We investigated the potential role of the 75 kD receptor for tumor necrosis factor-alpha (TNF-alpha) (TNFRSF1B, located on chromosome 1 band p36.2) as a modifier gene in familial combined hyperlipidemia (FCH), based on previous linkage and association data. Age-corrected values for the soluble (s) extracellular domain of TNF-R p75 were lower in 156 well-characterized hyperlipidemic (HL) FCH relatives than in 168 normolipidemic (NL) relatives (P ( 0.01). Plasma concentrations of the soluble domain of the 55 kD receptor (sTNF-R p55, the other TNF-alpha receptor) did not differ between HL and NL relatives. In conditional logistic regression analysis, plasma sTNF-R p75 concentration was the only non-lipid variable that contributed significantly to prediction of affected FCH status (regression coefficient = -0.413, P=0.01). The present findings have potentially important diagnostic and therapeutic implications in FCH.
van Greevenbroek, M. M. J., van der Kallen, C. J. H., Geurts, J. M. W., Janssen, R. G. J. H., Buurman, W. A., & de Bruin, T. W. A. (2000). Soluble receptors for tumor necrosis factor alpha (TNF-R p55 and TNF-R p75) in familial combined hyperlipidemia. Atherosclerosis, 153(1), 1-8. https://doi.org/10.1016/S0021-9150(00)00375-0