Single nucleotide polymorphisms in immune response genes in acute Q fever cases with differences in self-reported symptoms

C.C.H. Wielders; V.H. Hackert; B. Schimmer; H.M. Hodemaekers; A. de Klerk; C.J.P.A. Hoebe; P.M. Schneeberger; Y.H.T.P. van Duynhoven; R. Janssen

doi:10.1007/s10096-014-2310-9

Single nucleotide polymorphisms in immune response genes in acute Q fever cases with differences in self-reported symptoms

C.C.H. Wielders^*, V.H. Hackert, B. Schimmer, H.M. Hodemaekers, A. de Klerk, C.J.P.A. Hoebe, P.M. Schneeberger, Y.H.T.P. van Duynhoven, R. Janssen

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Genes involved in human immune response are well recognized to influence the clinical course of infection. The association of host genetics with susceptibility to and severity of clinical symptoms in acute Q fever was investigated. Single nucleotide polymorphisms (SNPs) in the IFNG (rs2430561/rs1861493), STAT1 (rs1914408), and VDR (rs2228570) genes were determined in 85 patients from the 2007 Dutch acute Q fever outbreak, and a symptom score was calculated. IFNG rs1861493 showed a significant association with the symptom score; IFNG rs2430561 showed a similar trend. These SNPs were then used to reproduce results in a 2009 outbreak population (n = 123). The median symptom score differed significantly in both populations: 2 versus 7. The significant association of IFNG rs1861493 with symptom score in the first population was not reproduced in the second population. We hypothesize that individuals in the second outbreak were exposed to a higher Coxiella burnetii dose compared to the first, which overruled the protection conferred by the A-allele of IFNG rs1861493 in the first population.

Original language	English
Pages (from-to)	943-950
Number of pages	8
Journal	European Journal of Clinical Microbiology & Infectious Diseases
Volume	34
Issue number	5
DOIs	https://doi.org/10.1007/s10096-014-2310-9
Publication status	Published - May 2015

Keywords

RESPIRATORY SYNCYTIAL VIRUS
INTERFERON-GAMMA GENE
D-RECEPTOR GENE
COXIELLA-BURNETII
INFECTIOUS-DISEASES
FATIGUE SYNDROME
ASSOCIATION
TUBERCULOSIS
SUSCEPTIBILITY
NETHERLANDS

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Cite this

Wielders, C. C. H., Hackert, V. H., Schimmer, B., Hodemaekers, H. M., de Klerk, A., Hoebe, C. J. P. A., Schneeberger, P. M., van Duynhoven, Y. H. T. P., & Janssen, R. (2015). Single nucleotide polymorphisms in immune response genes in acute Q fever cases with differences in self-reported symptoms. European Journal of Clinical Microbiology & Infectious Diseases, 34(5), 943-950. https://doi.org/10.1007/s10096-014-2310-9

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abstract = "Genes involved in human immune response are well recognized to influence the clinical course of infection. The association of host genetics with susceptibility to and severity of clinical symptoms in acute Q fever was investigated. Single nucleotide polymorphisms (SNPs) in the IFNG (rs2430561/rs1861493), STAT1 (rs1914408), and VDR (rs2228570) genes were determined in 85 patients from the 2007 Dutch acute Q fever outbreak, and a symptom score was calculated. IFNG rs1861493 showed a significant association with the symptom score; IFNG rs2430561 showed a similar trend. These SNPs were then used to reproduce results in a 2009 outbreak population (n = 123). The median symptom score differed significantly in both populations: 2 versus 7. The significant association of IFNG rs1861493 with symptom score in the first population was not reproduced in the second population. We hypothesize that individuals in the second outbreak were exposed to a higher Coxiella burnetii dose compared to the first, which overruled the protection conferred by the A-allele of IFNG rs1861493 in the first population.",

keywords = "RESPIRATORY SYNCYTIAL VIRUS, INTERFERON-GAMMA GENE, D-RECEPTOR GENE, COXIELLA-BURNETII, INFECTIOUS-DISEASES, FATIGUE SYNDROME, ASSOCIATION, TUBERCULOSIS, SUSCEPTIBILITY, NETHERLANDS",

author = "C.C.H. Wielders and V.H. Hackert and B. Schimmer and H.M. Hodemaekers and {de Klerk}, A. and C.J.P.A. Hoebe and P.M. Schneeberger and {van Duynhoven}, Y.H.T.P. and R. Janssen",

