCH), based on previous linkage and association data. Age-corrected values for the soluble (s) extracellular domain of TNF-R p75 were lower in 156 well-characterized hyperlipidemic (HL) FCH relatives than in 168 normolipidemic (NL) relatives (P ( 0.01). Plasma concentrations of the soluble domain of the 55 kD receptor (sTNF-R p55, the other TNF-alpha receptor) did not differ between HL and NL relatives. In conditional logistic regression analysis, plasma sTNF-R p75 concentration was the only non-lipid variable that contributed significantly to prediction of affected FCH status (regression coefficient = -0.413, P=0.01). The present findings have potentially important diagnostic and therapeutic implications in FCH.

AB - We investigated the potential role of the 75 kD receptor for tumor necrosis factor-alpha (TNF-alpha) (TNFRSF1B, located on chromosome 1 band p36.2) as a modifier gene in familial combined hyperlipidemia (FCH), based on previous linkage and association data. Age-corrected values for the soluble (s) extracellular domain of TNF-R p75 were lower in 156 well-characterized hyperlipidemic (HL) FCH relatives than in 168 normolipidemic (NL) relatives (P ( 0.01). Plasma concentrations of the soluble domain of the 55 kD receptor (sTNF-R p55, the other TNF-alpha receptor) did not differ between HL and NL relatives. In conditional logistic regression analysis, plasma sTNF-R p75 concentration was the only non-lipid variable that contributed significantly to prediction of affected FCH status (regression coefficient = -0.413, P=0.01). The present findings have potentially important diagnostic and therapeutic implications in FCH.

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DO - 10.1016/S0021-9150(00)00375-0

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