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Wielders, CCH, Hackert, VH, Schimmer, B, Hodemaekers, HM, de Klerk, A, Hoebe, CJPA, Schneeberger, PM, van Duynhoven, YHTP & Janssen, R 2015, 'Single nucleotide polymorphisms in immune response genes in acute Q fever cases with differences in self-reported symptoms', European Journal of Clinical Microbiology & Infectious Diseases, vol. 34, no. 5, pp. 943-950. https://doi.org/10.1007/s10096-014-2310-9

TY - JOUR

T1 - Single nucleotide polymorphisms in immune response genes in acute Q fever cases with differences in self-reported symptoms

AU - Wielders, C.C.H.

AU - Hackert, V.H.

AU - Schimmer, B.

AU - Hodemaekers, H.M.

AU - de Klerk, A.

AU - Hoebe, C.J.P.A.

AU - Schneeberger, P.M.

AU - van Duynhoven, Y.H.T.P.

AU - Janssen, R.

PY - 2015/5

Y1 - 2015/5

N2 - Genes involved in human immune response are well recognized to influence the clinical course of infection. The association of host genetics with susceptibility to and severity of clinical symptoms in acute Q fever was investigated. Single nucleotide polymorphisms (SNPs) in the IFNG (rs2430561/rs1861493), STAT1 (rs1914408), and VDR (rs2228570) genes were determined in 85 patients from the 2007 Dutch acute Q fever outbreak, and a symptom score was calculated. IFNG rs1861493 showed a significant association with the symptom score; IFNG rs2430561 showed a similar trend. These SNPs were then used to reproduce results in a 2009 outbreak population (n = 123). The median symptom score differed significantly in both populations: 2 versus 7. The significant association of IFNG rs1861493 with symptom score in the first population was not reproduced in the second population. We hypothesize that individuals in the second outbreak were exposed to a higher Coxiella burnetii dose compared to the first, which overruled the protection conferred by the A-allele of IFNG rs1861493 in the first population.

AB - Genes involved in human immune response are well recognized to influence the clinical course of infection. The association of host genetics with susceptibility to and severity of clinical symptoms in acute Q fever was investigated. Single nucleotide polymorphisms (SNPs) in the IFNG (rs2430561/rs1861493), STAT1 (rs1914408), and VDR (rs2228570) genes were determined in 85 patients from the 2007 Dutch acute Q fever outbreak, and a symptom score was calculated. IFNG rs1861493 showed a significant association with the symptom score; IFNG rs2430561 showed a similar trend. These SNPs were then used to reproduce results in a 2009 outbreak population (n = 123). The median symptom score differed significantly in both populations: 2 versus 7. The significant association of IFNG rs1861493 with symptom score in the first population was not reproduced in the second population. We hypothesize that individuals in the second outbreak were exposed to a higher Coxiella burnetii dose compared to the first, which overruled the protection conferred by the A-allele of IFNG rs1861493 in the first population.

KW - RESPIRATORY SYNCYTIAL VIRUS

KW - INTERFERON-GAMMA GENE

KW - D-RECEPTOR GENE

KW - COXIELLA-BURNETII

KW - INFECTIOUS-DISEASES

KW - FATIGUE SYNDROME

KW - ASSOCIATION

KW - TUBERCULOSIS

KW - SUSCEPTIBILITY

KW - NETHERLANDS

U2 - 10.1007/s10096-014-2310-9

DO - 10.1007/s10096-014-2310-9

M3 - Article

SN - 0934-9723

VL - 34

SP - 943

EP - 950

JO - European Journal of Clinical Microbiology & Infectious Diseases

JF - European Journal of Clinical Microbiology & Infectious Diseases

IS - 5

ER -